IL91814A - Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation - Google Patents

Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation

Info

Publication number: IL91814A
Authority: IL; Israel
Prior art keywords: methyl; group; morpholino; pteridine; phenyl
Prior art date: 1988-10-01

Application number

IL9181489A

Other languages

English (en)

Other versions

IL91814A0 (en

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-01

Filing date

1989-09-28

Publication date

1994-02-27

1989-09-28 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1990-06-10 Publication of IL91814A0 publication Critical patent/IL91814A0/xx

1994-02-27 Publication of IL91814A publication Critical patent/IL91814A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL9181489A 1988-10-01 1989-09-28 Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation IL91814A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3833393A DE3833393A1 (de)	1988-10-01	1988-10-01	Verwendung von pteridinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number	Publication Date
IL91814A0 IL91814A0 (en)	1990-06-10
IL91814A true IL91814A (en)	1994-02-27

Family

ID=6364156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9181489A IL91814A (en)	1988-10-01	1989-09-28	Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation

Country Status (19)

Country	Link
EP (1)	EP0362645B1 (fr)
JP (1)	JPH02256676A (fr)
KR (1)	KR910006289A (fr)
AT (1)	ATE106728T1 (fr)
AU (1)	AU620645B2 (fr)
DD (1)	DD299062A5 (fr)
DE (2)	DE3833393A1 (fr)
DK (1)	DK480489A (fr)
ES (1)	ES2056174T3 (fr)
FI (1)	FI92699C (fr)
HU (1)	HU205761B (fr)
IL (1)	IL91814A (fr)
MX (1)	MX9203034A (fr)
NO (1)	NO175979C (fr)
NZ (1)	NZ230833A (fr)
PT (1)	PT91836B (fr)
SU (1)	SU1720491A3 (fr)
UA (1)	UA8028A1 (fr)
ZA (1)	ZA897414B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7276506B2 (en)	1998-12-28	2007-10-02	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
AU770551B2 (en) *	1998-12-28	2004-02-26	4-Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
DE10202468A1 (de) *	2002-01-23	2004-09-30	Faustus Forschungs Cie. Translational Cancer Research Gmbh	Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
DE602004008304T2 (de) *	2003-09-12	2008-05-08	4 Aza Ip Nv	Pteridin-derivate zur behandlung von erkrankungen im zusammenhang mit tnf-alpha
EP1673092B1 (fr) *	2003-10-17	2007-08-15	4 Aza Ip Nv	Derives de pteridine substitues par des heterocycles et leur utilisation a des fins therapeutiques
RU2447074C2 (ru) *	2005-05-12	2012-04-10	Тиботек Фармасьютикалз Лтд.	Птеридины, полезные в качестве ингибиторов hcv, и способы получения птеридинов
WO2008009078A2 (fr)	2006-07-20	2008-01-24	Gilead Sciences, Inc.	Dérivés de la quinazoline tri-substitués en 4,6-dl et en 2,4,6 utilisables pour traiter les infections virales
US10144736B2 (en)	2006-07-20	2018-12-04	Gilead Sciences, Inc.	Substituted pteridines useful for the treatment and prevention of viral infections
PL3321265T3 (pl)	2015-03-04	2020-11-16	Gilead Sciences, Inc.	Związki 4,6-diamino-pirydo[3,2-d]pirymidynowe i ich wykorzystanie jako modulatorów receptorów toll-podobnych
KR20160003575A (ko)	2015-11-09	2016-01-11	정민시	발전기용 동력전달장치
EP3507288B1 (fr)	2016-09-02	2020-08-26	Gilead Sciences, Inc.	Dérivés de 4,6-diamino-pyrido[3,2-d]pyrimidine en tant que modulateurs du recepteur de type toll
CA3035346A1 (fr)	2016-09-02	2018-03-08	Gilead Sciences, Inc.	Composes modulateurs du recepteur de type toll
TW202210480A (zh)	2019-04-17	2022-03-16	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TW202212339A (zh)	2019-04-17	2022-04-01	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TWI879779B (zh)	2019-06-28	2025-04-11	美商基利科學股份有限公司	類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3574206A (en) *	1965-04-15	1971-04-06	Boehringer Sohn Ingelheim	2,7-dimorpholino-4-amino-6-phenyl-pteridines
NL129630C (fr) *	1966-10-14
DE1617336C2 (de) *	1966-11-25	1982-07-01	C.H. Boehringer Sohn, 6507 Ingelheim	Arzneimittel gegen Angina pectoris
DE1795515A1 (de) *	1967-08-18	1972-03-30	Thomae Gmbh Dr K	Verfahren zur Herstellung von neuen Pteridinen
DE1795516A1 (de) *	1967-12-15	1972-01-27	Thomae Gmbh Dr K	4-AEthanolisopropanolamino-2-(2'-methylmorpholino)-7-morpholino-6-phenyl-pteridin
DE1921308A1 (de) *	1969-04-25	1971-01-07	Boehringer Sohn Ingelheim	Herzwirksame Zubereitungen
US4767761A (en) *	1987-11-04	1988-08-30	Dana-Farber Cancer Institute, Inc.	Ornithine derivatives and their use as methotrexate-resistant cell inhibitors

1988
- 1988-10-01 DE DE3833393A patent/DE3833393A1/de not_active Withdrawn
1989
- 1989-09-23 AT AT89117610T patent/ATE106728T1/de not_active IP Right Cessation
- 1989-09-23 ES ES89117610T patent/ES2056174T3/es not_active Expired - Lifetime
- 1989-09-23 DE DE58907824T patent/DE58907824D1/de not_active Expired - Fee Related
- 1989-09-23 EP EP89117610A patent/EP0362645B1/fr not_active Expired - Lifetime
- 1989-09-26 AU AU41749/89A patent/AU620645B2/en not_active Ceased
- 1989-09-28 PT PT91836A patent/PT91836B/pt not_active IP Right Cessation
- 1989-09-28 IL IL9181489A patent/IL91814A/en not_active IP Right Cessation
- 1989-09-29 KR KR1019890014002A patent/KR910006289A/ko not_active Ceased
- 1989-09-29 NO NO893879A patent/NO175979C/no unknown
- 1989-09-29 FI FI894615A patent/FI92699C/fi not_active IP Right Cessation
- 1989-09-29 UA UA4742036A patent/UA8028A1/uk unknown
- 1989-09-29 DD DD89333128A patent/DD299062A5/de not_active IP Right Cessation
- 1989-09-29 ZA ZA897414A patent/ZA897414B/xx unknown
- 1989-09-29 DK DK480489A patent/DK480489A/da not_active Application Discontinuation
- 1989-09-29 NZ NZ230833A patent/NZ230833A/en unknown
- 1989-09-29 JP JP1255126A patent/JPH02256676A/ja active Pending
- 1989-09-29 SU SU894742036A patent/SU1720491A3/ru active
- 1989-09-29 HU HU895131A patent/HU205761B/hu not_active IP Right Cessation
1992
- 1992-06-19 MX MX9203034A patent/MX9203034A/es unknown

Also Published As

Publication number	Publication date
FI894615A0 (fi)	1989-09-29
SU1720491A3 (ru)	1992-03-15
UA8028A1 (uk)	1995-12-26
ZA897414B (en)	1991-06-26
DK480489D0 (da)	1989-09-29
FI92699B (fi)	1994-09-15
PT91836A (pt)	1990-04-30
DD299062A5 (de)	1992-03-26
AU4174989A (en)	1990-04-05
ES2056174T3 (es)	1994-10-01
PT91836B (pt)	1995-07-18
HU205761B (en)	1992-06-29
ATE106728T1 (de)	1994-06-15
DE3833393A1 (de)	1990-04-05
IL91814A0 (en)	1990-06-10
FI92699C (fi)	1994-12-27
EP0362645A3 (fr)	1992-03-25
NO175979B (no)	1994-10-03
NO893879D0 (no)	1989-09-29
AU620645B2 (en)	1992-02-20
JPH02256676A (ja)	1990-10-17
HUT52504A (en)	1990-07-28
NZ230833A (en)	1991-05-28
FI894615A7 (fi)	1990-04-02
NO175979C (no)	1995-01-11
NO893879L (no)	1990-04-02
KR910006289A (ko)	1991-04-29
DE58907824D1 (de)	1994-07-14
EP0362645A2 (fr)	1990-04-11
DK480489A (da)	1990-04-02
MX9203034A (es)	1992-07-01
EP0362645B1 (fr)	1994-06-08

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IL91814A (en)	1994-02-27	Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation
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Legal Events

Date	Code	Title	Description
1996-07-23	RH	Patent void