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UA8028A1 - Спосіб отримання похідних птерідіна - Google Patents

Спосіб отримання похідних птерідіна

Info

Publication number
UA8028A1
UA8028A1 UA4742036A UA4742036A UA8028A1 UA 8028 A1 UA8028 A1 UA 8028A1 UA 4742036 A UA4742036 A UA 4742036A UA 4742036 A UA4742036 A UA 4742036A UA 8028 A1 UA8028 A1 UA 8028A1
Authority
UA
Ukraine
Prior art keywords
obtaining
pteridine derivatives
methyl
isopropanolamino
ethanolamino
Prior art date
Application number
UA4742036A
Other languages
English (en)
Russian (ru)
Inventor
Хекель Армін
Лебзанфт Єрг
Бамбергер Уве
Раму Авнер
Original Assignee
"Др.Карл Томе Гмбх"
"Др. Карл Томе Гмбх"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "Др.Карл Томе Гмбх", "Др. Карл Томе Гмбх" filed Critical "Др.Карл Томе Гмбх"
Publication of UA8028A1 publication Critical patent/UA8028A1/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Спосіб отримання похідних птеридину загальної формули де R и R3 – заміщена в положенні 2 або в положеннях 2 і 6 метилом морфоліногрупа; R1 і R2 разом з атомом азоту між ними утворюють N-етил-етаноламіно, N-етил-ізопропаноламіно, етанол-ізопропаноламіно, N-(2-окси-2-метил-н-пропіл)-етаноламіно; R4 – водень або метил; n = 0 або 1.
UA4742036A 1988-10-01 1989-09-29 Спосіб отримання похідних птерідіна UA8028A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3833393A DE3833393A1 (de) 1988-10-01 1988-10-01 Verwendung von pteridinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
UA8028A1 true UA8028A1 (uk) 1995-12-26

Family

ID=6364156

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4742036A UA8028A1 (uk) 1988-10-01 1989-09-29 Спосіб отримання похідних птерідіна

Country Status (19)

Country Link
EP (1) EP0362645B1 (uk)
JP (1) JPH02256676A (uk)
KR (1) KR910006289A (uk)
AT (1) ATE106728T1 (uk)
AU (1) AU620645B2 (uk)
DD (1) DD299062A5 (uk)
DE (2) DE3833393A1 (uk)
DK (1) DK480489A (uk)
ES (1) ES2056174T3 (uk)
FI (1) FI92699C (uk)
HU (1) HU205761B (uk)
IL (1) IL91814A (uk)
MX (1) MX9203034A (uk)
NO (1) NO175979C (uk)
NZ (1) NZ230833A (uk)
PT (1) PT91836B (uk)
SU (1) SU1720491A3 (uk)
UA (1) UA8028A1 (uk)
ZA (1) ZA897414B (uk)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
ATE277929T1 (de) * 1998-12-28 2004-10-15 4 Aza Bioscience Nv Immunsuppressive wirkungen von pteridinderivaten
DE10202468A1 (de) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
JP2007533617A (ja) * 2003-09-12 2007-11-22 ４・アー・ゼット・アー・バイオサイエンス・ナムローゼ・フエンノートシャップ 敗血性ショックおよびＴＮＦ−α−関連疾病の処置のためのプテリジン誘導体
DK1673092T3 (da) * 2003-10-17 2007-12-17 4 Aza Ip Nv Heterocyklylsubstituerede pteridinderivater og anvendelsen deraf i terapi
RU2447074C2 (ru) * 2005-05-12 2012-04-10 Тиботек Фармасьютикалз Лтд. Птеридины, полезные в качестве ингибиторов hcv, и способы получения птеридинов
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
HUE038059T2 (hu) 2015-03-04 2018-10-29 Gilead Sciences Inc Toll-like receptor moduláló 4,6-diamino-pirido[3,2-D]pirimidin vegyületek
KR20160003575A (ko) 2015-11-09 2016-01-11 정민시 발전기용 동력전달장치
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574206A (en) * 1965-04-15 1971-04-06 Boehringer Sohn Ingelheim 2,7-dimorpholino-4-amino-6-phenyl-pteridines
NL129630C (uk) * 1966-10-14
DE1617336C2 (de) * 1966-11-25 1982-07-01 C.H. Boehringer Sohn, 6507 Ingelheim Arzneimittel gegen Angina pectoris
DE1795515A1 (de) * 1967-08-18 1972-03-30 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Pteridinen
DE1795516A1 (de) * 1967-12-15 1972-01-27 Thomae Gmbh Dr K 4-AEthanolisopropanolamino-2-(2'-methylmorpholino)-7-morpholino-6-phenyl-pteridin
DE1921308A1 (de) * 1969-04-25 1971-01-07 Boehringer Sohn Ingelheim Herzwirksame Zubereitungen
US4767761A (en) * 1987-11-04 1988-08-30 Dana-Farber Cancer Institute, Inc. Ornithine derivatives and their use as methotrexate-resistant cell inhibitors

Also Published As

Publication number Publication date
MX9203034A (es) 1992-07-01
EP0362645A2 (de) 1990-04-11
NO893879D0 (no) 1989-09-29
EP0362645B1 (de) 1994-06-08
ZA897414B (en) 1991-06-26
NO175979C (no) 1995-01-11
NZ230833A (en) 1991-05-28
HUT52504A (en) 1990-07-28
AU620645B2 (en) 1992-02-20
DE3833393A1 (de) 1990-04-05
DE58907824D1 (de) 1994-07-14
DD299062A5 (de) 1992-03-26
JPH02256676A (ja) 1990-10-17
ES2056174T3 (es) 1994-10-01
IL91814A0 (en) 1990-06-10
EP0362645A3 (de) 1992-03-25
ATE106728T1 (de) 1994-06-15
DK480489D0 (da) 1989-09-29
DK480489A (da) 1990-04-02
PT91836B (pt) 1995-07-18
FI92699B (fi) 1994-09-15
PT91836A (pt) 1990-04-30
NO175979B (no) 1994-10-03
AU4174989A (en) 1990-04-05
NO893879L (no) 1990-04-02
SU1720491A3 (ru) 1992-03-15
IL91814A (en) 1994-02-27
FI894615A0 (fi) 1989-09-29
FI894615A7 (fi) 1990-04-02
HU205761B (en) 1992-06-29
FI92699C (fi) 1994-12-27
KR910006289A (ko) 1991-04-29

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