IL84309A - Esters of hexahydro-8-hydroxy-2,6-methano-2h-quino-lizin-3(4h)-one and related compounds,processes for their preparation and pharmaceutical compositions containing them - Google Patents

Esters of hexahydro-8-hydroxy-2,6-methano-2h-quino-lizin-3(4h)-one and related compounds,processes for their preparation and pharmaceutical compositions containing them

Info

Publication number: IL84309A
Authority: IL; Israel
Prior art keywords: lizin; quino; methano; hexahydro; hydroxy
Prior art date: 1986-11-03

Application number

IL84309A

Other languages

English (en)

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-03

Filing date

1987-10-29

Publication date

1991-09-16

1987-10-29 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-09-16 Publication of IL84309A publication Critical patent/IL84309A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL84309A 1986-11-03 1987-10-29 Esters of hexahydro-8-hydroxy-2,6-methano-2h-quino-lizin-3(4h)-one and related compounds,processes for their preparation and pharmaceutical compositions containing them IL84309A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92661986A	1986-11-03	1986-11-03

Publications (1)

Publication Number	Publication Date
IL84309A true IL84309A (en)	1991-09-16

Family

ID=25453460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL84309A IL84309A (en)	1986-11-03	1987-10-29	Esters of hexahydro-8-hydroxy-2,6-methano-2h-quino-lizin-3(4h)-one and related compounds,processes for their preparation and pharmaceutical compositions containing them

Country Status (21)

Country	Link
EP (1)	EP0266730B1 (xx)
JP (2)	JP2542225B2 (xx)
KR (1)	KR950011737B1 (xx)
CN (1)	CN1021654C (xx)
AR (1)	AR246264A1 (xx)
AT (1)	ATE109779T1 (xx)
AU (1)	AU600318B2 (xx)
CA (1)	CA1329203C (xx)
DE (2)	DE3750359T2 (xx)
DK (1)	DK171116B1 (xx)
ES (1)	ES2061469T3 (xx)
FI (1)	FI87786C (xx)
HU (1)	HU197008B (xx)
IE (1)	IE63670B1 (xx)
IL (1)	IL84309A (xx)
NL (1)	NL970043I2 (xx)
NO (2)	NO165922C (xx)
NZ (1)	NZ222349A (xx)
PH (2)	PH24664A (xx)
PT (1)	PT86060B (xx)
ZA (1)	ZA878096B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5011846A (en) *	1988-02-23	1991-04-30	Merrell Dow Pharmaceuticals Inc.	Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
EP0329905A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for increasing gastric motility
EP0329904A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of anxiety
EP0329903A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of glaucoma
EP0329902A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of psychosis
DE68924545T2 (de) *	1988-02-23	1996-03-21	Merrell Dow Pharma	Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln.
EP0330788A1 (en) *	1988-03-01	1989-09-06	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
ZA893008B (en) *	1988-04-29	1989-12-27	Merrell Dow Pharma	Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one
GB8928837D0 (en) *	1989-12-21	1990-02-28	Beecham Group Plc	Pharmaceuticals
EP0492020A1 (en) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
BR9813480A (pt) *	1997-12-17	2000-10-10	Biocryst Pharm Inc	Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza-
CN100390172C (zh) *	2004-09-10	2008-05-28	成都欣捷高新技术开发有限公司	一种甲磺酸多拉司琼晶型及其制备方法
WO2006056081A1 (de) *	2004-11-25	2006-06-01	Cilag Ltd.	Verfahren zur herstellung von estern von hexahydro-8-hydroxy-2,6-methano-2h-chinolizin-3(4h)-on
ES2264901B1 (es)	2005-07-06	2007-12-01	Inke, S.A.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
EP1904492B1 (en) *	2005-07-06	2008-10-15	Inke, S.A.	Method for obtaining the pharmaceutically active compound dolasetron, synthesis intermediates thereof and methods for obtaining them
EP1874767A2 (en) *	2006-01-05	2008-01-09	Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság	Production of dolasetron
EP2060557B1 (en)	2007-11-13	2012-06-06	Inke, S.A.	Intermediate compounds useful to prepare dolasetron
KR101779991B1 (ko)	2009-05-20	2017-09-19	인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)	병소성 전정 질환을 치료하기 위한 세로토닌 5-ｈｔ3 수용체 길항제의 용도
ES2432618T3 (es)	2009-05-20	2013-12-04	Inserm (Institut National De La Santé Et De La Recherche Medicale)	Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
US20180250270A1 (en)	2015-09-11	2018-09-06	Chase Pharmaceuticals Corporation	Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
CN108976230A (zh) *	2018-06-18	2018-12-11	东莞市联洲知识产权运营管理有限公司	一种基于石墨烯活化制备甲磺酸多拉司琼关键中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
DE3429830A1 (de) *	1983-08-26	1985-03-07	Sandoz-Patent-GmbH, 7850 Lörrach	Automatische carbonsaeure- und sulfonsaeureester oder -amide
ATE86110T1 (de) *	1984-12-20	1993-03-15	Sandoz Ag	Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.

1987
- 1987-10-28 ZA ZA878096A patent/ZA878096B/xx unknown
- 1987-10-29 CA CA000550612A patent/CA1329203C/en not_active Expired - Lifetime
- 1987-10-29 NZ NZ222349A patent/NZ222349A/xx unknown
- 1987-10-29 FI FI874768A patent/FI87786C/fi not_active IP Right Cessation
- 1987-10-29 IL IL84309A patent/IL84309A/xx not_active IP Right Cessation
- 1987-10-30 AR AR87309166A patent/AR246264A1/es active
- 1987-10-30 PH PH36006A patent/PH24664A/en unknown
- 1987-11-02 ES ES87116119T patent/ES2061469T3/es not_active Expired - Lifetime
- 1987-11-02 DE DE3750359T patent/DE3750359T2/de not_active Expired - Lifetime
- 1987-11-02 EP EP87116119A patent/EP0266730B1/en not_active Expired - Lifetime
- 1987-11-02 IE IE295587A patent/IE63670B1/en not_active IP Right Cessation
- 1987-11-02 DK DK572887A patent/DK171116B1/da not_active IP Right Cessation
- 1987-11-02 AT AT87116119T patent/ATE109779T1/de not_active IP Right Cessation
- 1987-11-02 CN CN87107629A patent/CN1021654C/zh not_active Expired - Lifetime
- 1987-11-02 AU AU80596/87A patent/AU600318B2/en not_active Expired
- 1987-11-02 HU HU874918A patent/HU197008B/hu unknown
- 1987-11-02 NO NO874550A patent/NO165922C/no not_active IP Right Cessation
- 1987-11-02 DE DE1997175092 patent/DE19775092I2/de active Active
- 1987-11-02 JP JP62275894A patent/JP2542225B2/ja not_active Expired - Lifetime
- 1987-11-02 PT PT86060A patent/PT86060B/pt unknown
- 1987-11-03 KR KR1019870012286A patent/KR950011737B1/ko not_active Expired - Lifetime
1990
- 1990-01-02 PH PH39830A patent/PH26261A/en unknown
1996
- 1996-02-27 JP JP8065408A patent/JP2657267B2/ja not_active Expired - Lifetime
1997
- 1997-12-17 NL NL970043C patent/NL970043I2/nl unknown
1999
- 1999-08-26 NO NO1999020C patent/NO1999020I1/no unknown

Also Published As

Publication number	Publication date
EP0266730A1 (en)	1988-05-11
JPH0977769A (ja)	1997-03-25
NO1999020I1 (no)	1999-08-26
KR950011737B1 (ko)	1995-10-09
EP0266730B1 (en)	1994-08-10
AR246264A1 (es)	1994-07-29
JP2542225B2 (ja)	1996-10-09
DE19775092I2 (de)	2001-11-22
FI87786C (fi)	1993-02-25
NL970043I1 (nl)	1998-03-02
FI87786B (fi)	1992-11-13
FI874768A0 (fi)	1987-10-29
PH26261A (en)	1992-04-01
DE3750359T2 (de)	1994-12-08
JP2657267B2 (ja)	1997-09-24
NO874550D0 (no)	1987-11-02
NL970043I2 (nl)	1998-10-01
JPS63258476A (ja)	1988-10-25
NO165922C (no)	1991-05-02
PH24664A (en)	1990-09-07
DE3750359D1 (de)	1994-09-15
AU600318B2 (en)	1990-08-09
CA1329203C (en)	1994-05-03
FI874768A7 (fi)	1988-05-04
CN87107629A (zh)	1988-06-15
HUT45055A (en)	1988-05-30
KR880006240A (ko)	1988-07-22
NO165922B (no)	1991-01-21
NO874550L (no)	1988-05-04
PT86060B (pt)	1990-07-31
HU197008B (en)	1989-02-28
DK572887A (da)	1988-05-04
PT86060A (en)	1987-12-01
IE63670B1 (en)	1995-05-31
IE872955L (en)	1988-05-03
DK572887D0 (da)	1987-11-02
DK171116B1 (da)	1996-06-17
AU8059687A (en)	1988-05-05
NZ222349A (en)	1990-05-28
CN1021654C (zh)	1993-07-21
ES2061469T3 (es)	1994-12-16
ATE109779T1 (de)	1994-08-15
ZA878096B (en)	1988-04-26

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Legal Events

Date	Code	Title	Description
1998-03-10	KB	Patent renewed
2002-02-10	KB	Patent renewed
2006-02-05	KB	Patent renewed
2006-09-05	HC	Change of name of proprietor(s)	Owner name: AVENTIS INC. Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.
2008-01-06	EXP	Patent expired