PT84860A - Process for the preparation of novel tetrahydronaphtalene derivatives and of pharmaceutical compositions containing the same - Google Patents

Process for the preparation of novel tetrahydronaphtalene derivatives and of pharmaceutical compositions containing the same

Info

Publication number: PT84860A
Authority: PT; Portugal
Prior art keywords: novel; preparation; same; pharmaceutical compositions; compositions containing
Prior art date: 1986-05-13

Application number

PT84860A

Other languages

Portuguese (pt)

Other versions

PT84860B (en

Inventor

Michael Klaus

Peter Loeliger

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-13

Filing date

1987-05-12

Publication date

1987-06-01

1986-05-13 Priority claimed from CH1938/86A external-priority patent/CH668962A5/en

1987-05-12 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1987-06-01 Publication of PT84860A publication Critical patent/PT84860A/en

1990-02-08 Publication of PT84860B publication Critical patent/PT84860B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

PT84860A 1986-05-13 1987-05-12 METHOD FOR PREPARING NEW TETRAHYDROFOLANTALEN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PT84860B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH1938/86A CH668962A5 (en)	1986-05-13	1986-05-13	New hydroxy:phenyl:propenyl substd. naphthalene cpds.
CH74287		1987-02-26

Publications (2)

Publication Number	Publication Date
PT84860A true PT84860A (en)	1987-06-01
PT84860B PT84860B (en)	1990-02-08

Family

ID=25685550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT84860A PT84860B (en)	1986-05-13	1987-05-12	METHOD FOR PREPARING NEW TETRAHYDROFOLANTALEN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (20)

Country	Link
CN (1)	CN87103524A (en)
AU (1)	AU7277987A (en)
BE (1)	BE1001668A5 (en)
DE (1)	DE3715809A1 (en)
DK (1)	DK232087A (en)
ES (1)	ES2005572A6 (en)
FI (1)	FI872027A7 (en)
FR (1)	FR2598706B1 (en)
GB (1)	GB2190378B (en)
HU (1)	HU198002B (en)
IL (1)	IL82448A0 (en)
IT (1)	IT1203954B (en)
LU (1)	LU86866A1 (en)
MC (1)	MC1817A1 (en)
NL (1)	NL8701101A (en)
NO (1)	NO871961L (en)
NZ (1)	NZ220215A (en)
PT (1)	PT84860B (en)
SE (1)	SE8701933L (en)
ZW (1)	ZW6587A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5264578A (en)	1987-03-20	1993-11-23	Allergan, Inc.	Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US5602130A (en) *	1987-03-20	1997-02-11	Allergan	Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
CA2017956A1 (en) *	1989-07-06	1991-01-06	Werner Bollag	Use of retinoids
US5272156A (en) *	1989-09-19	1993-12-21	Allergan, Inc.	Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5183827A (en) *	1989-09-19	1993-02-02	Allergan, Inc.	Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5264456A (en) *	1989-12-29	1993-11-23	Allergan, Inc.	Acetylenes disubstituted with a furyl group and a substituted phenyl group having retinoid like activity
US5324840A (en)	1992-06-11	1994-06-28	Allergan, Inc.	Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
US5455265A (en)	1993-02-11	1995-10-03	Allergan, Inc.	Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US6172115B1 (en)	1993-02-11	2001-01-09	Allergan Sales, Inc.	Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid
US5475022A (en) *	1993-10-18	1995-12-12	Allergan, Inc.	Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity
US5426118A (en) *	1993-12-30	1995-06-20	Allergan, Inc.	[4-(1,2-epoxycyclohexanyl)but-3-en-1-ynyl]aromatic and heteroaromatic acids and derivatives having retinoid-like biological activity
US5498755A (en) *	1994-08-23	1996-03-12	Chandraratna; Roshantha A.	Disubstituted aryl and heteroaryl imines having retinoid-like biological activity
US5534641A (en) *	1994-12-29	1996-07-09	Allergan	Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
US5618943A (en) *	1994-12-29	1997-04-08	Allergan	Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5618931A (en) *	1994-12-29	1997-04-08	Allergan	Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5514825A (en) *	1994-12-29	1996-05-07	Allergan, Inc.	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5556996A (en) *	1994-12-29	1996-09-17	Allergan	Oxiranyls disubstituted with a phenyl group and a substituted chromanyl or tetrahydroquinolinyl group having retinoid like activity
US5489584A (en) *	1994-12-29	1996-02-06	Allergan, Inc.	Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5599967A (en) *	1994-12-29	1997-02-04	Allergan	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity
US5648514A (en)	1994-12-29	1997-07-15	Allergan	Substituted acetylenes having retinoid-like biological activity
US5543534A (en) *	1994-12-29	1996-08-06	Allergan	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5534261A (en) *	1995-01-17	1996-07-09	University Of Southern California	Retinoid-based compositions and method for preventing adhesion formation using the same
US6025388A (en)	1995-04-26	2000-02-15	Allergan Sales, Inc.	Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids
US5616712A (en) *	1995-05-16	1997-04-01	Allergan	Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity
US5917082A (en)	1995-06-06	1999-06-29	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5675033A (en)	1995-06-06	1997-10-07	Allergan	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6008204A (en)	1995-09-01	1999-12-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5958954A (en)	1995-09-01	1999-09-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6218128B1 (en)	1997-09-12	2001-04-17	Allergan Sales, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US5952345A (en)	1995-09-01	1999-09-14	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6942980B1 (en)	1995-09-01	2005-09-13	Allergan, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
AU7598596A (en) *	1995-11-01	1997-05-22	Allergan, Inc.	Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity
US5663357A (en)	1995-11-22	1997-09-02	Allergan	Substituted heteroarylamides having retinoid-like biological activity
US5675024A (en)	1995-11-22	1997-10-07	Allergan	Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5965606A (en)	1995-12-29	1999-10-12	Allergan Sales, Inc.	Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
US5688957A (en) *	1995-12-29	1997-11-18	Allergan	(3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!aryl and (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!heteroaryl carboxylic acids and esters having retinoid-like biological activity
US5747542A (en) *	1996-06-21	1998-05-05	Allergan	Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity
US5741896A (en)	1996-06-21	1998-04-21	Allergan	O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5763635A (en)	1996-06-21	1998-06-09	Allergan	Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
US5723666A (en) *	1996-06-21	1998-03-03	Allergan	Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5808124A (en) *	1996-06-21	1998-09-15	Allergan	O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6555690B2 (en)	1996-06-21	2003-04-29	Allergan, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5773594A (en)	1996-06-21	1998-06-30	Allergan	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5739338A (en) *	1996-11-05	1998-04-14	Allergan	N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
US5728846A (en)	1996-12-12	1998-03-17	Allergan	Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5760276A (en)	1997-03-06	1998-06-02	Allergan	Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US6037488A (en)	1997-04-19	2000-03-14	Allergan Sales, Inc.	Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US5919970A (en)	1997-04-24	1999-07-06	Allergan Sales, Inc.	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US6369225B1 (en)	2000-08-29	2002-04-09	Allergan Sales, Inc.	Compounds having activity as inhibitors of cytochrome P450RAI
US6380256B1 (en)	2000-08-29	2002-04-30	Allergan Sales, Inc.	Compounds having activity as inhibitors of cytochrome P450RAI
US6313107B1 (en)	2000-08-29	2001-11-06	Allergan Sales, Inc.	Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4326055A (en) *	1977-12-22	1982-04-20	Hoffmann-La Roche Inc.	Stilbene derivatives
CA1162200A (en) *	1981-02-13	1984-02-14	Michael Klaus	Process for the manufacture of indanyl (or tetrahydronaphthyl)propenyl phenyl derivatives
EP0084667B1 (en) *	1982-01-23	1985-09-18	BASF Aktiengesellschaft	Phenylethylene derivatives, their preparation and use as medicines
DE3202100A1 (en) *	1982-01-23	1983-08-04	Basf Ag, 6700 Ludwigshafen	SUBSTITUTED 4-HYDROXYANILIDES, ITS PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3602473A1 (en) *	1986-01-28	1987-07-30	Basf Ag	VINYLPHENOL DERIVATIVES, THEIR PRODUCTION AND USE

1987
- 1987-04-10 ZW ZW65/87A patent/ZW6587A1/en unknown
- 1987-04-23 IT IT20232/87A patent/IT1203954B/en active
- 1987-05-06 DK DK232087A patent/DK232087A/en not_active Application Discontinuation
- 1987-05-06 NZ NZ220215A patent/NZ220215A/en unknown
- 1987-05-06 LU LU86866A patent/LU86866A1/en unknown
- 1987-05-07 IL IL82448A patent/IL82448A0/en unknown
- 1987-05-07 FI FI872027A patent/FI872027A7/en not_active Application Discontinuation
- 1987-05-08 NL NL8701101A patent/NL8701101A/en not_active Application Discontinuation
- 1987-05-11 HU HU872103A patent/HU198002B/en not_active IP Right Cessation
- 1987-05-11 BE BE8700505A patent/BE1001668A5/en not_active IP Right Cessation
- 1987-05-11 MC MC871883A patent/MC1817A1/en unknown
- 1987-05-11 SE SE8701933A patent/SE8701933L/en not_active Application Discontinuation
- 1987-05-11 FR FR878706564A patent/FR2598706B1/en not_active Expired - Lifetime
- 1987-05-12 AU AU72779/87A patent/AU7277987A/en not_active Abandoned
- 1987-05-12 PT PT84860A patent/PT84860B/en not_active IP Right Cessation
- 1987-05-12 GB GB8711205A patent/GB2190378B/en not_active Expired - Lifetime
- 1987-05-12 DE DE19873715809 patent/DE3715809A1/en not_active Withdrawn
- 1987-05-12 CN CN198787103524A patent/CN87103524A/en active Pending
- 1987-05-12 NO NO871961A patent/NO871961L/en unknown
- 1987-05-12 ES ES8701419A patent/ES2005572A6/en not_active Expired

Also Published As

Publication number	Publication date
IT1203954B (en)	1989-02-23
IL82448A0 (en)	1987-11-30
NZ220215A (en)	1990-06-26
SE8701933L (en)	1987-11-14
DK232087D0 (en)	1987-05-06
PT84860B (en)	1990-02-08
FI872027L (en)	1987-11-14
GB2190378B (en)	1990-11-14
FR2598706B1 (en)	1990-07-06
AU7277987A (en)	1987-11-19
BE1001668A5 (en)	1990-02-06
NO871961L (en)	1987-11-16
GB8711205D0 (en)	1987-06-17
DK232087A (en)	1987-11-14
ZW6587A1 (en)	1987-12-02
GB2190378A (en)	1987-11-18
DE3715809A1 (en)	1987-11-19
HU198002B (en)	1989-07-28
FI872027A0 (en)	1987-05-07
SE8701933D0 (en)	1987-05-11
IT8720232A0 (en)	1987-04-23
NL8701101A (en)	1987-12-01
FI872027A7 (en)	1987-11-14
LU86866A1 (en)	1988-06-13
FR2598706A1 (en)	1987-11-20
CN87103524A (en)	1987-12-02
ES2005572A6 (en)	1989-03-16
HUT43806A (en)	1987-12-28
MC1817A1 (en)	1988-03-18
NO871961D0 (en)	1987-05-12

Publication	Publication Date	Title
PT84860A (en)	1987-06-01	Process for the preparation of novel tetrahydronaphtalene derivatives and of pharmaceutical compositions containing the same
PT85329A (en)	1987-08-01	Process for the preparation of tetrahydronaphtaline and indane derivatives and of pharmaceutical compositions containing the same
PT84936A (en)	1987-06-01	Process for the preparation of tetrahydronaphthaline and indanederivatives and of pharmaceutical compositions containing the same
PT86236A (en)	1987-12-01	Process for the preparation of catechol derivatives and of pharmaceutical compositions containing them
PT84964A (en)	1987-06-01	Process for the preparation of 1,5-diaryl-3-substituted-pyrazoles and of pharmaceutical compositions containing them
PT81015B (en)	1987-08-24	Process for the preparation of piridazo-diazocine derivatives and pharmaceutical compositions therewith
PT85071A (en)	1987-07-01	Process for the preparation of derivatives of fused cyclic azepin-2-ones and of pharmaceutical compositions containing the same
PT85762A (en)	1987-10-01	Process for the preparation of new cephem compounds and pharmaceutical compositions containing same
PT86365A (en)	1988-01-01	Process for the preparation of pyridazodiazepine derivatives and of pharmaceutical compositions containing the same
HU902693D0 (en)	1990-09-28	Process for the preparation of n-heteroaryl-4-quinolin-amine compounds and pharmaceutical compositions containing them
PT86516A (en)	1988-02-01	Process for the preparation of heteroaryl-3-oxo-propani-nitrile derivatives and of pharmaceutical compositions containing the same
PT86419A (en)	1988-01-01	Process for the preparation of novel chroman derivatives and of pharmaceutical compositions containing the same
PT86407A (en)	1988-01-01	Process for the preparation of new alkanesulfonanilide derivatives and pharmaceutical compositions comprising the same
PT84358A (en)	1987-03-01	Process for the preparation of naphthothiazepinones and of pharmaceutical compositions containing the same
PT82984A (en)	1986-08-01	Process for the preparation of poly-4-aminopyrrole-2-carboxamido derivatives and of pharmaceutical compositions containing the same
PT84064A (en)	1987-02-01	Process for the preparation of novel amino acid derivatives and of pharmaceutical compositions containing the same
PT83604A (en)	1986-11-01	Process for the preparation of flavone derivatives and of pharmaceutical compositions containing the same
HU896612D0 (en)	1990-02-28	Process for the preparation of 2-iminebenzothiazole derivatives and pharmaceutical compositions thereof
HU896479D0 (en)	1990-02-28	Process for the preparation of capsaycin derivatives and pharmaceutical compositions thereof
PT85337A (en)	1987-08-01	Process for the preparation of cycloalkyl-substituted 4-pyridil derivatives and of pharmaceutical compositions containing the same
PT83188A (en)	1986-09-01	Process for the preparation of benzimidazole derivatives and of pharmaceutical compositions containing the same
PT82395A (en)	1986-05-01	Process for the preparation of synthetic derivatives of pseudopterosin and of pharmaceutical compositions containing the same
PT87024A (en)	1988-04-01	PROCESS FOR THE PREPARATION OF PROPIOLOPHENONE DERIVATIVES AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
PT85513A (en)	1987-09-01	Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same
PT85522A (en)	1987-09-01	Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same

Legal Events

Date	Code	Title	Description
1992-06-30	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19920106

Date

Code

Title

Description

1992-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19920106