GR3035587T3 - Thienobenzodiazepine derivatives for treatment of CNS disorders. - Google Patents
Thienobenzodiazepine derivatives for treatment of CNS disorders.Info
- Publication number
- GR3035587T3 GR3035587T3 GR20010400431T GR20010400431T GR3035587T3 GR 3035587 T3 GR3035587 T3 GR 3035587T3 GR 20010400431 T GR20010400431 T GR 20010400431T GR 20010400431 T GR20010400431 T GR 20010400431T GR 3035587 T3 GR3035587 T3 GR 3035587T3
- Authority
- GR
- Greece
- Prior art keywords
- treatment
- cns disorders
- alkyl
- optionally substituted
- thienobenzodiazepine
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929211379A GB9211379D0 (en) | 1992-05-29 | 1992-05-29 | Pharmaceutical compounds |
| GB939309025A GB9309025D0 (en) | 1993-04-30 | 1993-04-30 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3035587T3 true GR3035587T3 (en) | 2001-06-29 |
Family
ID=26300951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010400431T GR3035587T3 (en) | 1992-05-29 | 2001-03-15 | Thienobenzodiazepine derivatives for treatment of CNS disorders. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0582368B1 (el) |
| JP (1) | JP3219541B2 (el) |
| CN (1) | CN1043994C (el) |
| AT (1) | ATE198891T1 (el) |
| AU (1) | AU668159B2 (el) |
| CA (1) | CA2097016A1 (el) |
| CZ (1) | CZ282783B6 (el) |
| DE (1) | DE69329887T2 (el) |
| DK (1) | DK0582368T3 (el) |
| ES (1) | ES2153373T3 (el) |
| FI (1) | FI101538B (el) |
| GR (1) | GR3035587T3 (el) |
| HU (1) | HU218278B (el) |
| IL (1) | IL105827A (el) |
| MX (1) | MX9303124A (el) |
| MY (1) | MY109943A (el) |
| NO (1) | NO305125B1 (el) |
| NZ (1) | NZ247703A (el) |
| PT (1) | PT582368E (el) |
| RU (1) | RU2125574C1 (el) |
| TW (1) | TW268005B (el) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457101A (en) * | 1994-06-03 | 1995-10-10 | Eli Lilly And Company | Thieno[1,5]benzoidiazepine use |
| US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
| EG24221A (en) * | 1995-03-24 | 2008-11-10 | Lilly Co Eli | Process for preparing olanzapine |
| CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
| US5891461A (en) * | 1995-09-14 | 1999-04-06 | Cygnus, Inc. | Transdermal administration of olanzapine |
| CN1219878A (zh) * | 1996-03-25 | 1999-06-16 | 伊莱利利公司 | 治疗疼痛的方法 |
| NZ332039A (en) * | 1996-03-25 | 2000-06-23 | Lilly Co Eli | Method for treating pain using olanzapine and NSAIDs |
| UA44838C2 (uk) * | 1996-03-25 | 2002-03-15 | Елі Ліллі Енд Компані | Спосіб лікування мігрені |
| TR199900639T2 (xx) | 1996-09-23 | 1999-06-21 | Eli Lilly And Company | Olanzapin dihidrat D. |
| ZA978515B (en) * | 1996-09-23 | 1999-03-23 | Lilly Co Eli | Intermediates and process for preparing olanzapine |
| ID21762A (id) * | 1996-09-24 | 1999-07-22 | Lilly Co Eli | Formulasi partikel bersaput |
| RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
| PT3354751T (pt) | 2012-08-21 | 2019-12-17 | Janssen Pharmaceutica Nv | Anticorpos contra aripiprazole e seu uso |
| CN104736566A (zh) | 2012-08-21 | 2015-06-24 | 奥索临床诊断有限公司 | 帕潘立酮半抗原的抗体及其用途 |
| WO2014031668A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to quetiapine and use thereof |
| PT2888258T (pt) | 2012-08-21 | 2019-08-21 | Janssen Pharmaceutica Nv | Hapteno de paliperidona |
| CN104755479B (zh) | 2012-08-21 | 2016-11-09 | 詹森药业有限公司 | 利培酮和帕潘立酮的半抗原 |
| WO2014031662A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine and use thereof |
| PL2888284T3 (pl) | 2012-08-21 | 2023-02-27 | Janssen Pharmaceutica Nv | Przeciwciała przeciwko haptenom rysperydonu i ich zastosowanie |
| AU2013305935B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Haptens of quetiapine for use in immunoassays |
| EP3385284B1 (en) | 2012-08-21 | 2020-02-26 | Janssen Pharmaceutica NV | Antibodies to quetiapine haptens and use thereof |
| CA2882490A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone and use thereof |
| PT2888234T (pt) | 2012-08-21 | 2018-02-22 | Janssen Pharmaceutica Nv | Haptenos de aripiprazol e seu uso em imunoensaios |
| PT2888593T (pt) | 2012-08-21 | 2018-12-12 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilizações dos mesmos |
| WO2014031635A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to aripiprazole haptens and use thereof |
| CA2882454C (en) * | 2012-08-21 | 2020-08-11 | Matthew Garrett DONAHUE | Haptens of olanzapine |
| CN104755093B (zh) | 2012-08-21 | 2018-11-16 | 詹森药业有限公司 | 奥氮平半抗原的抗体及其用途 |
| CA3008812A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3962248A (en) * | 1972-04-04 | 1976-06-08 | Sandoz, Inc. | Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines |
| CH569730A5 (el) * | 1972-04-04 | 1975-11-28 | Wander Ag Dr A | |
| SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
| US4061752A (en) * | 1975-08-06 | 1977-12-06 | Sandoz Ltd. | 6-Piperazino-11-methylene-dibenzazepines[b,e] |
| SE7610219L (sv) * | 1975-09-24 | 1977-03-25 | Sandoz Ag | Nya dibenso /b,e//1,4/ diazepiner |
| CH624682A5 (el) * | 1976-11-10 | 1981-08-14 | Sandoz Ag | |
| US4761411A (en) * | 1983-05-18 | 1988-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
| GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1993
- 1993-05-26 CA CA002097016A patent/CA2097016A1/en not_active Abandoned
- 1993-05-26 AT AT93304102T patent/ATE198891T1/de not_active IP Right Cessation
- 1993-05-26 AU AU39807/93A patent/AU668159B2/en not_active Ceased
- 1993-05-26 NZ NZ247703A patent/NZ247703A/en unknown
- 1993-05-26 DE DE69329887T patent/DE69329887T2/de not_active Expired - Fee Related
- 1993-05-26 EP EP93304102A patent/EP0582368B1/en not_active Expired - Lifetime
- 1993-05-26 ES ES93304102T patent/ES2153373T3/es not_active Expired - Lifetime
- 1993-05-26 NO NO931917A patent/NO305125B1/no not_active IP Right Cessation
- 1993-05-26 PT PT93304102T patent/PT582368E/pt unknown
- 1993-05-26 DK DK93304102T patent/DK0582368T3/da active
- 1993-05-26 TW TW082104161A patent/TW268005B/zh active
- 1993-05-27 MX MX9303124A patent/MX9303124A/es not_active IP Right Cessation
- 1993-05-28 CN CN93108212A patent/CN1043994C/zh not_active Expired - Fee Related
- 1993-05-28 IL IL10582793A patent/IL105827A/xx not_active IP Right Cessation
- 1993-05-28 RU RU93005057A patent/RU2125574C1/ru active
- 1993-05-28 JP JP12642993A patent/JP3219541B2/ja not_active Expired - Fee Related
- 1993-05-28 FI FI932445A patent/FI101538B/fi active
- 1993-05-28 CZ CZ931024A patent/CZ282783B6/cs not_active IP Right Cessation
- 1993-05-28 HU HU9301579A patent/HU218278B/hu not_active IP Right Cessation
- 1993-05-28 MY MYPI93001036A patent/MY109943A/en unknown
-
2001
- 2001-03-15 GR GR20010400431T patent/GR3035587T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO305125B1 (no) | 1999-04-06 |
| CN1043994C (zh) | 1999-07-07 |
| FI101538B1 (fi) | 1998-07-15 |
| FI932445A0 (fi) | 1993-05-28 |
| JP3219541B2 (ja) | 2001-10-15 |
| ATE198891T1 (de) | 2001-02-15 |
| HU9301579D0 (en) | 1993-09-28 |
| CZ102493A3 (en) | 1993-12-15 |
| DK0582368T3 (da) | 2001-02-05 |
| FI932445L (fi) | 1993-11-30 |
| CZ282783B6 (cs) | 1997-10-15 |
| PT582368E (pt) | 2001-05-31 |
| MX9303124A (es) | 1993-11-01 |
| IL105827A0 (en) | 1993-09-22 |
| HU218278B (en) | 2000-07-28 |
| NO931917L (no) | 1993-11-30 |
| EP0582368B1 (en) | 2001-01-24 |
| DE69329887T2 (de) | 2001-05-23 |
| TW268005B (el) | 1996-01-11 |
| HUT66180A (en) | 1994-09-28 |
| AU3980793A (en) | 1993-12-02 |
| RU2125574C1 (ru) | 1999-01-27 |
| CN1085903A (zh) | 1994-04-27 |
| ES2153373T3 (es) | 2001-03-01 |
| CA2097016A1 (en) | 1993-11-30 |
| MY109943A (en) | 1997-10-31 |
| NZ247703A (en) | 1995-07-26 |
| JPH0687862A (ja) | 1994-03-29 |
| AU668159B2 (en) | 1996-04-26 |
| DE69329887D1 (de) | 2001-03-01 |
| IL105827A (en) | 1997-02-18 |
| NO931917D0 (no) | 1993-05-26 |
| EP0582368A1 (en) | 1994-02-09 |
| FI101538B (fi) | 1998-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |