IL105827A - 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them - Google Patents
10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL105827A IL105827A IL10582793A IL10582793A IL105827A IL 105827 A IL105827 A IL 105827A IL 10582793 A IL10582793 A IL 10582793A IL 10582793 A IL10582793 A IL 10582793A IL 105827 A IL105827 A IL 105827A
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- benzodiazepines
- thieno
- piperazinyl
- substituted
- Prior art date
Links
- -1 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929211379A GB9211379D0 (en) | 1992-05-29 | 1992-05-29 | Pharmaceutical compounds |
| GB939309025A GB9309025D0 (en) | 1993-04-30 | 1993-04-30 | Pharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL105827A0 IL105827A0 (en) | 1993-09-22 |
| IL105827A true IL105827A (en) | 1997-02-18 |
Family
ID=26300951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10582793A IL105827A (en) | 1992-05-29 | 1993-05-28 | 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0582368B1 (xx) |
| JP (1) | JP3219541B2 (xx) |
| CN (1) | CN1043994C (xx) |
| AT (1) | ATE198891T1 (xx) |
| AU (1) | AU668159B2 (xx) |
| CA (1) | CA2097016A1 (xx) |
| CZ (1) | CZ282783B6 (xx) |
| DE (1) | DE69329887T2 (xx) |
| DK (1) | DK0582368T3 (xx) |
| ES (1) | ES2153373T3 (xx) |
| FI (1) | FI101538B1 (xx) |
| GR (1) | GR3035587T3 (xx) |
| HU (1) | HU218278B (xx) |
| IL (1) | IL105827A (xx) |
| MX (1) | MX9303124A (xx) |
| MY (1) | MY109943A (xx) |
| NO (1) | NO305125B1 (xx) |
| NZ (1) | NZ247703A (xx) |
| PT (1) | PT582368E (xx) |
| RU (1) | RU2125574C1 (xx) |
| TW (1) | TW268005B (xx) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457101A (en) * | 1994-06-03 | 1995-10-10 | Eli Lilly And Company | Thieno[1,5]benzoidiazepine use |
| US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
| EG24221A (en) * | 1995-03-24 | 2008-11-10 | Lilly Co Eli | Process for preparing olanzapine |
| EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
| US5891461A (en) * | 1995-09-14 | 1999-04-06 | Cygnus, Inc. | Transdermal administration of olanzapine |
| BR9708246A (pt) * | 1996-03-25 | 1999-07-27 | Lilly Co Eli | Metodo para tratamento de dor |
| UA44838C2 (uk) * | 1996-03-25 | 2002-03-15 | Елі Ліллі Енд Компані | Спосіб лікування мігрені |
| CZ296263B6 (cs) * | 1996-03-25 | 2006-02-15 | Eli Lilly And Company | Farmaceutická kompozice pro lécení bolesti a jejípouzití |
| ZA978515B (en) * | 1996-09-23 | 1999-03-23 | Lilly Co Eli | Intermediates and process for preparing olanzapine |
| AU720366B2 (en) * | 1996-09-23 | 2000-06-01 | Eli Lilly And Company | Olanzapine dihydrate D |
| TR199900651T2 (xx) * | 1996-09-24 | 1999-07-21 | Eli Lilly And Company | Kaplanm�� par�ac�k form�lasyonu. |
| RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
| JP6270845B2 (ja) | 2012-08-21 | 2018-01-31 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールに対する抗体及びその使用 |
| PL2888257T3 (pl) | 2012-08-21 | 2018-02-28 | Janssen Pharmaceutica Nv | Hapteny kwetiapiny do zastosowania w testach immunologicznych |
| PT2888284T (pt) | 2012-08-21 | 2022-11-18 | Janssen Pharmaceutica Nv | Anticorpos dirigidos contra haptenos de risperidona e a sua utilização |
| PT3321254T (pt) | 2012-08-21 | 2020-10-20 | Janssen Pharmaceutica Nv | Haptenos de aripiprazol e seu uso em imunoensaios |
| PL2888258T3 (pl) | 2012-08-21 | 2019-10-31 | Janssen Pharmaceutica Nv | Hapteny paliperydonu |
| PL2888592T3 (pl) | 2012-08-21 | 2018-03-30 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| CA2882489A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone haptens and use thereof |
| CN110054694B (zh) | 2012-08-21 | 2024-02-20 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
| PL2888263T3 (pl) | 2012-08-21 | 2018-10-31 | Janssen Pharmaceutica Nv | Hapteny rysperydonu i paliperydonu |
| WO2014031662A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine and use thereof |
| CA2882595C (en) | 2012-08-21 | 2019-06-04 | Ortho-Clinical Diagnostics, Inc. | Antibodies to olanzapine haptens and use thereof |
| ES2701062T3 (es) * | 2012-08-21 | 2019-02-20 | Janssen Pharmaceutica Nv | Haptenos de olanzapina |
| PT2888593T (pt) | 2012-08-21 | 2018-12-12 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilizações dos mesmos |
| CN104736564B (zh) | 2012-08-21 | 2019-02-05 | 詹森药业有限公司 | 喹硫平半抗原的抗体及其用途 |
| EP2888277A4 (en) | 2012-08-21 | 2016-05-18 | Ortho Clinical Diagnostics Inc | ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF |
| JP6994461B2 (ja) | 2015-12-17 | 2022-02-04 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンに対する抗体及びその使用 |
| WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH569730A5 (xx) * | 1972-04-04 | 1975-11-28 | Wander Ag Dr A | |
| US3962248A (en) * | 1972-04-04 | 1976-06-08 | Sandoz, Inc. | Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines |
| SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
| US4061752A (en) * | 1975-08-06 | 1977-12-06 | Sandoz Ltd. | 6-Piperazino-11-methylene-dibenzazepines[b,e] |
| FI762646A7 (xx) * | 1975-09-24 | 1977-03-25 | Sandoz Ag | |
| CH624682A5 (xx) * | 1976-11-10 | 1981-08-14 | Sandoz Ag | |
| US4761411A (en) * | 1983-05-18 | 1988-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
| GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1993
- 1993-05-26 ES ES93304102T patent/ES2153373T3/es not_active Expired - Lifetime
- 1993-05-26 DE DE69329887T patent/DE69329887T2/de not_active Expired - Fee Related
- 1993-05-26 AT AT93304102T patent/ATE198891T1/de not_active IP Right Cessation
- 1993-05-26 PT PT93304102T patent/PT582368E/pt unknown
- 1993-05-26 AU AU39807/93A patent/AU668159B2/en not_active Ceased
- 1993-05-26 DK DK93304102T patent/DK0582368T3/da active
- 1993-05-26 CA CA002097016A patent/CA2097016A1/en not_active Abandoned
- 1993-05-26 NZ NZ247703A patent/NZ247703A/en unknown
- 1993-05-26 EP EP93304102A patent/EP0582368B1/en not_active Expired - Lifetime
- 1993-05-26 TW TW082104161A patent/TW268005B/zh active
- 1993-05-26 NO NO931917A patent/NO305125B1/no not_active IP Right Cessation
- 1993-05-27 MX MX9303124A patent/MX9303124A/es not_active IP Right Cessation
- 1993-05-28 CZ CZ931024A patent/CZ282783B6/cs not_active IP Right Cessation
- 1993-05-28 FI FI932445A patent/FI101538B1/fi active
- 1993-05-28 MY MYPI93001036A patent/MY109943A/en unknown
- 1993-05-28 IL IL10582793A patent/IL105827A/xx not_active IP Right Cessation
- 1993-05-28 JP JP12642993A patent/JP3219541B2/ja not_active Expired - Fee Related
- 1993-05-28 RU RU93005057A patent/RU2125574C1/ru active
- 1993-05-28 HU HU9301579A patent/HU218278B/hu not_active IP Right Cessation
- 1993-05-28 CN CN93108212A patent/CN1043994C/zh not_active Expired - Fee Related
-
2001
- 2001-03-15 GR GR20010400431T patent/GR3035587T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ247703A (en) | 1995-07-26 |
| CN1085903A (zh) | 1994-04-27 |
| DK0582368T3 (da) | 2001-02-05 |
| HU9301579D0 (en) | 1993-09-28 |
| HUT66180A (en) | 1994-09-28 |
| CA2097016A1 (en) | 1993-11-30 |
| HU218278B (en) | 2000-07-28 |
| RU2125574C1 (ru) | 1999-01-27 |
| FI101538B (fi) | 1998-07-15 |
| EP0582368B1 (en) | 2001-01-24 |
| AU668159B2 (en) | 1996-04-26 |
| EP0582368A1 (en) | 1994-02-09 |
| NO305125B1 (no) | 1999-04-06 |
| NO931917D0 (no) | 1993-05-26 |
| JP3219541B2 (ja) | 2001-10-15 |
| DE69329887D1 (de) | 2001-03-01 |
| MX9303124A (es) | 1993-11-01 |
| FI932445L (fi) | 1993-11-30 |
| CN1043994C (zh) | 1999-07-07 |
| JPH0687862A (ja) | 1994-03-29 |
| ES2153373T3 (es) | 2001-03-01 |
| PT582368E (pt) | 2001-05-31 |
| TW268005B (xx) | 1996-01-11 |
| FI101538B1 (fi) | 1998-07-15 |
| MY109943A (en) | 1997-10-31 |
| NO931917L (no) | 1993-11-30 |
| FI932445A0 (fi) | 1993-05-28 |
| GR3035587T3 (en) | 2001-06-29 |
| CZ282783B6 (cs) | 1997-10-15 |
| DE69329887T2 (de) | 2001-05-23 |
| ATE198891T1 (de) | 2001-02-15 |
| IL105827A0 (en) | 1993-09-22 |
| AU3980793A (en) | 1993-12-02 |
| CZ102493A3 (en) | 1993-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL105827A (en) | 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them | |
| HUT67691A (en) | 7-(substituted)-8-(substituted)-9-[(substituted-glycyl)amido]6-demethyl-6-deoxytetracyclines, pharmaceutical compositions containing them and process to prepare them | |
| LV10270B (en) | Novel pharmacological compounds | |
| IL100572A (en) | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them | |
| PL337126A1 (en) | Novel compounds | |
| HUP9802824A2 (hu) | Egy 2-metil-tieno-benzodiazepin-származék kristályformái és eljárás azok előállítására | |
| GR3019765T3 (en) | Use of a dihydrothienopyridine-derivative for inhibiting the release of cerebral glutamate | |
| IL110151A0 (en) | Amide and urea derivatives and pharmaceutical compositions containing the same | |
| IL114785A0 (en) | Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them | |
| HUT64026A (en) | Process for producing 4-alkyl-3-amino-2-chloropyridines | |
| AU630575B2 (en) | Benzodiazepine derivatives | |
| IL97999A0 (en) | Pyrido(2,3-f)(1,4)thiazepines and pyrido(3,2-b)(1,5)-benzothiazepines,their preparation and pharmaceutical compositions containing them | |
| IL107614A0 (en) | Vitamin d3 analogs their preparation and pharmaceutical compositions containing them | |
| PH22851A (en) | Pyrrolidone derivatives | |
| GR3022398T3 (en) | Method for the preparation of 3-amino-2-chloro-4-alkylpyridines | |
| UA41981C2 (uk) | Біотинові сполуки, спосіб їх отримання, фармацевтична композиція та спосіб її отримання | |
| TW275629B (xx) | ||
| HUP9902086A3 (en) | Thieno[2,3-b]pyrazolo[3,4-d]pyridin-3-ones, their use, pharmaceutical compositions containing them, process for their preparation, intermediates | |
| IL113650A0 (en) | 8-amino-10- (azabicycloalkyl)-pyrido [1,2,3-d, e][1,3,4] benzoxadiazine derivatives their preparartion and pharmaceutical compositions containing them | |
| GB8823040D0 (en) | Organic compounds & their use as pharmaceuticals | |
| KR937000511A (ko) | 신규한 화합물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |