[go: up one dir, main page]

FR22C1057I2 - Optimisation des anticorps humains qui se lient au gene 3 d'activation des lymphocytes (lag-3), et leurs utilisations - Google Patents

Optimisation des anticorps humains qui se lient au gene 3 d'activation des lymphocytes (lag-3), et leurs utilisations

Info

Publication number
FR22C1057I2
FR22C1057I2 FR22C1057C FR22C1057C FR22C1057I2 FR 22C1057 I2 FR22C1057 I2 FR 22C1057I2 FR 22C1057 C FR22C1057 C FR 22C1057C FR 22C1057 C FR22C1057 C FR 22C1057C FR 22C1057 I2 FR22C1057 I2 FR 22C1057I2
Authority
FR
France
Prior art keywords
lag
bind
optimization
human antibodies
lymphocyte activation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1057C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48795938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR22C1057(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FR22C1057I1 publication Critical patent/FR22C1057I1/fr
Application granted granted Critical
Publication of FR22C1057I2 publication Critical patent/FR22C1057I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR22C1057C 2012-07-02 2022-11-30 Optimisation des anticorps humains qui se lient au gene 3 d'activation des lymphocytes (lag-3), et leurs utilisations Active FR22C1057I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261667058P 2012-07-02 2012-07-02
PCT/US2013/048999 WO2014008218A1 (fr) 2012-07-02 2013-07-02 Optimisation d'anticorps se liant à la protéine lag-3 exprimée par le gène 3 d'activation des lymphocytes, et leurs utilisations

Publications (2)

Publication Number Publication Date
FR22C1057I1 FR22C1057I1 (fr) 2023-01-06
FR22C1057I2 true FR22C1057I2 (fr) 2023-12-15

Family

ID=48795938

Family Applications (1)

Application Number Title Priority Date Filing Date
FR22C1057C Active FR22C1057I2 (fr) 2012-07-02 2022-11-30 Optimisation des anticorps humains qui se lient au gene 3 d'activation des lymphocytes (lag-3), et leurs utilisations

Country Status (39)

Country Link
US (7) US9505839B2 (fr)
EP (4) EP4553086A2 (fr)
JP (5) JP6320376B2 (fr)
KR (6) KR102461102B1 (fr)
CN (2) CN104411723B (fr)
AR (3) AR091649A1 (fr)
AU (5) AU2013286914B2 (fr)
BR (1) BR112014032999B1 (fr)
CA (2) CA2877746C (fr)
CL (1) CL2014003637A1 (fr)
CO (1) CO7170127A2 (fr)
CY (3) CY1119563T1 (fr)
DK (3) DK3795592T3 (fr)
EA (2) EA035013B1 (fr)
ES (3) ES2987734T3 (fr)
FI (2) FI3795592T3 (fr)
FR (1) FR22C1057I2 (fr)
HR (3) HRP20171315T1 (fr)
HU (4) HUE052406T2 (fr)
IL (1) IL236517B (fr)
LT (4) LT2867258T (fr)
LU (1) LUC00286I2 (fr)
MX (2) MX365417B (fr)
MY (3) MY169383A (fr)
NL (1) NL301205I2 (fr)
NO (2) NO2023008I1 (fr)
NZ (1) NZ628528A (fr)
PE (4) PE20191324A1 (fr)
PH (2) PH12021552200A1 (fr)
PL (2) PL2867258T3 (fr)
PT (3) PT3795592T (fr)
RS (3) RS65997B1 (fr)
SG (2) SG11201408780XA (fr)
SI (3) SI3275899T1 (fr)
SM (3) SMT201700449T1 (fr)
TN (1) TN2014000536A1 (fr)
TW (7) TWI576355B (fr)
UY (1) UY34887A (fr)
WO (1) WO2014008218A1 (fr)

Families Citing this family (567)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109485727A (zh) * 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
KR101411165B1 (ko) * 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
AU2010229994B2 (en) 2009-03-25 2016-08-18 Genentech, Inc. Anti-FGFR3 antibodies and methods using same
US9416132B2 (en) 2011-07-21 2016-08-16 Tolero Pharmaceuticals, Inc. Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
AR091649A1 (es) * 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
SI2970464T1 (sl) * 2013-03-15 2020-08-31 Glaxosmithkline Intellectual Propety Development Limited Anti-LAG-3 vezavni proteini
JP6433085B2 (ja) 2013-04-09 2018-12-05 ボストン バイオメディカル， インコーポレイテッド がんの処置に使用するための２−アセチルナフト［２，３−ｂ］フラン−４，９−ジオン
CN105682683A (zh) * 2013-08-02 2016-06-15 阿杜罗生物科技控股有限公司 结合cd27激动剂以及免疫检查点抑制以用于免疫刺激
US10081681B2 (en) * 2013-09-20 2018-09-25 Bristol-Myers Squibb Company Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
EP3757130A1 (fr) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Méthodes de traitement de cancers hématologiques
WO2015066413A1 (fr) 2013-11-01 2015-05-07 Novartis Ag Composés d'acide oxazolidinone-hydroxamique pour le traitement d'infections bactériennes
PE20160953A1 (es) 2013-12-12 2016-09-26 Shanghai hengrui pharmaceutical co ltd Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este
MA39211B1 (fr) 2013-12-24 2019-01-31 Bristol Myers Squibb Co Composés tricycliques comme agents anti-cancers
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
SI3556775T1 (sl) * 2014-01-28 2022-02-28 Bristol-Myers Squibb Company Protitelesa proti-LAG-3 za zdravljenje hematoloških malignosti
WO2015115892A1 (fr) * 2014-01-31 2015-08-06 Aimm Therapeutics B.V. Moyens et procédés de production d'anticorps stables
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
ES3040431T3 (en) 2014-03-12 2025-10-31 Yeda Res & Dev Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
ME03558B (fr) 2014-03-14 2020-07-20 Novartis Ag Molécules d'anticorps anti-lag-3 et leurs utilisations
HRP20190501T1 (hr) 2014-03-24 2019-05-03 Novartis Ag Monobaktam organski spojevi za liječenje bakterijskih infekcija
DK3151921T3 (da) 2014-06-06 2019-12-02 Bristol Myers Squibb Co Antistoffer mod glucocorticoid-induceret tumornekrosefaktor- receptorer (gitr) og anvendelser deraf
CA2951259A1 (fr) 2014-06-06 2015-12-10 Flexus Biosciences, Inc. Agents immunoregulateurs
US10092645B2 (en) * 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
TWI693232B (zh) * 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
JP2017523213A (ja) 2014-08-06 2017-08-17 ノバルティス アーゲー 抗菌薬としてのキノロン誘導体
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
KR20170060042A (ko) 2014-09-13 2017-05-31 노파르티스 아게 Alk 억제제의 조합 요법
EA201790737A1 (ru) 2014-10-03 2017-08-31 Новартис Аг Комбинированная терапия
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
MX389663B (es) 2014-10-14 2025-03-20 Novartis Ag Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas.
US10532106B2 (en) 2014-10-29 2020-01-14 Bicyclerd Limited Bicyclic peptide ligands specific for MT1-MMP
WO2016073738A2 (fr) 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Agents immunorégulateurs
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
DK3221363T3 (da) 2014-11-21 2020-08-10 Bristol Myers Squibb Co Antistoffer mod cd73 og anvendelser deraf
WO2016094639A1 (fr) * 2014-12-10 2016-06-16 Wisconsin Alumni Research Foundation Vaccins d'adn de plasmide mini-introniques en combinaison avec un blocage lag3
EA032138B1 (ru) 2014-12-16 2019-04-30 Новартис Аг СОЕДИНЕНИЯ ИЗОКСАЗОЛГИДРОКСАМИНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LpxC
WO2016100882A1 (fr) 2014-12-19 2016-06-23 Novartis Ag Polythérapies
TW201630907A (zh) 2014-12-22 2016-09-01 必治妥美雅史谷比公司 ＴＧＦβＲ拮抗劑
SG10202006538TA (en) 2014-12-23 2020-08-28 Bristol Myers Squibb Co Antibodies to tigit
KR20240132103A (ko) 2015-01-29 2024-09-02 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 관문 억제제 및 백신 조합 및 면역요법을 위한 이들의 사용
EP3250250A4 (fr) 2015-01-30 2019-05-22 President and Fellows of Harvard College Matériaux péritumoraux et intratumoraux pour traitement anticancéreux
MA41463A (fr) 2015-02-03 2017-12-12 Anaptysbio Inc Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3)
US10983128B2 (en) 2015-02-05 2021-04-20 Bristol-Myers Squibb Company CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
WO2016134234A1 (fr) * 2015-02-19 2016-08-25 Bioclin Therapeutics, Inc. Méthodes, compositions et trousses pour le traitement du cancer
EP3265454B1 (fr) 2015-03-02 2020-02-26 Rigel Pharmaceuticals, Inc. Inhibiteurs de tgf-beta
US10449211B2 (en) 2015-03-10 2019-10-22 Aduro Biotech, Inc. Compositions and methods for activating “stimulator of interferon gene”—dependent signalling
WO2016161279A1 (fr) 2015-04-03 2016-10-06 Bristol-Myers Squibb Company Inhibiteurs de l'indoleamine 2,3-dioxygénase pour le traitement du cancer
LT3283527T (lt) 2015-04-13 2021-03-25 Five Prime Therapeutics, Inc. Kompleksinė terapija vėžio gydymui
NZ735820A (en) * 2015-04-17 2025-02-28 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
WO2016183114A1 (fr) 2015-05-11 2016-11-17 Bristol-Myers Squibb Company Composés tricycliques utilisés en tant qu'agents anticancéreux
US9725449B2 (en) 2015-05-12 2017-08-08 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
ES2770349T3 (es) 2015-05-12 2020-07-01 Bristol Myers Squibb Co Compuestos de 5H-pirido[3,2-b]indol como agentes antineoplásicos
JP6510075B2 (ja) 2015-05-18 2019-05-08 トレロ ファーマシューティカルズ， インコーポレイテッド バイオアベイラビリティが高いアルボシジブプロドラッグ
CN111234027A (zh) 2015-05-21 2020-06-05 哈普恩治疗公司 三特异性结合蛋白质及使用方法
CN107849144B (zh) 2015-05-29 2021-09-17 艾吉纳斯公司 抗-ctla-4抗体及其使用方法
LT3303396T (lt) 2015-05-29 2023-01-10 Bristol-Myers Squibb Company Antikūnai prieš ox40 ir jų panaudojimo būdai
EA201792623A1 (ru) 2015-06-03 2018-04-30 Бостон Биомедикал, Инк. Композиции, содержащие ингибитор стволовости рака и иммунотерапевтический агент, для применения в лечении рака
EA039293B1 (ru) * 2015-06-05 2021-12-30 Мерк Шарп И Доум Корп. Антитела против lag3 и антигенсвязывающие фрагменты
TWI773646B (zh) * 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
MX2017016502A (es) 2015-06-29 2018-03-12 Univ Rockefeller Anticuerpos contra cd40 con actividad agonista mejorada.
CA2986705A1 (fr) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Inhibiteur de cxcr4 et antagoniste de proteine disulfure isomerase a utiliser dans le traitement du cancer
AR105444A1 (es) * 2015-07-22 2017-10-04 Sorrento Therapeutics Inc Anticuerpos terapéuticos que se unen a la proteína codificada por el gen de activación de linfocitos 3 (lag3)
EP3328861A1 (fr) 2015-07-28 2018-06-06 Bristol-Myers Squibb Company Antagonistes des récepteurs du tgf bêta
DK3317301T3 (da) 2015-07-29 2021-06-28 Immutep Sas Kombinationsterapier omfattende antistofmolekyler mod lag-3
EP3878465A1 (fr) 2015-07-29 2021-09-15 Novartis AG Polythérapies comprenant des molécules d'anticorps tim-3
US20180222982A1 (en) 2015-07-29 2018-08-09 Novartis Ag Combination therapies comprising antibody molecules to pd-1
CN116333138A (zh) 2015-07-30 2023-06-27 宏观基因有限公司 Pd-1结合分子和其使用方法
US20180250303A1 (en) 2015-08-25 2018-09-06 Bristol-Myers Squibb Company Tgf beta receptor antagonists
CN108699145A (zh) 2015-09-02 2018-10-23 伊缪泰普有限公司 抗lag-3抗体
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
US10981991B2 (en) * 2015-09-29 2021-04-20 Shanghai Zhangjiang Biotechnology Co., Ltd. PD-1 antibodies and uses thereof
PE20180773A1 (es) 2015-10-02 2018-05-07 Hoffmann La Roche Anticuerpos biespecificos para pd1 y tim3
TWI756187B (zh) * 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
US10149887B2 (en) 2015-10-23 2018-12-11 Canbas Co., Ltd. Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment
EP3368074A2 (fr) 2015-10-30 2018-09-05 Hoffmann-La Roche AG Anticorps et conjugués anti-facteur d
MA43163A (fr) 2015-11-02 2018-09-12 Five Prime Therapeutics Inc Polypeptides à domaine extracellulaire cd80 et leur utilisation dans le traitement du cancer
JP2018536404A (ja) 2015-11-09 2018-12-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃｈｏ細胞において産生したポリペプチドの品質特性を操作する方法
JP6945456B2 (ja) * 2015-11-13 2021-10-06 マクロジェニクス，インコーポレーテッド Ｌａｇ‐３結合分子及びその使用方法
SG10201911035QA (en) 2015-11-18 2020-01-30 Merck Sharp & Dohme Pd1 and/or lag3 binders
BR112018010172A2 (pt) 2015-11-19 2018-11-21 Bristol Myers Squibb Co anticorpos contra receptor de fator de necrose de tumor induzido por glicocorticoide (gitr) e usos dos mesmos
PT3376857T (pt) * 2015-11-20 2021-05-27 Regeneron Pharma Animais não humanos com um gene humanizado 3 de ativação de linfócitos
BR112018010410A8 (pt) 2015-11-23 2019-02-26 Five Prime Therapeutics Inc método para tratar câncer em um sujeito, composição e métodos de aumento do número de células nk e de aumento do número de uma ou mais células positivas para pd-l1
TW202208440A (zh) 2015-12-14 2022-03-01 美商宏觀基因股份有限公司 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法
CN108602829A (zh) 2015-12-15 2018-09-28 百时美施贵宝公司 Cxcr4受体拮抗剂
MX2018007406A (es) * 2015-12-16 2018-08-15 Merck Sharp & Dohme Anticuerpos anti-lag3 y fragmentos de enlace al antigeno.
EP3389712B1 (fr) 2015-12-17 2024-04-10 Novartis AG Molécules d'anticorps anti-pd-1 et leurs utilisations
UY37030A (es) 2015-12-18 2017-07-31 Novartis Ag Anticuerpos dirigidos a cd32b y métodos de uso de los mismos
BR112018014150A2 (en) 2016-01-11 2018-12-11 Novartis Ag immunostimulating humanized monoclonal antibodies to human interleukin-2, and fusion proteins thereof
ES2897913T3 (es) 2016-02-19 2022-03-03 Novartis Ag Compuestos de piridona tetracíclicos como antivirales
KR20180118725A (ko) 2016-03-04 2018-10-31 브리스톨-마이어스 스큅 컴퍼니 항-cd73 항체와의 조합 요법
CA3016534A1 (fr) * 2016-03-04 2017-09-08 The Rockefeller University Anticorps anti-cd40 presentant une activite agoniste renforcee
FI3433257T3 (fi) 2016-03-24 2024-01-08 Novartis Ag Alkynyylinukleosidianalogeja ihmisen rinoviruksen estäjinä
CA3020830A1 (fr) 2016-04-13 2017-10-19 Vivia Biotech, S.L Lymphocytes t actives ex vivo par bite.rtm.
EP3445783A2 (fr) 2016-04-18 2019-02-27 Celldex Therapeutics, Inc. Anticorps agonistes se liant au cd40 humain et leurs utilisations
US10323004B2 (en) 2016-05-04 2019-06-18 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
JP2019516687A (ja) 2016-05-04 2019-06-20 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
WO2017192811A1 (fr) 2016-05-04 2017-11-09 Bristol-Myers Squibb Company Inhibiteurs d'indoleamine 2,3-dioxygénase et leurs méthodes d'utilisation
JP2019519485A (ja) 2016-05-04 2019-07-11 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
US10633342B2 (en) 2016-05-04 2020-04-28 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
MA55697A (fr) 2016-05-18 2022-02-23 Boehringer Ingelheim Int Molécules d'anticorps pour le traitement du cancer
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
HRP20240617T1 (hr) 2016-05-20 2024-07-19 Biohaven Therapeutics Ltd. Primjena riluzola, prolijekova riluzola ili analoga riluzola sa imunoterapijama za liječenje raka
CA3029813A1 (fr) 2016-06-13 2017-12-21 Torque Therapeutics, Inc. Methodes et procedes pour favoriser la fonction des cellules immunitaires
CA3026356A1 (fr) 2016-06-14 2017-12-21 Novartis Ag Forme cristalline du (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide en tant qu'agent antibacterien
WO2017216685A1 (fr) 2016-06-16 2017-12-21 Novartis Ag Composés pyridones pentacycliques utiles en tant qu'agents antiviraux
WO2017216686A1 (fr) 2016-06-16 2017-12-21 Novartis Ag Composés de 2-oxo-6,7-dihydropyrido-isoquinoline fusionnés en 8,9 utilisés comme antiviraux
US11214618B2 (en) 2016-06-20 2022-01-04 F-Star Therapeutics Limited LAG-3 binding members
BR112018076260A2 (pt) 2016-06-20 2019-03-26 Kymab Limited anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
US11214620B2 (en) 2016-06-20 2022-01-04 F-Star Therapeutics Limited Binding molecules binding PD-L1 and LAG-3
HUE058657T2 (hu) 2016-06-23 2022-09-28 Jiangsu Hengrui Medicine Co Lag-3 antitest, antigénkötõ fragmentuma és gyógyszerészeti alkalmazása
EP3474856B1 (fr) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Therapies combinées
US11098077B2 (en) 2016-07-05 2021-08-24 Chinook Therapeutics, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
AU2017297603A1 (en) 2016-07-14 2019-02-14 Fred Hutchinson Cancer Research Center Multiple bi-specific binding domain constructs with different epitope binding to treat cancer
AU2017297506A1 (en) 2016-07-14 2019-02-21 Bristol-Myers Squibb Company Antibodies against TIM3 and uses thereof
GB201612520D0 (en) 2016-07-19 2016-08-31 F-Star Beta Ltd Binding molecules
WO2018017633A1 (fr) 2016-07-21 2018-01-25 Bristol-Myers Squibb Company ANTAGONISTES DU RÉCEPTEUR TGF-β
CN109790532B (zh) * 2016-08-15 2022-06-17 国立大学法人北海道大学 抗lag-3抗体
JP2019528300A (ja) 2016-08-26 2019-10-10 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ インドールアミン２，３−ジオキシゲナーゼの阻害剤およびその使用方法
JP7080219B2 (ja) * 2016-08-30 2022-06-03 ゼンコア インコーポレイテッド 共刺激受容体およびチェックポイント受容体に連結する二重特異性免疫調節抗体
WO2018047109A1 (fr) 2016-09-09 2018-03-15 Novartis Ag Composés pyridones polycycliques utiles en tant qu'agents antiviraux
US11673971B2 (en) 2016-09-23 2023-06-13 Marengo Therapeutics, Inc. Multispecific antibody molecules comprising lambda and kappa light chains
JOP20190061A1 (ar) 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
CA3037380A1 (fr) 2016-10-11 2018-04-19 Agenus Inc. Anticorps anti-lag-3 et leurs procedes d'utilisation
UA127050C2 (uk) 2016-10-13 2023-03-29 Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд. Ahtи-lag-3 антитіло i композиція, що містить його
WO2018073753A1 (fr) 2016-10-18 2018-04-26 Novartis Ag Composés pyridones tétracycliques fusionnés en tant qu'agents antiviraux
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
US11279694B2 (en) 2016-11-18 2022-03-22 Sumitomo Dainippon Pharma Oncology, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
FI3551660T3 (fi) 2016-12-07 2023-12-11 Agenus Inc Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä
WO2018132279A1 (fr) 2017-01-05 2018-07-19 Bristol-Myers Squibb Company ANTAGONISTES DU RÉCEPTEUR TGF-β
MX389798B (es) 2017-01-20 2025-03-20 Arcus Biosciences Inc Azolopirimidina para el tratamiento de trastornos relacionados con el cáncer.
BR112019016336A2 (pt) 2017-02-10 2020-03-31 Regeneron Pharmaceuticals, Inc. Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto.
US20200291089A1 (en) 2017-02-16 2020-09-17 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
KR102236259B1 (ko) * 2017-02-22 2021-04-06 아이-맵 바이오파마 유에스 리미티드 항-lag-3 항체 및 그것의 사용
KR20250036268A (ko) 2017-03-31 2025-03-13 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
WO2018183608A1 (fr) 2017-03-31 2018-10-04 Five Prime Therapeutics, Inc. Polythérapie pour le cancer à l'aide d'anticorps anti-gitr
PT3606946T (pt) 2017-04-03 2022-10-17 Hoffmann La Roche Imunoconjugados de um anticorpo anti-pd-1 com uma il-2 mutante ou com il-15
LT3606954T (lt) * 2017-04-05 2022-09-26 F. Hoffmann-La Roche Ag Anti-lag3 antikūnai
CN110621698B (zh) 2017-04-05 2024-04-12 法国施维雅药厂 靶向pd-1、tim-3及lag-3的组合疗法
CN116375876A (zh) 2017-04-05 2023-07-04 豪夫迈·罗氏有限公司 特异性结合pd1和lag3的双特异性抗体
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
AU2018256406A1 (en) 2017-04-19 2019-10-17 Marengo Therapeutics, Inc. Multispecific molecules and uses thereof
KR102668371B1 (ko) 2017-04-21 2024-05-28 이케나 온콜로지, 인코포레이티드 인돌 ahr 억제제 및 이의 용도
WO2018200430A1 (fr) 2017-04-26 2018-11-01 Bristol-Myers Squibb Company Procédés de production d'anticorps qui réduisent au minimum la réduction de liaison disulfure
AR111419A1 (es) 2017-04-27 2019-07-10 Novartis Ag Compuestos fusionados de indazol piridona como antivirales
NZ759517A (en) * 2017-04-27 2025-02-28 Tesaro Inc Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
AR111651A1 (es) 2017-04-28 2019-08-07 Novartis Ag Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
JP2020517913A (ja) 2017-04-28 2020-06-18 ファイブ プライム セラピューティクス， インコーポレイテッド Ｃｄ８０細胞外ドメインポリペプチドによる治療方法
EP3615566B1 (fr) 2017-04-28 2023-12-20 Marengo Therapeutics, Inc. Molécule multispécifique avec un domain de hétérodimérisation non-immunoglobulinaire
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
AR111658A1 (es) 2017-05-05 2019-08-07 Novartis Ag 2-quinolinonas tricíclicas como agentes antibacteriales
CN110621337B (zh) * 2017-05-10 2021-11-09 浙江时迈药业有限公司 抗lag3人单克隆抗体及其用途
CA3063359A1 (fr) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Proteines de liaison a la mesotheline
WO2018209049A1 (fr) 2017-05-12 2018-11-15 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
ES2951809T3 (es) 2017-05-17 2023-10-25 Arcus Biosciences Inc Derivados de quinazolina-pirazol para el tratamiento de trastornos relacionados con el cáncer
WO2018213424A1 (fr) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Méthodes pour le traitement du cancer
BR112019018759A2 (pt) 2017-05-30 2020-05-05 Bristol-Myers Squibb Company composições compreendendo uma combinação de um anticorpo anti-lag-3, um inibidor da via pd-1, e um agente imunoterápico
BR112019021847A2 (pt) * 2017-05-30 2020-06-02 Bristol-Myers Squibb Company Composições compreendendo um anticorpo anti-lag-3 ou um anticorpo anti-lag-3 e um anticorpo anti-pd-1 ou anti-pd-l1
HUE065242T2 (hu) 2017-05-30 2024-05-28 Bristol Myers Squibb Co LAG-3-pozitív tumorok kezelése
EP3630836A1 (fr) 2017-05-31 2020-04-08 Elstar Therapeutics, Inc. Molécules multispécifiques se liant à une protéine de leucémie myéloproliférative (mpl) et leurs utilisations
US20200181274A1 (en) 2017-06-01 2020-06-11 Novartis Ag Bispecific antibodies that bind cd 123 cd3
WO2018223004A1 (fr) 2017-06-01 2018-12-06 Xencor, Inc. Anticorps bispécifiques se liant à cd20 et cd3
WO2018229715A1 (fr) 2017-06-16 2018-12-20 Novartis Ag Compositions comprenant des anticorps anti-cd32b et procédés d'utilisation correspondants
WO2018235056A1 (fr) 2017-06-22 2018-12-27 Novartis Ag Anticorps se liant à il-1beta destinés à être utilisés dans le traitement du cancer
WO2018237173A1 (fr) 2017-06-22 2018-12-27 Novartis Ag Molécules d'anticorps dirigées contre cd73 et utilisations correspondantes
EP3641812A1 (fr) 2017-06-22 2020-04-29 Novartis AG Molécules d'anticorps se liant à cd73 et leurs utilisations
AU2018287519B2 (en) 2017-06-22 2021-07-22 Novartis Ag IL-1beta binding antibodies for use in treating cancer
AU2018292618A1 (en) 2017-06-27 2019-12-19 Novartis Ag Dosage regimens for anti-TIM-3 antibodies and uses thereof
IL271601B2 (en) 2017-06-30 2024-05-01 Bristol Myers Squibb Co Amorphous and crystalline forms of ido inhibitors
US10844121B2 (en) * 2017-07-13 2020-11-24 Nanjing Leads Biolabs Co., Ltd Antibodies binding LAG-3 and uses thereof
KR20250025039A (ko) 2017-07-20 2025-02-20 노파르티스 아게 항-lag-3 항체의 투여 요법 및 그의 용도
CN110997691B (zh) 2017-07-28 2023-11-07 百时美施贵宝公司 作为抗癌剂的环二核苷酸
CN111183147B (zh) 2017-08-04 2024-07-05 拜斯科技术开发有限公司 Cd137特异性的双环肽配体
WO2019035938A1 (fr) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. Molécules multispécifiques se liant à bcma et leurs utilisations
JP7269917B2 (ja) 2017-08-17 2023-05-09 イケナ オンコロジー， インコーポレイテッド Ａｈｒ阻害剤およびその使用
KR102758037B1 (ko) 2017-08-18 2025-01-22 코테라 바이오사이언스 인코포레이티드 Tg02의 다형성 형태
EP3675898A4 (fr) * 2017-08-30 2021-09-01 Phanes Therapeutics, Inc. Anticorps anti-lag-3 et leurs utilisations
US10947263B2 (en) 2017-08-31 2021-03-16 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
EP3676279B1 (fr) 2017-08-31 2021-12-01 Bristol-Myers Squibb Company Dinucléotides cycliques utilisés en tant qu'agents anticancéreux
KR20250021628A (ko) 2017-08-31 2025-02-13 브리스톨-마이어스 스큅 컴퍼니 항암제로서의 시클릭 디뉴클레오티드
WO2019055579A1 (fr) 2017-09-12 2019-03-21 Tolero Pharmaceuticals, Inc. Régime de traitement pour des cancers qui sont insensibles aux inhibiteurs de bcl-2 à l'aide de l'inhibiteur de mcl-1 alvocidib
WO2019060742A1 (fr) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc Agents de dégradation des protéines et utilisations de ces derniers
EP3684366A4 (fr) 2017-09-22 2021-09-08 Kymera Therapeutics, Inc. Ligands crbn et utilisations de ces derniers
CN111447952A (zh) * 2017-10-05 2020-07-24 第一三共株式会社 用于细胞毒性t细胞耗竭的组合物
WO2019074822A1 (fr) 2017-10-09 2019-04-18 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
US11203592B2 (en) 2017-10-09 2021-12-21 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2019074887A1 (fr) 2017-10-10 2019-04-18 Bristol-Myers Squibb Company Dinucléotides cycliques utilisés en tant qu'agents anticancéreux
EP3694552A1 (fr) 2017-10-10 2020-08-19 Tilos Therapeutics, Inc. Anticorps anti-lap et leurs utilisations
UA129446C2 (uk) 2017-10-13 2025-04-30 Гарпун Терап'Ютікс, Інк. Триспецифічні білки і способи їх застосування
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
JP2020536894A (ja) 2017-10-15 2020-12-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 腫瘍処置法
JP7254821B2 (ja) 2017-10-16 2023-04-10 ブリストル－マイヤーズ スクイブ カンパニー 抗がん剤としての環状ジヌクレオチド
EP3697434A1 (fr) 2017-10-18 2020-08-26 Vivia Biotech, S.L. Cellules car-t activées par des bite
US20210040205A1 (en) 2017-10-25 2021-02-11 Novartis Ag Antibodies targeting cd32b and methods of use thereof
JP2021501801A (ja) 2017-11-01 2021-01-21 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 癌の処置に用いるための免疫刺激アゴニスト抗体
ES2925450T3 (es) 2017-11-06 2022-10-18 Bristol Myers Squibb Co Compuestos de isofuranona útiles como inhibidores de HPK1
AU2018368731A1 (en) 2017-11-16 2020-05-14 Novartis Ag Combination therapies
US20210079015A1 (en) 2017-11-17 2021-03-18 Novartis Ag Novel dihydroisoxazole compounds and their use for the treatment of hepatitis b
TW201925782A (zh) 2017-11-30 2019-07-01 瑞士商諾華公司 靶向bcma之嵌合抗原受體及其用途
JP7348899B2 (ja) 2017-12-08 2023-09-21 マレンゴ・セラピューティクス，インコーポレーテッド 多重特異性分子及びその使用
CN111741976B (zh) 2017-12-19 2024-09-17 英沃克斯制药有限公司 包括pd-l1抗原结合位点的fc结合片段
CN111433210A (zh) 2017-12-20 2020-07-17 诺华股份有限公司 作为抗病毒药的稠合三环吡唑并-二氢吡嗪基-吡啶酮化合物
BR112020011664A2 (pt) * 2017-12-22 2020-11-17 Jiangsu Hengrui Medicine Co., Ltd. composição farmacêutica do anticorpo lag-3 e seu uso
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2019129137A1 (fr) 2017-12-27 2019-07-04 信达生物制药(苏州)有限公司 Anticorps anti-lag-3 et utilisations associées
CN109970857B (zh) 2017-12-27 2022-09-30 信达生物制药(苏州)有限公司 抗pd-l1抗体及其用途
WO2019129136A1 (fr) 2017-12-27 2019-07-04 信达生物制药(苏州)有限公司 Anticorps anti-pd-l1 et ses applications
KR102813744B1 (ko) 2017-12-27 2025-05-28 브리스톨-마이어스 스큅 컴퍼니 항-cd40 항체 및 그의 용도
CN109970856B (zh) * 2017-12-27 2022-08-23 信达生物制药(苏州)有限公司 抗lag-3抗体及其用途
WO2019136112A1 (fr) 2018-01-05 2019-07-11 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
TW201930591A (zh) 2018-01-08 2019-08-01 瑞士商諾華公司 用於與嵌合抗原受體療法併用之免疫增強rna
EP3737692A4 (fr) 2018-01-09 2021-09-29 Elstar Therapeutics, Inc. Constructions de liaison à la calréticuline et lymphocytes t modifiés pour le traitement de maladies
KR102813913B1 (ko) 2018-01-12 2025-05-30 브리스톨-마이어스 스큅 컴퍼니 Tim3에 대한 항체 및 그의 용도
EP3737675A4 (fr) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Ligands crbn et leurs utilisations
WO2019140380A1 (fr) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Agents de dégradation de protéines et utilisations associées
WO2019141092A1 (fr) * 2018-01-18 2019-07-25 四川科伦博泰生物医药股份有限公司 Anticorps anti-lag-3 et son utilisation
SG11202006701TA (en) 2018-01-29 2020-08-28 Merck Patent Gmbh Gcn2 inhibitors and uses thereof
IL312674A (en) 2018-01-29 2024-07-01 Merck Patent Gmbh GCN2 inhibitors and uses thereof
CA3090249A1 (fr) 2018-01-31 2019-08-08 Novartis Ag Polytherapie utilisant un recepteur antigenique chimerique
JP2021511782A (ja) 2018-01-31 2021-05-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 安定化された免疫グロブリンドメイン
EP3746480A1 (fr) 2018-01-31 2020-12-09 F. Hoffmann-La Roche AG Anticorps bispécifiques comprenant un site de liaison à l'antigène se liant à lag3
US10519187B2 (en) 2018-02-13 2019-12-31 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2019160956A1 (fr) 2018-02-13 2019-08-22 Novartis Ag Thérapie par récepteur antigénique chimérique en combinaison avec il-15 r et il15
US11478479B2 (en) 2018-02-16 2022-10-25 Arcus Biosciences, Inc. Dosing with an azolopyrimidine compound
WO2019165315A1 (fr) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Méthode de traitement du cancer à l'aide d'antagonistes de chimiokine seuls ou en combinaison
JP2021514953A (ja) 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
WO2019165982A1 (fr) 2018-02-28 2019-09-06 WuXi Biologics Ireland Limited Anticorps monoclonal contre la lag-3 humaine, méthode permettant de le préparer, et utilisation de ce dernier
CN115057931B (zh) * 2018-02-28 2025-08-22 广州誉衡生物科技有限公司 抗人lag-3抗体及其用途
WO2019166951A1 (fr) 2018-02-28 2019-09-06 Novartis Ag Composés d'indole-2-carbonyle et leur utilisation dans le traitement de l'hépatite b
KR102656571B1 (ko) 2018-03-05 2024-04-11 아르커스 바이오사이언시즈 인코포레이티드 아르기나아제 억제제
KR20200130362A (ko) 2018-03-08 2020-11-18 브리스톨-마이어스 스큅 컴퍼니 항암제로서의 시클릭 디뉴클레오티드
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
US20210009711A1 (en) 2018-03-14 2021-01-14 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
US11661452B2 (en) 2018-03-20 2023-05-30 WuXi Biologics Ireland Limited Anti-lag-3 antibody polypeptide
MX2020009786A (es) 2018-03-21 2020-10-12 Five Prime Therapeutics Inc Anticuerpos de union a supresor de la activacion de celulas t que contiene el dominio variable de inmunoglobulina (vista) a ph acido.
JP7351845B2 (ja) 2018-03-23 2023-09-27 ブリストル－マイヤーズ スクイブ カンパニー Ｍｉｃａおよび／またはｍｉｃｂに対する抗体ならびにそれらの使用
KR20200139724A (ko) 2018-03-30 2020-12-14 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
WO2019192432A1 (fr) 2018-04-02 2019-10-10 上海博威生物医药有限公司 Anticorps se liant au gène d'activation lymphocytaire 3 (lag-3) et son utilisation
CN110343178B (zh) * 2018-04-03 2022-07-22 上海开拓者生物医药有限公司 抗人lag-3单克隆抗体及其应用
US20210147547A1 (en) 2018-04-13 2021-05-20 Novartis Ag Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
US10973834B2 (en) 2018-04-16 2021-04-13 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
AU2019256539A1 (en) 2018-04-18 2020-11-26 Xencor, Inc. PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof
CA3097625A1 (fr) 2018-04-18 2019-10-24 Xencor, Inc. Proteines de fusion fc heterodimeres il-15/il-15ra et leurs utilisations
US12037323B2 (en) 2018-05-03 2024-07-16 Bristol-Myers Squibb Company Uracil derivatives as Mer-AXL inhibitors
TWI869346B (zh) 2018-05-30 2025-01-11 瑞士商諾華公司 Ｅｎｔｐｄ２抗體、組合療法、及使用該等抗體和組合療法之方法
US20210214459A1 (en) 2018-05-31 2021-07-15 Novartis Ag Antibody molecules to cd73 and uses thereof
WO2019232528A1 (fr) 2018-06-01 2019-12-05 Xencor, Inc. Dosage d'un anticorps bispécifique qui se lie à cd123 et cd3
TWI848951B (zh) 2018-06-01 2024-07-21 瑞士商諾華公司 針對ｂｃｍａ之結合分子及其用途
CN119185533A (zh) 2018-06-11 2024-12-27 耶鲁大学 新型免疫检查点抑制剂
CN110606892B (zh) * 2018-06-14 2023-09-26 华博生物医药技术（上海）有限公司 一种高亲和力高生物活性的lag-3抗体及其应用
CN110615840A (zh) * 2018-06-19 2019-12-27 信达生物制药(苏州)有限公司 全人源的抗lag-3抗体及其应用
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
MX2020013373A (es) 2018-06-27 2021-03-09 Bristol Myers Squibb Co Compuestos de naftiridinona utiles como activadores de celulas t.
WO2020006018A1 (fr) 2018-06-27 2020-01-02 Bristol-Myers Squibb Company Composés de naphtyridinone substitués utiles en tant qu'activateurs de lymphocytes t
WO2020005003A1 (fr) 2018-06-29 2020-01-02 주식회사 와이바이오로직스 Anticorps monoclonal se liant de manière spécifique à lag-3 et son utilisation
AU2019297451A1 (en) 2018-07-03 2021-01-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
WO2020010227A1 (fr) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Agents de dégradation de protéines et leurs utilisations
AU2019302454A1 (en) 2018-07-09 2021-02-25 Bristol-Myers Squibb Company Antibodies binding to ILT4
CA3103385A1 (fr) 2018-07-10 2020-01-16 Novartis Ag Derives de 3-(5-hydroxy-1-oxoisoindoline-2-yl)piperidine-2,6-dione et leur utilisation dans le traitement de maladies dependantes du doigt de zinc 2 de la famille ikaros (ikzf2)
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
US12091462B2 (en) 2018-07-11 2024-09-17 Five Prime Therapeutics, Inc. Antibodies binding to vista at acidic pH
GB201811403D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Antibody molecules
GB201811408D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd CD137 Binding Molecules
CN112423845B (zh) 2018-07-12 2024-07-30 F-星治疗有限公司 结合pd-l1和cd137的抗体分子
GB201811450D0 (en) 2018-07-12 2018-08-29 F Star Delta Ltd Mesothelin and CD137 binding molecules
GB201811415D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-Mesothelin Anti bodies
GB201811410D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd OX40 Binding molecules
CA3106048A1 (fr) 2018-07-12 2020-01-16 F-Star Beta Limited Molecules d'anticorps se liant a cd137 et ox40
CA3106366A1 (fr) 2018-07-18 2020-01-23 Arcus Biosciences, Inc. Formes solides d'un compose azolopyrimidine
EP3823673A4 (fr) 2018-07-20 2022-05-11 Surface Oncology, Inc. Compositions anti-cd112r et procédés
WO2020023356A1 (fr) 2018-07-23 2020-01-30 Bristol-Myers Squibb Company Inhibiteurs de l'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
WO2020023355A1 (fr) 2018-07-23 2020-01-30 Bristol-Myers Squibb Company Inhibiteurs de l'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
WO2020021465A1 (fr) 2018-07-25 2020-01-30 Advanced Accelerator Applications (Italy) S.R.L. Procédé de traitement de tumeurs neuroendocrines
KR20210040080A (ko) * 2018-07-26 2021-04-12 브리스톨-마이어스 스큅 컴퍼니 암의 치료를 위한 lag-3 조합 요법
CN110172099B (zh) * 2018-08-16 2020-03-03 上海健信生物医药科技有限公司 抗lag-3人源化单克隆抗体分子，抗原结合片段及其医药用途
US11253525B2 (en) 2018-08-29 2022-02-22 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US10959986B2 (en) 2018-08-29 2021-03-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
EP3846793B1 (fr) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Inhibiteurs d'eif4e et leurs utilisations
CA3112326A1 (fr) 2018-09-12 2020-03-19 Novartis Ag Composes antiviraux de pyridopyrazinedione
US20210213102A1 (en) 2018-09-21 2021-07-15 Innovent Biologics (Suzhou) Co., Ltd. Novel interleukin-2 and use thereof
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
JP7512210B2 (ja) 2018-09-21 2024-07-08 イノベント バイオロジックス （スウツォウ） カンパニー，リミテッド 新規インターロイキン２およびその使用
EP3856771A4 (fr) 2018-09-25 2022-06-29 Harpoon Therapeutics, Inc. Protéines de liaison à dll3 et méthodes d'utilisation
CN113164777B (zh) 2018-09-27 2024-12-13 马伦戈治疗公司 Csf1r/ccr2多特异性抗体
CA3113379A1 (fr) 2018-09-29 2020-04-02 Novartis Ag Procede de fabrication d'un compose pour inhiber l'activite de shp2
SG11202103192RA (en) 2018-10-03 2021-04-29 Xencor Inc Il-12 heterodimeric fc-fusion proteins
WO2020076969A2 (fr) 2018-10-10 2020-04-16 Tilos Therapeutics, Inc. Variants d'anticorps anti-lap et leurs utilisations
CR20210239A (es) 2018-10-12 2021-12-15 Xencor Inc Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas
PL3866850T3 (pl) * 2018-10-19 2024-10-14 Bristol-Myers Squibb Company Terapia skojarzona czerniaka
WO2020089811A1 (fr) 2018-10-31 2020-05-07 Novartis Ag Conjugué médicament-anticorps anti-dc-sign
WO2020102646A2 (fr) 2018-11-16 2020-05-22 Arcus Biosciences, Inc. Inhibiteurs d'arg1 et/ou d'arg2
TW202033555A (zh) 2018-11-16 2020-09-16 美商必治妥美雅史谷比公司 抗nkg2a抗體及其用途
US11352350B2 (en) 2018-11-30 2022-06-07 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
EP3670659A1 (fr) 2018-12-20 2020-06-24 Abivax Biomarqueurs et leurs utilisations dans le traitement d'infections virales, d'inflammations ou du cancer
WO2020128972A1 (fr) 2018-12-20 2020-06-25 Novartis Ag Schéma posologique et combinaison pharmaceutique comprenant des dérivés de 3-(1-oxoisoindoline-2-yl) pipéridine-2,6-dione
US11618776B2 (en) 2018-12-20 2023-04-04 Xencor, Inc. Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15RA and NKG2D antigen binding domains
EP3898674A1 (fr) 2018-12-21 2021-10-27 Novartis AG Utilisation d'anticorps se liant à il-1bêta
AU2019406840A1 (en) 2018-12-21 2021-06-03 Novartis Ag Use of IL-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome
WO2020128637A1 (fr) 2018-12-21 2020-06-25 Novartis Ag UTILISATION D'ANTICORPS DE LIAISON À IL-1β DANS LE TRAITEMENT D'UN CANCER MSI-H
EP3897613A1 (fr) 2018-12-21 2021-10-27 Novartis AG Utilisation d'anticorps de liaison à il-1bêta
WO2020128526A1 (fr) 2018-12-21 2020-06-25 Bicycletx Limited Ligands peptidiques bicycliques spécifiques pour pd-l1
CN113166762B (zh) 2018-12-21 2025-01-14 瓦莱里奥治疗公司 新的偶联核酸分子及其用途
CA3127502A1 (fr) 2019-02-12 2020-08-20 Sumitomo Dainippon Pharma Oncology, Inc. Formulations comprenant des inhibiteurs de proteine kinase heterocycliques
ES3032659T3 (en) 2019-02-15 2025-07-23 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
ES2982474T3 (es) 2019-02-15 2024-10-16 Novartis Ag Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos
CN119661722A (zh) 2019-02-21 2025-03-21 马伦戈治疗公司 结合t细胞相关癌细胞的多功能分子及其用途
EP3927747A1 (fr) 2019-02-21 2021-12-29 Marengo Therapeutics, Inc. Molécules d'anticorps se liant à nkp30 et utilisations associees
CN111620949A (zh) 2019-02-28 2020-09-04 三生国健药业（上海）股份有限公司 结合人lag-3的抗体、其制备方法和用途
AU2020239048B2 (en) 2019-03-12 2025-10-16 Arcus Biosciences, Inc. Treatment of oncogene-driven cancers
KR20220012839A (ko) 2019-03-19 2022-02-04 펀다시오 프리바다 인스티튜트 드인베스티가시오 온콜로지카 데 발 헤브론 Omomyc와 pd-1 또는 ctla-4에 결합하는 항체를 이용한 암 치료용 조합 요법
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure
WO2020198077A1 (fr) 2019-03-22 2020-10-01 Sumitomo Dainippon Pharma Oncology, Inc. Compositions comprenant des modulateurs de pkm2 et méthodes de traitement les utilisant
MX2021011753A (es) 2019-03-26 2022-01-31 Univ Michigan Regents Degradadores de moleculas peque?as de stat3.
KR20210144821A (ko) 2019-03-29 2021-11-30 아르커스 바이오사이언시즈 인코포레이티드 규명된 아데노신 지문을 이용한 암의 치료방법
EP3947403A1 (fr) 2019-03-29 2022-02-09 The Regents Of The University Of Michigan Agents de dégradation de protéines stat3
JP2022528887A (ja) 2019-04-02 2022-06-16 バイスクルテクス・リミテッド バイシクルトキシンコンジュゲートおよびその使用
SG11202110829YA (en) 2019-04-05 2021-10-28 Kymera Therapeutics Inc Stat degraders and uses thereof
EP3725370A1 (fr) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Anticorps anti-pd-l1 modifiés et procédés et utilisations pour le traitement d'une maladie neurodégénérative
WO2020231766A1 (fr) 2019-05-13 2020-11-19 Bristol-Myers Squibb Company Agonistes de gammat ror
US12012374B2 (en) 2019-05-13 2024-06-18 Bristol-Myers Squibb Company Agonists of ROR GAMMAt
PH12021552675A1 (en) 2019-05-13 2022-07-04 Regeneron Pharma Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer
JP2022534982A (ja) 2019-05-30 2022-08-04 ブリストル－マイヤーズ スクイブ カンパニー 細胞局在化シグネチャーおよびその使用
WO2020243570A1 (fr) 2019-05-30 2020-12-03 Bristol-Myers Squibb Company Signature de localisation cellulaire et polythérapie
US20220363760A1 (en) 2019-05-30 2022-11-17 Bristol-Myers Squibb Company Multi-tumor gene signature for suitability to immuno-oncology therapy
KR20220034739A (ko) 2019-05-31 2022-03-18 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
WO2020252336A1 (fr) 2019-06-12 2020-12-17 Vanderbilt University Dibenzylamines utilisables comme inhibiteurs du transport des acides aminés
CN114222729A (zh) 2019-06-12 2022-03-22 范德比尔特大学 氨基酸转运抑制剂及其用途
AU2020304108A1 (en) * 2019-06-24 2022-01-27 Innovent Biologics (Suzhou) Co., Ltd. Preparations containing anti-LAG-3 antibody, and preparation method therefor and use thereof
US12485174B2 (en) 2019-06-27 2025-12-02 The George Washington University, A Congressionally Chartered Not-For-Profit Corporation HDAC6-activated macrophages, compositions, and uses thereof
US11529350B2 (en) 2019-07-03 2022-12-20 Sumitomo Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof
IT201900011676A1 (it) 2019-07-12 2021-01-12 St Superiore Di Sanita Anticorpo ricombinante umano contro il recettore di membrana LAG3, suoi usi medici e diagnostici.
WO2021011713A1 (fr) 2019-07-16 2021-01-21 The Regents Of The University Of Michigan Imidazopyrimidines utilisées en tant qu'inhibiteurs de eed et leur utilisation
WO2021026179A1 (fr) 2019-08-06 2021-02-11 Bristol-Myers Squibb Company Agonistes de ror gammat
WO2021024020A1 (fr) 2019-08-06 2021-02-11 Astellas Pharma Inc. Polythérapie impliquant des anticorps dirigés contre la claudine 18.2 et inhibiteurs de point de contrôle immunitaire pour le traitement du cancer
WO2021041664A1 (fr) 2019-08-27 2021-03-04 The Regents Of The University Of Michigan Inhibiteurs de ligase e3 cereblon
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
US12215105B2 (en) 2019-09-13 2025-02-04 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
US20220348651A1 (en) 2019-09-18 2022-11-03 Novartis Ag Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
CN114729043A (zh) 2019-09-19 2022-07-08 百时美施贵宝公司 在酸性pH下结合至VISTA的抗体
CN115023267A (zh) 2019-09-19 2022-09-06 密歇根大学董事会 螺环雄激素受体蛋白质降解剂
WO2021055994A1 (fr) 2019-09-22 2021-03-25 Bristol-Myers Squibb Company Profilage spatial quantitatif pour une thérapie par antagoniste de lag-3
WO2021061898A1 (fr) 2019-09-26 2021-04-01 Novartis Ag Composés antiviraux de pyrazolopyridinone
CA3157024A1 (fr) 2019-10-03 2021-04-08 Xencor, Inc. Proteines de fusion fc heterodimeres d'il-12 ciblees
JP2022552282A (ja) * 2019-10-09 2022-12-15 エスティーキューブ アンド カンパニー グリコシル化ｌａｇ３に対して特異的な抗体およびその使用方法
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
CN114786680A (zh) 2019-10-21 2022-07-22 诺华股份有限公司 Tim-3抑制剂及其用途
CN114786679A (zh) 2019-10-21 2022-07-22 诺华股份有限公司 具有维奈托克和tim-3抑制剂的组合疗法
JP2023500506A (ja) 2019-11-04 2023-01-06 アストラゼネカ・アクチエボラーグ 癌を治療するための組み合わせ療法
US20220411499A1 (en) * 2019-11-08 2022-12-29 Bristol-Myers Squibb Company LAG-3 Antagonist Therapy for Melanoma
IL293027A (en) 2019-11-19 2022-07-01 Bristol Myers Squibb Co Compounds useful as inhibitors of Helios protein
PL4065582T3 (pl) 2019-11-26 2025-08-18 Ikena Oncology, Inc. Polimorficzne pochodne karbazolu i ich zastosowania
KR20220104794A (ko) 2019-11-26 2022-07-26 브리스톨-마이어스 스큅 컴퍼니 (r)-n-(4-클로로페닐)-2-((1s,4s)-4-(6-플루오로퀴놀린-4-일)시클로헥실)프로판아미드의 염/공결정
WO2021127283A2 (fr) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Agents de dégradation d'irak et leurs utilisations
EP4076520A4 (fr) 2019-12-17 2024-03-27 Kymera Therapeutics, Inc. Agents de dégradation d'irak et leurs utilisations
MX2022007759A (es) 2019-12-20 2022-07-19 Novartis Ag Combinacion del anticuerpo anti tim-3 mbg453 y anticuerpo anti tgf-beta nis793, con o sin decitabina o el anticuerpo anti pd-1 spartalizumab, para el tratamiento de mielofibrosis y sindrome mielodisplasico.
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
BR112022012410A2 (pt) 2019-12-23 2022-08-30 Kymera Therapeutics Inc Degradadores smarca e usos dos mesmos
EP4081524B1 (fr) 2019-12-23 2025-01-29 Bristol-Myers Squibb Company Composés hétéroaryle substitués utiles en tant qu'activateurs de lymphocytes t
CA3162992A1 (fr) 2019-12-23 2021-07-01 Louis S. Chupak Composes de quinolinonyle piperazine substitues utiles en tant qu'activateurs de lymphocytes t
KR20220119454A (ko) 2019-12-23 2022-08-29 브리스톨-마이어스 스큅 컴퍼니 T 세포 활성화제로서 유용한 치환된 퀴나졸리닐 화합물
JP7712274B2 (ja) 2019-12-23 2025-07-23 ブリストル－マイヤーズ スクイブ カンパニー Ｔ細胞アクティベーターとして有用な置換ピペラジン誘導体
GB2609554B (en) 2020-01-03 2025-08-20 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof
WO2021138407A2 (fr) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Molécules multifonctionnelles se liant à cd33 et utilisations associées
WO2021141907A1 (fr) 2020-01-06 2021-07-15 Hifibio (Hong Kong) Limited Anticorps anti-tnfr2 et ses utilisations
WO2021139682A1 (fr) 2020-01-07 2021-07-15 Hifibio (Hk) Limited Anticorps anti-galectine-9 et ses utilisations
TW202140473A (zh) 2020-01-15 2021-11-01 美商纜圖藥品公司 Map4k1抑制劑
EP4090335A1 (fr) 2020-01-17 2022-11-23 Novartis AG Polythérapies comprenant un inhibiteur tim-3 et un agent d'hypométhylation à utiliser dans le traitement du syndrome myélodysplasique ou de la leucémie myélomonocytaire chronique
CN111205371B (zh) * 2020-01-22 2022-03-29 北京吉尔麦迪生物医药科技有限公司 一种抗淋巴细胞激活基因3的抗体及应用
TW202146452A (zh) 2020-02-28 2021-12-16 瑞士商諾華公司 結合ｃｄ１２３和ｃｄ３之雙特異性抗體的給藥
BR112022017727A2 (pt) 2020-03-03 2022-11-16 Pic Therapeutics Inc Inibidores de eif4e e usos dos mesmos
WO2021183428A1 (fr) 2020-03-09 2021-09-16 Bristol-Myers Squibb Company Anticorps dirigés contre cd40 à activité agoniste améliorée
PH12022552458A1 (en) 2020-03-19 2024-01-22 Kymera Therapeutics Inc Mdm2 degraders and uses thereof
KR20220155593A (ko) 2020-03-19 2022-11-23 아르커스 바이오사이언시즈 인코포레이티드 Hif-2알파의 억제제로서의 테트랄린 및 테트라히드로퀴놀린 화합물
TW202140441A (zh) 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
US20230159573A1 (en) 2020-03-26 2023-05-25 The Regents Of The University Of Michigan Small molecule stat protein degraders
CN115666648A (zh) * 2020-04-03 2023-01-31 索伦托药业有限公司 结合lag3的工程化抗体
EP4132971A1 (fr) 2020-04-09 2023-02-15 Merck Sharp & Dohme LLC Anticorps anti-lap à maturation d'affinité et leurs utilisations
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
CR20220611A (es) 2020-06-02 2023-06-07 Arcus Biosciences Inc Anticuerpos anti-tigit
US20230250110A1 (en) 2020-06-03 2023-08-10 Kymera Therapeutics, Inc. Deuterated irak degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
WO2021258010A1 (fr) 2020-06-19 2021-12-23 Gossamer Bio Services, Inc. Composés oxime utiles comme activateurs de lymphocytes t
AR122644A1 (es) 2020-06-19 2022-09-28 Onxeo Nuevas moléculas de ácido nucleico conjugado y sus usos
MX2022015852A (es) 2020-06-23 2023-01-24 Novartis Ag Regimen de dosificacion que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona.
CN115867355A (zh) * 2020-06-30 2023-03-28 艾瑞克斯疗法有限公司 用于治疗系统性硬化病的抗s100a4抗体
MX2023000197A (es) 2020-07-07 2023-02-22 BioNTech SE Arn terapeutico para el cancer positivo para vph.
WO2022011205A1 (fr) 2020-07-10 2022-01-13 The Regents Of The University Of Michigan Agents de dégradation de protéine de récepteur des androgènes
US20230257365A1 (en) 2020-07-10 2023-08-17 The Regents Of The University Of Michigan Small molecule androgen receptor protein degraders
CN116133692A (zh) 2020-07-30 2023-05-16 凯麦拉医疗公司 治疗突变淋巴瘤的方法
EP4188549A1 (fr) 2020-08-03 2023-06-07 Novartis AG Dérivés de 3-(1-oxoisoindolin-2-yl)pipéridine-2,6-dione substitués par hétéroaryle et leurs utilisations
CN116724051A (zh) 2020-08-10 2023-09-08 上海寻百会生物技术有限公司 用于通过靶向igsf8来治疗自身免疫性疾病和癌症的组合物和方法
CN116194480A (zh) 2020-08-13 2023-05-30 百时美施贵宝公司 将il-2重定向到目的靶细胞的方法
KR20230074721A (ko) 2020-08-17 2023-05-31 바이사이클티엑스 리미티드 Nectin-4에 특이적인 이환 콘쥬게이트 및 이의 용도
GB2616354A (en) 2020-08-26 2023-09-06 Marengo Therapeutics Inc Methods of detecting TRBC1 or TRBC2
CA3193421A1 (fr) 2020-08-28 2022-03-03 Bristol-Myers Squibb Company Therapie par antagoniste de lag-3 pour le carcinome hepatocellulaire
EP4204020A1 (fr) 2020-08-31 2023-07-05 Advanced Accelerator Applications International S.A. Méthode de traitement de cancers exprimant le psma
EP4204453A1 (fr) 2020-08-31 2023-07-05 Bristol-Myers Squibb Company Signature de localisation cellulaire et immunothérapie
US20230321285A1 (en) 2020-08-31 2023-10-12 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
EP4221842A4 (fr) 2020-10-02 2024-11-20 Dracen Pharmaceuticals, Inc. Composition lyophilisée comprenant du (s)-isopropyl 2-((s)-2-acétamido-3-(1h-indol-3-yl) propanamido)-6-diazo-5-oxohexanoate pour une administration sous-cutanée et son utilisation
CA3198456A1 (fr) 2020-10-14 2022-04-21 Five Prime Therapeutics, Inc. Anticorps anti-recepteur de chimiokine c-c 8 (ccr8) et leurs procedes d'utilisation
EP4232019A1 (fr) 2020-10-23 2023-08-30 Bristol-Myers Squibb Company Thérapie par antagoniste de lag-3 pour le cancer du poumon
AU2021373366A1 (en) 2020-11-06 2023-06-01 Novartis Ag Cd19 binding molecules and uses thereof
CA3200814A1 (fr) 2020-12-02 2022-06-09 Alfredo C. Castro Inhibiteurs de tead et utilisations associees
JP2024508207A (ja) 2020-12-02 2024-02-26 ブイアイビー ブイゼットダブリュ がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト
WO2022120353A1 (fr) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
WO2022120179A1 (fr) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Signatures géniques multi-tumorales et leurs utilisations
CA3204091A1 (fr) 2020-12-08 2022-06-16 Infinity Pharmaceuticals, Inc. Eganelisib destine a etre utilise dans le traitement d'un cancer pd-l1 negatif
TW202237119A (zh) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Ａｌｋ﹘５抑制劑和彼之用途
CN114621344B (zh) * 2020-12-10 2022-08-30 北京东方百泰生物科技股份有限公司 一种抗lag-3单克隆抗体的纯化方法
CA3202330A1 (fr) 2020-12-16 2022-06-23 Anthony Casarez Composes utiles en tant qu'activateurs de lymphocytes t
WO2022135667A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Arn thérapeutique pour le traitement du cancer
WO2022135666A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Programme de traitement faisant intervenir des protéines cytokines
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
RS66849B1 (sr) 2020-12-28 2025-06-30 Bristol Myers Squibb Co Kompozicije antitela i postupci njihove upotrebe
US20220233689A1 (en) 2020-12-28 2022-07-28 Bristol-Myers Squibb Company Methods of treating tumors
TW202241891A (zh) 2020-12-30 2022-11-01 美商凱麥拉醫療公司 Irak降解劑及其用途
US20250186539A2 (en) 2021-01-11 2025-06-12 Bicycletx Limited Methods for treating cancer
WO2022165260A1 (fr) 2021-01-29 2022-08-04 Iovance Biotherapeutics, Inc. Procédés de fabrication de lymphocytes infiltrant les tumeurs modifiés et leur utilisation dans la thérapie cellulaire adoptive
US20240384350A1 (en) 2021-01-29 2024-11-21 Board Of Regents, The University Of Texas System Methods of treating cancer with kinase inhibitors
EP4288427A1 (fr) 2021-02-02 2023-12-13 Liminal Biosciences Limited Antagonistes de gpr84 et leurs utilisations
KR20230152692A (ko) 2021-02-02 2023-11-03 리미널 바이오사이언시스 리미티드 Gpr84 길항제 및 이의 용도
US20240109899A1 (en) 2021-02-04 2024-04-04 Bristol-Myers Squibb Company Benzofuran compounds as sting agonists
US12252488B2 (en) 2021-02-12 2025-03-18 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
EP4291558A1 (fr) 2021-02-12 2023-12-20 F. Hoffmann-La Roche AG Dérivés bicycliques de tétrahydroazépine pour le traitement du cancer
IL304905A (en) 2021-02-15 2023-10-01 Kymera Therapeutics Inc IRAK4 joints and their uses
JP2024506656A (ja) 2021-02-15 2024-02-14 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ４分解剤およびその使用
WO2022187423A1 (fr) 2021-03-03 2022-09-09 The Regents Of The University Of Michigan Ligands de céréblon
US20240190874A1 (en) 2021-03-03 2024-06-13 The Regents Of The University Of Michigan Small molecule degraders of androgen receptor
WO2022187856A1 (fr) 2021-03-05 2022-09-09 Nimbus Saturn, Inc. Antagonistes de hpk1 et leurs utilisations
JP2024510176A (ja) 2021-03-08 2024-03-06 ブループリント メディシンズ コーポレイション Ｍａｐ４ｋ１阻害剤
WO2022197641A1 (fr) 2021-03-15 2022-09-22 Rapt Therapeutics, Inc. Dérivés de 1h-pyrazolo[3,4-d]pyrimidin-6-yl-amine servant de modulateurs et/ou d'inhibiteurs de kinase progénitrice hématopoïétique 1 (hpk1) pour traiter le cancer et d'autres maladies
US12071442B2 (en) 2021-03-29 2024-08-27 Nimbus Saturn, Inc. Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists
KR20240005700A (ko) 2021-03-29 2024-01-12 주노 쎄러퓨티크스 인코퍼레이티드 체크포인트 억제제 요법 및 car t 세포 요법의 조합을 사용한 투여 및 치료 방법
US20240376224A1 (en) 2021-04-02 2024-11-14 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
IL307338A (en) 2021-04-05 2023-11-01 Bristol Myers Squibb Co Pyridinyl substituted oxisoisoindoline compounds for cancer therapy
RS66982B1 (sr) 2021-04-06 2025-07-31 Bristol Myers Squibb Co Piridinil supstituisana oksoizoindolinska jedinjenja
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
WO2022216979A1 (fr) 2021-04-08 2022-10-13 Board Of Regents, The University Of Texas System Composés et procédés pour le ciblage théranostique d'une activité parp
KR20240004462A (ko) 2021-04-08 2024-01-11 마렝고 테라퓨틱스, 인크. Tcr에 결합하는 다기능성 분자 및 이의 용도
WO2022217276A1 (fr) 2021-04-09 2022-10-13 Nimbus Clio, Inc. Modulateurs de cbl-b et leurs utilisations
EP4323356A1 (fr) 2021-04-13 2024-02-21 Nuvalent, Inc. Hétérocycles amino-substitués pour le traitement de cancers avec des mutations egfr
AU2022258968A1 (en) 2021-04-16 2023-10-19 Ikena Oncology, Inc. Mek inhibitors and uses thereof
US12097261B2 (en) 2021-05-07 2024-09-24 Kymera Therapeutics, Inc. CDK2 degraders and uses thereof
US20240285740A1 (en) 2021-05-12 2024-08-29 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating cancer
AR125874A1 (es) 2021-05-18 2023-08-23 Novartis Ag Terapias de combinación
JP2024521706A (ja) 2021-05-21 2024-06-04 アーカス バイオサイエンシーズ，インコーポレーテッド Ａｘｌ化合物
CN117337288A (zh) 2021-05-21 2024-01-02 艾库斯生物科学有限公司 Axl抑制剂化合物
CA3225254A1 (fr) 2021-07-13 2023-01-19 BioNTech SE Agents de liaison multispecifiques contre cd40 et cd137 en polytherapie du cancer
AR126442A1 (es) 2021-07-14 2023-10-11 Blueprint Medicines Corp Inhibidores de map4k1
AR126453A1 (es) 2021-07-15 2023-10-11 Blueprint Medicines Corp Inhibidores de map4k1
EP4392421A1 (fr) 2021-08-25 2024-07-03 PIC Therapeutics, Inc. Inhibiteurs d'eif4e et leurs utilisations
JP2024534127A (ja) 2021-08-25 2024-09-18 ピク セラピューティクス， インコーポレイテッド ｅＩＦ４Ｅ阻害剤及びその使用
US20240376100A1 (en) 2021-09-08 2024-11-14 Redona Therapeutics, Inc. Papd5 and/or papd7 inhibiting 4-oxo-1, 4-dihydroquinoline-3-carboxylic acid derivatives
WO2023051621A1 (fr) * 2021-09-29 2023-04-06 中山康方生物医药有限公司 Anticorps anti-lag3, composition pharmaceutique et utilisation
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023077090A1 (fr) 2021-10-29 2023-05-04 Bristol-Myers Squibb Company Thérapie par antagoniste de lag-3 pour cancer hématologique
WO2023076556A1 (fr) 2021-10-29 2023-05-04 Kymera Therapeutics, Inc. Agents de dégradation d'irak4 et leur synthèse
WO2023077046A1 (fr) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibiteurs d'hif-2alpha et leurs procédés d'utilisation
IL313439A (en) 2021-12-16 2024-08-01 Valerio Therapeutics New conjugated nucleic acid molecules and their uses
WO2023114984A1 (fr) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
WO2023122778A1 (fr) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Dérivés de pyridazinone utiles en tant qu'activateurs de lymphocytes t
WO2023122772A1 (fr) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Dérivés d'oxime utiles comme activateurs de lymphocytes t
WO2023122777A1 (fr) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Dérivés d'oxime utiles en tant qu'activateurs de lymphocytes t
JP2025503962A (ja) 2022-01-26 2025-02-06 ブリストル－マイヤーズ スクイブ カンパニー 肝細胞がんのための併用療法
US20250099588A1 (en) 2022-01-28 2025-03-27 Iovance Biotherapeutics, Inc. Cytokine associated tumor infiltrating lymphocytes compositions and methods
JP2025504059A (ja) 2022-01-31 2025-02-06 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋデグレーダー及びその使用
EP4472963A1 (fr) 2022-02-01 2024-12-11 Arvinas Operations, Inc. Composés de ciblage de dgk et utilisations associées
WO2023154905A1 (fr) 2022-02-14 2023-08-17 Gilead Sciences, Inc. Composés de pyrazolopyridinone antiviraux
JP2025507694A (ja) 2022-02-25 2025-03-21 ブリストル－マイヤーズ スクイブ カンパニー 結腸直腸癌に対する組み合わせ療法
WO2023173057A1 (fr) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Inhibiteurs de mek et leurs utilisations
WO2023173053A1 (fr) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Inhibiteurs de mek et leurs utilisations
JP2025509832A (ja) 2022-03-15 2025-04-11 コンピュジェン リミテッド Ｉｌ－１８ｂｐアンタゴニスト抗体、並びに癌の治療での単剤療法及び併用療法におけるそれらの使用
KR20240159621A (ko) 2022-03-18 2024-11-05 브리스톨-마이어스 스큅 컴퍼니 폴리펩티드를 단리하는 방법
WO2023211889A1 (fr) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Composés polymorphes et leurs utilisations
WO2023214325A1 (fr) 2022-05-05 2023-11-09 Novartis Ag Dérivés de pyrazolopyrimidine et leurs utilisations en tant qu'inhibiteurs de tet2
CN114874324B (zh) * 2022-05-13 2023-02-03 苏州旭光科星抗体生物科技有限公司 一种检测可溶性lag-3蛋白含量的酶联免疫检测试剂盒及应用
US11878958B2 (en) 2022-05-25 2024-01-23 Ikena Oncology, Inc. MEK inhibitors and uses thereof
AU2023281061A1 (en) 2022-06-02 2024-12-05 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
EP4556493A1 (fr) 2022-07-11 2025-05-21 Genuv Inc. Protéine de fusion à base de cytokine
US20240124490A1 (en) 2022-07-15 2024-04-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (fr) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Inhibiteurs de cbl-b et leurs procédés d'utilisation
WO2024028364A1 (fr) 2022-08-02 2024-02-08 Liminal Biosciences Limited Aryl-triazolyle et antagonistes de gpr84 apparentés et leurs utilisations
JP2025527248A (ja) 2022-08-02 2025-08-20 リミナル・バイオサイエンシーズ・リミテッド 置換ピリドンｇｐｒ８４アンタゴニスト及びその使用
EP4565568A1 (fr) 2022-08-02 2025-06-11 Liminal Biosciences Limited Hétéroaryl-carboxamide et antagonistes de gpr84 associés et leurs utilisations
KR20250046309A (ko) 2022-08-08 2025-04-02 브리스톨-마이어스 스큅 컴퍼니 T 세포 활성화제로서 유용한 치환된 테트라졸릴 화합물
WO2024036101A1 (fr) 2022-08-09 2024-02-15 Bristol-Myers Squibb Company Composés bicycliques substitués par amine tertiaire utiles comme activateurs de lymphocytes t
TW202417439A (zh) 2022-08-11 2024-05-01 瑞士商赫孚孟拉羅股份公司 雙環四氫噻吖呯衍生物
JP2025526726A (ja) 2022-08-11 2025-08-15 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 二環式テトラヒドロアゼピン誘導体
PE20251399A1 (es) 2022-08-11 2025-05-22 Hoffmann La Roche Derivados de tetrahidrotiazepina biciclicos
IL316935A (en) 2022-08-11 2025-01-01 Hoffmann La Roche TETRAHYDROTHIAZEPINE DERIVATIVES CYCLES
CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
EP4602041A1 (fr) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Inhibiteurs de hpk1 et leurs procédés d'utilisation
US20240180947A1 (en) 2022-10-20 2024-06-06 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
JP2025535474A (ja) 2022-10-24 2025-10-24 キャンサー・リサーチ・テクノロジー・リミテッド 酸化還元状態改変剤によるチェックポイント阻害剤に対する腫瘍の感応化
WO2024089417A1 (fr) 2022-10-24 2024-05-02 Memorial Sloan-Kettering Cancer Center Stratification de tumeurs pour déterminer la sensibilité à un inhibiteur de point de contrôle immunitaire
US20240208961A1 (en) 2022-11-22 2024-06-27 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
AU2023393653A1 (en) 2022-12-14 2025-05-22 Astellas Pharma Europe Bv Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
AU2023409221A1 (en) 2022-12-21 2025-06-12 Bristol-Myers Squibb Company Combination therapy for lung cancer
WO2024137865A1 (fr) 2022-12-22 2024-06-27 Gossamer Bio Services, Inc. Composés utiles en tant qu'activateurs de lymphocytes t
CN115819595B (zh) * 2023-01-03 2023-05-16 上海百英生物科技股份有限公司 一种抗lag3纳米抗体及其制备方法与应用
WO2024150017A1 (fr) 2023-01-13 2024-07-18 Akrivia Biomedics Limited Procédé de profilage de maladies
WO2024163477A1 (fr) 2023-01-31 2024-08-08 University Of Rochester Thérapie de blocage de point de contrôle immunitaire pour le traitement d'infections par staphylococcus aureus
KR20250155054A (ko) 2023-03-13 2025-10-29 리제너론 파마슈티칼스 인코포레이티드 흑색종 치료에서의 효능 강화를 위한 pd-1 억제제와 lag-3 억제제의 병용
WO2024196952A1 (fr) 2023-03-20 2024-09-26 Bristol-Myers Squibb Company Évaluation de sous-type de tumeur pour une thérapie anticancéreuse
AU2024252845A1 (en) 2023-04-06 2025-10-16 Glaxosmithkline Intellectual Property (No.4) Limited Methods for treating and monitoring cancer
US20240425497A1 (en) 2023-05-05 2024-12-26 Arcus Biosciences, Inc. Cbl-b Inhibitors and Methods of Use Thereof
CN121057732A (zh) 2023-05-08 2025-12-02 百时美施贵宝公司 经取代的苯基噁唑酮化合物
TW202509014A (zh) 2023-05-10 2025-03-01 美商纜圖藥品公司 ＧＳＫ３α抑制劑及其使用方法
WO2024233853A2 (fr) * 2023-05-11 2024-11-14 Elixiron Immunotherapeutics (hong Kong) Limited Combinaison comprenant fraction de ciblage lag-3 et interleukine-10
US20250011318A1 (en) 2023-05-25 2025-01-09 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024249540A1 (fr) 2023-05-31 2024-12-05 Bristol-Myers Squibb Company Composé d'oxazolone substitué pour diminuer les taux de protéines ikzf 1-4
WO2024249894A2 (fr) 2023-06-02 2024-12-05 Arcus Biosciences, Inc. Biomarqueurs pour prédire l'efficacité d'un traitement du cancer
WO2024254227A1 (fr) 2023-06-07 2024-12-12 Bristol-Myers Squibb Company Composé oxoisoindolinyle pipéridine-2,6-dione spirocyclique substitué
IL321486A (en) 2023-06-23 2025-08-01 Kymera Therapeutics Inc Iraqi joints and their uses
WO2024263853A1 (fr) 2023-06-23 2024-12-26 Bristol-Myers Squibb Company Composé oxoisoindolinyl pipéridine -2,6-dione substitué utilisé comme agent anticancéreux
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途
WO2025030002A2 (fr) 2023-08-02 2025-02-06 Arvinas Operations, Inc. Composés ciblant dgk et leurs utilisations
WO2025038763A1 (fr) 2023-08-15 2025-02-20 Bristol-Myers Squibb Company Procédé de chromatographie en flux continu d'hydroxyapatite céramique
WO2025038857A1 (fr) 2023-08-16 2025-02-20 Arcus Biosciences, Inc. TÉTRALINES CIBLANT HIF-2α MUTANT
WO2025064197A1 (fr) 2023-09-02 2025-03-27 Bristol-Myers Squibb Company Composés d'azétidinyl oxoisoindolinyl pipéridine-2,6-dione substitués
WO2025049840A1 (fr) 2023-09-02 2025-03-06 Bristol-Myers Squibb Company Composés de phényl oxooxazolyl pipéridine dione substitués
WO2025054339A1 (fr) 2023-09-08 2025-03-13 Arcus Biosciences, Inc. Composés triazolopyridine utilisés en tant qu'inhibiteurs de kit
KR20250068738A (ko) 2023-09-13 2025-05-16 브리스톨-마이어스 스큅 컴퍼니 치환된 옥소이소인돌리닐 피페리딘-2,6-디온 화합물
WO2025072330A1 (fr) 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Composés inhibiteurs de kit et leurs procédés d'utilisation
WO2025068461A1 (fr) 2023-09-29 2025-04-03 Negio Therapeutics Dérivés de guanfacine et leur utilisation dans le traitement du cancer
WO2025068452A1 (fr) 2023-09-29 2025-04-03 Negio Therapeutics Dérivés du guanfacine et leur utilisation dans le traitement du cancer
TW202517260A (zh) 2023-10-06 2025-05-01 美商阿克思生物科學有限公司 Ｃｂｌ—ｂ抑制劑及其使用方法
TW202535865A (zh) 2023-10-31 2025-09-16 美商必治妥美雅史谷比公司 泛素特異性加工蛋白酶1 (usp1) 化合物
WO2025096490A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de type protéase 1 spécifique de l'ubiquitine (usp1)
WO2025096487A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de type protéase 1 spécifique de l'ubiquitine (usp1)
WO2025096494A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de protéase 1 de traitement spécifique de l'ubiquitine (usp1)
WO2025096505A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de type protéase 1 spécifique de l'ubiquitine (usp1)
WO2025096488A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés relatifs à la protéase 1 spécifique de l'ubiquitine (usp1)
TW202523302A (zh) 2023-11-02 2025-06-16 美商阿克思生物科學有限公司 噻唑化合物及其使用方法
WO2025106736A2 (fr) 2023-11-15 2025-05-22 Regeneron Pharmaceuticals, Inc. Combinaison d'inhibiteurs de pd-1 et d'inhibiteurs de lag-3 pour une efficacité améliorée dans le traitement du cancer du poumon
WO2025120866A1 (fr) 2023-12-08 2025-06-12 Astellas Pharma Inc. Polythérapie impliquant des agents de liaison bispécifiques se liant à cldn18.2 et cd3 et agents stabilisant ou augmentant l'expression de cldn18.2
WO2025121445A1 (fr) 2023-12-08 2025-06-12 Astellas Pharma Inc. Polythérapie impliquant des agents de liaison bispécifiques se liant à cldn18.2 et cd3 et agents stabilisant ou augmentant l'expression de cldn18.2
WO2025120867A1 (fr) 2023-12-08 2025-06-12 Astellas Pharma Inc. Polythérapie impliquant des agents de liaison bispécifiques se liant à cldn18.2 et cd3 et anticorps anti-vegfr2
WO2025132831A1 (fr) 2023-12-19 2025-06-26 Universite D'aix-Marseille Dérivés de n-hétéroaryle et leurs utilisations pour le traitement du cancer
US20250230173A1 (en) 2023-12-20 2025-07-17 Arcus Biosciences, Inc. Salt forms of an axl inhibitor
WO2025145207A1 (fr) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Polythérapie d'inhibiteur de kras et d'agent de déplétion des treg
WO2025151487A2 (fr) 2024-01-08 2025-07-17 Regents Of The University Of Michigan Inhibiteurs d'adar1 à petites molécules
EP4658320A1 (fr) 2024-02-27 2025-12-10 Bristol-Myers Squibb Company Conjugués anticorps anti-ceacam5-médicament
US20250361320A1 (en) 2024-02-27 2025-11-27 Bristol-Myers Squibb Company Anti-ceacam5 antibodies and uses thereof
WO2025193571A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193573A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193569A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193572A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193583A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193574A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193759A1 (fr) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Formes solides d'un composé azolopyrimidine
WO2025193770A1 (fr) 2024-03-13 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques
WO2025226767A1 (fr) 2024-04-24 2025-10-30 Bristol-Myers Squibb Company Composés de 3-(5-(6-aminopyridin-2-yl)-4-fluoro-1-oxoisoindolin-2-yl)pipéridine-2,6-dione substitués destinés à être utilisés dans le traitement du cancer
WO2025245489A1 (fr) 2024-05-24 2025-11-27 Bristol-Myers Squibb Company Traitement de tumeurs chez des sujets dont les échantillons sont positifs à fgl-1
WO2025250011A1 (fr) 2024-05-29 2025-12-04 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Traitement contre le cancer

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1081681A (en) 1910-08-31 1913-12-16 Otis Elevator Co Alternating-current-motor control.
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
EP0154316B1 (fr) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Lymphokine chimiquement modifiée et son procédé de préparation
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5476996A (en) 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
EP0401384B1 (fr) 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Facteur de stimulation de colonies de granulocytes modifies chimiquement
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
FR2656800B1 (fr) 1990-01-08 1992-05-15 Roussy Inst Gustave Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5976877A (en) 1990-01-08 1999-11-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
GB9108652D0 (en) 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
CA2124967C (fr) 1991-12-17 2008-04-08 Nils Lonberg Animaux transgeniques non humains capables de produire des anticorps heterologues
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
CA2118508A1 (fr) 1992-04-24 1993-11-11 Elizabeth S. Ward Production par recombinaison genetique de domaines semblables aux immunoglobulines dans les cellules procaryotes
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5762905A (en) 1992-09-16 1998-06-09 The Scripps Research Institute Human neutralizing monoclonal antibodies to respiratory syncytial virus
JP3919830B2 (ja) 1992-11-28 2007-05-30 財団法人化学及血清療法研究所 抗ネコヘルペスウイルス−１組換え抗体および該抗体をコードする遺伝子断片
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1994029351A2 (fr) 1993-06-16 1994-12-22 Celltech Limited Anticorps
WO1995018634A1 (fr) 1994-01-04 1995-07-13 The Scripps Research Institute Anticorps humains monoclonaux du virus de l'herpes simplex et methodes associees
ES2281899T3 (es) 1994-05-06 2007-10-01 Institut Gustave Roussy Fracciones polipeptidicas solubles de la proteina lag-3; procedimiento de produccion; composicion terapeutica; anticuerpo anti-idiotipo.
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
CA2227334A1 (fr) 1995-07-21 1997-02-06 Applied Research Systems Ars Holding N.V. Procedes pour detecter, identifier, isoler, marquer et cibler selectivement les lymphocytes th1, au moyen de la proteine lag-3
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
AU2071597A (en) 1996-03-07 1997-09-22 Eastman Chemical Company Near infrared fluorescent security thermal transfer printing and marking ribbons
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
IL130123A (en) 1996-11-28 2007-07-24 Roussy Inst Gustave LAG-3 protein mutants, their expression, use and method of production
UA73270C2 (en) 1996-11-29 2005-07-15 Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
WO1998042752A1 (fr) 1997-03-21 1998-10-01 Brigham And Women's Hospital Inc. Peptides immunotherapeutiques se liant a ctla-4
ES2258817T3 (es) 1997-05-21 2006-09-01 Biovation Limited Metodo para la produccion de proteinas no inmunogenas.
EP0900841A1 (fr) 1997-06-18 1999-03-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Variantes d'épissure de LAG-3
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
JP4334141B2 (ja) 1998-04-20 2009-09-30 グリカート バイオテクノロジー アクチェンゲゼルシャフト 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
GB9814383D0 (en) 1998-07-02 1998-09-02 Cambridge Antibody Tech Improvements relating to antibodies
US6951646B1 (en) 1998-07-21 2005-10-04 Genmab A/S Anti hepatitis C virus antibody and uses thereof
WO2000037504A2 (fr) 1998-12-23 2000-06-29 Pfizer Inc. Anticorps monoclonaux humains diriges contre l'antigene ctla-4
BR0008758A (pt) 1999-01-15 2001-12-04 Genentech Inc Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
CA2369292C (fr) 1999-04-09 2010-09-21 Kyowa Hakko Kogyo Co. Ltd. Methode de modulation de l'activite de molecules immunitaires fonctionnelles
GB9911569D0 (en) 1999-05-18 1999-07-21 Oxford Biomedica Ltd Antibodies
EP1210428B1 (fr) 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, recepteur de b7-4, et son utilisation
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
EP1212422B1 (fr) 1999-08-24 2007-02-21 Medarex, Inc. Anticorps contre l'antigene ctla-4 humain et utilisation
US6794132B2 (en) 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
EP2275449B1 (fr) 2000-06-16 2016-09-28 Human Genome Sciences, Inc. Anticorps se liant de manière immunospécifique à un stimulateur de lymphocyte B (BLyS)
US6818216B2 (en) 2000-11-28 2004-11-16 Medimmune, Inc. Anti-RSV antibodies
DK1354034T3 (da) 2000-11-30 2008-03-25 Medarex Inc Transgene transchromosomale gnavere til fremstilling af humane antistoffer
CN1277843C (zh) 2001-02-22 2006-10-04 巴斯德研究院 分枝杆菌比较基因组学作为鉴定分枝杆菌病的诊断、预防或治疗靶的工具
US20020146753A1 (en) 2001-04-06 2002-10-10 Henrik Ditzel Autoantibodies to glucose-6-phosphate isomerase and their participation in autoimmune disease
DE60227067D1 (de) 2001-05-11 2008-07-24 Kirin Pharma Kk Künstliches menschliches chromosom mit dem gen für die lambda-leichte kette menschlicher antikörper
US6989452B2 (en) 2001-05-31 2006-01-24 Medarex, Inc. Disulfide prodrugs and linkers and stabilizers useful therefor
ATE519779T1 (de) 2001-09-19 2011-08-15 Roussy Inst Gustave An das glu-pro motiv-bindende proteine und peptide, diese enthaltende therapeutische zusammensetzungen und deren anwendungen
AU2002341752B2 (en) 2001-09-19 2008-04-03 Alexion Pharmaceuticals, Inc. Engineered templates and their use in single primer amplification
ATE430580T1 (de) 2001-10-25 2009-05-15 Genentech Inc Glycoprotein-zusammensetzungen
WO2003072035A2 (fr) 2002-02-22 2003-09-04 Genentech, Inc. Compositions et methodes de traitement de maladies relatives au systeme immunitaire
CN1930288B (zh) 2002-04-09 2012-08-08 协和发酵麒麟株式会社 基因组被修饰的细胞
NZ535925A (en) 2002-04-16 2008-06-30 Genentech Inc An isolated antibody that binds to a particular polypeptide
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
EP2322203A3 (fr) 2002-10-29 2011-07-27 Genentech, Inc. Les compositions et les methodes pour le traitement de maladies liees immunisees
WO2005035732A2 (fr) 2003-02-19 2005-04-21 Dyax Corporation Ligands de papp-a
JP2006523226A (ja) 2003-02-28 2006-10-12 ザ ジョンズ ホプキンス ユニバーシティ Ｔ細胞調節方法
WO2005034733A2 (fr) 2003-10-08 2005-04-21 North Shore-Long Island Jewish Research Institute Techniques et compositions pour le diagnostic et le traitement de la leucemie lymphocytaire chronique des cellules beta
DK1711207T3 (da) * 2003-12-10 2013-03-11 Medarex Inc Interferon-alpha-antistoffer og anvendelse heraf
BR122019012028B1 (pt) 2004-04-13 2023-09-26 F. Hoffmann-La Roche Ag Anticorpos anti-p-selectina, molécula de ácido nucléico, vetor, e composição
EP1740946B1 (fr) 2004-04-20 2013-11-06 Genmab A/S Anticorps monoclonaux humains diriges contre cd20
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
MXPA06013413A (es) 2004-05-19 2007-01-23 Medarex Inc Enlazadores quimicos y conjugados de los mismos.
BRPI0513706A (pt) 2004-07-20 2008-05-13 Symphogen As anticorpo policlonal recombinante anti-rhesus d e métodos de produção
WO2006017538A2 (fr) 2004-08-03 2006-02-16 Dyax Corp. Proteines de liaison a la proteine hk1
EP1793858A4 (fr) 2004-09-08 2008-12-10 Univ Ohio State Res Found Anticorps monoclonaux humains anti-ctla4 dans le traitement du cancer
KR20070083899A (ko) 2004-10-01 2007-08-24 메다렉스, 인코포레이티드 Ｃｄ30 양성 림프종의 치료 방법
PT3428191T (pt) 2004-10-06 2024-12-30 Mayo Found Medical Education & Res B7-h1 e tratamento do carcinona de células renais
WO2006089231A2 (fr) 2005-02-18 2006-08-24 Medarex, Inc. Anticorps monoclonaux diriges contre l'antigene d'enveloppe specifique de la prostate (psma) depourvus de residus fucosyle
US20080279865A1 (en) 2005-03-23 2008-11-13 Pfizer, Inc., Pfizer Products, Inc. Therapy of Prostate Cancer With Ctla-4 Antibodies and Hormonal Therapy
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
KR101411165B1 (ko) 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
JP5290756B2 (ja) 2005-09-26 2013-09-18 メダレックス インコーポレイテッド 抗体−薬剤コンジュゲート及びその使用
EP1940789B1 (fr) 2005-10-26 2011-11-23 Medarex, Inc. Procede et composes pour la preparation d'analogues de cc-1065
EP2465870A1 (fr) 2005-11-07 2012-06-20 Genentech, Inc. Polypeptides de liaison dotés de séquences hypvervariables VH/VL diversifiées et consensuelles
WO2007059404A2 (fr) 2005-11-10 2007-05-24 Medarex, Inc. Composes et conjugues cytotoxiques
JP2009518320A (ja) 2005-12-05 2009-05-07 シュムフォウエン アクティーゼルスカブ 抗オルトポックスウイルス組換えポリクローナル抗体
EP2975057A1 (fr) 2006-07-10 2016-01-20 Fujita Health University Nouvel anticorps anti-cd73
WO2008073160A2 (fr) 2006-08-17 2008-06-19 The Trustees Of Columbia University In The City Of New York Procédés de conversion ou d'induction d'une immunité protectrice
EP3018144A1 (fr) 2006-08-18 2016-05-11 XOMA Technology Ltd. Anticorps prlr spécifique et ses utilisations
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
JP2010519310A (ja) 2007-02-21 2010-06-03 メダレックス インコーポレイテッド 単一のアミノ酸を有する化学リンカーおよびその複合体
AU2008232903B9 (en) 2007-03-30 2013-09-05 Medimmune Llc Antibodies with decreased deamidation profiles
EP1987839A1 (fr) * 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Anticorps monoclonal cytotoxique anti-LAG-3 et son utilisation pour le traitement ou la prévention d'un rejet de greffe d'organe et de maladies auto-immunes
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
US20090028857A1 (en) 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
HUE029164T2 (hu) 2007-09-14 2017-02-28 Univ Brussel Vrije Humán antigén-prezentáló sejtek T-sejteket stimuláló képességének fokozása és azok alkalmazása vakcinázásra
KR101554753B1 (ko) 2007-10-01 2015-09-22 브리스톨-마이어스 스큅 컴퍼니 메소텔린에 결합하는 인간 항체 및 이의 용도
TW200938224A (en) 2007-11-30 2009-09-16 Medarex Inc Anti-B7H4 monoclonal antibody-drug conjugate and methods of use
CN101939028A (zh) 2007-11-30 2011-01-05 百时美施贵宝公司 针对蛋白酪氨酸激酶7(ptk7)的单克隆抗体伴侣分子偶联物
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EP2927240A1 (fr) 2008-08-25 2015-10-07 Amplimmune, Inc. Compositions d'antagonistes pd-1 et procédés d'utilisation
CA2735006A1 (fr) 2008-08-25 2010-03-11 Amplimmune, Inc. Antagonistes de pd-1 et leurs procedes d'utilisation
WO2010077634A1 (fr) 2008-12-09 2010-07-08 Genentech, Inc. Anticorps anti-pd-l1 et leur utilisation pour améliorer la fonction des lymphocytes t
CA2768204A1 (fr) * 2009-07-15 2011-01-20 Aimm Therapeutics B.V. Composes de liaison specifiques de bacteries a gram positif
NZ599405A (en) 2009-11-24 2014-09-26 Medimmune Ltd Targeted binding agents against b7-h1
JP5934203B2 (ja) * 2010-07-14 2016-06-15 メルク・シャープ・エンド・ドーム・コーポレイション 抗ａｄｄｌモノクローナル抗体およびこの使用
WO2012054438A1 (fr) * 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
US9856320B2 (en) 2012-05-15 2018-01-02 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
SI2970464T1 (sl) 2013-03-15 2020-08-31 Glaxosmithkline Intellectual Propety Development Limited Anti-LAG-3 vezavni proteini
CN105682683A (zh) 2013-08-02 2016-06-15 阿杜罗生物科技控股有限公司 结合cd27激动剂以及免疫检查点抑制以用于免疫刺激
US10081681B2 (en) 2013-09-20 2018-09-25 Bristol-Myers Squibb Company Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
SI3556775T1 (sl) 2014-01-28 2022-02-28 Bristol-Myers Squibb Company Protitelesa proti-LAG-3 za zdravljenje hematoloških malignosti
NZ735820A (en) 2015-04-17 2025-02-28 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途

Also Published As

Publication number Publication date
ES2987734T3 (es) 2024-11-18
TW201938198A (zh) 2019-10-01
CN104411723B (zh) 2018-01-30
PL2867258T3 (pl) 2017-11-30
NL301205I1 (fr) 2023-04-19
MX365417B (es) 2019-06-03
EP3275899B1 (fr) 2020-08-26
AU2017221874A1 (en) 2017-09-21
DK3275899T3 (da) 2020-11-30
AU2013286914A1 (en) 2015-01-29
CY2022035I1 (el) 2023-01-05
AR091649A1 (es) 2015-02-18
HK1249535A1 (en) 2018-11-02
JP6668405B2 (ja) 2020-03-18
TWI771721B (zh) 2022-07-21
HRP20171315T1 (hr) 2017-10-20
FI3795592T3 (fi) 2024-10-01
EA202090227A1 (ru) 2020-05-31
KR20200075891A (ko) 2020-06-26
US10377824B2 (en) 2019-08-13
LUC00286I2 (fr) 2025-05-12
SMT202400395T1 (it) 2024-11-15
NL301205I2 (nl) 2023-05-24
TWI576355B (zh) 2017-04-01
CY1123609T1 (el) 2022-03-24
BR112014032999A2 (pt) 2017-08-01
FR22C1057I1 (fr) 2023-01-06
MX2019006411A (es) 2019-08-14
PH12021552200A1 (en) 2022-05-02
US11345752B2 (en) 2022-05-31
BR112014032999B1 (pt) 2022-10-18
KR102290633B1 (ko) 2021-08-19
KR20220150417A (ko) 2022-11-10
CN108101991B (zh) 2022-02-11
TWI701045B (zh) 2020-08-11
PE20191759A1 (es) 2019-12-12
LTPA2022015I1 (fr) 2022-12-12
LTC2867258I2 (fr) 2025-06-10
SI3795592T1 (sl) 2024-10-30
TW202313688A (zh) 2023-04-01
PE20241623A1 (es) 2024-08-07
CL2014003637A1 (es) 2015-03-27
EP2867258A1 (fr) 2015-05-06
EP3275899A1 (fr) 2018-01-31
TWI662046B (zh) 2019-06-11
US20150307609A1 (en) 2015-10-29
MY197322A (en) 2023-06-13
AU2019204803B2 (en) 2021-06-10
US10266591B2 (en) 2019-04-23
SI2867258T1 (sl) 2017-10-30
AU2021225177A1 (en) 2021-09-30
PT3275899T (pt) 2020-11-17
TWI617581B (zh) 2018-03-11
TW201831515A (zh) 2018-09-01
HUE069061T2 (hu) 2025-02-28
HUE052406T2 (hu) 2021-04-28
HRP20201852T1 (hr) 2021-01-08
IL236517A0 (en) 2015-02-26
HRP20201852T8 (hr) 2021-06-25
NO2023020I1 (no) 2023-05-03
US20230077348A1 (en) 2023-03-16
JP2022064901A (ja) 2022-04-26
CA3161329A1 (fr) 2014-01-09
EP3795592A1 (fr) 2021-03-24
CA2877746A1 (fr) 2014-01-09
MX2015000116A (es) 2015-04-14
UY34887A (es) 2013-12-31
SG11201408780XA (en) 2015-01-29
US20140093511A1 (en) 2014-04-03
RS56398B1 (sr) 2017-12-29
NO2023008I1 (no) 2023-02-07
PH12014502854B1 (en) 2015-02-23
PL3795592T3 (pl) 2024-10-07
AR129651A2 (es) 2024-09-18
HUS2300002I1 (hu) 2023-01-28
CN104411723A (zh) 2015-03-11
EP2867258B1 (fr) 2017-06-28
US20250136684A1 (en) 2025-05-01
AU2019204803A1 (en) 2019-07-25
PT3795592T (pt) 2024-09-17
TW201406784A (zh) 2014-02-16
AU2013286914B2 (en) 2017-06-29
MY169383A (en) 2019-03-26
US20170137514A1 (en) 2017-05-18
EA201590138A1 (ru) 2015-07-30
JP2015527880A (ja) 2015-09-24
PH12014502854A1 (en) 2015-02-23
CO7170127A2 (es) 2015-01-28
JP2024041966A (ja) 2024-03-27
AU2017221874B2 (en) 2019-05-02
KR20150023909A (ko) 2015-03-05
TW202118789A (zh) 2021-05-16
LT3275899T (lt) 2020-12-10
PE20150221A1 (es) 2015-02-19
RS65997B1 (sr) 2024-10-31
TW201726743A (zh) 2017-08-01
AR125268A2 (es) 2023-06-28
EP4553086A2 (fr) 2025-05-14
SMT201700449T1 (it) 2017-11-15
SMT202000628T1 (it) 2021-01-05
KR20240168469A (ko) 2024-11-29
MY197544A (en) 2023-06-22
EA035013B1 (ru) 2020-04-17
PT2867258T (pt) 2017-08-31
IL236517B (en) 2018-06-28
JP7009531B2 (ja) 2022-02-10
TN2014000536A1 (en) 2016-03-30
HK1207386A1 (en) 2016-01-29
PE20191324A1 (es) 2019-09-24
DK3795592T3 (da) 2024-10-14
RS61084B1 (sr) 2020-12-31
HUE034553T2 (en) 2018-02-28
ES2638545T3 (es) 2017-10-23
US20190256594A1 (en) 2019-08-22
LT2867258T (lt) 2017-09-11
CN108101991A (zh) 2018-06-01
JP2018126149A (ja) 2018-08-16
EP3795592B1 (fr) 2024-07-24
JP2020103301A (ja) 2020-07-09
SI3275899T1 (sl) 2020-11-30
AU2019204803C1 (en) 2023-06-29
NZ628528A (en) 2016-07-29
KR102461102B1 (ko) 2022-10-31
KR20230159625A (ko) 2023-11-21
DK2867258T3 (en) 2017-10-02
KR102126596B1 (ko) 2020-06-24
SG10201610960YA (en) 2017-02-27
WO2014008218A1 (fr) 2014-01-09
AU2025200257A1 (en) 2025-02-20
CA2877746C (fr) 2022-07-19
CY1119563T1 (el) 2018-03-07
US20180371087A1 (en) 2018-12-27
LT3795592T (lt) 2024-09-25
CY2022035I2 (el) 2023-01-27
US9505839B2 (en) 2016-11-29
KR20210102485A (ko) 2021-08-19
JP6320376B2 (ja) 2018-05-09
FIC20230009I1 (fi) 2023-02-09
TW202432599A (zh) 2024-08-16
ES2831406T3 (es) 2021-06-08
HRP20241357T1 (hr) 2024-12-20

Similar Documents

Publication Publication Date Title
FR22C1057I2 (fr) Optimisation des anticorps humains qui se lient au gene 3 d'activation des lymphocytes (lag-3), et leurs utilisations
MA53750A (fr) Anticorps anti-bcma, molécules de liaison d'antigène bispécifiques qui se lient au bcma et cd3 et leurs utilisations
EP2320940A4 (fr) Anticorps humains qui se lient au gène 3 d'activation des lymphocytes (lag-3), et leurs utilisations
EP2699264A4 (fr) Anticorps et autres molécules qui se lient à b7-h1 et à pd-1
FR21C1061I2 (fr) Anticorps anti-angptl3 et utilisations de ceux-ci
MA49565A (fr) Anticorps agonistes qui lient cd137 humain et leurs utilisations
MA45712A (fr) Anticorps anti-gprc5d, molécules bispécifiques de liaison à l'antigène qui se lient à gprc5d et cd3 et leurs utilisations
MA52022A (fr) Anticorps qui se lient à cd39 et leurs utilisations
MA47130A (fr) Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations
EP2847223A4 (fr) Anticorps anti-b7-h6, protéines de fusion, et leurs procédés d'utilisation
EP2961774A4 (fr) Anticorps d'alpha-synucléine et leurs utilisations
EP2621955A4 (fr) Anticorps anti-ceacam6 et leurs utilisations
EP2825200A4 (fr) Anticorps anti-cd27 humains, leurs procédés et leurs utilisations
EP3383412A4 (fr) Anticorps spécifiques de la protéine pd-1 glycosylée et leurs procédés d'utilisation
MA44723A (fr) Anticorps agonistes se liant au cd40 humain et leurs utilisations
EP2342226A4 (fr) Anticorps anti-pd-1, pd-l1, et pd-l2 humains et leurs utilisations
EP2812442A4 (fr) Glyco-ingénierie chimio-enzymatique d'anticorps et de leurs fragments fc
EP2780460A4 (fr) Protéines de liaison d'adn modifiées et utilisations de celles-ci
EP2794654A4 (fr) Anticorps anti-phf-tau et leurs utilisations
EP2841458A4 (fr) Régions modifiées d'anticorps et leurs utilisations
EA201370081A1 (ru) Антитела к cd48 и их применение
EP2668210A4 (fr) Anticorps anti-kit et leurs utilisations
EP2766382A4 (fr) Méditopes et anticorps de liaison à un méditope, et leurs utilisations
EP2892559A4 (fr) Formulations d'anticorps et leurs utilisations
EP2968552A4 (fr) Conjugués d'anticorps et d'agent de ciblage et leurs utilisations