[go: up one dir, main page]

FR14C0051I1 - - Google Patents

Info

Publication number
FR14C0051I1
FR14C0051I1 FR14C0051C FR14C0051I1 FR 14C0051 I1 FR14C0051 I1 FR 14C0051I1 FR 14C0051 C FR14C0051 C FR 14C0051C FR 14C0051 I1 FR14C0051 I1 FR 14C0051I1
Authority
FR
France
Prior art keywords
dialkyl fumarates
transplantation medicine
cyclosporines
pellets
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7888396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR14C0051(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR14C0051I1 publication Critical patent/FR14C0051I1/fr
Application granted granted Critical
Publication of FR14C0051I2 publication Critical patent/FR14C0051I2/fr
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
FR14C0051C 1998-11-19 2014-06-25 Dialkylfumarates pour le traitement de maladies autoimmunes Active FR14C0051I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853487A DE19853487A1 (de) 1998-11-19 1998-11-19 Verwendung von Dialkylfumaraten
PCT/EP1999/008215 WO2000030622A2 (fr) 1998-11-19 1999-10-29 Utilisation de dialkylfumarates

Publications (2)

Publication Number Publication Date
FR14C0051I1 true FR14C0051I1 (fr) 2014-08-08
FR14C0051I2 FR14C0051I2 (fr) 2019-01-18

Family

ID=7888396

Family Applications (1)

Application Number Title Priority Date Filing Date
FR14C0051C Active FR14C0051I2 (fr) 1998-11-19 2014-06-25 Dialkylfumarates pour le traitement de maladies autoimmunes

Country Status (34)

Country Link
US (9) US6509376B1 (fr)
EP (1) EP1131065B1 (fr)
JP (7) JP2002530324A (fr)
CN (2) CN1615839A (fr)
AT (1) ATE242633T1 (fr)
BE (1) BE2014C040I2 (fr)
BG (1) BG64837B1 (fr)
BR (1) BR9914606A (fr)
CA (1) CA2346438C (fr)
CY (1) CY2014027I2 (fr)
CZ (1) CZ299409B6 (fr)
DE (2) DE19853487A1 (fr)
DK (1) DK1131065T3 (fr)
EE (1) EE04389B1 (fr)
ES (1) ES2195664T3 (fr)
FR (1) FR14C0051I2 (fr)
HK (1) HK1042242B (fr)
HU (2) HU226689B1 (fr)
IL (2) IL142728A0 (fr)
LT (1) LTC1131065I2 (fr)
LU (1) LU92488I2 (fr)
ME (1) ME00731B (fr)
MX (1) MXPA01005007A (fr)
NO (3) NO333257B1 (fr)
NZ (1) NZ510247A (fr)
PL (2) PL205948B1 (fr)
PT (1) PT1131065E (fr)
RS (1) RS49995B (fr)
RU (1) RU2215524C2 (fr)
SI (1) SI1131065T1 (fr)
SK (1) SK285601B6 (fr)
TR (1) TR200101204T2 (fr)
WO (1) WO2000030622A2 (fr)
ZA (1) ZA200202335B (fr)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US6912052B2 (en) * 2000-11-17 2005-06-28 Cymer, Inc. Gas discharge MOPA laser spectral analysis module
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
AU2002219236B2 (en) * 2001-01-12 2006-02-09 Biogen International Gmbh Fumaric acid amides
US20050259709A1 (en) * 2002-05-07 2005-11-24 Cymer, Inc. Systems and methods for implementing an interaction between a laser shaped as a line beam and a film deposited on a substrate
DE10217314A1 (de) 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
WO2004112773A1 (fr) * 2003-04-24 2004-12-29 Shin-Jen Shiao Compositions pharmaceutiques utilisees pour le traitement de maladie immune et amelioration
US7277188B2 (en) * 2003-04-29 2007-10-02 Cymer, Inc. Systems and methods for implementing an interaction between a laser shaped as a line beam and a film deposited on a substrate
ATE380027T1 (de) 2003-09-09 2007-12-15 Fumapharm Ag Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
DE10342423A1 (de) * 2003-09-13 2005-04-14 Heidland, August, Prof. Dr.med. Dr.h.c. Verwendung von Fumarsäurederivaten zur Prophylaxe und zur Behandlung von Genomschäden
US6873418B1 (en) 2003-09-30 2005-03-29 Cymer, Inc. Optical mountings for gas discharge MOPA laser spectral analysis module
US6894785B2 (en) * 2003-09-30 2005-05-17 Cymer, Inc. Gas discharge MOPA laser spectral analysis module
CA2478458A1 (fr) * 2004-08-20 2006-02-20 Michael Panzara Traitement de la sclerose en plaques pediatrique
DE14172396T1 (de) 2004-10-08 2015-01-08 Forward Pharma A/S Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester
US20080004344A1 (en) * 2004-11-10 2008-01-03 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
US7653095B2 (en) * 2005-06-30 2010-01-26 Cymer, Inc. Active bandwidth control for a laser
DE602006011910D1 (de) 2005-07-07 2010-03-11 Aditech Pharma Ag Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung
US20080227847A1 (en) * 2005-07-07 2008-09-18 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
WO2007042035A2 (fr) * 2005-10-07 2007-04-19 Aditech Pharma Ab Therapie de combinaison pour le traitement d'un trouble auto-immun et/ou inflammatoire et de conditions associees
EP1951206A1 (fr) * 2005-10-07 2008-08-06 Aditech Pharma AB Compositions pharmaceutiques a liberation controlee comportant un ester de l'acide fumarique
US7679029B2 (en) * 2005-10-28 2010-03-16 Cymer, Inc. Systems and methods to shape laser light as a line beam for interaction with a substrate having surface variations
US7317179B2 (en) * 2005-10-28 2008-01-08 Cymer, Inc. Systems and methods to shape laser light as a homogeneous line beam for interaction with a film deposited on a substrate
PT2137537E (pt) 2007-02-08 2013-08-22 Biogen Idec Inc Composições e respectivas utilizações para o tratamento da esclerose múltipla
WO2008096271A2 (fr) 2007-02-08 2008-08-14 Ralf Gold Neuroprotection dans des maladies démyélinisantes
RU2361605C2 (ru) * 2007-08-01 2009-07-20 Федеральное агентство по высокотехнологичной медицинской помощи Федеральное государственное учреждение "Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии" (ФГУ УрНИИДВиИ Росмедтехнологий) Способ лечения псориаза
DE102008030023A1 (de) 2008-06-16 2009-12-17 Eberhard-Karls-Universität Tübingen Universitätsklinikum Arzneimittel zur Behandlung einer durch Parasiten verursachten Krankheit
RU2554347C2 (ru) * 2008-08-19 2015-06-27 Ксенопорт, Инк. Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения
CN109044985A (zh) 2009-01-09 2018-12-21 前进制药知识产权有限公司 包含溶蚀骨架中的一种或多种富马酸酯的药物制剂
NZ617130A (en) 2009-04-29 2015-06-26 Biogen Ma Inc Treatment of neurodegeneration and neuroinflammation
ME02317B (me) * 2010-02-12 2016-06-20 Biogen Ma Inc Neuroprotekcija kod demijelinizacijskih bolesti
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
WO2011116091A1 (fr) 2010-03-17 2011-09-22 Novartis Ag Distributeur
PT2558499T (pt) 2010-04-16 2017-07-14 Biogen Ma Inc Anticorpos anti-vla-4
MX339243B (es) 2011-02-03 2016-05-18 Vtv Therapeutics Llc Derivados fusionados sustituidos de imidazol, composiciones farmaceuticas y metodos de uso de los mismos.
CN103732062A (zh) * 2011-05-26 2014-04-16 比奥根艾迪克Ma公司 治疗多发性硬化以及保持和/或增加髓磷脂含量的方法
MX355421B (es) 2011-06-08 2018-04-18 Biogen Ma Inc Proceso para preparar fumarato de dimetilo cristalino y de alta pureza.
WO2013076216A1 (fr) 2011-11-24 2013-05-30 Synthon Bv Libération contrôlée de particules comprenant du diméthylfumarate
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
AU2013203445C1 (en) * 2012-02-07 2017-04-20 Biogen Ma Inc. Pharmaceutical compositions containing dimethyl fumarate
CN104169261A (zh) * 2012-02-07 2014-11-26 什诺波特有限公司 富马酸吗啉代烃基酯化合物、药物组合物和使用方法
SG11201407322QA (en) * 2012-05-23 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of multiple sclerosis
US20200000758A1 (en) * 2012-08-22 2020-01-02 Xenoport, Inc. Oral Dosage Forms Of Methyl Hydrogen Fumarate And Prodrugs Thereof
EP2887934A1 (fr) 2012-08-22 2015-07-01 XenoPort, Inc. Méthodes d'administration du monométhyl fumarate et des promédicaments associés présentant des effets secondaires réduits
AU2013305684B2 (en) 2012-08-22 2016-11-24 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
CN103483194B (zh) * 2012-11-30 2016-03-09 杨寅柯 一种2-氟代富马酸酯(结构式i)及其制备方法及应用
US20140171504A1 (en) 2012-12-14 2014-06-19 Georgia Regents Research Institute, Inc. Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters
EP3566701A1 (fr) 2012-12-21 2019-11-13 Biogen MA Inc. Dérivés de fumarate substitués par du deutérium
KR101379427B1 (ko) * 2013-02-13 2014-03-28 경북대학교병원 디메틸푸마레이트를 유효성분으로 포함하는 신섬유증의 예방 또는 치료용 조성물
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
UA116648C2 (uk) 2013-03-14 2018-04-25 Алкермес Фарма Айерленд Лімітед Фумарати як проліки та їх застосування при лікуванні різних захворювань
WO2014160633A1 (fr) 2013-03-24 2014-10-02 Xenoport, Inc. Compositions pharmaceutiques de fumarate de diméthyle
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (fr) 2013-06-21 2014-12-24 Xenoport, Inc. Co-cristaux de diméthyl fumarate
CN109453133A (zh) 2013-08-26 2019-03-12 前进制药知识产权有限公司 用于以低的日剂量施用的含富马酸二甲酯的药物组合物
CN104415026A (zh) * 2013-08-31 2015-03-18 成都渊源生物科技有限公司 氘代富马酸衍生物在治疗多发性硬化症中的应用
WO2015035184A1 (fr) 2013-09-06 2015-03-12 Xenoport, Inc. Formes cristallines de méthyl(2e)but-2-ène-1,4-dioate de (n,n-diéthylcarbamoyl)méthyle, procédés de synthèse et d'utilisation
WO2015042294A1 (fr) 2013-09-18 2015-03-26 Xenoport, Inc. Compositions de nanoparticules de fumarate de diméthyle
CN104434904B (zh) * 2013-09-22 2018-09-04 深圳翰宇药业股份有限公司 一种复方微丸胶囊的制备方法及其制备的复方微丸胶囊
SG11201602175VA (en) * 2013-09-27 2016-04-28 Teva Pharma Laquinimod combination therapy for treatment of multiple sclerosis
DK3079666T3 (da) * 2013-12-12 2021-03-22 Almirall Sa Farmaceutiske sammensætninger omfattende dimethylfumarat
US10172794B2 (en) 2013-12-13 2019-01-08 Biogen Ma Inc. Controlled release dosage form for once daily administration of dimethyl fumarate
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
EP3501510B1 (fr) 2014-02-28 2020-07-01 Banner Life Sciences LLC Capsules entériques molles à libération contrôlée d'esters de fumarate
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
EP3650042A1 (fr) 2014-03-14 2020-05-13 Biogen MA Inc. Fumarate de diméthyle et régimes de vaccination
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
CN104027311A (zh) * 2014-05-09 2014-09-10 万特制药(海南)有限公司 一种含有富马酸二甲酯的肠溶缓释微丸
WO2016061393A1 (fr) 2014-10-15 2016-04-21 Xenoport, Inc. Composés de fumarate, compositions pharmaceutiques et procédés d'utilisation
DE102014015314A1 (de) 2014-10-17 2016-04-21 Ppm-Medical Holding Gmbh Mittel zur unterstützenden Immunmodulation
MA40985A (fr) 2014-11-17 2017-09-26 Biogen Ma Inc Méthodes de traitement de la sclérose en plaques
CN104490849A (zh) * 2014-11-24 2015-04-08 广东东阳光药业有限公司 一种高密度的富马酸二甲酯肠溶颗粒及其制备方法
WO2016089648A1 (fr) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Inhibiteurs de bach1 en combinaison avec des activateurs de nrf2 et compositions pharmaceutiques les contenant
AU2015360502A1 (en) 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
AU2015359346B2 (en) 2014-12-11 2020-05-07 Laboratoires Juvise Pharmaceuticals Dosing regimen for a selective S1P1 receptor agonist
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
KR102283582B1 (ko) 2014-12-23 2021-07-30 한미약품 주식회사 푸마르산 에스테르를 함유하는 미니-정제 형태의 약제학적 제제
HK1253050A1 (zh) * 2015-02-02 2019-06-06 英仕柏集团有限责任公司 稳定的富马酸二烷基酯组合物
JP2018503651A (ja) * 2015-02-08 2018-02-08 アルカーメス ファーマ アイルランド リミテッド フマル酸モノメチルプロドラッグ組成物
AU2016231883B2 (en) * 2015-03-17 2019-03-07 Hetero Labs Limited Pharmaceutical compositions of dimethyl fumarate
ES2826825T3 (es) 2015-03-27 2021-05-19 Symbionyx Pharmaceuticals Inc Composiciones y métodos para el tratamiento de la psoriasis
CA2987895A1 (fr) 2015-06-01 2016-12-08 Sun Pharmaceutical Industries Ltd. Compositions pharmaceutiques de fumarate de dimethyle
JP2018517735A (ja) 2015-06-17 2018-07-05 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． フマル酸ジメチル粒子及びそれらの医薬組成物
US10213411B2 (en) 2015-08-27 2019-02-26 Vijaykumar Rajasekhar Use of prodrugs of fumarates in treating heart failure diseases
WO2017056107A1 (fr) 2015-09-28 2017-04-06 Natco Pharma Ltd Compositions pharmaceutiques de fumarate de diméthyle
WO2017060420A1 (fr) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Métabolites à base d'acide fumarique protégé destinés au traitement de maladies auto-immunes
DE102016103242A1 (de) 2016-02-24 2017-08-24 Flexopharm Brain Gmbh & Co. Kg Mittel zur unterstützenden Immunmodulation
WO2017072699A1 (fr) * 2015-10-28 2017-05-04 Sun Pharmaceutical Industries Limited Compositions pharmaceutiques de fumarate de diméthyle
US10463642B2 (en) 2016-02-01 2019-11-05 Vijaykumar Rajasekhar Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate
WO2017145036A1 (fr) * 2016-02-25 2017-08-31 Aurobindo Pharma Ltd Compositions pharmaceutiques contenant du fumarate de diméthyle
CN106265621B (zh) * 2016-09-19 2019-05-17 苏州大学 富马酸二甲酯在制备预防和治疗移植物抗宿主病及移植物抗白血病药物中的应用
GR1009149B (el) 2016-10-25 2017-10-31 Φαρματεν Αβεε Φαρμακευτικα σκευασματα που περιλαμβανουν εναν εστερα φουμαρικου οξεως και μεθοδος παραγωγης αυτων
TR201616998A1 (en) * 2016-11-23 2018-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi DELAYED RELEASE DOSING FORMS WITH DIMETHYL FUMARATE
DE102017105036A1 (de) 2017-03-09 2018-09-13 Flexopharm Brain Gmbh & Co. Kg Mittel zur Anwendung bei der Behandlung der Dyslipidämie
CN110636838A (zh) 2017-06-23 2019-12-31 阿尔米雷尔有限公司 包含反丁烯二酸二甲酯的药物组合物
US12037398B2 (en) 2018-06-04 2024-07-16 Biogen Ma Inc. Anti-VLA-4 antibodies having reduced effector function
JP7224067B2 (ja) * 2019-05-31 2023-02-17 キュラクル カンパニー リミテッド フマル酸ジメチルを含有する腸溶性錠剤
RU2742745C1 (ru) * 2019-09-24 2021-02-10 Акционерное общество "Исследовательский Институт Химического Разнообразия" Лекарственная форма в виде капсулы, содержащая таблетки с диметилфурмаратом
WO2021142062A1 (fr) 2020-01-10 2021-07-15 Banner Life Sciences Llc Formes posologiques d'ester de fumarate présentant une tolérabilité gastro-intestinale améliorée
TW202146015A (zh) 2020-03-06 2021-12-16 瑞士商艾克泰聯製藥有限公司 減緩腦體積損失之方法
EP4117785A4 (fr) 2020-03-13 2024-04-17 Marc J. Simard Méthodes de traitement de la sclérose en plaques
CN111418675A (zh) * 2020-04-23 2020-07-17 王坤全 一种幼儿保健茶
CA3182369A1 (fr) 2020-05-06 2021-07-22 Imcyse Sa Polytherapie pour le traitement de maladies associees au fumarate
KR20220133807A (ko) 2021-03-25 2022-10-05 주식회사 큐라클 특정 약동학적 매개변수를 나타내는 디메틸푸마레이트를 유효성분으로 함유한 약학적 조성물
AU2022285951A1 (en) 2021-06-04 2024-01-04 Zim Laboratories Limited Delayed release compositions of dimethyl fumarate
CA3220684A1 (fr) 2021-10-11 2023-04-20 Actelion Pharmaceuticals Ltd Methodes de traitement de la sclerose en plaques
WO2023062511A1 (fr) 2021-10-11 2023-04-20 Actelion Pharmaceuticals Ltd Méthodes de traitement de la sclérose en plaques
CA3220702A1 (fr) 2022-02-11 2023-08-17 Actelion Pharmaceuticals Ltd Methodes de ralentissement d'une augmentation du volume ventriculaire cerebral
CN115590831A (zh) * 2022-10-26 2023-01-13 力品药业（厦门）股份有限公司（Cn） 一种富马酸二甲酯缓释微片及其制备方法

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1972109U (de) 1965-10-20 1967-11-09 Qualitrol Corp Schnellventil zum schutz elektrischer geraete.
DE1618162B1 (de) 1967-05-20 1971-05-19 Basf Ag Verfahren zur Herstellung con Cyclohexan-1.2.3.4.5.6-hexan-carbonsäure
US3832287A (en) * 1972-03-02 1974-08-27 Lilly Co Eli Dipeptide antibiotic and method for the production thereof
DE2212369A1 (de) 1972-03-15 1973-09-20 Basf Ag Cyclohexanhexacarbonsaeure
DE2530372A1 (de) * 1975-07-08 1977-01-13 Walter Dr Schweckendiek Pharmazeutische zubereitungen zur behandlung von psoriasis
DE2621214C3 (de) * 1976-05-13 1981-11-12 Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen
DE2840498C2 (de) * 1978-09-18 1980-04-10 Walter Dr. 6700 Ludwigshafen Schweckendiek Pharmazeutische Zubereitungen zur Behandlung von Psoriasis
DE3127432A1 (de) 1981-07-11 1983-02-03 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von fumarsaeuremonoester
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
CH664150A5 (de) * 1985-01-15 1988-02-15 Peter Paul Prof Dr Speiser Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen.
US5149695A (en) 1985-01-15 1992-09-22 Speiser Peter P Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
JPS61194020A (ja) 1985-02-22 1986-08-28 Dai Ichi Seiyaku Co Ltd 網膜症治療剤
GB2176999B (en) 1985-06-22 1989-07-12 Stanley Stewart Davis Sustained release medicament
DE3531597A1 (de) 1985-09-04 1987-03-05 Bioferon Biochem Substanz Verwendung von interferon-gamma (ifn-gamma) enthaltenden praeparationen zur behandlung psoriatischer erkrankungen
IL83775A (en) 1987-09-04 1991-12-15 Dexter Chemical Corp Amino acid esters and amides of fumaric acid and pharmaceutical compositions containing them for use in the treatment of psoriasis
US5242905A (en) * 1987-09-04 1993-09-07 Dexter Chemical Corporation Pharmaceutical compositions for the treatment of psoriasis
US5214196A (en) 1987-09-04 1993-05-25 Dexter Chemical Corporation Diethyl ester of di-glycyl fumaramide
US4959389A (en) * 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5424332A (en) 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
DE3834794A1 (de) 1988-10-12 1990-04-19 F Schielein Oral zu verabreichendes mittel zur behandlung von psoriasis
AU1271592A (en) 1991-01-18 1992-08-27 Dexter Chemical Corporation Malic acid derivatives and compositions for the treatment of psoriasis
IT1251166B (it) 1991-08-09 1995-05-04 Chiesi Farma Spa Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono
WO1994028883A1 (fr) 1993-06-08 1994-12-22 Brown Raymond K Compositions therapeutiques et procedes d'utilisation
CA2125763C (fr) * 1993-07-02 2007-08-28 Maurice Kent Gately Homodimere p40 de l'interleukine-12
US7888458B1 (en) 1993-11-30 2011-02-15 John B. Harley Diagnostics and therapy of epstein-barr virus in autoimmune disorders
US5407772A (en) 1993-11-30 1995-04-18 Xerox Corporation Unsaturated polyesters
JPH09510222A (ja) 1994-03-16 1997-10-14 ノボ ノルディスク アクティーゼルスカブ ２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピン化合物の酸付加塩
US6576236B1 (en) 1994-07-01 2003-06-10 Dana Farber Cancer Institute Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain
GB2291422A (en) 1994-07-18 1996-01-24 Fujisawa Pharmaceutical Co 4-phenyl-pyrido[2,3-b]pyrazin-4-ones
IL110380A0 (en) 1994-07-20 1994-10-21 Agis Ind 1983 Ltd Antiviral topical pharmaceutical compositions
US5589504A (en) * 1994-07-26 1996-12-31 Cornell Research Foundation, Inc. Treatment of newborn jaundice
CN1125141A (zh) 1994-12-22 1996-06-26 杭州中美华东制药有限公司 一种含环孢菌素a的固体分散物及其外用剂型上的用途
US6011000A (en) 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
JPH1067658A (ja) * 1995-09-13 1998-03-10 Takeda Chem Ind Ltd 免疫抑制剤
HUP9900169A2 (hu) 1995-09-13 2000-03-28 Takeda Chemical Industries, Ltd. Immunoszuppresszáns hatású kinolin- vagy kinozalinszármazékok és ezeket tartalmazó gyógyászati készítmények
JP4004567B2 (ja) 1996-02-14 2007-11-07 アステラス製薬株式会社 Ｗｂ２６６３ｂ物質を含有する免疫抑制剤
KR970064620A (ko) * 1996-03-05 1997-10-13 임성기 사이클로스포린-함유 외용약제 조성물
ATE199083T1 (de) 1996-04-22 2001-02-15 Shionogi & Co Terphenylverbindungen und sie enthaltende arzneimittel
WO1997044054A2 (fr) 1996-05-22 1997-11-27 University Of Alberta Proteines de fixation de la chimiokine de type 2 et leurs procedes d'utilisation
US6046180A (en) 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
EP2298350A3 (fr) 1996-07-26 2011-06-08 Susan P. Perrine Compositions contenant un agent inducteur ainsi qu'un agent antiviral et destinees au traitement de troubles viraux
DE19651551C2 (de) * 1996-12-11 2000-02-03 Klinge Co Chem Pharm Fab Opioidantagonisthaltige galenische Formulierung
WO1998027970A2 (fr) 1996-12-24 1998-07-02 National Research Council Of Canada Traitement de maladies ou prevention de dommages cellulaires causes par des radicaux libres contenant de l'oxygene
US5972363A (en) 1997-04-11 1999-10-26 Rohm And Haas Company Use of an encapsulated bioactive composition
DE19721099C2 (de) 1997-05-20 1999-12-02 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten
US6537969B1 (en) 1997-10-24 2003-03-25 John P. Blass Nutritional supplement for cerebral metabolic insufficiencies
DE19814358C2 (de) * 1998-03-31 2002-01-17 Fumapharm Ag Muri Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn
DE19839566C2 (de) * 1998-08-31 2002-01-17 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
DE19848260C2 (de) 1998-10-20 2002-01-17 Fumapharm Ag Muri Fumarsäure-Mikrotabletten
DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
ATE370225T1 (de) 2000-02-11 2007-09-15 Philadelphia Health & Educatio Differenzierung von knochenmarkzellen in neuronale zellen und deren verwendungen
WO2002002190A2 (fr) 2000-07-05 2002-01-10 Johns Hopkins School Of Medicine Prevention et traitement de maladies degeneratives par le glutathion et des enzymes de detoxification de phase ii
DE10101307A1 (de) 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
AU2002219236B2 (en) 2001-01-12 2006-02-09 Biogen International Gmbh Fumaric acid amides
WO2003032969A2 (fr) 2001-10-15 2003-04-24 National Research Council Of Canada Agents anti-glycation destines a la prevention des complications liees a l'age, au diabete et au tabagisme
DE10217314A1 (de) 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
EP1477166B1 (fr) 2003-04-28 2006-08-23 Biofrontera Bioscience GmbH Utilisation du rilusole combiné avec des excipients et des additifs pour le traitement de troubles caractérisés par une hyperprolifération de kératinocytes, notamment la névrodermite et le psoriasis
ATE380027T1 (de) 2003-09-09 2007-12-15 Fumapharm Ag Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma
DE10342423A1 (de) 2003-09-13 2005-04-14 Heidland, August, Prof. Dr.med. Dr.h.c. Verwendung von Fumarsäurederivaten zur Prophylaxe und zur Behandlung von Genomschäden
US20050096369A1 (en) 2003-11-04 2005-05-05 Hoang Ba X. Compositions and methods for treating cellular proliferation disorders
AU2005259864A1 (en) * 2004-06-30 2006-01-12 Combinatorx, Incorporated Methods and reagents for the treatment of metabolic disorders
DE14172396T1 (de) 2004-10-08 2015-01-08 Forward Pharma A/S Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester
EP1812374A1 (fr) 2004-11-10 2007-08-01 Aditech Pharma AB Nouveaux sels de monoalkylesters d'acide fumarique et leur utilisation pharmaceutique
JP2008520717A (ja) 2004-11-19 2008-06-19 バイオジェン・アイデック・エムエイ・インコーポレイテッド 多発性硬化症についての処置
DE102005022845A1 (de) 2005-05-18 2006-11-23 Fumapharm Ag Thiobernsteinsäurederivate und deren Verwendung
WO2008096271A2 (fr) 2007-02-08 2008-08-14 Ralf Gold Neuroprotection dans des maladies démyélinisantes
PT2137537E (pt) 2007-02-08 2013-08-22 Biogen Idec Inc Composições e respectivas utilizações para o tratamento da esclerose múltipla
NZ617130A (en) 2009-04-29 2015-06-26 Biogen Ma Inc Treatment of neurodegeneration and neuroinflammation

Also Published As

Publication number Publication date
BE2014C040I2 (fr) 2019-03-13
AU1157200A (en) 2000-06-13
CY2014027I1 (el) 2015-12-09
LTC1131065I2 (lt) 2019-05-27
JP2012255020A (ja) 2012-12-27
HUP0103182A3 (en) 2002-02-28
EE200100266A (et) 2002-12-16
AU752733B2 (en) 2002-09-26
ME00731B (fr) 2008-09-29
YU29901A (sh) 2003-04-30
WO2000030622A2 (fr) 2000-06-02
NO2014016I2 (no) 2018-08-20
PL205948B1 (pl) 2010-06-30
DE19853487A1 (de) 2000-05-25
NO20121479L (no) 2001-05-18
PL348147A1 (en) 2002-05-06
LU92488I2 (fr) 2015-11-02
JP2009256384A (ja) 2009-11-05
CY2014027I2 (el) 2015-12-09
JP2005097323A (ja) 2005-04-14
HUS1400034I1 (hu) 2018-11-28
DK1131065T3 (da) 2003-08-25
US20110293711A1 (en) 2011-12-01
RU2215524C2 (ru) 2003-11-10
IL142728A (en) 2006-12-10
US7320999B2 (en) 2008-01-22
JP2002530324A (ja) 2002-09-17
CN1182844C (zh) 2005-01-05
CZ299409B6 (cs) 2008-07-16
JP2016047830A (ja) 2016-04-07
US20030018072A1 (en) 2003-01-23
SI1131065T1 (en) 2003-10-31
DE59905954D1 (de) 2003-07-17
HK1042242A1 (en) 2002-08-09
EE04389B1 (et) 2004-12-15
EP1131065B1 (fr) 2003-06-11
CZ2001939A3 (cs) 2002-05-15
IL142728A0 (en) 2002-03-10
ZA200202335B (en) 2003-08-27
HK1042242B (zh) 2005-08-19
RS49995B (sr) 2008-09-29
NO333257B1 (no) 2013-04-22
CA2346438A1 (fr) 2000-06-02
US20070248663A1 (en) 2007-10-25
CA2346438C (fr) 2006-10-03
NO2014016I1 (no) 2014-06-26
US20090181085A1 (en) 2009-07-16
US7915310B2 (en) 2011-03-29
BR9914606A (pt) 2001-07-03
JP2019123738A (ja) 2019-07-25
JP2017226681A (ja) 2017-12-28
CN1325302A (zh) 2001-12-05
PT1131065E (pt) 2003-10-31
MXPA01005007A (es) 2002-04-24
BG64837B1 (bg) 2006-06-30
NO20011242L (no) 2001-05-18
NZ510247A (en) 2003-10-31
CN1615839A (zh) 2005-05-18
HUP0103182A2 (hu) 2002-01-28
FR14C0051I2 (fr) 2019-01-18
NO20011242D0 (no) 2001-03-12
SK5762001A3 (en) 2002-03-05
US7619001B2 (en) 2009-11-17
US6509376B1 (en) 2003-01-21
PL226074B1 (pl) 2017-06-30
US7803840B2 (en) 2010-09-28
TR200101204T2 (tr) 2001-09-21
WO2000030622A3 (fr) 2000-11-02
US20090182047A1 (en) 2009-07-16
US8524773B2 (en) 2013-09-03
US20130004526A1 (en) 2013-01-03
ES2195664T3 (es) 2003-12-01
EP1131065A2 (fr) 2001-09-12
SK285601B6 (sk) 2007-04-05
JP5828614B2 (ja) 2015-12-09
US20070248662A1 (en) 2007-10-25
HU226689B1 (en) 2009-06-29
ATE242633T1 (de) 2003-06-15
US8759393B2 (en) 2014-06-24
US20140066505A1 (en) 2014-03-06
US7612110B2 (en) 2009-11-03
BG105396A (en) 2001-12-29

Similar Documents

Publication Publication Date Title
BE2014C040I2 (fr)
IL102848A0 (en) Polypeptides having growth hormone releasing activity,their use and pharmaceutical compositions containing them
UA66417C2 (en) Recombinant adenovirus affecting canines, pharmaceutical composition
PL347671A1 (en) Compounds and compositions for delivering active agents
CA2189250A1 (fr) Agents regulateurs des cytokines et leurs procedes d'utilisation dans des affections et etats pathologiques associes a des taux de cytokines modifies
PL347359A1 (en) The use of fumaric acid derivatives in transplant medicine
DE69531741D1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
AU6628496A (en) Polyether block copolymer micellar compositions for targeting biological agents
GB9806632D0 (en) Peptide factor
DE69434121D1 (de) Pharmazeutische zusammensetzung zur immunstimulierenden therapie
EP0663835A1 (fr) Utilisation de parathormone, de ses fragments a activite biologique et de peptides associes pour le traitement de problemes de grossesse.
ES2013321A6 (es) Un metodo de produccion de anticuerpos monoclonales
IE861494L (en) Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a
GB9727424D0 (en) Liposomes containing multiple branch peptide constructions for use against human immunodeficiency virus
GR3001850T3 (en) Expellants of phytopathogenic microbes
WO2002012336A3 (fr) THERAPEUTIQUES DU TGF-β, COMPOSITIONS ET PROCEDES D'UTILISATION
UA41326C2 (uk) Фармацевтична композиція для профілактики або лікування вірусних захворювань, засіб для профілактики або лікування вірусних захворювань
UA28284A (uk) Природний лікувальний засіб (його варіанти)
UA26246C2 (uk) Коhтрацептивhий комбіhоваhий препарат
IT1254742B (it) Impiego della beta-endorfina quale farmaco immunosoppressore nei trapianti d'organo
MX9600383A (es) W-ifn como un agente anti-hiv.
YU61302A (sh) Analozi nukleozida sa modifikovanom karboksamidinskom bicikličnom bazom