DE602006011910D1 - Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung - Google Patents
Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendungInfo
- Publication number
- DE602006011910D1 DE602006011910D1 DE602006011910T DE602006011910T DE602006011910D1 DE 602006011910 D1 DE602006011910 D1 DE 602006011910D1 DE 602006011910 T DE602006011910 T DE 602006011910T DE 602006011910 T DE602006011910 T DE 602006011910T DE 602006011910 D1 DE602006011910 D1 DE 602006011910D1
- Authority
- DE
- Germany
- Prior art keywords
- glucopyranoseester
- glucofuranoseester
- repellers
- new
- acid alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002253 acid Substances 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- AVVWPBAENSWJCB-IVMDWMLBSA-N D-glucofuranose Chemical class OC[C@@H](O)[C@H]1OC(O)[C@H](O)[C@H]1O AVVWPBAENSWJCB-IVMDWMLBSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical class OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501002 | 2005-07-07 | ||
| PCT/DK2006/000403 WO2007006308A1 (en) | 2005-07-07 | 2006-07-07 | Novel glucopyranose esters and glucofuranose esters of alkyl- fu marates and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006011910D1 true DE602006011910D1 (de) | 2010-03-11 |
Family
ID=36840436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006011910T Active DE602006011910D1 (de) | 2005-07-07 | 2006-07-07 | Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100144651A1 (de) |
| EP (2) | EP1915387B1 (de) |
| AT (1) | ATE455783T1 (de) |
| DE (1) | DE602006011910D1 (de) |
| WO (1) | WO2007006308A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE380027T1 (de) | 2003-09-09 | 2007-12-15 | Fumapharm Ag | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
| ES2525497T3 (es) * | 2004-10-08 | 2015-10-09 | Forward Pharma A/S | Composiciones farmacéuticas de liberación controlada que comprenden un éster de ácido fumárico |
| ES2916604T1 (es) | 2007-02-08 | 2022-07-04 | Biogen Ma Inc | Ensayos de detección de nrf2 y métodos y composiciones relacionados |
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| DK2379063T4 (da) | 2009-01-09 | 2021-05-25 | Fwp Ip Aps | Farmaceutisk præparat omfattende en eller flere fumarsyreestere i en erosionsmatrix |
| CA2760133A1 (en) | 2009-04-29 | 2010-11-04 | Biogen Idec Ma Inc. | Treatment of neurodegeneration and neuroinflammation |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US20130259856A1 (en) * | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| US20140056973A1 (en) | 2012-08-22 | 2014-02-27 | Xenoport, Inc. | Oral Dosage Forms Having a High Loading of a Methyl Hydrogen Fumarate Prodrug |
| US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| US20140179779A1 (en) | 2012-12-21 | 2014-06-26 | Biogen Idec Ma Inc. | Deuterium Substituted Fumarate Derivatives |
| DK2970101T4 (da) | 2013-03-14 | 2025-11-17 | Alkermes Pharma Ireland Ltd | Pro-drugs af fumarater og deres anvendelse i behandling af forskellige sygdomme |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| US9416096B2 (en) | 2013-09-06 | 2016-08-16 | Xenoport, Inc. | Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use |
| US20160214948A1 (en) * | 2013-09-27 | 2016-07-28 | Ratiopharm Gmbh | Prodrugs of monomethyl fumarate (mmf) |
| EP3110793B1 (de) | 2014-02-24 | 2019-08-21 | Alkermes Pharma Ireland Limited | Sulfonamid und sulfinamid-prodrugs von fumaraten und deren verwendung zur behandlung verschiedener erkrankungen |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| ES2826825T3 (es) | 2015-03-27 | 2021-05-19 | Symbionyx Pharmaceuticals Inc | Composiciones y métodos para el tratamiento de la psoriasis |
| SG11202011698VA (en) | 2018-06-05 | 2020-12-30 | Flagship Pioneering Innovations V Inc | Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease |
| KR20210100120A (ko) * | 2018-12-06 | 2021-08-13 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 모노메틸 푸마르산염-담체 접합체 및 그 사용 방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2530372A1 (de) * | 1975-07-08 | 1977-01-13 | Walter Dr Schweckendiek | Pharmazeutische zubereitungen zur behandlung von psoriasis |
| EP0332702A4 (de) | 1987-08-24 | 1990-06-05 | Le T I Tsellyulozno Bumazhnoj | Verfahren zur herstellung eines reliefbildes auf einen träger. |
| US4959389A (en) | 1987-10-19 | 1990-09-25 | Speiser Peter P | Pharmaceutical preparation for the treatment of psoriatic arthritis |
| US5424332A (en) | 1987-10-19 | 1995-06-13 | Speiser; Peter P. | Pharmaceutical composition and process for the production thereof |
| US5484610A (en) * | 1991-01-02 | 1996-01-16 | Macromed, Inc. | pH and temperature sensitive terpolymers for oral drug delivery |
| DE19814358C2 (de) * | 1998-03-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn |
| DE19839566C2 (de) * | 1998-08-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten in der Transplantationsmedizin |
| DE19848260C2 (de) * | 1998-10-20 | 2002-01-17 | Fumapharm Ag Muri | Fumarsäure-Mikrotabletten |
| DE19853487A1 (de) * | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| US6537584B1 (en) | 1999-11-12 | 2003-03-25 | Macromed, Inc. | Polymer blends that swell in an acidic environment and deswell in a basic environment |
| DE10000577A1 (de) * | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
| RS52083B (sr) * | 2001-01-12 | 2012-06-30 | Fumapharm Ag | Amidi fumarne kiseline |
| AU2002325192B2 (en) | 2001-07-06 | 2008-05-22 | Veloxis Pharmaceuticals, Inc. | Controlled agglomeration |
| DE10214031A1 (de) | 2002-03-27 | 2004-02-19 | Pharmatech Gmbh | Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation |
-
2006
- 2006-07-07 WO PCT/DK2006/000403 patent/WO2007006308A1/en not_active Ceased
- 2006-07-07 DE DE602006011910T patent/DE602006011910D1/de active Active
- 2006-07-07 AT AT06753340T patent/ATE455783T1/de not_active IP Right Cessation
- 2006-07-07 EP EP06753340A patent/EP1915387B1/de active Active
- 2006-07-07 US US11/993,369 patent/US20100144651A1/en not_active Abandoned
- 2006-07-07 EP EP10151082A patent/EP2186819A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1915387B1 (de) | 2010-01-20 |
| US20100144651A1 (en) | 2010-06-10 |
| WO2007006308A1 (en) | 2007-01-18 |
| EP2186819A1 (de) | 2010-05-19 |
| EP1915387A1 (de) | 2008-04-30 |
| ATE455783T1 (de) | 2010-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |