FI971784L - Apolipoproteiini B-synteesin estäjiä - Google Patents

Apolipoproteiini B-synteesin estäjiä Download PDF

Info

Publication number: FI971784L
Authority: FI; Finland
Prior art keywords: apolipoprotein; synthesis inhibitors; inhibitors; synthesis
Prior art date: 1994-10-27

Application number

FI971784A

Other languages

English (en)

Swedish (sv)

Other versions

FI971784A0 (fi

FI119548B (fi

Inventor

Jan Heeres

Leo Jacobus Jozef Backx

Robert Jozef Maria Hendrickx

Der Eycken Luc Alfons Leo Van

Chaffoy De Courcelles Didie De

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-27

Filing date

1997-04-25

Publication date

1997-04-25

1995-05-31 Priority claimed from US08/455,304 external-priority patent/US5521186A/en

1997-04-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1997-04-25 Publication of FI971784A0 publication Critical patent/FI971784A0/fi

1997-04-25 Publication of FI971784L publication Critical patent/FI971784L/fi

2008-12-31 Application granted granted Critical

2008-12-31 Publication of FI119548B publication Critical patent/FI119548B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI971784A 1994-10-27 1997-04-25 Apolipoproteiini B-synteesin estäjiä FI119548B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
EP94203120		1994-10-27
EP94203120		1994-10-27
US45530495		1995-05-31
US08/455,304 US5521186A (en)	1994-10-27	1995-05-31	Apolipoprotein-β synthesis inhibitors
PCT/EP1995/004111 WO1996013499A1 (en)	1994-10-27	1995-10-19	Apolipoprotein-b synthesis inhibitors
EP9504111		1995-10-19

Publications (3)

Publication Number	Publication Date
FI971784A0 FI971784A0 (fi)	1997-04-25
FI971784L true FI971784L (fi)	1997-04-25
FI119548B FI119548B (fi)	2008-12-31

Family

ID=26136684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI971784A FI119548B (fi)	1994-10-27	1997-04-25	Apolipoproteiini B-synteesin estäjiä

Country Status (30)

Country	Link
US (1)	US5929075A (fi)
EP (1)	EP0788496B1 (fi)
JP (1)	JP3025907B2 (fi)
KR (1)	KR100227231B1 (fi)
CN (1)	CN1068000C (fi)
AP (1)	AP779A (fi)
AT (1)	ATE198889T1 (fi)
AU (1)	AU697744C (fi)
BG (1)	BG63694B1 (fi)
BR (1)	BR9509436A (fi)
CA (1)	CA2203274C (fi)
CY (1)	CY2256B1 (fi)
CZ (1)	CZ286476B6 (fi)
DE (3)	DE69519995T2 (fi)
DK (1)	DK0788496T3 (fi)
ES (1)	ES2155535T3 (fi)
FI (1)	FI119548B (fi)
GR (1)	GR3035519T3 (fi)
HR (1)	HRP950532B1 (fi)
HU (1)	HU219862B (fi)
IL (1)	IL115771A (fi)
LU (1)	LU91306I2 (fi)
NO (1)	NO311937B1 (fi)
NZ (1)	NZ295353A (fi)
OA (1)	OA10479A (fi)
PT (1)	PT788496E (fi)
RO (1)	RO118715B1 (fi)
SK (1)	SK281908B6 (fi)
TR (1)	TR199501295A2 (fi)
WO (1)	WO1996013499A1 (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE216238T1 (de)	1997-11-03	2002-05-15	Janssen Pharmaceutica Nv	Arzneimittel enthaltend lipidsenkende verbindungen
KR20010041460A (ko) *	1998-04-27	2001-05-25	디르크 반테	지질 저하제 및 중합체로 피복된 핵을 갖는 펠릿
CA2355822A1 (en)	1998-12-22	2000-06-29	Janssen Pharmaceutica N.V.	S-oxide lipid lowering compounds
DE19945982A1 (de) *	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) *	2003-12-12	2005-06-16	International Business Machines Corporation	Computer system with LAN-based I/O
AU2005205933B2 (en) *	2004-01-21	2010-02-18	Elanco Animal Health Ireland Limited	Mitratapide oral solution
US7649002B2 (en)	2004-02-04	2010-01-19	Pfizer Inc	(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20080280922A1 (en) *	2004-04-09	2008-11-13	Marc Alois Celine Maria Engelen	Intermittent Dosing Regimen For Overweight and Obese Subjects
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
JP2008542255A (ja) *	2005-05-27	2008-11-27	ファイザー・プロダクツ・インク	肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
CA2617654A1 (en) *	2005-08-04	2007-02-08	Pfizer Limited	Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
ES2402581T3 (es) *	2006-02-23	2013-05-06	Pfizer Limited	Piperidinoilpirrolidinas como agonistas del receptor de melanocortina tipo 4
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
MX2009004314A (es)	2006-11-13	2009-05-05	Pfizer Prod Inc	Diaril, dipiridinil y arilpiridinilderivados y usos de los mismos.
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US8765979B2 (en) *	2007-05-25	2014-07-01	Janssen Pharmaceutica	Synthesis of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3 dioxolane-4-methanol methanesulfonate(ester)
WO2010015972A1 (en) *	2008-08-06	2010-02-11	Pfizer Limited	Diazepine and diazocane compounds as mc4 agonists
EP2571871B1 (en) *	2010-05-19	2017-06-21	Sandoz AG	Process for the preparation of chiral triazolones
RS63124B1 (sr)	2018-03-08	2022-05-31	Incyte Corp	Aminopirazin diol jedinjenja kao pi3k-y inhibitori
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4313953A (en) *	1978-06-23	1982-02-02	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4267179A (en) *	1978-06-23	1981-05-12	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) *	1981-06-23	1988-08-23	Janssen Pharmaceutica N.V.	N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) *	1983-02-28	1986-10-28	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) *	1985-12-03	1991-11-26	Alfonsus Guilielmus Knaeps	Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl\|-1,3-dioxolan-2-yl\|methyl\|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) *	1987-03-25	1989-12-21	Janssen Pharmaceutica Nv	Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) *	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) *	1993-03-04	1994-09-26	Cytoven International N.V.	Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) *	1994-10-27	1996-05-28	Janssen Pharmaceutica N.V.	Apolipoprotein-β synthesis inhibitors

1995
- 1995-10-19 CN CN95195885A patent/CN1068000C/zh not_active Expired - Fee Related
- 1995-10-19 AP APAP/P/1997/000968A patent/AP779A/en active
- 1995-10-19 AU AU38680/95A patent/AU697744C/en not_active Ceased
- 1995-10-19 HU HU9701956A patent/HU219862B/hu not_active IP Right Cessation
- 1995-10-19 NZ NZ295353A patent/NZ295353A/en not_active IP Right Cessation
- 1995-10-19 DK DK95937804T patent/DK0788496T3/da active
- 1995-10-19 US US08/817,247 patent/US5929075A/en not_active Expired - Lifetime
- 1995-10-19 SK SK507-97A patent/SK281908B6/sk not_active IP Right Cessation
- 1995-10-19 ES ES95937804T patent/ES2155535T3/es not_active Expired - Lifetime
- 1995-10-19 WO PCT/EP1995/004111 patent/WO1996013499A1/en not_active Ceased
- 1995-10-19 JP JP8514288A patent/JP3025907B2/ja not_active Expired - Fee Related
- 1995-10-19 DE DE69519995T patent/DE69519995T2/de not_active Expired - Lifetime
- 1995-10-19 DE DE122007000005C patent/DE122007000005I2/de active Active
- 1995-10-19 PT PT95937804T patent/PT788496E/pt unknown
- 1995-10-19 CZ CZ19971198A patent/CZ286476B6/cs not_active IP Right Cessation
- 1995-10-19 AT AT95937804T patent/ATE198889T1/de active
- 1995-10-19 EP EP95937804A patent/EP0788496B1/en not_active Expired - Lifetime
- 1995-10-19 CA CA002203274A patent/CA2203274C/en not_active Expired - Fee Related
- 1995-10-19 KR KR1019970702662A patent/KR100227231B1/ko not_active Expired - Fee Related
- 1995-10-19 RO RO97-00812A patent/RO118715B1/ro unknown
- 1995-10-19 DE DE1995619995 patent/DE122007000005I1/de active Pending
- 1995-10-19 BR BR9509436A patent/BR9509436A/pt not_active IP Right Cessation
- 1995-10-20 TR TR95/01295A patent/TR199501295A2/xx unknown
- 1995-10-26 IL IL11577195A patent/IL115771A/xx not_active IP Right Cessation
- 1995-10-27 HR HR950532A patent/HRP950532B1/xx not_active IP Right Cessation
1997
- 1997-04-10 BG BG101402A patent/BG63694B1/bg unknown
- 1997-04-24 NO NO19971895A patent/NO311937B1/no not_active IP Right Cessation
- 1997-04-25 OA OA60997A patent/OA10479A/en unknown
- 1997-04-25 FI FI971784A patent/FI119548B/fi not_active IP Right Cessation
2001
- 2001-03-05 GR GR20010400359T patent/GR3035519T3/el unknown
2002
- 2002-01-04 CY CY0200004A patent/CY2256B1/xx unknown
2007
- 2007-01-17 LU LU91306C patent/LU91306I2/fr unknown

Also Published As

Publication number	Publication date
CY2256B1 (en)	2003-07-04
NO971895L (no)	1997-04-24
CA2203274A1 (en)	1996-05-09
FI971784A0 (fi)	1997-04-25
CN1161695A (zh)	1997-10-08
BG101402A (en)	1997-10-31
IL115771A0 (en)	1996-01-19
JPH09511759A (ja)	1997-11-25
DE122007000005I1 (de)	2007-04-26
HU219862B (hu)	2001-08-28
HUT77360A (hu)	1998-03-30
ES2155535T3 (es)	2001-05-16
BR9509436A (pt)	1998-01-06
AU3868095A (en)	1996-05-23
HRP950532B1 (en)	2001-06-30
SK281908B6 (sk)	2001-09-11
US5929075A (en)	1999-07-27
MX9703074A (es)	1997-07-31
ATE198889T1 (de)	2001-02-15
AP9700968A0 (en)	1997-04-30
AU697744B2 (en)	1998-10-15
GR3035519T3 (en)	2001-06-29
CA2203274C (en)	2002-02-19
NO971895D0 (no)	1997-04-24
EP0788496A1 (en)	1997-08-13
DE69519995D1 (en)	2001-03-01
IL115771A (en)	2000-02-29
PT788496E (pt)	2001-07-31
BG63694B1 (bg)	2002-09-30
CZ119897A3 (cs)	1998-03-18
RO118715B1 (ro)	2003-09-30
FI119548B (fi)	2008-12-31
CZ286476B6 (en)	2000-04-12
JP3025907B2 (ja)	2000-03-27
DE122007000005I2 (de)	2008-04-24
HRP950532A2 (en)	1997-08-31
DK0788496T3 (da)	2001-06-18
KR100227231B1 (ko)	1999-11-01
WO1996013499A1 (en)	1996-05-09
OA10479A (en)	2002-04-09
DE69519995T2 (de)	2001-08-23
NZ295353A (en)	1998-08-26
AU697744C (en)	2002-08-22
CN1068000C (zh)	2001-07-04
EP0788496B1 (en)	2001-01-24
TR199501295A2 (tr)	1996-06-21
LU91306I2 (fr)	2007-03-19
SK50797A3 (en)	1998-04-08
AP779A (en)	1999-11-03
NO311937B1 (no)	2002-02-18

Publication	Publication Date	Title
FI963597A7 (fi)	1996-11-14	Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no)	1997-06-23	Fibronectin-adhesjonsinhibitorer
FI972160A0 (fi)	1997-05-21	Matriisimetalloproteaasi-inhibiittorit
FI971784L (fi)	1997-04-25	Apolipoproteiini B-synteesin estäjiä
FI951553L (fi)	1995-10-02	1H-indoli-glyoksyyliamidi-sPLA2-inhibiittoreita
NO942064D0 (no)	1994-06-03	yminhibitorer
ATE249212T1 (de)	2003-09-15	Refluxinhibitoren
FI964317A7 (fi)	1996-10-25	Tekijän-Xa-inhibiittoreita
FI965019A7 (fi)	1996-12-13	Entsyymi-inhibiittoreita
DK1027332T3 (da)	2004-10-04	Hidtil ukendte lactametalloproteaseinhibitorer
DK0958287T3 (da)	2003-01-20	Sulfamidmetalloprotease-inhibitorer
ATE230275T1 (de)	2003-01-15	Angiogense-inhibitor
EE04241B1 (et)	2004-02-16	Apolipoproteiin-B sünteesi inhibiitorid
DE69736109D1 (de)	2006-07-27	Differenzierungsinhibitor
FI971156A0 (fi)	1997-03-19	5alfa-reduktaasi-inhibiittoreita
FI964781L (fi)	1997-01-29	Uusia elastaasi-inhibiittoreita
DE69720957T2 (de)	2004-01-29	Ace-hemmer
BR9610514A (pt)	1999-03-30	Inibidores cicloantihelmínticos
EP1007548A4 (en)	2002-07-03	THROMBIN INHIBITOR FROM TSE-TSE FLY
CY2007006I1 (el)	2009-11-04	Αναστολεις συνθεσης απολιποπρωτεινης-β
FI1878U1 (fi)	1995-04-27	Maskmetspoe utan floete
FI943697A0 (fi)	1994-08-10	Riktningventil utan roera delar
KR970703937A (ko)	1997-08-09	금속단백질 분해효소 억제제(Metallproteinase inhibitors)

Legal Events

Date	Code	Title	Description
2009-04-15	SPCF	Supplementary protection certificate application filed	Free format text: SPC C20090011 Spc suppl protection certif: C20090011
2011-11-23	PC	Transfer of assignment of patent	Owner name: ELANCO ANIMAL HEALTH IRELAND LIMITED Free format text: ELANCO ANIMAL HEALTH IRELAND LIMITED
2012-10-01	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: 358 Extension date: 20201019
2013-06-04	MM	Patent lapsed