DK0788496T3 - Inhibitorer for syntese af apolipoprotein-B - Google Patents

Inhibitorer for syntese af apolipoprotein-B

Info

Publication number: DK0788496T3
Authority: DK; Denmark
Prior art keywords: apolipoprotein; inhibitors; synthesis
Prior art date: 1994-10-27

Application number

DK95937804T

Other languages

English (en)

Inventor

Jan Heeres

Leo Jacobus Jozef Backx

Luc Alfons Leo Van Der Eycken

Robert Jozef Maria Hendrickx

Chaffoy De Courcelles Didie De

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-27

Filing date

1995-10-19

Publication date

2001-06-18

1995-05-31 Priority claimed from US08/455,304 external-priority patent/US5521186A/en

1995-10-19 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-06-18 Application granted granted Critical

2001-06-18 Publication of DK0788496T3 publication Critical patent/DK0788496T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK95937804T 1994-10-27 1995-10-19 Inhibitorer for syntese af apolipoprotein-B DK0788496T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94203120		1994-10-27
US08/455,304 US5521186A (en)	1994-10-27	1995-05-31	Apolipoprotein-β synthesis inhibitors
PCT/EP1995/004111 WO1996013499A1 (en)	1994-10-27	1995-10-19	Apolipoprotein-b synthesis inhibitors

Publications (1)

Publication Number	Publication Date
DK0788496T3 true DK0788496T3 (da)	2001-06-18

Family

ID=26136684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95937804T DK0788496T3 (da)	1994-10-27	1995-10-19	Inhibitorer for syntese af apolipoprotein-B

Country Status (30)

Country	Link
US (1)	US5929075A (da)
EP (1)	EP0788496B1 (da)
JP (1)	JP3025907B2 (da)
KR (1)	KR100227231B1 (da)
CN (1)	CN1068000C (da)
AP (1)	AP779A (da)
AT (1)	ATE198889T1 (da)
AU (1)	AU697744C (da)
BG (1)	BG63694B1 (da)
BR (1)	BR9509436A (da)
CA (1)	CA2203274C (da)
CY (1)	CY2256B1 (da)
CZ (1)	CZ286476B6 (da)
DE (3)	DE69519995T2 (da)
DK (1)	DK0788496T3 (da)
ES (1)	ES2155535T3 (da)
FI (1)	FI119548B (da)
GR (1)	GR3035519T3 (da)
HR (1)	HRP950532B1 (da)
HU (1)	HU219862B (da)
IL (1)	IL115771A (da)
LU (1)	LU91306I2 (da)
NO (1)	NO311937B1 (da)
NZ (1)	NZ295353A (da)
OA (1)	OA10479A (da)
PT (1)	PT788496E (da)
RO (1)	RO118715B1 (da)
SK (1)	SK281908B6 (da)
TR (1)	TR199501295A2 (da)
WO (1)	WO1996013499A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE216238T1 (de)	1997-11-03	2002-05-15	Janssen Pharmaceutica Nv	Arzneimittel enthaltend lipidsenkende verbindungen
KR20010041460A (ko) *	1998-04-27	2001-05-25	디르크 반테	지질 저하제 및 중합체로 피복된 핵을 갖는 펠릿
CA2355822A1 (en)	1998-12-22	2000-06-29	Janssen Pharmaceutica N.V.	S-oxide lipid lowering compounds
DE19945982A1 (de) *	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) *	2003-12-12	2005-06-16	International Business Machines Corporation	Computer system with LAN-based I/O
AU2005205933B2 (en) *	2004-01-21	2010-02-18	Elanco Animal Health Ireland Limited	Mitratapide oral solution
US7649002B2 (en)	2004-02-04	2010-01-19	Pfizer Inc	(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20080280922A1 (en) *	2004-04-09	2008-11-13	Marc Alois Celine Maria Engelen	Intermittent Dosing Regimen For Overweight and Obese Subjects
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
JP2008542255A (ja) *	2005-05-27	2008-11-27	ファイザー・プロダクツ・インク	肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
CA2617654A1 (en) *	2005-08-04	2007-02-08	Pfizer Limited	Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
ES2402581T3 (es) *	2006-02-23	2013-05-06	Pfizer Limited	Piperidinoilpirrolidinas como agonistas del receptor de melanocortina tipo 4
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
MX2009004314A (es)	2006-11-13	2009-05-05	Pfizer Prod Inc	Diaril, dipiridinil y arilpiridinilderivados y usos de los mismos.
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US8765979B2 (en) *	2007-05-25	2014-07-01	Janssen Pharmaceutica	Synthesis of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3 dioxolane-4-methanol methanesulfonate(ester)
WO2010015972A1 (en) *	2008-08-06	2010-02-11	Pfizer Limited	Diazepine and diazocane compounds as mc4 agonists
EP2571871B1 (en) *	2010-05-19	2017-06-21	Sandoz AG	Process for the preparation of chiral triazolones
RS63124B1 (sr)	2018-03-08	2022-05-31	Incyte Corp	Aminopirazin diol jedinjenja kao pi3k-y inhibitori
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4313953A (en) *	1978-06-23	1982-02-02	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4267179A (en) *	1978-06-23	1981-05-12	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) *	1981-06-23	1988-08-23	Janssen Pharmaceutica N.V.	N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) *	1983-02-28	1986-10-28	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) *	1985-12-03	1991-11-26	Alfonsus Guilielmus Knaeps	Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl\|-1,3-dioxolan-2-yl\|methyl\|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) *	1987-03-25	1989-12-21	Janssen Pharmaceutica Nv	Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) *	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) *	1993-03-04	1994-09-26	Cytoven International N.V.	Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) *	1994-10-27	1996-05-28	Janssen Pharmaceutica N.V.	Apolipoprotein-β synthesis inhibitors

1995
- 1995-10-19 CN CN95195885A patent/CN1068000C/zh not_active Expired - Fee Related
- 1995-10-19 AP APAP/P/1997/000968A patent/AP779A/en active
- 1995-10-19 AU AU38680/95A patent/AU697744C/en not_active Ceased
- 1995-10-19 HU HU9701956A patent/HU219862B/hu not_active IP Right Cessation
- 1995-10-19 NZ NZ295353A patent/NZ295353A/en not_active IP Right Cessation
- 1995-10-19 DK DK95937804T patent/DK0788496T3/da active
- 1995-10-19 US US08/817,247 patent/US5929075A/en not_active Expired - Lifetime
- 1995-10-19 SK SK507-97A patent/SK281908B6/sk not_active IP Right Cessation
- 1995-10-19 ES ES95937804T patent/ES2155535T3/es not_active Expired - Lifetime
- 1995-10-19 WO PCT/EP1995/004111 patent/WO1996013499A1/en not_active Ceased
- 1995-10-19 JP JP8514288A patent/JP3025907B2/ja not_active Expired - Fee Related
- 1995-10-19 DE DE69519995T patent/DE69519995T2/de not_active Expired - Lifetime
- 1995-10-19 DE DE122007000005C patent/DE122007000005I2/de active Active
- 1995-10-19 PT PT95937804T patent/PT788496E/pt unknown
- 1995-10-19 CZ CZ19971198A patent/CZ286476B6/cs not_active IP Right Cessation
- 1995-10-19 AT AT95937804T patent/ATE198889T1/de active
- 1995-10-19 EP EP95937804A patent/EP0788496B1/en not_active Expired - Lifetime
- 1995-10-19 CA CA002203274A patent/CA2203274C/en not_active Expired - Fee Related
- 1995-10-19 KR KR1019970702662A patent/KR100227231B1/ko not_active Expired - Fee Related
- 1995-10-19 RO RO97-00812A patent/RO118715B1/ro unknown
- 1995-10-19 DE DE1995619995 patent/DE122007000005I1/de active Pending
- 1995-10-19 BR BR9509436A patent/BR9509436A/pt not_active IP Right Cessation
- 1995-10-20 TR TR95/01295A patent/TR199501295A2/xx unknown
- 1995-10-26 IL IL11577195A patent/IL115771A/xx not_active IP Right Cessation
- 1995-10-27 HR HR950532A patent/HRP950532B1/xx not_active IP Right Cessation
1997
- 1997-04-10 BG BG101402A patent/BG63694B1/bg unknown
- 1997-04-24 NO NO19971895A patent/NO311937B1/no not_active IP Right Cessation
- 1997-04-25 OA OA60997A patent/OA10479A/en unknown
- 1997-04-25 FI FI971784A patent/FI119548B/fi not_active IP Right Cessation
2001
- 2001-03-05 GR GR20010400359T patent/GR3035519T3/el unknown
2002
- 2002-01-04 CY CY0200004A patent/CY2256B1/xx unknown
2007
- 2007-01-17 LU LU91306C patent/LU91306I2/fr unknown

Also Published As

Publication number	Publication date
CY2256B1 (en)	2003-07-04
NO971895L (no)	1997-04-24
CA2203274A1 (en)	1996-05-09
FI971784A0 (fi)	1997-04-25
CN1161695A (zh)	1997-10-08
BG101402A (en)	1997-10-31
IL115771A0 (en)	1996-01-19
JPH09511759A (ja)	1997-11-25
DE122007000005I1 (de)	2007-04-26
HU219862B (hu)	2001-08-28
HUT77360A (hu)	1998-03-30
ES2155535T3 (es)	2001-05-16
BR9509436A (pt)	1998-01-06
AU3868095A (en)	1996-05-23
HRP950532B1 (en)	2001-06-30
SK281908B6 (sk)	2001-09-11
US5929075A (en)	1999-07-27
MX9703074A (es)	1997-07-31
ATE198889T1 (de)	2001-02-15
AP9700968A0 (en)	1997-04-30
AU697744B2 (en)	1998-10-15
GR3035519T3 (en)	2001-06-29
CA2203274C (en)	2002-02-19
NO971895D0 (no)	1997-04-24
FI971784L (fi)	1997-04-25
EP0788496A1 (en)	1997-08-13
DE69519995D1 (en)	2001-03-01
IL115771A (en)	2000-02-29
PT788496E (pt)	2001-07-31
BG63694B1 (bg)	2002-09-30
CZ119897A3 (cs)	1998-03-18
RO118715B1 (ro)	2003-09-30
FI119548B (fi)	2008-12-31
CZ286476B6 (en)	2000-04-12
JP3025907B2 (ja)	2000-03-27
DE122007000005I2 (de)	2008-04-24
HRP950532A2 (en)	1997-08-31
KR100227231B1 (ko)	1999-11-01
WO1996013499A1 (en)	1996-05-09
OA10479A (en)	2002-04-09
DE69519995T2 (de)	2001-08-23
NZ295353A (en)	1998-08-26
AU697744C (en)	2002-08-22
CN1068000C (zh)	2001-07-04
EP0788496B1 (en)	2001-01-24
TR199501295A2 (tr)	1996-06-21
LU91306I2 (fr)	2007-03-19
SK50797A3 (en)	1998-04-08
AP779A (en)	1999-11-03
NO311937B1 (no)	2002-02-18

Publication	Publication Date	Title
DK0788496T3 (da)	2001-06-18	Inhibitorer for syntese af apolipoprotein-B
DK0773940T4 (da)	2011-02-07	Fremgangsmåde til syntese af substituerede sulfoxider
DK1445259T3 (da)	2006-10-16	Anvendelse af krystalformer for 2-methyl-thieno-benzodiazepin
LV11178A (lv)	1996-04-20	3-Ú4-(2-aminoetoksi) benzoil¾-2-aril-6-hidroksibenzoÚb¾tiofenu sintezes panemiens
FI963597A7 (fi)	1996-11-14	Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no)	1997-06-23	Fibronectin-adhesjonsinhibitorer
BR9612465A (pt)	1999-07-13	Compostos heterocíclicos
FI972160A0 (fi)	1997-05-21	Matriisimetalloproteaasi-inhibiittorit
FI950800L (fi)	1995-08-23	Menetelmä heterosyklisten yhdisteiden sulfinyloimiseksi
FI962749L (fi)	1996-09-04	Uusia heterosyklisiä yhdisteitä
FI963761A7 (fi)	1996-09-20	Kefalosporiinin synteesi
DK0820451T3 (da)	2003-05-12	Hidtil ukendte heterocykliske forbindelser
FI973207A7 (fi)	1997-10-01	Heterosyklisiä yhdisteitä
EE9700093A (et)	1997-10-15	Apolipoproteiin-B sünteesi inhiibitorid
IT1295934B1 (it)	1999-05-28	Procedimento migliorato per la sintesi di alchilpoliglucosidi
NO963187D0 (no)	1996-07-30	Fremgangsmåte for syntese av gamma-pyroner
DK1023292T3 (da)	2003-11-10	Fremgangsmåde til syntese af chlorpurinintermediater
BR9708718A (pt)	1999-08-03	Sínteses de aminas substituídas
DK0857720T3 (da)	2004-07-26	Fremgangsmåde til syntese af desoxypyridinolin
ITMI941144A0 (it)	1994-06-02	Procedimento per la formazione di timbri
CY2007006I1 (el)	2009-11-04	Αναστολεις συνθεσης απολιποπρωτεινης-β
KR960015946U (ko)	1996-05-17	레이져 트리머의 양면 부품용 척
DK0851865T3 (da)	2002-10-14	Hidtil ukendte heterocykliske forbindelser
KR960005897U (ko)	1996-02-17	측량용자 고정대
UA852S (uk)	1995-06-30	Набір ваз