FI915136A0 - Cykliska iminoderivat, dessa foereningar innehaollande laekemede och foerfarande foer deras framstaellning. - Google Patents

Cykliska iminoderivat, dessa foereningar innehaollande laekemede och foerfarande foer deras framstaellning.

Info

Publication number: FI915136A0
Authority: FI; Finland
Prior art keywords: laekemede; iminoderivat; cycliska; foerfarande foer; och foerfarande
Prior art date: 1990-11-02

Application number

FI915136A

Other languages

English (en)

Other versions

FI915136L (fi

FI107606B (fi

Inventor

Frank Himmelsbach

Volkhard Austel

Helmut Pieper

Wolfgang Eisert

Thomas Mueller

Johannes Weisenberger

Guenter Linz

Gerd Krueger

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-02

Filing date

1991-10-31

Publication date

1991-10-31

1991-10-31 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1991-10-31 Publication of FI915136A0 publication Critical patent/FI915136A0/fi

1992-05-03 Publication of FI915136L publication Critical patent/FI915136L/fi

2001-09-14 Application granted granted Critical

2001-09-14 Publication of FI107606B publication Critical patent/FI107606B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Detergent Compositions (AREA)

FI915136A 1990-11-02 1991-10-31 Menetelmä valmistaa farmaseuttisesti arvokkaita 1-, 3-, 5-substituoituja pyrrolidin-2-oneja FI107606B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4035961		1990-11-02
DE4035961A DE4035961A1 (de)	1990-11-02	1990-11-02	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (3)

Publication Number	Publication Date
FI915136A0 true FI915136A0 (fi)	1991-10-31
FI915136L FI915136L (fi)	1992-05-03
FI107606B FI107606B (fi)	2001-09-14

Family

ID=6418111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI915136A FI107606B (fi)	1990-11-02	1991-10-31	Menetelmä valmistaa farmaseuttisesti arvokkaita 1-, 3-, 5-substituoituja pyrrolidin-2-oneja

Country Status (25)

Country	Link
US (2)	US5541343A (fi)
EP (1)	EP0483667B1 (fi)
JP (1)	JP2937589B2 (fi)
KR (1)	KR100223135B1 (fi)
AT (1)	ATE163008T1 (fi)
BG (1)	BG62025B2 (fi)
BR (1)	BR1100445A (fi)
CA (1)	CA2054850C (fi)
DE (2)	DE4035961A1 (fi)
DK (1)	DK0483667T3 (fi)
EE (1)	EE03099B1 (fi)
ES (1)	ES2113867T3 (fi)
FI (1)	FI107606B (fi)
GR (1)	GR3026508T3 (fi)
HK (1)	HK1008742A1 (fi)
HU (2)	HUT67288A (fi)
IE (1)	IE913822A1 (fi)
IL (1)	IL99926A (fi)
MX (1)	MX9203677A (fi)
NO (1)	NO174806B (fi)
NZ (1)	NZ240463A (fi)
PT (1)	PT99402B (fi)
RU (1)	RU2040519C1 (fi)
SG (1)	SG81852A1 (fi)
ZA (1)	ZA918734B (fi)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4127404A1 (de) *	1991-08-19	1993-02-25	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU646966B2 (en) *	1991-08-23	1994-03-10	Takeda Chemical Industries Ltd.	2-piperazinone compounds, their production and use
DE4213919A1 (de) *	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK0567967T3 (da) *	1992-04-28	1996-11-18	Thomae Gmbh Dr K	Tritium-mærkede fibrinogen-receptor-antagonister, deres anvendelse og fremgangsmåde til deres fremstilling
DE4213931A1 (de) *	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4219158A1 (de) *	1992-06-11	1993-12-16	Thomae Gmbh Dr K	Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4241632A1 (de) *	1992-12-10	1994-06-16	Thomae Gmbh Dr K	Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5314902A (en) *	1993-01-27	1994-05-24	Monsanto Company	Urea derivatives useful as platelet aggregation inhibitors
ATE195117T1 (de) *	1993-03-31	2000-08-15	Searle & Co	1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren
US6169107B1 (en)	1993-04-28	2001-01-02	Sumitomo Pharmaceutical Co., Ltd.	Indoloylguanidine derivatives
DE4424975A1 (de) *	1994-07-15	1996-01-18	Thomae Gmbh Dr K	2-Piperidinone, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EE9700141A (et) *	1994-12-23	1997-12-15	Dr. Karl Thomae Gmbh	Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod
CA2216162A1 (en) *	1995-04-26	1996-10-31	Takeda Chemical Industries, Ltd.	Piperazinones useful as inhibitors of platelet aggregation
DE19515500A1 (de) *	1995-04-27	1996-10-31	Thomae Gmbh Dr K	Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5719296A (en) *	1995-10-30	1998-02-17	Merck & Co., Inc.	Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
DE19604191A1 (de) *	1996-02-06	1997-08-07	Hoechst Schering Agrevo Gmbh	2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US5942544A (en) *	1996-02-22	1999-08-24	Dupont Pharmaceuticals Company	α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
DE19621483A1 (de) *	1996-05-29	1997-12-04	Hoechst Ag	Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19621482A1 (de)	1996-05-29	1997-12-04	Hoechst Ag	Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6057342A (en) *	1996-08-16	2000-05-02	Dupont Pharmaceutical Co.	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
WO1998006694A1 (en) *	1996-08-16	1998-02-19	Du Pont Pharmaceuticals Company	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
US6740682B2 (en)	1997-08-29	2004-05-25	Tularik Limited	Meta-benzamidine derivatives as serine protease inhibitors
AU8875798A (en) *	1997-08-29	1999-03-22	Proteus Molecular Design Ltd	Meta-benzamidine derivatives as serin protease inhibitors
WO1999012901A1 (en) *	1997-09-08	1999-03-18	Georgetown University	Substituted 2-pyrrolidinone activators of pkc
US6348478B1 (en)	1997-11-20	2002-02-19	Teijin Limited	Biphenylamidine derivatives
WO1999050249A2 (en)	1998-04-01	1999-10-07	Du Pont Pharmaceuticals Company	Pyrimidines and triazines as integrin antagonists
AU3406599A (en) *	1998-04-09	1999-11-01	Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin	Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
NZ508101A (en)	1998-04-10	2002-12-20	Japan Tobacco Inc	Amidine compounds useful as factor Xa inhibitors and as anticoagulants
CA2329422A1 (en) *	1998-04-23	1999-10-28	Abbott Laboratories	Pyrrolidines as inhibitors of neuraminidases
US6455571B1 (en)	1998-04-23	2002-09-24	Abbott Laboratories	Inhibitors of neuraminidases
US6518305B1 (en)	1998-04-23	2003-02-11	Abbott Laboratories	Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
ATE266662T1 (de) *	1998-07-22	2004-05-15	Daiichi Suntory Pharma Co Ltd	Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten
US6284796B1 (en) *	1998-08-06	2001-09-04	Abbott Laboratories	Ukokinase inhibitors
DE19844787A1 (de) *	1998-09-30	2000-04-13	Boehringer Ingelheim Pharma	Disubstituierte Pyrrolidinone, diese Verbindung enthaltende Arzneimittel und deren Verwendung sowie ihre Herstellung
AU3386500A (en)	1999-03-02	2000-09-21	Merck & Co., Inc.	3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
US6372764B1 (en)	1999-03-02	2002-04-16	Merck & Co., Inc.	Pyrrolidine modulators of chemokine receptor activity
JP2002538151A (ja)	1999-03-02	2002-11-12	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	カテプシンの可逆的インヒビターとして有用な化合物
AU3386400A (en) *	1999-03-02	2000-09-21	Merck & Co., Inc.	3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6420364B1 (en)	1999-09-13	2002-07-16	Boehringer Ingelheim Pharmaceuticals, Inc.	Compound useful as reversible inhibitors of cysteine proteases
RU2177317C1 (ru) *	2000-10-24	2001-12-27	Московский научно-исследовательский институт медицинской экологии (МНИИМЭ)	Производные хинолина для коррекции системы гемостаза, фармацевтическая композиция, средство для коррекции гемостаза
FR2817257B1 (fr) *	2000-11-30	2009-03-20	Sanofi Synthelabo	Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
WO2002060894A2 (en)	2001-01-30	2002-08-08	Bristol-Myers Squibb Company	Sulfonamide lactam inhibitors of factor xa
DE10121003A1 (de) *	2001-04-28	2002-12-19	Aventis Pharma Gmbh	Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
GB0114005D0 (en)	2001-06-08	2001-08-01	Glaxo Group Ltd	Chemical compounds
GB0114004D0 (en)	2001-06-08	2001-08-01	Glaxo Group Ltd	Chemical compounds
ES2290318T3 (es) *	2001-06-20	2008-02-16	Wyeth	Derivados sustituidos de acido indolico como inhibidores del inhibidor del activador del plasminogeno-1 (pai-1).
TWI224101B (en) *	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
UA80453C2 (en) *	2002-12-10	2007-09-25		Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
WO2004052855A2 (en) *	2002-12-10	2004-06-24	Wyeth	Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
AU2003296324A1 (en) *	2002-12-10	2004-06-30	Wyeth	Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
JP2006514640A (ja) *	2002-12-10	2006-05-11	ワイス	プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体
EP1594503A2 (en) *	2003-02-07	2005-11-16	Boehringer Ingelheim International GmbH	Use of dipyridamole or mopidamole for treatment and prevention of mmp-9-dependent disorders
KR20060007034A (ko)	2003-04-24	2006-01-23	베링거 인겔하임 인터내셔날 게엠베하	혈전색전증 질환 및 트롬빈의 과형성 및/또는 트롬빈수용체의 상승된 발현에 의해 유발된 질환 및 장애를치료하고 예방하기 위한, 디피리다몰 또는 모피다몰의 용도
WO2004101538A1 (en) *	2003-05-16	2004-11-25	Merck Sharp & Dohme Limited	Cyclohexyl sulphones as gamma-secretase inhibitors
US7351726B2 (en) *	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
US7446201B2 (en) *	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
US7534894B2 (en)	2003-09-25	2009-05-19	Wyeth	Biphenyloxy-acids
US7420083B2 (en) *	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7141592B2 (en) *	2003-09-25	2006-11-28	Wyeth	Substituted oxadiazolidinediones
US7442805B2 (en) *	2003-09-25	2008-10-28	Wyeth	Substituted sulfonamide-indoles
US7332521B2 (en) *	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7411083B2 (en) *	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
US7582773B2 (en) *	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
US7265148B2 (en) *	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7342039B2 (en) *	2003-09-25	2008-03-11	Wyeth	Substituted indole oximes
US7268159B2 (en) *	2003-09-25	2007-09-11	Wyeth	Substituted indoles
US7163954B2 (en) *	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
TW200524865A (en)	2003-10-08	2005-08-01	Nicholas Piramal India Ltd	Fibrinogen receptor antagonists and their use
EP1720847A1 (en) *	2004-02-02	2006-11-15	Pfizer Products Incorporated	Histamine-3 receptor modulators
NZ551077A (en) *	2004-05-07	2009-05-31	Janssen Pharmaceutica Nv	Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
BRPI0514572A (pt)	2004-08-23	2008-06-17	Wyeth Corp	ácidos de tiazolo-naftila
US7186749B2 (en) *	2004-08-23	2007-03-06	Wyeth	Pyrrolo-naphthyl acids and methods for using them
KR20070055563A (ko) *	2004-08-23	2007-05-30	와이어쓰	혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(ｐａｉ-1)의 조절제로서의옥사졸로-나프틸 산
DE602005017159D1 (de)	2004-08-30	2009-11-26	Janssen Pharmaceutica Nv	Oxysteroid-dehydrogenase-inhibitoren
CN101039908B (zh) *	2004-08-30	2010-06-23	詹森药业有限公司	作为11-β羟甾类脱氢酶抑制剂的三环内酰胺衍生物
KR101197674B1 (ko) *	2004-08-30	2012-11-07	얀센 파마슈티카 엔.브이.	１１-베타 하이드록시스테로이드 탈수소효소 저해제로서의 ｎ-2 아다만타닐-２-페녹시-아세트아미드 유도체
WO2006114096A1 (en) *	2005-04-25	2006-11-02	Danmarks Tekniske Universitet	Pyrrolidinone dipeptide analogs and use thereof as artificial sweeteners
US7683091B2 (en) *	2005-08-17	2010-03-23	Wyeth	Substituted indoles and methods of their use
RU2541430C2 (ru)	2007-10-05	2015-02-10	Акусела Инк.	Композиции и способы лечения нейродегенеративных заболеваний
WO2009055289A2 (en) *	2007-10-23	2009-04-30	Allergan, Inc.	Therapeutic substituted lactams
EP2448569B1 (en)	2009-07-02	2021-10-27	Acucela, Inc.	Pharmacology of visual cycle modulators
US8822679B2 (en) *	2011-06-24	2014-09-02	California Institute Of Technology	Quaternary heteroatom containing compounds
US20130267699A1 (en)	2011-06-24	2013-10-10	California Institute Of Technology	Quaternary heteroatom containing compounds
US9518034B2 (en)	2013-10-14	2016-12-13	California Institute Of Technology	Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof
EP3071541B1 (en)	2013-11-21	2023-06-07	Marquette University	Substituted (4'-hydroxyphenyl)cycloalkane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform
US10421696B2 (en)	2014-12-18	2019-09-24	California Institute Of Technology	Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
EP3274342B1 (en)	2015-03-27	2022-05-04	California Institute of Technology	Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
US10040784B2 (en)	2016-03-11	2018-08-07	California Institute Of Technology	Compositions and methods for acylating lactams
US10358422B2 (en)	2017-11-01	2019-07-23	California Institute Of Technology	Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
US11214568B2 (en)	2018-10-18	2022-01-04	California Institute Of Technology	Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4247466A (en) *	1979-07-05	1981-01-27	American Cyanamid Company	Lactone metabolites of 3-(4-biphenylylcarbonyl)propionic acid
EP0194548A3 (de) *	1985-03-12	1988-08-17	Dr. Karl Thomae GmbH	Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PT82200B (pt) *	1985-03-16	1990-02-08	Wellcome Found	Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
DE3823299A1 (de) *	1988-07-07	1990-01-11	Schering Ag	Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln

1990
- 1990-11-02 DE DE4035961A patent/DE4035961A1/de not_active Ceased
1991
- 1991-10-24 DK DK91118148T patent/DK0483667T3/da active
- 1991-10-24 DE DE59108930T patent/DE59108930D1/de not_active Expired - Lifetime
- 1991-10-24 EP EP91118148A patent/EP0483667B1/de not_active Expired - Lifetime
- 1991-10-24 AT AT91118148T patent/ATE163008T1/de not_active IP Right Cessation
- 1991-10-24 SG SG9601241A patent/SG81852A1/en unknown
- 1991-10-24 ES ES91118148T patent/ES2113867T3/es not_active Expired - Lifetime
- 1991-10-31 FI FI915136A patent/FI107606B/fi not_active IP Right Cessation
- 1991-10-31 PT PT99402A patent/PT99402B/pt not_active IP Right Cessation
- 1991-11-01 CA CA002054850A patent/CA2054850C/en not_active Expired - Lifetime
- 1991-11-01 IL IL9992691A patent/IL99926A/en not_active IP Right Cessation
- 1991-11-01 IE IE382291A patent/IE913822A1/en not_active IP Right Cessation
- 1991-11-01 HU HU913455A patent/HUT67288A/hu unknown
- 1991-11-01 NO NO914294A patent/NO174806B/no not_active IP Right Cessation
- 1991-11-01 JP JP3313154A patent/JP2937589B2/ja not_active Expired - Lifetime
- 1991-11-01 RU SU915001905A patent/RU2040519C1/ru active
- 1991-11-02 KR KR1019910019458A patent/KR100223135B1/ko not_active Expired - Lifetime
- 1991-11-04 ZA ZA918734A patent/ZA918734B/xx unknown
- 1991-11-04 NZ NZ240463A patent/NZ240463A/en not_active IP Right Cessation
1992
- 1992-06-29 MX MX9203677A patent/MX9203677A/es unknown
1994
- 1994-01-25 BG BG098416A patent/BG62025B2/bg unknown
- 1994-11-23 EE EE9400438A patent/EE03099B1/xx not_active IP Right Cessation
- 1994-12-28 US US08/365,336 patent/US5541343A/en not_active Expired - Lifetime
1995
- 1995-06-01 US US08/458,096 patent/US5591769A/en not_active Expired - Lifetime
- 1995-06-02 HU HU95P/P00156P patent/HU211563A9/hu unknown
1997
- 1997-05-06 BR BR1100445-2A patent/BR1100445A/pt active IP Right Grant
1998
- 1998-04-03 GR GR980400691T patent/GR3026508T3/el unknown
- 1998-07-17 HK HK98109250A patent/HK1008742A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL99926A (en)	1996-06-18
KR920009793A (ko)	1992-06-25
DK0483667T3 (da)	1998-09-23
PT99402B (pt)	1999-04-30
CA2054850C (en)	2001-01-02
ES2113867T3 (es)	1998-05-16
ZA918734B (en)	1993-05-04
NO174806C (fi)	1994-07-13
EP0483667B1 (de)	1998-02-04
EP0483667A2 (de)	1992-05-06
US5591769A (en)	1997-01-07
GR3026508T3 (en)	1998-07-31
CA2054850A1 (en)	1992-05-03
RU2040519C1 (ru)	1995-07-25
HUT67288A (en)	1995-03-28
HU913455D0 (en)	1992-01-28
NZ240463A (en)	1997-04-24
NO174806B (no)	1994-04-05
DE59108930D1 (de)	1998-03-12
MX9203677A (es)	1992-07-01
BG62025B2 (bg)	1998-12-30
JP2937589B2 (ja)	1999-08-23
EP0483667A3 (en)	1992-09-16
AU8692691A (en)	1992-05-07
FI915136L (fi)	1992-05-03
IL99926A0 (en)	1992-08-18
ATE163008T1 (de)	1998-02-15
DE4035961A1 (de)	1992-05-07
HU211563A9 (en)	1995-12-28
FI107606B (fi)	2001-09-14
EE03099B1 (et)	1998-06-15
BR1100445A (pt)	2000-07-18
AU650488B2 (en)	1994-06-23
NO914294L (no)	1992-05-04
HK1008742A1 (en)	1999-05-14
PT99402A (pt)	1992-09-30
US5541343A (en)	1996-07-30
SG81852A1 (en)	2001-07-24
KR100223135B1 (ko)	1999-10-15
IE913822A1 (en)	1992-05-22
JPH04264068A (ja)	1992-09-18
NO914294D0 (no)	1991-11-01

Publication	Publication Date	Title
FI915136A0 (fi)	1991-10-31	Cykliska iminoderivat, dessa foereningar innehaollande laekemede och foerfarande foer deras framstaellning.
FI923691A0 (fi)	1992-08-18	Cykliska iminoderivat, dessa foereningar innehaollande farmaceutiska blandningar och foerfarande foer deras framstaellning.
FI931880A0 (fi)	1993-04-27	Cykliska iminoderivat, foerfarande foer deras framstaellning och dessa foereningar innehaollande laekemedel
TW257753B (fi)	1995-09-21
NO178137C (no)	1996-01-31	Fremgangsmåte for fremstilling av et polyprenylholdig farmasöytisk preparat i form av harde kapsler
DE69011174D1 (de)	1994-09-08	Catecholaminester.

Legal Events

Date	Code	Title	Description
2011-11-25	MA	Patent expired