|
US4647576A
(en)
*
|
1984-09-24 |
1987-03-03 |
Warner-Lambert Company |
Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
|
|
NO881411L
(no)
*
|
1987-04-14 |
1988-10-17 |
Bayer Ag |
Substituerte pyrroler.
|
|
US5091378A
(en)
*
|
1987-05-22 |
1992-02-25 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
|
|
DE3722806A1
(de)
*
|
1987-07-10 |
1989-01-19 |
Hoechst Ag |
7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
|
|
DE3817808A1
(de)
*
|
1987-07-21 |
1989-02-02 |
Bayer Ag |
Verfahren zur herstellung von 2-substituierten pyrrolen
|
|
US4822799A
(en)
*
|
1988-01-27 |
1989-04-18 |
Sandoz Pharm. Corp. |
Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
|
|
NO890988L
(no)
*
|
1988-03-24 |
1989-09-25 |
Bayer Ag |
Disubstituerte pyrroler.
|
|
EP0339342A1
(fr)
*
|
1988-04-23 |
1989-11-02 |
Bayer Ag |
N-aminopyrrols N-substitués
|
|
EP0352575A3
(fr)
*
|
1988-07-28 |
1991-08-21 |
Bayer Ag |
Pyrroles annelés substitués
|
|
DE3826814A1
(de)
*
|
1988-08-06 |
1990-02-08 |
Hoechst Ag |
Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
|
|
US5506219A
(en)
*
|
1988-08-29 |
1996-04-09 |
E. R. Squibb & Sons, Inc. |
Pyridine anchors for HMG-CoA reductase inhibitors
|
|
DE3832570A1
(de)
*
|
1988-09-24 |
1990-03-29 |
Hoechst Ag |
7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
|
|
FI894648A7
(fi)
*
|
1988-10-03 |
1990-04-04 |
Glaxo Group Ltd |
Kemiallisia yhdisteitä
|
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
EP0422895A1
(fr)
*
|
1989-10-10 |
1991-04-17 |
Glaxo Group Limited |
Composés chimiques
|
|
IT1237792B
(it)
*
|
1989-12-21 |
1993-06-17 |
Zambon Spa |
Composti attivi come inibitori dell'enzima hmg-coa reduttasi
|
|
US5049577A
(en)
*
|
1990-01-29 |
1991-09-17 |
E. R. Squibb & Sons, Inc. |
2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith
|
|
US5049578A
(en)
*
|
1990-03-09 |
1991-09-17 |
E. R. Squibb & Sons, Inc. |
1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
|
|
US5128366A
(en)
*
|
1990-07-05 |
1992-07-07 |
Shinogi & Co., Ltd. |
Pyrrole derivatives
|
|
WO1992019239A1
(fr)
*
|
1991-05-01 |
1992-11-12 |
University Of New Mexico |
Traitement d'etats cellulaires aberrants a l'aide de biomodulateurs
|
|
WO1992019240A1
(fr)
*
|
1991-05-01 |
1992-11-12 |
University Of New Mexico |
Traitement d'aberrations cellulaires avec des biomodulateurs
|
|
US20010006644A1
(en)
|
1997-07-31 |
2001-07-05 |
David J. Bova |
Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
|
|
DE60024648T2
(de)
|
1999-09-14 |
2006-08-10 |
Merck Frosst Canada & Co, Kirkland |
Carbonsäuren und acylsulfonamide, diese verbindungen enthaltende zubereitungen und behandlungsmethoden
|
|
DE60008399T2
(de)
|
1999-09-14 |
2004-12-09 |
Merck Frosst Canada & Co, Kirkland |
Carbonsäuren und acylsulfonamide, solche verbindungen enthaltende zubereitungen und behandlungsmethoden
|
|
US7276249B2
(en)
|
2002-05-24 |
2007-10-02 |
Elan Pharma International, Ltd. |
Nanoparticulate fibrate formulations
|
|
JP2004536047A
(ja)
|
2001-04-11 |
2004-12-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
糖尿病処置用c−アリールグルコシドのアミノ酸複合体および方法
|
|
US7238671B2
(en)
|
2001-10-18 |
2007-07-03 |
Bristol-Myers Squibb Company |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
|
|
RU2353625C2
(ru)
|
2001-10-18 |
2009-04-27 |
Бристол-Маерс Сквибб Компани |
Миметики человеческого глюканоподобного пептида-1 и их применение в лечении диабета и родственных состояний
|
|
US6806381B2
(en)
|
2001-11-02 |
2004-10-19 |
Bristol-Myers Squibb Company |
Process for the preparation of aniline-derived thyroid receptor ligands
|
|
US6984645B2
(en)
|
2001-11-16 |
2006-01-10 |
Bristol-Myers Squibb Company |
Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
|
|
US6831102B2
(en)
|
2001-12-07 |
2004-12-14 |
Bristol-Myers Squibb Company |
Phenyl naphthol ligands for thyroid hormone receptor
|
|
WO2003094845A2
(fr)
|
2002-05-08 |
2003-11-20 |
Bristol-Myers Squibb Company |
Ligands du recepteur de la thyroide a base de pyridine
|
|
EP1511467A1
(fr)
|
2002-06-10 |
2005-03-09 |
Elan Pharma International Limited |
Formulation de polycosanol nanoparticulaires et nouvelles combinaisons de polycosanol
|
|
US6995180B2
(en)
|
2002-10-23 |
2006-02-07 |
Bristol Myers Squibb Company |
Glycinenitrile-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7098235B2
(en)
|
2002-11-14 |
2006-08-29 |
Bristol-Myers Squibb Co. |
Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
|
|
CA2508840A1
(fr)
|
2002-12-20 |
2004-07-08 |
Pfizer Products Inc. |
Formes posologiques comprenant un inhibiteur de cetp et un inhibiteur de hmg-coa reductase
|
|
TW200504021A
(en)
|
2003-01-24 |
2005-02-01 |
Bristol Myers Squibb Co |
Substituted anilide ligands for the thyroid receptor
|
|
US7557143B2
(en)
|
2003-04-18 |
2009-07-07 |
Bristol-Myers Squibb Company |
Thyroid receptor ligands
|
|
US7459474B2
(en)
|
2003-06-11 |
2008-12-02 |
Bristol-Myers Squibb Company |
Modulators of the glucocorticoid receptor and method
|
|
US6995183B2
(en)
|
2003-08-01 |
2006-02-07 |
Bristol Myers Squibb Company |
Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7250444B2
(en)
|
2003-08-11 |
2007-07-31 |
Pfizer Inc. |
Pyrrole-based HMG-CoA reductase inhibitors
|
|
JP2007512359A
(ja)
|
2003-11-19 |
2007-05-17 |
メタバシス・セラピューティクス・インコーポレイテッド |
新規なリン含有甲状腺ホルモン様物質
|
|
US8158362B2
(en)
|
2005-03-30 |
2012-04-17 |
Decode Genetics Ehf. |
Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
|
|
DK1725234T4
(en)
|
2004-03-05 |
2016-05-09 |
Univ Pennsylvania |
METHODS OF TREATING DISEASES OR DISEASES CONNECTED WITH HYPERLIPIDEMIA AND HYPERCOLESTEROLYMIA WITH MINIMIZATION OF SIDE EFFECTS
|
|
TW200611704A
(en)
|
2004-07-02 |
2006-04-16 |
Bristol Myers Squibb Co |
Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
|
|
US7534763B2
(en)
|
2004-07-02 |
2009-05-19 |
Bristol-Myers Squibb Company |
Sustained release GLP-1 receptor modulators
|
|
US7145040B2
(en)
|
2004-07-02 |
2006-12-05 |
Bristol-Myers Squibb Co. |
Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
|
|
AR051446A1
(es)
|
2004-09-23 |
2007-01-17 |
Bristol Myers Squibb Co |
Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
|
|
US7517991B2
(en)
|
2004-10-12 |
2009-04-14 |
Bristol-Myers Squibb Company |
N-sulfonylpiperidine cannabinoid receptor 1 antagonists
|
|
US7589088B2
(en)
|
2004-12-29 |
2009-09-15 |
Bristol-Myers Squibb Company |
Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7635699B2
(en)
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
WO2006076568A2
(fr)
|
2005-01-12 |
2006-07-20 |
Bristol-Myers Squibb Company |
Heterocycles bicycliques servant de modulateurs au recepteur de cannabinoides
|
|
US7368458B2
(en)
|
2005-01-12 |
2008-05-06 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid receptor modulators
|
|
US7314882B2
(en)
|
2005-01-12 |
2008-01-01 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid receptor modulators
|
|
US20060160850A1
(en)
|
2005-01-18 |
2006-07-20 |
Chongqing Sun |
Bicyclic heterocycles as cannabinoid receptor modulators
|
|
WO2006113261A2
(fr)
|
2005-04-14 |
2006-10-26 |
Bristol-Myers Squibb Company |
Inhibiteurs de la 11-beta hydroxysteroide deshydrogenase de type i
|
|
US7521557B2
(en)
|
2005-05-20 |
2009-04-21 |
Bristol-Myers Squibb Company |
Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7629342B2
(en)
|
2005-06-17 |
2009-12-08 |
Bristol-Myers Squibb Company |
Azabicyclic heterocycles as cannabinoid receptor modulators
|
|
US7572808B2
(en)
|
2005-06-17 |
2009-08-11 |
Bristol-Myers Squibb Company |
Triazolopyridine cannabinoid receptor 1 antagonists
|
|
US7632837B2
(en)
|
2005-06-17 |
2009-12-15 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid-1 receptor modulators
|
|
US7317012B2
(en)
|
2005-06-17 |
2008-01-08 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoind-1 receptor modulators
|
|
US7452892B2
(en)
|
2005-06-17 |
2008-11-18 |
Bristol-Myers Squibb Company |
Triazolopyrimidine cannabinoid receptor 1 antagonists
|
|
AR056155A1
(es)
|
2005-10-26 |
2007-09-19 |
Bristol Myers Squibb Co |
Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica
|
|
US7488725B2
(en)
|
2005-10-31 |
2009-02-10 |
Bristol-Myers Squibb Co. |
Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7592461B2
(en)
|
2005-12-21 |
2009-09-22 |
Bristol-Myers Squibb Company |
Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
|
|
US7553836B2
(en)
|
2006-02-06 |
2009-06-30 |
Bristol-Myers Squibb Company |
Melanin concentrating hormone receptor-1 antagonists
|
|
US8367112B2
(en)
|
2006-02-28 |
2013-02-05 |
Alkermes Pharma Ireland Limited |
Nanoparticulate carverdilol formulations
|
|
WO2007139589A1
(fr)
|
2006-05-26 |
2007-12-06 |
Bristol-Myers Squibb Company |
Modulateurs des récepteurs de glp-1 à libération prolongée
|
|
US7919598B2
(en)
|
2006-06-28 |
2011-04-05 |
Bristol-Myers Squibb Company |
Crystal structures of SGLT2 inhibitors and processes for preparing same
|
|
EP2089355A2
(fr)
|
2006-11-01 |
2009-08-19 |
Brystol-Myers Squibb Company |
Modulateurs de recepteur de glucocorticoide, d'activite ap-1 et/ou nf- kappa b, et leur utilisation
|
|
PE20090185A1
(es)
|
2007-03-22 |
2009-02-28 |
Bristol Myers Squibb Co |
Formulaciones farmaceuticas que contienen un inhibidor sglt2
|
|
PE20090696A1
(es)
|
2007-04-20 |
2009-06-20 |
Bristol Myers Squibb Co |
Formas cristalinas de saxagliptina y procesos para preparar las mismas
|
|
US20090011994A1
(en)
|
2007-07-06 |
2009-01-08 |
Bristol-Myers Squibb Company |
Non-basic melanin concentrating hormone receptor-1 antagonists and methods
|
|
CN101808995A
(zh)
|
2007-07-27 |
2010-08-18 |
百时美施贵宝公司 |
新颖的葡糖激酶激活剂及其使用方法
|
|
EP2197873B1
(fr)
|
2007-09-20 |
2014-07-16 |
Irm Llc |
Composés et compositions en tant que modulateurs de l'activité de gpr119
|
|
PE20091928A1
(es)
|
2008-05-29 |
2009-12-31 |
Bristol Myers Squibb Co |
Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos
|
|
WO2010093601A1
(fr)
|
2009-02-10 |
2010-08-19 |
Metabasis Therapeutics, Inc. |
Nouveaux thyromimetiques contenant de l'acide sulfonique et methodes d'utilisation associees
|
|
CA2756786A1
(fr)
|
2009-03-27 |
2010-09-30 |
Bristol-Myers Squibb Company |
Procedes destines a prevenir des evenements cardiovasculaires indesirables majeurs par des inhibiteurs de la dpp-iv
|
|
WO2011014520A2
(fr)
|
2009-07-29 |
2011-02-03 |
Irm Llc |
Composés et compositions pouvant servir de modulateurs de l'activité du gpr119
|
|
BR112012008004A2
(pt)
|
2009-10-09 |
2016-03-29 |
Irm Llc |
compostos e composições como moduladores da atividade de gpr119
|
|
ES2693686T3
(es)
|
2009-11-13 |
2018-12-13 |
Astrazeneca Ab |
Formulaciones de comprimidos de liberación inmediata
|
|
BR112012011274A2
(pt)
|
2009-11-13 |
2016-04-12 |
Astrazeneca Uk Ltd |
formulação de metformina de massa reduzida e sua combinação
|
|
WO2011060256A2
(fr)
|
2009-11-13 |
2011-05-19 |
Bristol-Myers Squibb Company |
Formulations de comprimé bicouche
|
|
US8394858B2
(en)
|
2009-12-03 |
2013-03-12 |
Novartis Ag |
Cyclohexane derivatives and uses thereof
|
|
TWI562775B
(en)
|
2010-03-02 |
2016-12-21 |
Lexicon Pharmaceuticals Inc |
Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
|
|
CN102971313A
(zh)
|
2010-04-14 |
2013-03-13 |
百时美施贵宝公司 |
新颖的葡糖激酶激活剂及其使用方法
|
|
EP2590634B1
(fr)
|
2010-07-09 |
2016-03-09 |
BHV Pharma, Inc. |
Système d'administration à libération immédiate/retardée en combinaison pour des médicaments à courte demi-vie comprenant de la rémogliflozine
|
|
US8697739B2
(en)
|
2010-07-29 |
2014-04-15 |
Novartis Ag |
Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
|
|
TWI631963B
(zh)
|
2011-01-05 |
2018-08-11 |
雷西肯製藥股份有限公司 |
包含鈉-葡萄糖共同輸送體1與2之抑制劑的組合物與應用方法
|
|
WO2014052619A1
(fr)
|
2012-09-27 |
2014-04-03 |
Irm Llc |
Dérivés et compositions de pipéridine comme modulateurs de l'activité de gpr119
|
|
RU2015123738A
(ru)
|
2012-11-20 |
2017-01-10 |
Лексикон Фармасьютикалз, Инк. |
Ингибиторы котранспортера натрий-глюкозы 1
|
|
US9593113B2
(en)
|
2013-08-22 |
2017-03-14 |
Bristol-Myers Squibb Company |
Imide and acylurea derivatives as modulators of the glucocorticoid receptor
|
|
WO2016040858A1
(fr)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Combinaisons et régimes posologiques pour traiter des tumeurs rb-positives
|
|
BR112017023158A2
(pt)
|
2015-04-30 |
2018-07-24 |
Harvard College |
anticorpos anti-ap2 e agentes de ligação de antígeno para tratar distúrbios metabólicos
|
|
PE20210644A1
(es)
|
2018-07-19 |
2021-03-23 |
Astrazeneca Ab |
METODOS DE TRATAMIENTO DE HFpEF EMPLEANDO DAPAGLIFLOZINA Y COMPOSICIONES QUE COMPRENDEN LA MISMA
|
|
BR112021004839A2
(pt)
|
2018-09-26 |
2021-06-08 |
Lexicon Pharmaceuticals, Inc. |
formas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2-metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5-triidróxi-6-(metiltio)tetraidro-2h-piran-2-il)benzil)fenil)butanamida e métodos de sua síntese
|
|
EP4188372A1
(fr)
|
2020-07-29 |
2023-06-07 |
Amryt Pharmaceuticals Inc. |
Lomitapide destiné à être utilisé dans des méthodes de traitement de l'hyperlipidémie et de l'hypercholestérolémie chez des patients pédiatriques
|
|
WO2025147589A1
(fr)
|
2024-01-05 |
2025-07-10 |
Osanni Bio, Inc. |
Implants, compositions et méthodes de traitement de maladies et de troubles de la rétine
|