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WO1987002662A3 - Analogues heterocycliques de mevalonolactone et leurs derives, procedes de production et utilisation en tant que produits pharmaceutiques - Google Patents

Analogues heterocycliques de mevalonolactone et leurs derives, procedes de production et utilisation en tant que produits pharmaceutiques Download PDF

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Publication number
WO1987002662A3
WO1987002662A3 PCT/EP1986/000598 EP8600598W WO8702662A3 WO 1987002662 A3 WO1987002662 A3 WO 1987002662A3 EP 8600598 W EP8600598 W EP 8600598W WO 8702662 A3 WO8702662 A3 WO 8702662A3
Authority
WO
WIPO (PCT)
Prior art keywords
3alkyl
hydrogen
group
formula
pharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1986/000598
Other languages
English (en)
Other versions
WO1987002662A2 (fr
Inventor
James Richard Wareing
Robert Edson Damon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Novartis Pharmaceuticals Corp
Original Assignee
Sandoz AG
Sandoz Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Pharmaceuticals Corp filed Critical Sandoz AG
Priority to HU865313A priority Critical patent/HUT48208A/hu
Priority to KR1019870700553A priority patent/KR900001212B1/ko
Publication of WO1987002662A2 publication Critical patent/WO1987002662A2/fr
Priority to FI872299A priority patent/FI872299A0/fi
Priority to DK321887A priority patent/DK321887D0/da
Publication of WO1987002662A3 publication Critical patent/WO1987002662A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés de formule (I) dans laquelle Ra est un groupe -X-Z, Rb est R2, Rc est R3, Rd est R4 et Y est un groupe (III) ou Ra est R1, Rb est un groupe -X-Z, Rc est R2, Rd est R3 et Y est O, S ou un groupe (IV); R1, R2, R3 et R4 sont chacun indépendamment C1-6alkyle ne contenant pas d'atome de carbone asymétrique, C3-7cycloalkyle ou un anneau (V) ou, dans le cas R3 et R4, également hydrogène, ou, lorsque Y est O ou S, R3 et représenté par (VI) où R17 est hydrogène ou C1-3alkyle et R18 et R19 sont indépendamment hydrogène, C1-3alkyle ou phényle; chaque R5 est indépendamment hydrogène, C1-3alkyle, n-butyle, i-butyle, t-butyle, C1-3alkoxy, n-butoxy, i-butoxy, trifluorométhyle, fluoro, chloro, bromo, phényle, phénoxy ou benzyloxy; chaque R6 est indépendamment hydrogène, C1-3alkyle, C1-3alkoxy, trifluorométhyle, fluoro, chloro, bromo, phénoxy ou benzyloxy, et chaque R7 est indépendamment hydrogène, C1-2alkyle, C1-2alkoxy, fluoro ou chloro, à condition que chaque anneau A ne puisse présenter qu'un élément parmi trifluorométhyle, phénoxy ou benzyloxy, X est (CH2)m ou (CH2)qCH=CH-(CH2)q, m vaut 0, 1, 2 ou 3 et les deux q valent 0 ou l'un d'entre eux vaut 0 et l'autre vaut 1, Z présente la formule (II) où R9 est hydrogène ou C1-3alkyle. Ces composés se présentent sous la forme d'un acide libre, ou sous la forme d'un ester ou d'un delta-lactone de celui-ci ou sous une forme de sel, selon les besoins, et sont indiqués pour être utilisés comme produits pharmaceutiques notamment en tant qu'agents hypolipoprotéinémiques et anti-artériosclérotiques.
PCT/EP1986/000598 1985-10-25 1986-10-21 Analogues heterocycliques de mevalonolactone et leurs derives, procedes de production et utilisation en tant que produits pharmaceutiques Ceased WO1987002662A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HU865313A HUT48208A (en) 1985-10-25 1986-10-21 Process for producing heterocyclic analogues of mevalolactone derivatives and pharmaceutical compositions comprising such compounds
KR1019870700553A KR900001212B1 (ko) 1985-10-25 1986-10-21 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도
FI872299A FI872299A0 (fi) 1985-10-25 1987-05-25 Heterocykliska analoger av mevalonolaktoner och deras derivat, foerfaranden foer deras framstaellning och deras anvaendning som farmaceutiska medel.
DK321887A DK321887D0 (da) 1985-10-25 1987-06-24 Mevalonolactonanaloge

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79119885A 1985-10-25 1985-10-25
US791,198 1985-10-25
US81666486A 1986-01-07 1986-01-07
US816,664 1986-01-07

Publications (2)

Publication Number Publication Date
WO1987002662A2 WO1987002662A2 (fr) 1987-05-07
WO1987002662A3 true WO1987002662A3 (fr) 1987-12-17

Family

ID=27121116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000598 Ceased WO1987002662A2 (fr) 1985-10-25 1986-10-21 Analogues heterocycliques de mevalonolactone et leurs derives, procedes de production et utilisation en tant que produits pharmaceutiques

Country Status (12)

Country Link
EP (1) EP0221025A1 (fr)
KR (1) KR900001212B1 (fr)
AU (1) AU598775B2 (fr)
CA (1) CA1278794C (fr)
DK (1) DK321887D0 (fr)
FI (1) FI872299A0 (fr)
HU (1) HUT48208A (fr)
IL (1) IL80403A (fr)
NZ (1) NZ218045A (fr)
PL (1) PL154130B1 (fr)
PT (1) PT83610B (fr)
WO (1) WO1987002662A2 (fr)

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DE1695941A1 (de) * 1966-04-25 1971-05-13 Upjohn Co Verfahren zur Herstellung von 5-gliedrigen N-Heterocyclen,die im Ring ungesaettigt sind
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EP0117228A1 (fr) * 1983-01-24 1984-08-29 Sandoz Ag Analogues de mévalonolactone et leur dérivés, leur procédé de production, compositions pharmaceutiques les contenant ainsi que leur utilisation comme médicaments
EP0125415A1 (fr) * 1983-03-16 1984-11-21 BASF Aktiengesellschaft Procédé de production de pyrroles
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US3168527A (en) * 1962-06-14 1965-02-02 Parke Davis & Co 1-aryl-5-(p-fluorophenyl)-pyrrole-2-propionic acid compounds
DE1695941A1 (de) * 1966-04-25 1971-05-13 Upjohn Co Verfahren zur Herstellung von 5-gliedrigen N-Heterocyclen,die im Ring ungesaettigt sind
FR2164857A1 (fr) * 1971-12-23 1973-08-03 Continental Pharma
US4035394A (en) * 1976-02-24 1977-07-12 Morton-Norwich Products, Inc. 5-Phenyl-2-furanyl-oxo or-hydroxy alkanoic acids and ethyl esters as gastric acid antisecretory agents
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EP0117228A1 (fr) * 1983-01-24 1984-08-29 Sandoz Ag Analogues de mévalonolactone et leur dérivés, leur procédé de production, compositions pharmaceutiques les contenant ainsi que leur utilisation comme médicaments
EP0125415A1 (fr) * 1983-03-16 1984-11-21 BASF Aktiengesellschaft Procédé de production de pyrroles
EP0155524A1 (fr) * 1984-03-01 1985-09-25 A. Nattermann & Cie. GmbH Composé omega-aryl-alkylthianyliques, leur procédé de préparation et produits pharmaceutiques les contenant
WO1986000307A2 (fr) * 1984-06-22 1986-01-16 Sandoz Ag Analogues pyrazole de la mevalonolactone et leurs derives, leurs procedes de preparation et leur utilisation

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KR870700602A (ko) 1987-12-30
KR900001212B1 (ko) 1990-02-28
IL80403A0 (en) 1987-01-30
FI872299A7 (fi) 1987-05-25
PL154130B1 (en) 1991-07-31
PT83610B (pt) 1989-05-31
PT83610A (en) 1986-11-01
EP0221025A1 (fr) 1987-05-06
IL80403A (en) 1990-09-17
NZ218045A (en) 1990-03-27
DK321887A (da) 1987-06-24
HUT48208A (en) 1989-05-29
CA1278794C (fr) 1991-01-08
AU6599486A (en) 1987-05-19
AU598775B2 (en) 1990-07-05
WO1987002662A2 (fr) 1987-05-07
DK321887D0 (da) 1987-06-24
FI872299A0 (fi) 1987-05-25
PL262032A1 (en) 1988-07-21

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