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FI20011189L - Menetelmä polyaktidien puhdistamiseksi ja menetelmällä puhdistettuja polyaktideja - Google Patents

Menetelmä polyaktidien puhdistamiseksi ja menetelmällä puhdistettuja polyaktideja Download PDF

Info

Publication number
FI20011189L
FI20011189L FI20011189A FI20011189A FI20011189L FI 20011189 L FI20011189 L FI 20011189L FI 20011189 A FI20011189 A FI 20011189A FI 20011189 A FI20011189 A FI 20011189A FI 20011189 L FI20011189 L FI 20011189L
Authority
FI
Finland
Prior art keywords
polyactides
purifying
purified
purifying polyactides
polyactides purified
Prior art date
Application number
FI20011189A
Other languages
English (en)
Swedish (sv)
Other versions
FI111268B (fi
Inventor
Walter Prikoszovich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI20011189L publication Critical patent/FI20011189L/fi
Application granted granted Critical
Publication of FI111268B publication Critical patent/FI111268B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI20011189A 1990-08-01 2001-06-05 Menetelmä polylaktidien puhdistamiseksi FI111268B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB9016840 1990-08-01
GB9016882 1990-08-01
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
FI20011189L true FI20011189L (fi) 2001-06-05
FI111268B FI111268B (fi) 2003-06-30

Family

ID=26297417

Family Applications (2)

Application Number Title Priority Date Filing Date
FI913641A FI108040B (fi) 1990-08-01 1991-07-30 Puhdistettuja polylaktideja
FI20011189A FI111268B (fi) 1990-08-01 2001-06-05 Menetelmä polylaktidien puhdistamiseksi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI913641A FI108040B (fi) 1990-08-01 1991-07-30 Puhdistettuja polylaktideja

Country Status (27)

Country Link
EP (2) EP0469520B1 (fi)
JP (1) JP3137368B2 (fi)
KR (1) KR100255904B1 (fi)
AT (1) AT402503B (fi)
AU (1) AU650277B2 (fi)
CA (1) CA2048200C (fi)
CH (1) CH683772A5 (fi)
CY (1) CY1986A (fi)
DE (1) DE4124468B4 (fi)
DK (2) DK0469520T3 (fi)
ES (2) ES2243966T3 (fi)
FI (2) FI108040B (fi)
FR (1) FR2665453B1 (fi)
GB (1) GB2246573B (fi)
GR (1) GR3026322T3 (fi)
HK (1) HK11797A (fi)
HU (1) HUT59837A (fi)
IE (1) IE66185B1 (fi)
IL (1) IL99007A (fi)
IT (1) IT1252944B (fi)
LU (1) LU87985A1 (fi)
MY (1) MY108621A (fi)
NO (1) NO912960D0 (fi)
NZ (1) NZ239184A (fi)
PH (1) PH31047A (fi)
PT (1) PT98491B (fi)
TW (2) TW218025B (fi)

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US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
JPH06116381A (ja) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) * 1993-04-21 1994-10-27 Basf Ag Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
CZ293764B6 (cs) 1993-11-19 2004-07-14 Janssen Pharmaceutica N. V. Farmaceutický prostředek s dostatečným a dlouhodobým uvolňováním léčiva, biodegradovatelné a biokompatibilní mikročástice, způsob jejich výroby a použití
IL128774A (en) * 1994-03-07 2001-05-20 Dow Chemical Co Composition comprising a dendritic poymer in complex with at least one unit of biological response modifier and a process for the preparation thereof
WO2000015273A1 (de) 1998-09-11 2000-03-23 Gerhard Schmidmaier Biologisch aktive implantate
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
US7067611B2 (en) 2001-07-10 2006-06-27 Kureha Corporation Polyhydroxycarboxylic acid and its production process
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
EP1450766B1 (fr) * 2001-10-10 2015-04-22 Pierre Fabre Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
PT1787658E (pt) 2005-11-10 2012-06-22 Chemi Spa Formulações de libertação sustentada de análogos de somatostatina inibidores da hormona do crescimento
CN101193531B (zh) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 散热装置
US8853351B2 (en) * 2007-12-31 2014-10-07 Samyang Biopharmaceuticals Corporation Highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid and process for the preparation thereof
US20100256746A1 (en) * 2009-03-23 2010-10-07 Micell Technologies, Inc. Biodegradable polymers
JP5594996B2 (ja) 2009-09-14 2014-09-24 三菱重工業株式会社 航空機の操縦システム
KR101130825B1 (ko) 2010-06-21 2012-03-28 주식회사 엘지화학 내열성이 우수한 폴리락타이드 수지 및 이의 제조방법
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
CN105820332B (zh) * 2015-01-09 2018-06-29 北京化工大学 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
EP3408305B1 (en) 2016-01-29 2024-03-06 Tolmar Inc. Purification and decolorization of polymers
SG11202001688WA (en) * 2017-08-31 2020-03-30 Evonik Corp Improved resorbable polymer purification process
GR1009392B (el) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CA1236641A (en) * 1984-07-06 1988-05-10 Motoaki Tanaka Copolymer of lactic acid and glycolic acid and method for producing same
DE3583988D1 (de) * 1984-11-13 1991-10-10 Asahi Chemical Ind Verfahren zur reinigung von polyalkylenaethern.
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
ATE168391T1 (de) * 1990-04-13 1998-08-15 Takeda Chemical Industries Ltd Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung

Also Published As

Publication number Publication date
EP0816413B1 (en) 2005-06-08
JP3137368B2 (ja) 2001-02-19
GB2246573A (en) 1992-02-05
EP0469520A3 (en) 1992-10-07
IE66185B1 (en) 1995-12-13
ITRM910553A0 (it) 1991-07-23
DK0469520T3 (da) 1998-09-23
ES2112259T3 (es) 1998-04-01
FI913641A0 (fi) 1991-07-30
KR920003990A (ko) 1992-03-27
HUT59837A (en) 1992-07-28
NO912960D0 (no) 1991-07-30
IL99007A (en) 1994-12-29
EP0469520A2 (en) 1992-02-05
GR3026322T3 (en) 1998-06-30
GB2246573B (en) 1994-05-11
IE912697A1 (en) 1992-02-12
EP0816413A2 (en) 1998-01-07
DE4124468A1 (de) 1992-02-06
GB9116396D0 (en) 1991-09-11
PT98491A (pt) 1992-06-30
CH683772A5 (de) 1994-05-13
AU8143091A (en) 1992-02-27
LU87985A1 (fr) 1993-02-15
FI913641L (fi) 1992-02-02
EP0816413A3 (en) 1998-11-11
ES2243966T3 (es) 2005-12-01
ATA151591A (de) 1996-10-15
ITRM910553A1 (it) 1993-01-23
NZ239184A (en) 1994-09-27
FR2665453B1 (fr) 1995-01-27
MY108621A (en) 1996-10-31
TW282477B (fi) 1996-08-01
IT1252944B (it) 1995-07-05
HK11797A (en) 1997-02-14
AT402503B (de) 1997-06-25
FI108040B (fi) 2001-11-15
EP0469520B1 (en) 1998-02-25
DE4124468B4 (de) 2010-10-28
DK0816413T3 (da) 2005-08-29
FI111268B (fi) 2003-06-30
IL99007A0 (en) 1992-07-15
FR2665453A1 (fr) 1992-02-07
CA2048200A1 (en) 1992-02-02
PH31047A (en) 1998-02-03
HU912452D0 (en) 1991-12-30
JPH0641279A (ja) 1994-02-15
KR100255904B1 (ko) 2000-05-01
CY1986A (en) 1997-09-05
TW218025B (fi) 1993-12-21
PT98491B (pt) 1997-12-31
CA2048200C (en) 1999-06-29
AU650277B2 (en) 1994-06-16

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