ES9000005A1 - Pyridinylpiperazine derivatives - Google Patents
Pyridinylpiperazine derivativesInfo
- Publication number
- ES9000005A1 ES9000005A1 ES557865A ES557865A ES9000005A1 ES 9000005 A1 ES9000005 A1 ES 9000005A1 ES 557865 A ES557865 A ES 557865A ES 557865 A ES557865 A ES 557865A ES 9000005 A1 ES9000005 A1 ES 9000005A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- substitute
- pyridine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GZRKXKUVVPSREJ-UHFFFAOYSA-N pyridinylpiperazine Chemical class C1CNCCN1C1=CC=CC=N1 GZRKXKUVVPSREJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 3
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000506 psychotropic effect Effects 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE PREPARAN DERIVADOS DISUSTITUIDOS DE 1,4 PIPERACINILO DE FORMULA GENERAL I, EN LOS QUE UN SUSTITUYENTE ES UN SISTEMA HETEROCICLICO DE ANILLO FUSIONADO BICICLICO DE FURO-, PIRROLO-, CICLOPENTADIENO-, O TIENO-PIRIDINA, Y EL SEGUNDO SUSTITUYENTE ES UNA CADENA DE ALQUILENO UNIDA A HETEROCICLOS DE IMICA CICLICA, COMO AZAESPIRO (4.5) DECANODIONAS, DIAQUIL-GENTARIMIDAS, TIAZOLIDINADIONAS, SUCCINIMIDAS Y MORFOLINA-2,6-DIONAS, O UNA PARTE CARBINO1-BENCILICA. LA PREPARACION DE ESTOS COMPUESTOS SE LLEVA A CABO HACIENDO REACCIONAR UN COMPUESTO DE FORMULA II CON UN COMPUESTO DE FORMULA III. R1, R2, X, Y, Z Y Q TIENEN EL SIGNIFICADO DESCRITO EN LA MEMORIA. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD SELECTIVA SOBRE EL SISTEMA NERVIOSO CENTRAL, TENIENDO PROPIEDADES PSICOTROPICAS ADECUADAS POR EMPLEARLOS COMO AGENTES ANTIPSICOTICOS. *FORMULA*DISUSTITUTED DERIVATIVES OF 1,4-PIPERACINYL OF GENERAL FORMULA I ARE PREPARED, IN WHICH A SUBSTITUTE IS A FURO-, PIRROLO-, CYCLOPENTADIENE-, A SECOND-PYRIDINE HETEROCYCLIC FUSED RING SYSTEM, OR A SUBSTITUTE CHAIN AND A SECOND PYRIDINE ALKYLENE JOINED TO HETEROCYCLES OF CYCLIC IMICA, SUCH AS AZAESPIRO (4.5) DECANODIONAS, DIAQUYL-GENTARIMIDES, THIAZOLIDINADIONES, SUCCINIMIDAS AND MORPHOLINE-2,6-DIONAS, OR A CARBINE1-BENZYLIC PART. THE PREPARATION OF THESE COMPOUNDS IS CARRIED OUT BY REACTING A COMPOUND OF FORMULA II WITH A COMPOUND OF FORMULA III. R1, R2, X, Y, Z AND Q HAVE THE MEANING DESCRIBED IN THE MEMORY. THESE COMPOUNDS PRESENT SELECTIVE ACTIVITY ON THE CENTRAL NERVOUS SYSTEM, HAVING SUITABLE PSYCHOTROPIC PROPERTIES BY USING THEM AS ANTIPSYCHOTIC AGENTS. *FORMULA*
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73120185A | 1985-05-06 | 1985-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES9000005A1 true ES9000005A1 (en) | 1989-11-01 |
Family
ID=24938510
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554659A Expired ES8801250A1 (en) | 1985-05-06 | 1986-05-05 | Pyridinylpiperazine derivatives |
| ES557757A Expired ES8802149A1 (en) | 1985-05-06 | 1987-09-25 | A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1,4-DISSTITUTED |
| ES557809A Expired ES8802614A1 (en) | 1985-05-06 | 1988-01-28 | A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1.4 DISSTITUTED |
| ES557839A Expired ES8900138A1 (en) | 1985-05-06 | 1988-05-26 | A PROCEDURE FOR THE PREPARATION OF 1-4-DISSTITUTED PIPERAZINYL DERIVATIVES. |
| ES557855A Expired ES8900253A1 (en) | 1985-05-06 | 1988-11-16 | Pyridinylpiperazine derivatives |
| ES557865A Expired ES9000005A1 (en) | 1985-05-06 | 1989-02-27 | Pyridinylpiperazine derivatives |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554659A Expired ES8801250A1 (en) | 1985-05-06 | 1986-05-05 | Pyridinylpiperazine derivatives |
| ES557757A Expired ES8802149A1 (en) | 1985-05-06 | 1987-09-25 | A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1,4-DISSTITUTED |
| ES557809A Expired ES8802614A1 (en) | 1985-05-06 | 1988-01-28 | A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1.4 DISSTITUTED |
| ES557839A Expired ES8900138A1 (en) | 1985-05-06 | 1988-05-26 | A PROCEDURE FOR THE PREPARATION OF 1-4-DISSTITUTED PIPERAZINYL DERIVATIVES. |
| ES557855A Expired ES8900253A1 (en) | 1985-05-06 | 1988-11-16 | Pyridinylpiperazine derivatives |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPH0753728B2 (en) |
| KR (1) | KR940000829B1 (en) |
| CN (1) | CN1017901B (en) |
| AT (1) | AT398572B (en) |
| AU (1) | AU593244B2 (en) |
| BE (1) | BE904724A (en) |
| CA (1) | CA1278792C (en) |
| CH (1) | CH672787A5 (en) |
| DE (1) | DE3615180C2 (en) |
| DK (1) | DK165745C (en) |
| EG (1) | EG18206A (en) |
| ES (6) | ES8801250A1 (en) |
| FI (1) | FI85484C (en) |
| FR (1) | FR2581385B1 (en) |
| GB (1) | GB2174703B (en) |
| GR (1) | GR861149B (en) |
| HU (1) | HU195509B (en) |
| IE (1) | IE59201B1 (en) |
| IT (1) | IT1208607B (en) |
| LU (1) | LU86421A1 (en) |
| MY (1) | MY100777A (en) |
| NL (1) | NL8601146A (en) |
| PT (1) | PT82523B (en) |
| SE (1) | SE465270B (en) |
| ZA (1) | ZA862046B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801186A (en) * | 1987-11-20 | 1998-09-01 | Hoechst Marion Roussel, Inc. | 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds |
| US4880930A (en) * | 1987-11-30 | 1989-11-14 | New James S | Psychotropic acyclic amide derivatives |
| US4780466A (en) * | 1988-03-17 | 1988-10-25 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylpiperazinylalkoxy derivatives of cyclic imides |
| IE903410A1 (en) * | 1989-10-09 | 1991-04-10 | Novo Nordisk As | Indole derivatives, their preparation and use |
| US5272148A (en) * | 1992-09-09 | 1993-12-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Heteroarenylpiperazines |
| FR2738824B1 (en) * | 1995-09-15 | 1997-10-31 | Synthelabo | DERIVATIVES OF 3- (OMEGA (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN-1 -YL) ALKYL) -3,4-DIHYDROQUINAZOLIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| DK0850235T3 (en) * | 1995-09-15 | 2000-05-29 | Sanofi Synthelabo | Derivatives of quinoline-2 (1H) -one as serotonin antagonists |
| FR2738822B1 (en) * | 1995-09-15 | 1997-10-31 | Synthelabo | DERIVATIVES OF 4- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) QUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| FR2738823B1 (en) * | 1995-09-15 | 1997-10-31 | Synthelabo | DERIVATIVES OF 3- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) -3,4-DIHYDROQUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS |
| FR2761071B1 (en) * | 1997-03-20 | 1999-12-03 | Synthelabo | DERIVATIVES OF QUINOLEIN-2 (1H) -ONE AND DIHYDROQUINOLEIN-2 (1H) - ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| FR2797874B1 (en) * | 1999-08-27 | 2002-03-29 | Adir | NOVEL PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US20040077605A1 (en) | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
| US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
| US4361565A (en) * | 1981-12-28 | 1982-11-30 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines |
-
1986
- 1986-03-11 CA CA000503794A patent/CA1278792C/en not_active Expired - Fee Related
- 1986-03-19 ZA ZA862046A patent/ZA862046B/en unknown
- 1986-04-29 GR GR861149A patent/GR861149B/en unknown
- 1986-04-29 AU AU56795/86A patent/AU593244B2/en not_active Expired
- 1986-04-29 EG EG250/86A patent/EG18206A/en active
- 1986-04-30 FI FI861820A patent/FI85484C/en not_active IP Right Cessation
- 1986-05-02 GB GB08610810A patent/GB2174703B/en not_active Expired
- 1986-05-02 KR KR1019860003445A patent/KR940000829B1/en not_active Expired - Fee Related
- 1986-05-05 SE SE8602061A patent/SE465270B/en not_active IP Right Cessation
- 1986-05-05 IE IE119386A patent/IE59201B1/en not_active IP Right Cessation
- 1986-05-05 CH CH1830/86A patent/CH672787A5/de not_active IP Right Cessation
- 1986-05-05 FR FR8606471A patent/FR2581385B1/en not_active Expired - Lifetime
- 1986-05-05 DE DE3615180A patent/DE3615180C2/en not_active Expired - Lifetime
- 1986-05-05 BE BE0/216623A patent/BE904724A/en not_active IP Right Cessation
- 1986-05-05 ES ES554659A patent/ES8801250A1/en not_active Expired
- 1986-05-05 DK DK207186A patent/DK165745C/en not_active IP Right Cessation
- 1986-05-05 NL NL8601146A patent/NL8601146A/en active Search and Examination
- 1986-05-05 LU LU86421A patent/LU86421A1/en unknown
- 1986-05-05 CN CN86103071A patent/CN1017901B/en not_active Expired
- 1986-05-06 HU HU861860A patent/HU195509B/en unknown
- 1986-05-06 PT PT82523A patent/PT82523B/en unknown
- 1986-05-06 JP JP61103726A patent/JPH0753728B2/en not_active Expired - Lifetime
- 1986-05-06 AT AT0121486A patent/AT398572B/en not_active IP Right Cessation
- 1986-05-06 IT IT8620313A patent/IT1208607B/en active
-
1987
- 1987-09-25 ES ES557757A patent/ES8802149A1/en not_active Expired
- 1987-10-01 MY MYPI87002712A patent/MY100777A/en unknown
-
1988
- 1988-01-28 ES ES557809A patent/ES8802614A1/en not_active Expired
- 1988-05-26 ES ES557839A patent/ES8900138A1/en not_active Expired
- 1988-11-16 ES ES557855A patent/ES8900253A1/en not_active Expired
-
1989
- 1989-02-27 ES ES557865A patent/ES9000005A1/en not_active Expired
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