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ES8801250A1 - Pyridinylpiperazine derivatives - Google Patents

Pyridinylpiperazine derivatives

Info

Publication number
ES8801250A1
ES8801250A1 ES554659A ES554659A ES8801250A1 ES 8801250 A1 ES8801250 A1 ES 8801250A1 ES 554659 A ES554659 A ES 554659A ES 554659 A ES554659 A ES 554659A ES 8801250 A1 ES8801250 A1 ES 8801250A1
Authority
ES
Spain
Prior art keywords
furo
substituent
piperazinyl
derivatives
antipsychotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554659A
Other languages
Spanish (es)
Other versions
ES554659A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8801250A1 publication Critical patent/ES8801250A1/en
Publication of ES554659A0 publication Critical patent/ES554659A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Disubstituted 1,4-piperazinyl derivatives are disclosed wherein one substituent is a bicyclic fused-ring furo-, pyrrolo-, cyclopentadieno-, or thieno-pyridine heterocyclic system and the second substituent is an alkylene chain attached to cyclic imide heterocycles, such as azospiro[4.5]decanediones, dialkylglutarimides, thiazolidinediones, succinimides, and morpholine-2,6-diones or a fluorobenzylic carbinol moiety. These compounds have potent antipsychotic and serotonin antagonist activities. 4-[4-[4- (4-Furo[3,2-c]pyridinyl]-1-piperazinyl]-butyl]-3,5-morpholinedione is an example of a typical embodiment having selective antipsychotic activity.
ES554659A 1985-05-06 1986-05-05 Pyridinylpiperazine derivatives Expired ES8801250A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73120185A 1985-05-06 1985-05-06

Publications (2)

Publication Number Publication Date
ES8801250A1 true ES8801250A1 (en) 1987-12-16
ES554659A0 ES554659A0 (en) 1987-12-16

Family

ID=24938510

Family Applications (6)

Application Number Title Priority Date Filing Date
ES554659A Expired ES8801250A1 (en) 1985-05-06 1986-05-05 Pyridinylpiperazine derivatives
ES557757A Expired ES8802149A1 (en) 1985-05-06 1987-09-25 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1,4-DISSTITUTED
ES557809A Expired ES8802614A1 (en) 1985-05-06 1988-01-28 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1.4 DISSTITUTED
ES557839A Expired ES8900138A1 (en) 1985-05-06 1988-05-26 A PROCEDURE FOR THE PREPARATION OF 1-4-DISSTITUTED PIPERAZINYL DERIVATIVES.
ES557855A Expired ES8900253A1 (en) 1985-05-06 1988-11-16 Pyridinylpiperazine derivatives
ES557865A Expired ES9000005A1 (en) 1985-05-06 1989-02-27 Pyridinylpiperazine derivatives

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES557757A Expired ES8802149A1 (en) 1985-05-06 1987-09-25 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1,4-DISSTITUTED
ES557809A Expired ES8802614A1 (en) 1985-05-06 1988-01-28 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1.4 DISSTITUTED
ES557839A Expired ES8900138A1 (en) 1985-05-06 1988-05-26 A PROCEDURE FOR THE PREPARATION OF 1-4-DISSTITUTED PIPERAZINYL DERIVATIVES.
ES557855A Expired ES8900253A1 (en) 1985-05-06 1988-11-16 Pyridinylpiperazine derivatives
ES557865A Expired ES9000005A1 (en) 1985-05-06 1989-02-27 Pyridinylpiperazine derivatives

Country Status (25)

Country Link
JP (1) JPH0753728B2 (en)
KR (1) KR940000829B1 (en)
CN (1) CN1017901B (en)
AT (1) AT398572B (en)
AU (1) AU593244B2 (en)
BE (1) BE904724A (en)
CA (1) CA1278792C (en)
CH (1) CH672787A5 (en)
DE (1) DE3615180C2 (en)
DK (1) DK165745C (en)
EG (1) EG18206A (en)
ES (6) ES8801250A1 (en)
FI (1) FI85484C (en)
FR (1) FR2581385B1 (en)
GB (1) GB2174703B (en)
GR (1) GR861149B (en)
HU (1) HU195509B (en)
IE (1) IE59201B1 (en)
IT (1) IT1208607B (en)
LU (1) LU86421A1 (en)
MY (1) MY100777A (en)
NL (1) NL8601146A (en)
PT (1) PT82523B (en)
SE (1) SE465270B (en)
ZA (1) ZA862046B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
IE903410A1 (en) * 1989-10-09 1991-04-10 Novo Nordisk As Indole derivatives, their preparation and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
FR2738823B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 3- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) -3,4-DIHYDROQUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
FR2738822B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 4- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) QUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2738824B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 3- (OMEGA (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN-1 -YL) ALKYL) -3,4-DIHYDROQUINAZOLIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CO4750663A1 (en) * 1995-09-15 1999-03-31 Sanofi Synthelabo DERIVATIVES OF QUINOLEIN-2 (1H) -ONE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS
FR2761071B1 (en) * 1997-03-20 1999-12-03 Synthelabo DERIVATIVES OF QUINOLEIN-2 (1H) -ONE AND DIHYDROQUINOLEIN-2 (1H) - ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2797874B1 (en) * 1999-08-27 2002-03-29 Adir NOVEL PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Also Published As

Publication number Publication date
ES8802149A1 (en) 1988-04-01
IE861193L (en) 1986-11-06
DK207186D0 (en) 1986-05-05
ES8900253A1 (en) 1989-05-16
GR861149B (en) 1986-09-09
DK165745B (en) 1993-01-11
ES557809A0 (en) 1988-09-01
GB8610810D0 (en) 1986-06-11
IT1208607B (en) 1989-07-10
ZA862046B (en) 1986-11-26
BE904724A (en) 1986-11-05
GB2174703A (en) 1986-11-12
LU86421A1 (en) 1986-12-05
ES557839A0 (en) 1989-01-16
ES557757A0 (en) 1988-04-01
FI85484B (en) 1992-01-15
FI861820A7 (en) 1986-11-07
IT8620313A0 (en) 1986-05-06
HU195509B (en) 1988-05-30
ES9000005A1 (en) 1989-11-01
FR2581385A1 (en) 1986-11-07
KR940000829B1 (en) 1994-02-02
GB2174703B (en) 1988-10-26
HUT43848A (en) 1987-12-28
PT82523A (en) 1986-06-01
CN1017901B (en) 1992-08-19
ES8802614A1 (en) 1988-09-01
AU593244B2 (en) 1990-02-08
CH672787A5 (en) 1989-12-29
DE3615180A1 (en) 1986-11-06
FR2581385B1 (en) 1991-10-04
KR860009008A (en) 1986-12-19
DE3615180C2 (en) 1996-03-07
FI85484C (en) 1992-04-27
ES557855A0 (en) 1989-05-16
SE465270B (en) 1991-08-19
FI861820A0 (en) 1986-04-30
PT82523B (en) 1988-10-14
DK165745C (en) 1993-06-14
ES8900138A1 (en) 1989-01-16
JPS61268681A (en) 1986-11-28
DK207186A (en) 1986-11-07
ES554659A0 (en) 1987-12-16
SE8602061L (en) 1986-11-07
SE8602061D0 (en) 1986-05-05
AU5679586A (en) 1986-11-13
IE59201B1 (en) 1994-01-26
ATA121486A (en) 1994-05-15
CN86103071A (en) 1987-03-18
AT398572B (en) 1994-12-27
MY100777A (en) 1991-02-14
JPH0753728B2 (en) 1995-06-07
NL8601146A (en) 1986-12-01
EG18206A (en) 1992-09-30
CA1278792C (en) 1991-01-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051020