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ES8900253A1 - Pyridinylpiperazine derivatives - Google Patents

Pyridinylpiperazine derivatives

Info

Publication number
ES8900253A1
ES8900253A1 ES557855A ES557855A ES8900253A1 ES 8900253 A1 ES8900253 A1 ES 8900253A1 ES 557855 A ES557855 A ES 557855A ES 557855 A ES557855 A ES 557855A ES 8900253 A1 ES8900253 A1 ES 8900253A1
Authority
ES
Spain
Prior art keywords
present
hydrocyclic
substitute
formula
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557855A
Other languages
Spanish (es)
Other versions
ES557855A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8900253A1 publication Critical patent/ES8900253A1/en
Publication of ES557855A0 publication Critical patent/ES557855A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN EN LA PRESENTE INVENCION DERIVADOS DE PIPERACINILO 1, 4-DISUSTITUIDOS DE FORMULA I, ASI COMO SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES; EN LOS QUE UN SUSTITUYENTE ES UN HETEROCICLICO DE ANILLOFUSIONADO BICICLICO DE FURO-, PIRROLO-, CILCOPENTADIENO-, O TIENO-PIRIDINA, Y EL SEGUNDO SUSTITUYENTE ES UNA CADENA DE ALQUILENO UNIDA A HETEROCICLICOS DE IMIDIDA CICLICA O UNA PARTE CARBINOL BENCILICA. LOS COMPUESTOS DE LA PRESENTE INVENCION SON AGENTES FARMACOLOGICOS UTILES CON PROPIEDADES PSICOTROPICAS; Y PRESENTAN ACTIVIDAD SELECTIVA SOBRE EL SISTEMA NERVIOSO CENTRAL, SIENDO DE PARTICULAR INTERES COMO AGENTES ANTIPSICOTICOS. *FORMULA*DESCRIBED IN THE PRESENT INVENTION PIPERACINYL 1, 4-DISUSTITUTED DERIVATIVES OF FORMULA I, AS WELL AS THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS; IN WHICH A SUBSTITUTE IS A FURO-, PIRROLO-, CYLCOPENTADIENE-, OR HAVE-PYRIDINE BICYCLIC FUSIONED RING HETEROCYCLIC, AND THE SECOND SUBSTITUTE IS AN ALKYLENE CHAIN LINKED TO A PARTICULAR CYCLIC HYDROCYCLIC HYDROCYCLIC IMMEDIUM. THE COMPOUNDS OF THE PRESENT INVENTION ARE USEFUL PHARMACOLOGICAL AGENTS WITH PSYCHOTROPIC PROPERTIES; AND PRESENT SELECTIVE ACTIVITY ON THE CENTRAL NERVOUS SYSTEM, BEING OF PARTICULAR INTEREST AS ANTIPSYCHOTIC AGENTS. *FORMULA*

ES557855A 1985-05-06 1988-11-16 Pyridinylpiperazine derivatives Expired ES8900253A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73120185A 1985-05-06 1985-05-06

Publications (2)

Publication Number Publication Date
ES8900253A1 true ES8900253A1 (en) 1989-05-16
ES557855A0 ES557855A0 (en) 1989-05-16

Family

ID=24938510

Family Applications (6)

Application Number Title Priority Date Filing Date
ES554659A Expired ES8801250A1 (en) 1985-05-06 1986-05-05 Pyridinylpiperazine derivatives
ES557757A Expired ES8802149A1 (en) 1985-05-06 1987-09-25 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1,4-DISSTITUTED
ES557809A Expired ES8802614A1 (en) 1985-05-06 1988-01-28 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1.4 DISSTITUTED
ES557839A Expired ES8900138A1 (en) 1985-05-06 1988-05-26 A PROCEDURE FOR THE PREPARATION OF 1-4-DISSTITUTED PIPERAZINYL DERIVATIVES.
ES557855A Expired ES8900253A1 (en) 1985-05-06 1988-11-16 Pyridinylpiperazine derivatives
ES557865A Expired ES9000005A1 (en) 1985-05-06 1989-02-27 Pyridinylpiperazine derivatives

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES554659A Expired ES8801250A1 (en) 1985-05-06 1986-05-05 Pyridinylpiperazine derivatives
ES557757A Expired ES8802149A1 (en) 1985-05-06 1987-09-25 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1,4-DISSTITUTED
ES557809A Expired ES8802614A1 (en) 1985-05-06 1988-01-28 A PROCEDURE FOR THE PREPARATION OF PIPERAZINYL DERIVATIVES 1.4 DISSTITUTED
ES557839A Expired ES8900138A1 (en) 1985-05-06 1988-05-26 A PROCEDURE FOR THE PREPARATION OF 1-4-DISSTITUTED PIPERAZINYL DERIVATIVES.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557865A Expired ES9000005A1 (en) 1985-05-06 1989-02-27 Pyridinylpiperazine derivatives

Country Status (25)

Country Link
JP (1) JPH0753728B2 (en)
KR (1) KR940000829B1 (en)
CN (1) CN1017901B (en)
AT (1) AT398572B (en)
AU (1) AU593244B2 (en)
BE (1) BE904724A (en)
CA (1) CA1278792C (en)
CH (1) CH672787A5 (en)
DE (1) DE3615180C2 (en)
DK (1) DK165745C (en)
EG (1) EG18206A (en)
ES (6) ES8801250A1 (en)
FI (1) FI85484C (en)
FR (1) FR2581385B1 (en)
GB (1) GB2174703B (en)
GR (1) GR861149B (en)
HU (1) HU195509B (en)
IE (1) IE59201B1 (en)
IT (1) IT1208607B (en)
LU (1) LU86421A1 (en)
MY (1) MY100777A (en)
NL (1) NL8601146A (en)
PT (1) PT82523B (en)
SE (1) SE465270B (en)
ZA (1) ZA862046B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
IE903410A1 (en) * 1989-10-09 1991-04-10 Novo Nordisk As Indole derivatives, their preparation and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
FR2738823B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 3- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) -3,4-DIHYDROQUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
FR2738822B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 4- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) QUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2738824B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 3- (OMEGA (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN-1 -YL) ALKYL) -3,4-DIHYDROQUINAZOLIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CO4750663A1 (en) * 1995-09-15 1999-03-31 Sanofi Synthelabo DERIVATIVES OF QUINOLEIN-2 (1H) -ONE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS
FR2761071B1 (en) * 1997-03-20 1999-12-03 Synthelabo DERIVATIVES OF QUINOLEIN-2 (1H) -ONE AND DIHYDROQUINOLEIN-2 (1H) - ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2797874B1 (en) * 1999-08-27 2002-03-29 Adir NOVEL PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Also Published As

Publication number Publication date
ES8802149A1 (en) 1988-04-01
IE861193L (en) 1986-11-06
DK207186D0 (en) 1986-05-05
GR861149B (en) 1986-09-09
DK165745B (en) 1993-01-11
ES557809A0 (en) 1988-09-01
GB8610810D0 (en) 1986-06-11
IT1208607B (en) 1989-07-10
ZA862046B (en) 1986-11-26
BE904724A (en) 1986-11-05
GB2174703A (en) 1986-11-12
LU86421A1 (en) 1986-12-05
ES557839A0 (en) 1989-01-16
ES557757A0 (en) 1988-04-01
FI85484B (en) 1992-01-15
FI861820A7 (en) 1986-11-07
IT8620313A0 (en) 1986-05-06
HU195509B (en) 1988-05-30
ES9000005A1 (en) 1989-11-01
FR2581385A1 (en) 1986-11-07
KR940000829B1 (en) 1994-02-02
GB2174703B (en) 1988-10-26
HUT43848A (en) 1987-12-28
ES8801250A1 (en) 1987-12-16
PT82523A (en) 1986-06-01
CN1017901B (en) 1992-08-19
ES8802614A1 (en) 1988-09-01
AU593244B2 (en) 1990-02-08
CH672787A5 (en) 1989-12-29
DE3615180A1 (en) 1986-11-06
FR2581385B1 (en) 1991-10-04
KR860009008A (en) 1986-12-19
DE3615180C2 (en) 1996-03-07
FI85484C (en) 1992-04-27
ES557855A0 (en) 1989-05-16
SE465270B (en) 1991-08-19
FI861820A0 (en) 1986-04-30
PT82523B (en) 1988-10-14
DK165745C (en) 1993-06-14
ES8900138A1 (en) 1989-01-16
JPS61268681A (en) 1986-11-28
DK207186A (en) 1986-11-07
ES554659A0 (en) 1987-12-16
SE8602061L (en) 1986-11-07
SE8602061D0 (en) 1986-05-05
AU5679586A (en) 1986-11-13
IE59201B1 (en) 1994-01-26
ATA121486A (en) 1994-05-15
CN86103071A (en) 1987-03-18
AT398572B (en) 1994-12-27
MY100777A (en) 1991-02-14
JPH0753728B2 (en) 1995-06-07
NL8601146A (en) 1986-12-01
EG18206A (en) 1992-09-30
CA1278792C (en) 1991-01-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060307