ES8403723A1 - A process for producing an insulin preparation. - Google Patents
A process for producing an insulin preparation.Info
- Publication number
- ES8403723A1 ES8403723A1 ES520249A ES520249A ES8403723A1 ES 8403723 A1 ES8403723 A1 ES 8403723A1 ES 520249 A ES520249 A ES 520249A ES 520249 A ES520249 A ES 520249A ES 8403723 A1 ES8403723 A1 ES 8403723A1
- Authority
- ES
- Spain
- Prior art keywords
- zinc
- insulin
- preparation
- ions
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
- 102000004877 Insulin Human genes 0.000 title abstract 5
- 108090001061 Insulin Proteins 0.000 title abstract 5
- 229940125396 insulin Drugs 0.000 title abstract 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 239000011701 zinc Substances 0.000 abstract 2
- 229910052725 zinc Inorganic materials 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 229910001415 sodium ion Inorganic materials 0.000 abstract 1
- -1 sodium ions Chemical class 0.000 abstract 1
- 150000003752 zinc compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A stable, quick-acting insulin preparation is produced by dissolving a zinc-free insulin in an aqueous medium containing monovalent ions, such as sodium ions, but substantially no di- or polyvalent ions, adjusting the pH to the range of 6.9 to 8.0, preferably 7.2 to 7.8, and adding a zinc compound corresponding to 0.5 to 1.0% zinc, preferably 0.7 to 0.9% zinc, based on the weight of insulin. The preparation has a great stability against aggregation at 25 to 37<o>C and therefore lends itself to be used particularly for portable or implantable insulin delivery devices.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK91882 | 1982-03-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES520249A0 ES520249A0 (en) | 1984-04-16 |
| ES8403723A1 true ES8403723A1 (en) | 1984-04-16 |
Family
ID=8099004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES520249A Expired ES8403723A1 (en) | 1982-03-03 | 1983-03-02 | A process for producing an insulin preparation. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0102976A1 (en) |
| ES (1) | ES8403723A1 (en) |
| WO (1) | WO1983003054A1 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI78616C (en) * | 1982-02-05 | 1989-09-11 | Novo Industri As | Process for preparing an infused stabilized insulin solution having an elevated zinc content |
| US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
| DE19733651A1 (en) * | 1997-08-04 | 1999-02-18 | Boehringer Ingelheim Pharma | Aqueous aerosol preparations containing biologically active marrow molecules and processes for producing corresponding aerosols |
| AU2002300833B2 (en) * | 1997-08-04 | 2007-05-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aqueous aerosol preparations containing biologically active macromolecules and method for producing the corresponding aerosols |
| RU2202365C2 (en) * | 2001-07-20 | 2003-04-20 | Институт биоорганической химии им. М.М.Шемякина и Ю.А.Овчинникова РАН | Method for preparing quick action insulin solution for making injections |
| UA46669C2 (en) * | 2001-12-29 | 2005-12-15 | Товариство З Обмеженою Відповідальністю "Мако" | Production of controlled-release dosage forms of insulin |
| UA46668C2 (en) * | 2001-12-29 | 2006-01-16 | Omakooe Ltd Liability Company | Method for preparing combined dosage form of human insulin |
| UA46666C2 (en) * | 2001-12-29 | 2006-01-16 | Omakooe Ltd Liability Company | Method for preparing dosage form of short-term acting insulin |
| RU2252752C2 (en) * | 2002-05-15 | 2005-05-27 | Ооо Мако | Human insulin drug of short action |
| RU2251426C1 (en) * | 2003-09-18 | 2005-05-10 | Цыганков Владимир Владимирович | Method for obtaining insulin out of natural source and insulin |
| RU2281756C2 (en) * | 2004-11-25 | 2006-08-20 | Институт биоорганичексой химии им. академиков М.М. Шемякина и. Ю.А. Овчинникова Российской Академии Наук | Method for preparing pharmaceutical composition suspension based on substance of human genetic engineering (recombinant) insulin |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| WO2010112358A2 (en) | 2009-03-31 | 2010-10-07 | Boehringer Ingelheim International Gmbh | Method for coating a surface of a component |
| EP3508239B1 (en) | 2009-05-18 | 2020-12-23 | Boehringer Ingelheim International GmbH | Adapter, inhalant apparatus and atomizer |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| AU2010323220B2 (en) | 2009-11-25 | 2015-04-23 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EP2694220B1 (en) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medical device comprising a container |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (en) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Atomiser with coding means |
| ES2836977T3 (en) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizer |
| JP6643231B2 (en) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Nebulizer |
| SG11201608891RA (en) | 2014-05-07 | 2016-11-29 | Boehringer Ingelheim Int | Nebulizer, indicator device and container |
| EP3139979B1 (en) | 2014-05-07 | 2023-07-05 | Boehringer Ingelheim International GmbH | Unit, nebulizer and method |
| US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1212679B (en) * | 1957-08-03 | 1966-03-17 | Novo Terapeutisk Labor As | Process for the preparation of insulin solutions |
| US3091573A (en) * | 1958-05-12 | 1963-05-28 | Novo Terapeutisk Labor As | Quick acting insulin preparation |
| DK116527B (en) * | 1967-03-01 | 1970-01-19 | Nordisk Insulinlab | Process for the preparation of a fast-acting, durable, neutral solution of pure crystalline bovine insulin or bovine insulin which is crystallizable in water by the addition of Zn, or mixtures of bovine insulin and insulin of other origin. |
| US3657425A (en) * | 1969-03-12 | 1972-04-18 | Burroughs Wellcome Co | Beef insulin preparations |
| US3719655A (en) * | 1969-12-05 | 1973-03-06 | Lilly Co Eli | Process for the crystallization of the ammonium and alkali metal salts in insulin |
| US3878186A (en) * | 1973-05-09 | 1975-04-15 | Lilly Co Eli | Process for purifying insulin |
| US3876623A (en) * | 1973-05-09 | 1975-04-08 | Lilly Co Eli | Process for purifying insulin |
| DK80781A (en) * | 1980-02-29 | 1981-08-30 | Hospital For Sick Children | SOLUTIONS OF POLYPEPTIDES |
-
1983
- 1983-03-02 ES ES520249A patent/ES8403723A1/en not_active Expired
- 1983-03-02 EP EP19830900834 patent/EP0102976A1/en not_active Withdrawn
- 1983-03-02 WO PCT/DK1983/000024 patent/WO1983003054A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1983003054A1 (en) | 1983-09-15 |
| ES520249A0 (en) | 1984-04-16 |
| EP0102976A1 (en) | 1984-03-21 |
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