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ES8403723A1 - Procedimiento de producir preparaciones de insulina. - Google Patents

Procedimiento de producir preparaciones de insulina.

Info

Publication number
ES8403723A1
ES8403723A1 ES520249A ES520249A ES8403723A1 ES 8403723 A1 ES8403723 A1 ES 8403723A1 ES 520249 A ES520249 A ES 520249A ES 520249 A ES520249 A ES 520249A ES 8403723 A1 ES8403723 A1 ES 8403723A1
Authority
ES
Spain
Prior art keywords
zinc
insulin
preparation
ions
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520249A
Other languages
English (en)
Other versions
ES520249A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordisk Insulinlaboratorium
Original Assignee
Nordisk Insulinlaboratorium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlaboratorium filed Critical Nordisk Insulinlaboratorium
Publication of ES520249A0 publication Critical patent/ES520249A0/es
Publication of ES8403723A1 publication Critical patent/ES8403723A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR PREPARADOS DE INSULINA, ESTABLES Y DE ACCION RAPODA, QUE CONSISTEN EN UNA DISOLUCION TRANSPARENTE PH NEUTRO Y QUE SON ADECUADAS PARA EL USO EN DISPOSITIVOS DE ENTREGA DE INSULINA A CONCENTRACIONES DE HASTA 1.500 IU/ML.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE DISUELVE INSULINA SUSTANCIALMENTE LIBRE DE ZINC EN UN MEDIO ACUOSO QUE CONTIENE IONES MONOVALENTES, PERO QUE NO CONTIENE SUSTANCIALMENTE IONES DI- O POLIVALENTES; SEGUNDA, SE AJUSTA EL PH A UN VALOR DESEADO COMPRENDIDO ENTRE 6,9 Y 8,0, UTILIZANDO SI SE DESEA UNTAMPON ACTIVO EN DICHA GAMA DE PH; TERCERA, SE AÑADE UN COMPUESTO DE ZINC EN UNA CANTIDAD CORRESPONDIENTE COMPRENDIDA ENTRE UN 0,5 Y UN 1,0 DE ZINC, BASADO EN EL PESO DE LA INSULINA; Y POR ULTIMO, SE AJUSTA OPCIONALMENTE EL CONTENIDO DE INSULINA AL VALOR DESEADO.DE APLICACION EN EL TRATAMIENTO DE DIABETICOS.
ES520249A 1982-03-03 1983-03-02 Procedimiento de producir preparaciones de insulina. Expired ES8403723A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK91882 1982-03-03

Publications (2)

Publication Number Publication Date
ES520249A0 ES520249A0 (es) 1984-04-16
ES8403723A1 true ES8403723A1 (es) 1984-04-16

Family

ID=8099004

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520249A Expired ES8403723A1 (es) 1982-03-03 1983-03-02 Procedimiento de producir preparaciones de insulina.

Country Status (3)

Country Link
EP (1) EP0102976A1 (es)
ES (1) ES8403723A1 (es)
WO (1) WO1983003054A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI78616C (fi) * 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
DE19733651A1 (de) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole
AU2002300833B2 (en) * 1997-08-04 2007-05-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aqueous aerosol preparations containing biologically active macromolecules and method for producing the corresponding aerosols
RU2202365C2 (ru) * 2001-07-20 2003-04-20 Институт биоорганической химии им. М.М.Шемякина и Ю.А.Овчинникова РАН Способ приготовления быстродействующего раствора инсулина для инъекций
UA46669C2 (uk) * 2001-12-29 2005-12-15 Товариство З Обмеженою Відповідальністю "Мако" Спосіб приготування готової лікарської форми інсуліну пролонгованої дії
UA46668C2 (en) * 2001-12-29 2006-01-16 Omakooe Ltd Liability Company Method for preparing combined dosage form of human insulin
UA46666C2 (en) * 2001-12-29 2006-01-16 Omakooe Ltd Liability Company Method for preparing dosage form of short-term acting insulin
RU2252752C2 (ru) * 2002-05-15 2005-05-27 Ооо Мако Готовая лекарственная форма инсулина человека короткого действия
RU2251426C1 (ru) * 2003-09-18 2005-05-10 Цыганков Владимир Владимирович Способ получения инсулина из природного источника и инсулин
RU2281756C2 (ru) * 2004-11-25 2006-08-20 Институт биоорганичексой химии им. академиков М.М. Шемякина и. Ю.А. Овчинникова Российской Академии Наук Способ приготовления суспензии фармацевтической композиции на основе субстанции генно-инженерного (рекомбинантного) инсулина человека
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
WO2010112358A2 (de) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh Verfahren zur beschichtung einer oberfläche eines bauteils
EP3508239B1 (de) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
AU2010323220B2 (en) 2009-11-25 2015-04-23 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
JP6643231B2 (ja) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
SG11201608891RA (en) 2014-05-07 2016-11-29 Boehringer Ingelheim Int Nebulizer, indicator device and container
EP3139979B1 (en) 2014-05-07 2023-07-05 Boehringer Ingelheim International GmbH Unit, nebulizer and method
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1212679B (de) * 1957-08-03 1966-03-17 Novo Terapeutisk Labor As Verfahren zur Herstellung von Insulinloesungen
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
US3719655A (en) * 1969-12-05 1973-03-06 Lilly Co Eli Process for the crystallization of the ammonium and alkali metal salts in insulin
US3878186A (en) * 1973-05-09 1975-04-15 Lilly Co Eli Process for purifying insulin
US3876623A (en) * 1973-05-09 1975-04-08 Lilly Co Eli Process for purifying insulin
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider

Also Published As

Publication number Publication date
WO1983003054A1 (en) 1983-09-15
ES520249A0 (es) 1984-04-16
EP0102976A1 (en) 1984-03-21

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