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ES529384A0 - Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable - Google Patents

Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable

Info

Publication number
ES529384A0
ES529384A0 ES529384A ES529384A ES529384A0 ES 529384 A0 ES529384 A0 ES 529384A0 ES 529384 A ES529384 A ES 529384A ES 529384 A ES529384 A ES 529384A ES 529384 A0 ES529384 A0 ES 529384A0
Authority
ES
Spain
Prior art keywords
propoximetil
dihidroxi
guanine
salt
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES529384A
Other languages
English (en)
Other versions
ES8701496A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES529384(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8701496A1 publication Critical patent/ES8701496A1/es
Publication of ES529384A0 publication Critical patent/ES529384A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES529384A 1981-05-21 1984-02-01 Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable Expired ES8701496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (2)

Publication Number Publication Date
ES8701496A1 ES8701496A1 (es) 1987-01-01
ES529384A0 true ES529384A0 (es) 1987-01-01

Family

ID=23017790

Family Applications (7)

Application Number Title Priority Date Filing Date
ES512414A Granted ES512414A0 (es) 1981-05-21 1982-05-20 "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables".
ES520849A Granted ES520849A0 (es) 1981-05-21 1983-03-22 Procedimiento para preparar n2-acil-9-(1,3-dihidroxi-2-propoximetil)-guaninas y sus sales famaceuticamente aceptables.
ES524900A Expired ES8601204A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables.
ES524899A Expired ES8507549A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable
ES529384A Expired ES8701496A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable
ES529383A Expired ES8606869A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables
ES533821A Granted ES533821A0 (es) 1981-05-21 1984-06-28 Procedimiento para preparar n2-acil-9-(1, 3-dihidroxi-2-propoximetil)-guaninas y sus sales farmaceuticamente aceptables

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES512414A Granted ES512414A0 (es) 1981-05-21 1982-05-20 "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables".
ES520849A Granted ES520849A0 (es) 1981-05-21 1983-03-22 Procedimiento para preparar n2-acil-9-(1,3-dihidroxi-2-propoximetil)-guaninas y sus sales famaceuticamente aceptables.
ES524900A Expired ES8601204A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables.
ES524899A Expired ES8507549A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES529383A Expired ES8606869A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables
ES533821A Granted ES533821A0 (es) 1981-05-21 1984-06-28 Procedimiento para preparar n2-acil-9-(1, 3-dihidroxi-2-propoximetil)-guaninas y sus sales farmaceuticamente aceptables

Country Status (33)

Country Link
US (1) US4355032B2 (es)
EP (1) EP0066208B1 (es)
JP (2) JPS57203086A (es)
KR (1) KR890004663B1 (es)
AR (1) AR244227A1 (es)
AT (1) ATE15899T1 (es)
AU (1) AU572086B2 (es)
BR (1) BR8202931A (es)
CA (3) CA1305139C (es)
CS (4) CS235044B2 (es)
DD (2) DD213218A5 (es)
DE (1) DE3266644D1 (es)
DK (2) DK150304C (es)
ES (7) ES512414A0 (es)
FI (1) FI73682C (es)
GR (1) GR76459B (es)
HK (1) HK67088A (es)
HU (2) HU186514B (es)
IE (1) IE53731B1 (es)
IL (1) IL65836A (es)
IN (1) IN156469B (es)
LU (1) LU88334I2 (es)
MY (1) MY8700793A (es)
NL (2) NL930022I1 (es)
NO (2) NO161740C (es)
NZ (1) NZ200691A (es)
PH (1) PH17975A (es)
PL (4) PL136332B1 (es)
PT (1) PT74934B (es)
RO (2) RO84860B (es)
SG (1) SG81687G (es)
SU (1) SU1176841A3 (es)
ZA (1) ZA823532B (es)

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US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
ZM6082A1 (en) * 1981-08-11 1984-04-23 Wellcome Found Antiviral compounds
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
IE830186L (en) * 1982-02-01 1983-08-01 Syntex Inc Purines
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
NZ214520A (en) * 1984-12-12 1989-08-29 Syntex Inc Alkoxymethyl ether and ester derivatives in the production of guanine derivatives
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
DE10299039I1 (de) * 1988-12-19 2003-02-20 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Praeparte
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
JP3468423B2 (ja) * 1993-06-23 2003-11-17 メレルファーマスーティカルズ インコーポレイテッド 抗ウィルス及び抗新生物剤としての炭素非環式ヌクレオシド誘導体類
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
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US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
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ZM6082A1 (en) * 1981-08-11 1984-04-23 Wellcome Found Antiviral compounds

Also Published As

Publication number Publication date
NL930139I2 (nl) 1997-07-01
ZA823532B (en) 1983-03-30
NL930139I1 (nl) 1993-11-01
KR830010112A (ko) 1983-12-26
PL236521A1 (en) 1984-01-02
FI821794A0 (fi) 1982-05-20
CS235044B2 (en) 1985-04-16
IN156469B (es) 1985-08-10
CS235042B2 (en) 1985-04-16
PL136579B1 (en) 1986-02-28
ATE15899T1 (de) 1985-10-15
JPH04217983A (ja) 1992-08-07
PL242100A1 (en) 1984-04-24
PL136004B1 (en) 1986-01-31
FI73682C (fi) 1987-11-09
DK504183D0 (da) 1983-11-03
ES524899A0 (es) 1985-09-16
CA1305140C (en) 1992-07-14
ES8404355A1 (es) 1984-05-01
NO161740B (no) 1989-06-12
ES512414A0 (es) 1984-05-01
ES8701496A1 (es) 1987-01-01
ES524900A0 (es) 1985-11-16
CA1305141C (en) 1992-07-14
JPS57203086A (en) 1982-12-13
PL136332B1 (en) 1986-02-28
SG81687G (en) 1989-07-07
DD203052A5 (de) 1983-10-12
ES8507549A1 (es) 1985-09-16
RO87387B (ro) 1985-08-31
IL65836A0 (en) 1982-08-31
DE3266644D1 (en) 1985-11-07
HU186514B (en) 1985-08-28
CS235018B2 (en) 1985-04-16
US4355032B1 (es) 1983-06-14
FI73682B (fi) 1987-07-31
ES8601204A1 (es) 1985-11-16
IE53731B1 (en) 1989-02-01
JPH046195B2 (es) 1992-02-05
NZ200691A (en) 1986-11-12
RO84860A (ro) 1984-09-29
EP0066208A1 (en) 1982-12-08
IL65836A (en) 1991-04-15
US4355032B2 (en) 1990-10-30
DK227782A (da) 1982-11-22
DK149001B (da) 1985-12-16
NL930022I1 (nl) 1993-05-03
ES8500276A1 (es) 1984-11-01
US4355032A (en) 1982-10-19
DK149001C (da) 1988-11-28
IE821210L (en) 1982-11-21
PT74934B (en) 1984-05-08
PH17975A (en) 1985-02-22
AU8389282A (en) 1982-11-25
PT74934A (en) 1982-06-01
ES529383A0 (es) 1986-05-16
ES8606869A1 (es) 1986-05-16
ES8505681A1 (es) 1985-06-16
KR890004663B1 (ko) 1989-11-24
JPH0529399B2 (es) 1993-04-30
DK150304C (da) 1988-01-04
DD213218A5 (de) 1984-09-05
RO87387A (ro) 1985-08-31
CS235043B2 (en) 1985-04-16
PL242101A1 (en) 1984-07-16
AU572086B2 (en) 1988-05-05
HU188000B (en) 1986-03-28
DK504183A (da) 1983-11-03
SU1176841A3 (ru) 1985-08-30
ES520849A0 (es) 1984-11-01
ES533821A0 (es) 1985-06-16
RO84860B (ro) 1984-10-30
NO1994005I1 (no) 1994-07-29
AR244227A1 (es) 1993-10-29
BR8202931A (pt) 1983-05-03
NO821676L (no) 1982-11-22
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
MY8700793A (en) 1987-12-31
NO161740C (no) 1989-09-20
GR76459B (es) 1984-08-10
PL246770A1 (en) 1984-08-27
HK67088A (en) 1988-09-02
PL136637B1 (en) 1986-03-31
LU88334I2 (fr) 1994-09-09
CA1305139C (en) 1992-07-14

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