[go: up one dir, main page]

ES8606869A1 - Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables - Google Patents

Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables

Info

Publication number
ES8606869A1
ES8606869A1 ES529383A ES529383A ES8606869A1 ES 8606869 A1 ES8606869 A1 ES 8606869A1 ES 529383 A ES529383 A ES 529383A ES 529383 A ES529383 A ES 529383A ES 8606869 A1 ES8606869 A1 ES 8606869A1
Authority
ES
Spain
Prior art keywords
propoxymethyl
guanine
dihydroxy
antiviral agent
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529383A
Other languages
English (en)
Other versions
ES529383A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8606869(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8606869A1 publication Critical patent/ES8606869A1/es
Publication of ES529383A0 publication Critical patent/ES529383A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 9-(1,3-DIHIDROXI-2-PROPOXIMETIL)GUANINA. COMPRENDE: A) DESARILALCOHILAR UN COMPUESTO DE FORMULA (III) POR HIDROGENACION CATALITICA, EN PRESENCIA DE UN CATALIZADOR COMO PLATINO SOBRE CARBON, EN UN ALCOHOL ALCOHILICO COMO DISOLVENTE, A C50JC, CON HIDROGENO A 2,1-5,6 KG/CM, PARA OBTENER UN COMPUESTO DE FORMULA (II); Y B) DESACILAR EL COMPUESTO DE FORMULA (II) POR SOLVOLISIS, EN PRESENCIA DE UN ALCANOL INFERIOR DE C 1 A 4, ENTRE 15 Y 25JC, CON UN HIDROXIDO ALCALINO, CON AGITACION DURANTE 10-24 HORAS, PARA OBTENER EL COMPUESTO DE FORMULA (I). SIENDO: R, GRUPO ACILO O RCO; R GRUPO PROTECTOR, TAL COMO BENCILO; Y R CADENA DE C 1 A 10. SE UTILIZA EN FARMACOLOGIA COMO AGENTE ANTIVIRICO EVITANDO GRANDES Y/O CONTINUAS DOSIS, QUE PUEDEN CAUSAR TOXICIDAD U OTROS EFECTOS SECUNDARIOS.
ES529383A 1981-05-21 1984-02-01 Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables Expired ES8606869A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (2)

Publication Number Publication Date
ES8606869A1 true ES8606869A1 (es) 1986-05-16
ES529383A0 ES529383A0 (es) 1986-05-16

Family

ID=23017790

Family Applications (7)

Application Number Title Priority Date Filing Date
ES512414A Granted ES512414A0 (es) 1981-05-21 1982-05-20 "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables".
ES520849A Expired ES8500276A1 (es) 1981-05-21 1983-03-22 Procedimiento para preparar n2-acil-9-(1,3-dihidroxi-2-propoximetil)-guaninas y sus sales famaceuticamente aceptables.
ES524899A Granted ES524899A0 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable
ES524900A Expired ES8601204A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables.
ES529384A Expired ES8701496A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable
ES529383A Expired ES8606869A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables
ES533821A Granted ES533821A0 (es) 1981-05-21 1984-06-28 Procedimiento para preparar n2-acil-9-(1, 3-dihidroxi-2-propoximetil)-guaninas y sus sales farmaceuticamente aceptables

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES512414A Granted ES512414A0 (es) 1981-05-21 1982-05-20 "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables".
ES520849A Expired ES8500276A1 (es) 1981-05-21 1983-03-22 Procedimiento para preparar n2-acil-9-(1,3-dihidroxi-2-propoximetil)-guaninas y sus sales famaceuticamente aceptables.
ES524899A Granted ES524899A0 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable
ES524900A Expired ES8601204A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables.
ES529384A Expired ES8701496A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES533821A Granted ES533821A0 (es) 1981-05-21 1984-06-28 Procedimiento para preparar n2-acil-9-(1, 3-dihidroxi-2-propoximetil)-guaninas y sus sales farmaceuticamente aceptables

Country Status (33)

Country Link
US (1) US4355032B2 (es)
EP (1) EP0066208B1 (es)
JP (2) JPS57203086A (es)
KR (1) KR890004663B1 (es)
AR (1) AR244227A1 (es)
AT (1) ATE15899T1 (es)
AU (1) AU572086B2 (es)
BR (1) BR8202931A (es)
CA (3) CA1305140C (es)
CS (4) CS235044B2 (es)
DD (2) DD213218A5 (es)
DE (1) DE3266644D1 (es)
DK (2) DK150304C (es)
ES (7) ES512414A0 (es)
FI (1) FI73682C (es)
GR (1) GR76459B (es)
HK (1) HK67088A (es)
HU (2) HU188000B (es)
IE (1) IE53731B1 (es)
IL (1) IL65836A (es)
IN (1) IN156469B (es)
LU (1) LU88334I2 (es)
MY (1) MY8700793A (es)
NL (2) NL930022I1 (es)
NO (2) NO161740C (es)
NZ (1) NZ200691A (es)
PH (1) PH17975A (es)
PL (4) PL136579B1 (es)
PT (1) PT74934B (es)
RO (2) RO87387B (es)
SG (1) SG81687G (es)
SU (1) SU1176841A3 (es)
ZA (1) ZA823532B (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
FI76086C (fi) * 1981-08-11 1988-09-09 Wellcome Found Foerfarande foer framstaellning av antivirala purinderivat.
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
PL143974B1 (en) * 1982-02-01 1988-03-31 Syntex Inc Method of obtaining novel 9-/1,3-diacyloxy-2-propoxymethyl/-purines
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
IE58569B1 (en) * 1984-12-12 1993-10-06 Syntex Inc Alkoxy methyl ether and alkoxy methyl ester derivatives
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
AU618436B2 (en) * 1988-12-19 1991-12-19 Wellcome Foundation Limited, The Antiviral cytosine and guanine derivatives
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
HUT73410A (en) * 1993-06-23 1996-07-29 Merrell Pharma Inc Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
IN179493B (es) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0976751A1 (en) * 1996-04-09 2000-02-02 Lupin Laboratories Limited A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides
US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
EP2316469A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
WO2004037263A1 (en) * 2002-10-22 2004-05-06 Ranbaxy Laboratories Limited Pharmaceutical compositions of ganciclovir
WO2004039808A2 (en) * 2002-10-31 2004-05-13 Ranbaxy Laboratories Limited Process for the preparation of ganciclovir
WO2004048380A1 (en) * 2002-11-22 2004-06-10 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
US20040224917A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
ITMI20031202A1 (it) * 2003-06-13 2004-12-14 Lyogen Ltd Forma di cristallina del ganciclovir
CA2537132A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Amorphous valganciclovir hydrochloride
JP4746866B2 (ja) * 2004-11-19 2011-08-10 Ｔｃｍ株式会社 キャリッジ用ガタ抑制装置
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8551973B2 (en) * 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
NZ593647A (en) 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
SG172359A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside phosphoramidates
CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
US9550803B2 (en) * 2011-05-06 2017-01-24 University Of Southern California Method to improve antiviral activity of nucleotide analogue drugs
CN102627643B (zh) * 2012-04-10 2014-01-08 常州康丽制药有限公司 更昔洛韦的精制方法
AU2013340559B2 (en) 2012-10-29 2018-03-15 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
WO2014070976A1 (en) * 2012-11-03 2014-05-08 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN103059023B (zh) * 2012-12-31 2015-09-30 浙江车头制药股份有限公司 一种制备更昔洛韦晶型ⅱ的方法
US9486530B1 (en) 2013-08-30 2016-11-08 Exela Pharma Sciences, LLC Ganciclovir compositions and related methods
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113476413B (zh) * 2021-08-09 2022-06-28 海南海灵化学制药有限公司 一种注射用更昔洛韦钠冻干粉的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
FI76086C (fi) * 1981-08-11 1988-09-09 Wellcome Found Foerfarande foer framstaellning av antivirala purinderivat.

Also Published As

Publication number Publication date
JPH04217983A (ja) 1992-08-07
NO821676L (no) 1982-11-22
DK149001C (da) 1988-11-28
DD213218A5 (de) 1984-09-05
JPH046195B2 (es) 1992-02-05
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
ES8505681A1 (es) 1985-06-16
JPH0529399B2 (es) 1993-04-30
MY8700793A (en) 1987-12-31
GR76459B (es) 1984-08-10
ES8404355A1 (es) 1984-05-01
NO161740C (no) 1989-09-20
PL136637B1 (en) 1986-03-31
ES524900A0 (es) 1985-11-16
NL930139I1 (nl) 1993-11-01
NL930022I1 (nl) 1993-05-03
PT74934B (en) 1984-05-08
PH17975A (en) 1985-02-22
CA1305140C (en) 1992-07-14
HK67088A (en) 1988-09-02
PT74934A (en) 1982-06-01
NO161740B (no) 1989-06-12
CS235018B2 (en) 1985-04-16
AR244227A1 (es) 1993-10-29
CS235043B2 (en) 1985-04-16
IE821210L (en) 1982-11-21
AU8389282A (en) 1982-11-25
DK504183A (da) 1983-11-03
RO87387A (ro) 1985-08-31
FI73682C (fi) 1987-11-09
ATE15899T1 (de) 1985-10-15
NO1994005I1 (no) 1994-07-29
US4355032B1 (es) 1983-06-14
IL65836A0 (en) 1982-08-31
IL65836A (en) 1991-04-15
ES533821A0 (es) 1985-06-16
DE3266644D1 (en) 1985-11-07
ZA823532B (en) 1983-03-30
BR8202931A (pt) 1983-05-03
PL242101A1 (en) 1984-07-16
ES520849A0 (es) 1984-11-01
RO84860B (ro) 1984-10-30
PL246770A1 (en) 1984-08-27
KR830010112A (ko) 1983-12-26
PL136332B1 (en) 1986-02-28
NL930139I2 (nl) 1997-07-01
IE53731B1 (en) 1989-02-01
CS235044B2 (en) 1985-04-16
FI821794A0 (fi) 1982-05-20
ES8701496A1 (es) 1987-01-01
CS235042B2 (en) 1985-04-16
HU186514B (en) 1985-08-28
ES8507549A1 (es) 1985-09-16
DK150304C (da) 1988-01-04
DD203052A5 (de) 1983-10-12
NZ200691A (en) 1986-11-12
PL136579B1 (en) 1986-02-28
EP0066208A1 (en) 1982-12-08
AU572086B2 (en) 1988-05-05
HU188000B (en) 1986-03-28
ES529383A0 (es) 1986-05-16
US4355032B2 (en) 1990-10-30
ES524899A0 (es) 1985-09-16
LU88334I2 (fr) 1994-09-09
DK149001B (da) 1985-12-16
DK227782A (da) 1982-11-22
DK504183D0 (da) 1983-11-03
PL242100A1 (en) 1984-04-24
SG81687G (en) 1989-07-07
CA1305141C (en) 1992-07-14
PL236521A1 (en) 1984-01-02
ES8601204A1 (es) 1985-11-16
US4355032A (en) 1982-10-19
JPS57203086A (en) 1982-12-13
ES529384A0 (es) 1987-01-01
RO84860A (ro) 1984-09-29
CA1305139C (en) 1992-07-14
KR890004663B1 (ko) 1989-11-24
RO87387B (ro) 1985-08-31
SU1176841A3 (ru) 1985-08-30
FI73682B (fi) 1987-07-31
ES512414A0 (es) 1984-05-01
PL136004B1 (en) 1986-01-31
ES8500276A1 (es) 1984-11-01
IN156469B (es) 1985-08-10

Similar Documents

Publication Publication Date Title
ES8606869A1 (es) Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables
AU1261488A (en) Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
IT1174791B (it) Composizioni farmaceutiche a base di inf.alcanoli applicabili per via topica e procedimento per la loro produzione ed impiego
GR870783B (en) Diastereoisomeric tetrahydropyrido (2,3-d) pyrimidine derivatives
DE3169208D1 (en) Pharmacologically active benzopyrano-(2,3-d)-v-triazoles
FI833504A7 (fi) 9-(1,3-dihydroksi-2- propoksimetyyli)guaniinin 1- monofosfaattiesterit, 1,3-bisfosfaattiestbisfosfaattiesterit ja sykliset fosfaattiesterit antiviraalisina aineiaineina.
EP0066475A3 (en) Pharmaceutical composition for use in inducing cytoprotection
NZ185823A (en) 3,4-dihydropyrimido(1,2-a)benzimidazol-2(ih)-ones
ZA83626B (en) Substituted 9-(1 or 3-monoacyloxy or 1, 3-diacyloxy-2-propoxy-methyl purines as antiviral agent
NO874847D0 (no) 9-(1,3-dihydroksy-2-propoksymetyl)-guanin-derivater.
GB8329344D0 (en) Bronchodilatory azepino(1,2-a)pyrimidine derivatives
FI921177L (fi) Menetelmä 9-(1,3-dihydroksi-2-propoksimetyyli)-guaniinijohdannaisten valmistamiseksi
AU516645B2 (en) Thino (2, 3-d) pyrimidine antallergic agents
NO890477L (no) Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse av 9-(1,3-dihydroksy-2-propoksymetyl)guanin.
ZA776109B (en) Thieno(2,3-d)pyrimidine antiallergic agents

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051213