ES2531241T3 - Composición farmacéutica líquida estable a base de trazodona - Google Patents
Composición farmacéutica líquida estable a base de trazodona Download PDFInfo
- Publication number
- ES2531241T3 ES2531241T3 ES12170235T ES12170235T ES2531241T3 ES 2531241 T3 ES2531241 T3 ES 2531241T3 ES 12170235 T ES12170235 T ES 12170235T ES 12170235 T ES12170235 T ES 12170235T ES 2531241 T3 ES2531241 T3 ES 2531241T3
- Authority
- ES
- Spain
- Prior art keywords
- peg
- polyethylene glycol
- pharmaceutical composition
- trazodone
- stable liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 title abstract 2
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003991 trazodone Drugs 0.000 title abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- 239000008118 PEG 6000 Substances 0.000 abstract 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 abstract 1
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 abstract 1
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 abstract 1
- 229920002560 Polyethylene Glycol 3000 Polymers 0.000 abstract 1
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 abstract 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 abstract 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 abstract 1
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 abstract 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 abstract 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 abstract 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 abstract 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 abstract 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 abstract 1
- 229940113125 polyethylene glycol 3000 Drugs 0.000 abstract 1
- 229940050929 polyethylene glycol 3350 Drugs 0.000 abstract 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 abstract 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 abstract 1
- 229940057847 polyethylene glycol 600 Drugs 0.000 abstract 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Composición farmacéutica líquida estable que comprende una solución acuosa de una sal de adición ácida de trazodona farmacéuticamente aceptable caracterizada por que dicha composición farmacéutica presenta un valor de pH entre 5,0 y 6,0, y comprende por lo menos dos codisolventes seleccionados de entre el grupo que consiste en propilenglicol, polietilenglicol 200 (PEG 200), polietilenglicol 300 (PEG 300), polietilenglicol 400 (PEG 400), polietilenglicol 600 (PEG 600), polietilenglicol 1000 (PEG 1000), polietilenglicol 1500 (PEG 1500), polietilenglicol 3000 (PEG 3000), polietilenglicol 3350 (PEG 3350); polietilenglicol 4000 (PEG 4000), y polietilenglicol 6000 (PEG 6000).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001573A ITMI20071573A1 (it) | 2007-07-31 | 2007-07-31 | Composizione farmaceutica liquida stabile a base di trazodone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2531241T3 true ES2531241T3 (es) | 2015-03-12 |
Family
ID=38858941
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12170235T Active ES2531241T3 (es) | 2007-07-31 | 2008-07-22 | Composición farmacéutica líquida estable a base de trazodona |
| ES08775278T Active ES2399569T3 (es) | 2007-07-31 | 2008-07-22 | Composición farmacéutica líquida estable a base de trazodona |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08775278T Active ES2399569T3 (es) | 2007-07-31 | 2008-07-22 | Composición farmacéutica líquida estable a base de trazodona |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10292931B2 (es) |
| EP (2) | EP2494955B1 (es) |
| JP (1) | JP5426548B2 (es) |
| KR (1) | KR101493370B1 (es) |
| CN (1) | CN101784257B (es) |
| AR (1) | AR068327A1 (es) |
| AU (1) | AU2008281858B2 (es) |
| CA (1) | CA2692975C (es) |
| CY (1) | CY1116189T1 (es) |
| DK (2) | DK2182920T3 (es) |
| EA (1) | EA016822B1 (es) |
| ES (2) | ES2531241T3 (es) |
| GE (1) | GEP20125525B (es) |
| HR (1) | HRP20150349T1 (es) |
| IL (1) | IL203167A (es) |
| IT (1) | ITMI20071573A1 (es) |
| MX (1) | MX2010001092A (es) |
| PL (2) | PL2494955T3 (es) |
| PT (2) | PT2494955E (es) |
| SG (1) | SG183659A1 (es) |
| SI (2) | SI2182920T1 (es) |
| UA (1) | UA102376C2 (es) |
| WO (1) | WO2009016069A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20071603A1 (it) | 2007-08-03 | 2009-02-04 | Acraf | Trazodone e trazodone cloridrato in forma purificata |
| WO2012072665A1 (en) | 2010-11-30 | 2012-06-07 | Pharmaneuroboost N.V. | Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors |
| RU2706700C1 (ru) * | 2019-09-24 | 2019-11-20 | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях |
| BR112022005343A2 (pt) * | 2019-09-26 | 2022-06-14 | Angelini S P A | Trazodona ou um sal da mesma para uso em um método para tratar insônia, composição farmacêutica, xarope, e, método para tratar insônia |
| CN111568861A (zh) * | 2020-05-25 | 2020-08-25 | 河北科星药业有限公司 | 畜禽用盐酸溴己新口服液及其制备方法和应用 |
| US20240390277A1 (en) * | 2023-04-15 | 2024-11-28 | Rubicon Research Private Limited | Liquid formulations of trazodone |
| CN119280155B (zh) * | 2024-12-11 | 2025-02-25 | 新基元(北京)医药科技有限公司 | 一种改善稳定性的盐酸曲唑酮液体药物组合物及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4154832A (en) * | 1974-08-26 | 1979-05-15 | Bruno Silvestrini | Novel treatment for acute organic cerebral syndromes (strokes) |
| IT1233412B (it) * | 1987-12-02 | 1992-03-30 | Acraf | Uso del trazodone |
| JP4790123B2 (ja) * | 1998-07-24 | 2011-10-12 | ヨー、セオ、ホン | 胆汁酸を有する透明水溶液型製剤の調剤 |
| AU2003903597A0 (en) * | 2003-07-11 | 2003-07-24 | Jakov Vaisman | Treatment of premature ejaculation |
| ITMI20071603A1 (it) | 2007-08-03 | 2009-02-04 | Acraf | Trazodone e trazodone cloridrato in forma purificata |
-
2007
- 2007-07-31 IT IT001573A patent/ITMI20071573A1/it unknown
-
2008
- 2008-07-22 PT PT12170235T patent/PT2494955E/pt unknown
- 2008-07-22 EA EA201070194A patent/EA016822B1/ru not_active IP Right Cessation
- 2008-07-22 AU AU2008281858A patent/AU2008281858B2/en active Active
- 2008-07-22 DK DK08775278.8T patent/DK2182920T3/da active
- 2008-07-22 KR KR1020107002151A patent/KR101493370B1/ko active Active
- 2008-07-22 ES ES12170235T patent/ES2531241T3/es active Active
- 2008-07-22 WO PCT/EP2008/059605 patent/WO2009016069A2/en not_active Ceased
- 2008-07-22 SG SG2012055679A patent/SG183659A1/en unknown
- 2008-07-22 ES ES08775278T patent/ES2399569T3/es active Active
- 2008-07-22 CN CN2008801012992A patent/CN101784257B/zh active Active
- 2008-07-22 MX MX2010001092A patent/MX2010001092A/es active IP Right Grant
- 2008-07-22 UA UAA201000864A patent/UA102376C2/ru unknown
- 2008-07-22 EP EP12170235.1A patent/EP2494955B1/en active Active
- 2008-07-22 GE GEAP200811704A patent/GEP20125525B/en unknown
- 2008-07-22 SI SI200830897T patent/SI2182920T1/sl unknown
- 2008-07-22 JP JP2010518618A patent/JP5426548B2/ja active Active
- 2008-07-22 PT PT87752788T patent/PT2182920E/pt unknown
- 2008-07-22 PL PL12170235T patent/PL2494955T3/pl unknown
- 2008-07-22 CA CA2692975A patent/CA2692975C/en active Active
- 2008-07-22 EP EP08775278A patent/EP2182920B1/en active Active
- 2008-07-22 DK DK12170235T patent/DK2494955T3/en active
- 2008-07-22 PL PL08775278T patent/PL2182920T3/pl unknown
- 2008-07-22 US US12/667,694 patent/US10292931B2/en active Active
- 2008-07-22 SI SI200831393T patent/SI2494955T1/sl unknown
- 2008-07-30 AR ARP080103285A patent/AR068327A1/es not_active Application Discontinuation
-
2010
- 2010-01-06 IL IL203167A patent/IL203167A/en active IP Right Grant
-
2015
- 2015-03-27 HR HRP20150349TT patent/HRP20150349T1/hr unknown
- 2015-04-09 CY CY20151100342T patent/CY1116189T1/el unknown
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