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ES2422730T3 - Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen - Google Patents

Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen

Info

Publication number
ES2422730T3
ES2422730T3 ES09157299T ES09157299T ES2422730T3 ES 2422730 T3 ES2422730 T3 ES 2422730T3 ES 09157299 T ES09157299 T ES 09157299T ES 09157299 T ES09157299 T ES 09157299T ES 2422730 T3 ES2422730 T3 ES 2422730T3
Authority
ES
Spain
Prior art keywords
medicines
formulations
procedure
contain
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09157299T
Other languages
English (en)
Inventor
Rolf Banholzer
Peter Sieger
Waldemar Pfrengle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530661&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2422730(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2422730T3 publication Critical patent/ES2422730T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cloruro de tiotropio cristalino, el cual se caracteriza porque en el diagrama de rayos X en polvo presenta, entre otros, los valores característicos d >= 6,15 Å; 5,58 Å; 4,45 Å y 3,93 Å.
ES09157299T 2003-11-03 2004-10-29 Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen Expired - Lifetime ES2422730T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025076 2003-11-03

Publications (1)

Publication Number Publication Date
ES2422730T3 true ES2422730T3 (es) 2013-09-13

Family

ID=34530661

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09157299T Expired - Lifetime ES2422730T3 (es) 2003-11-03 2004-10-29 Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen
ES04791030T Expired - Lifetime ES2350981T3 (es) 2003-11-03 2004-10-29 Procedimiento para la preparación de nuevas sales de tiotropio.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04791030T Expired - Lifetime ES2350981T3 (es) 2003-11-03 2004-10-29 Procedimiento para la preparación de nuevas sales de tiotropio.

Country Status (28)

Country Link
US (1) US20050096341A1 (es)
EP (5) EP1682543B1 (es)
JP (1) JP5165245B2 (es)
KR (1) KR20060102561A (es)
CN (3) CN101648950B (es)
AR (1) AR046318A1 (es)
AT (1) ATE478071T1 (es)
AU (1) AU2004285685B2 (es)
CA (1) CA2544357A1 (es)
CO (1) CO5690554A2 (es)
DE (1) DE502004011562D1 (es)
DK (2) DK1682543T3 (es)
EA (1) EA012369B1 (es)
EC (2) ECSP066545A (es)
ES (2) ES2422730T3 (es)
IL (1) IL175127A (es)
MY (1) MY145166A (es)
NO (1) NO20061441L (es)
NZ (1) NZ547523A (es)
PE (1) PE20050485A1 (es)
PL (1) PL2083007T3 (es)
RS (1) RS20060293A (es)
SG (1) SG149876A1 (es)
TW (1) TW200523263A (es)
UA (1) UA82414C2 (es)
UY (1) UY28589A1 (es)
WO (1) WO2005042528A1 (es)
ZA (1) ZA200602343B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100549010C (zh) * 2003-11-03 2009-10-14 贝林格尔.英格海姆国际有限公司 制备噻托铵盐类的方法,噻托铵盐类及含有该盐类的医药制剂
NZ583872A (en) * 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
CA2611907A1 (en) * 2005-06-17 2006-12-21 Boehringer Ingelheim International Gmbh Mrp iv inhibitors for the treatment of respiratory diseases
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
EP1869035B2 (en) * 2005-12-19 2015-08-12 Sicor, Inc. Novel crystalline form of tiotropium bromide and process for preparation thereof
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
TW200734333A (en) * 2005-12-19 2007-09-16 Sicor Inc Pure and stable tiotropium bromide
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
WO2010110760A1 (en) * 2009-03-27 2010-09-30 Mahmut Bilgic Compositions comprising water with deuterium for the prevention or treatment of allergic diseases and a process for the preparation thereof
PL388070A1 (pl) * 2009-05-19 2010-11-22 Adamed Spółka Z Ograniczoną Odpowiedzialnością Nowe sole tiotropium
CZ201241A3 (cs) * 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
JP6335798B2 (ja) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規噴射剤含有チオトロピウム製剤

Family Cites Families (40)

* Cited by examiner, † Cited by third party
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US2597329A (en) * 1947-08-06 1952-05-20 Merck & Co Inc Process for anion exchange of thiamin salts
US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
FI88112C (fi) 1985-07-30 1993-04-13 Glaxo Group Ltd Anordning foer administrering av laekemedel till patienter
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) * 1999-12-27 2007-12-19 和光純薬工業株式会社 スルホニウム塩化合物
PT1292281E (pt) 2000-10-12 2004-11-30 Boehringer Ingelheim Pharma Novos pos para inalacao contendo tiotropio
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
PT1326862E (pt) * 2000-10-12 2004-11-30 Boehringer Ingelheim Pharma Mono-hidrato cristalino de brometo de tiotropio, processo para a sua preparacaoe sua utilizacao na preparacao de um medicamento
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
HU229411B1 (en) * 2000-10-31 2013-12-30 Boehringer Ingelheim Pharma Inhalative solution formulation containing a tiotropium salt
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193393A1 (en) * 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10061877A1 (de) * 2000-12-12 2002-06-13 Basf Ag Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
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US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
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US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US6908055B2 (en) * 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
CN100549010C (zh) * 2003-11-03 2009-10-14 贝林格尔.英格海姆国际有限公司 制备噻托铵盐类的方法,噻托铵盐类及含有该盐类的医药制剂
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
NZ583872A (en) * 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
AU2004285685B2 (en) 2011-03-24
HK1099753A1 (zh) 2007-08-24
CO5690554A2 (es) 2006-10-31
ZA200602343B (en) 2007-12-27
AU2004285685A1 (en) 2005-05-12
SG149876A1 (en) 2009-02-27
JP5165245B2 (ja) 2013-03-21
CN1875020A (zh) 2006-12-06
EA200600854A1 (ru) 2006-10-27
CN101648950B (zh) 2014-05-07
CN102964344B (zh) 2014-12-31
CN102964344A (zh) 2013-03-13
JP2007509895A (ja) 2007-04-19
EP2336127A1 (de) 2011-06-22
EP2083007B1 (de) 2013-04-24
UA82414C2 (uk) 2008-04-10
IL175127A0 (en) 2006-09-05
TW200523263A (en) 2005-07-16
EP2322522A1 (de) 2011-05-18
DK2083007T3 (da) 2013-07-29
EP1682543B1 (de) 2010-08-18
DK1682543T3 (da) 2010-12-13
ECSP066544A (es) 2006-10-17
US20050096341A1 (en) 2005-05-05
CA2544357A1 (en) 2005-05-12
ATE478071T1 (de) 2010-09-15
PL2083007T3 (pl) 2013-09-30
EA012369B1 (ru) 2009-10-30
AR046318A1 (es) 2005-11-30
CN1875020B (zh) 2010-04-28
NO20061441L (no) 2006-07-12
ES2350981T3 (es) 2011-01-28
IL175127A (en) 2011-10-31
EP2319844A1 (de) 2011-05-11
MY145166A (en) 2011-12-30
NZ547523A (en) 2009-07-31
EP1682543A1 (de) 2006-07-26
WO2005042528A1 (de) 2005-05-12
ECSP066545A (es) 2006-10-17
CN101648950A (zh) 2010-02-17
DE502004011562D1 (de) 2010-09-30
UY28589A1 (es) 2005-06-30
KR20060102561A (ko) 2006-09-27
RS20060293A (sr) 2008-08-07
EP2083007A1 (de) 2009-07-29
PE20050485A1 (es) 2005-10-05

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