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CO5690554A2 - Nuevas sales de tiotropio, procedimientos para su preparacion asi como formulaciones medicamentosas que las contienen - Google Patents

Nuevas sales de tiotropio, procedimientos para su preparacion asi como formulaciones medicamentosas que las contienen

Info

Publication number
CO5690554A2
CO5690554A2 CO06041175A CO06041175A CO5690554A2 CO 5690554 A2 CO5690554 A2 CO 5690554A2 CO 06041175 A CO06041175 A CO 06041175A CO 06041175 A CO06041175 A CO 06041175A CO 5690554 A2 CO5690554 A2 CO 5690554A2
Authority
CO
Colombia
Prior art keywords
salts
tiotrope
procedures
preparation
new
Prior art date
Application number
CO06041175A
Other languages
English (en)
Inventor
Rolf Banholzer
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530661&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5690554(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO5690554A2 publication Critical patent/CO5690554A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1.- Procedimiento para preparar nuevas sales de tiotropio de la fórmula 1 en la cual X- significa un anión, caracterizado porque se hace reaccionar una sal de tiotropio de la fórmula 2 en donde Y- significa un anión distinto de X-, seleccionado del grupo de los halogenuros, con una sal AgX, en la cual X puede tener los significados indicados con anterioridad, en un disolvente apropiado.2.- Procedimiento de acuerdo con la reivindicación 1, caracterizado porque el disolvente se selecciona del grupo compuesto por amidas, éteres y nitrilos.3.- Procedimiento de acuerdo con la reivindicación 1, caracterizado porque como disolvente se usa acetonitrilo.4.- Procedimiento de acuerdo con una de las reivindicaciones 1 a 3, caracterizado porque se emplean aquellos compuestos de la fórmula 2 como producto de partida, en los cuales Y- significa un halogenuro distinto de X-, seleccionado del grupo compuesto por fluoruro, cloruro, bromuro y yoduro.
CO06041175A 2003-11-03 2006-05-02 Nuevas sales de tiotropio, procedimientos para su preparacion asi como formulaciones medicamentosas que las contienen CO5690554A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025076 2003-11-03

Publications (1)

Publication Number Publication Date
CO5690554A2 true CO5690554A2 (es) 2006-10-31

Family

ID=34530661

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06041175A CO5690554A2 (es) 2003-11-03 2006-05-02 Nuevas sales de tiotropio, procedimientos para su preparacion asi como formulaciones medicamentosas que las contienen

Country Status (28)

Country Link
US (1) US20050096341A1 (es)
EP (5) EP2336127A1 (es)
JP (1) JP5165245B2 (es)
KR (1) KR20060102561A (es)
CN (3) CN102964344B (es)
AR (1) AR046318A1 (es)
AT (1) ATE478071T1 (es)
AU (1) AU2004285685B2 (es)
CA (1) CA2544357A1 (es)
CO (1) CO5690554A2 (es)
DE (1) DE502004011562D1 (es)
DK (2) DK2083007T3 (es)
EA (1) EA012369B1 (es)
EC (2) ECSP066545A (es)
ES (2) ES2350981T3 (es)
IL (1) IL175127A (es)
MY (1) MY145166A (es)
NO (1) NO20061441L (es)
NZ (1) NZ547523A (es)
PE (1) PE20050485A1 (es)
PL (1) PL2083007T3 (es)
RS (1) RS20060293A (es)
SG (1) SG149876A1 (es)
TW (1) TW200523263A (es)
UA (1) UA82414C2 (es)
UY (1) UY28589A1 (es)
WO (1) WO2005042528A1 (es)
ZA (1) ZA200602343B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY28590A1 (es) 2003-11-03 2005-06-30 Boehringer Ingelheim Int Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
EP1898894A1 (en) * 2005-06-17 2008-03-19 Boehringer Ingelheim International GmbH Mrp iv inhibitors for the treatment of respiratory diseases
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
WO2007075838A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Pure and stable tiotropium bromide
JP5086267B2 (ja) * 2005-12-19 2012-11-28 シコール インコーポレイティド 臭化チオトロピウムの新規な形態およびそれを製造する方法
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP2411008B1 (en) * 2009-03-27 2017-03-22 Mahmut Bilgic Complexes of tiotropium with improved properties of solubility and stability
PL388070A1 (pl) * 2009-05-19 2010-11-22 Adamed Spółka Z Ograniczoną Odpowiedzialnością Nowe sole tiotropium
CZ201241A3 (cs) * 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
JP6335798B2 (ja) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規噴射剤含有チオトロピウム製剤

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2597329A (en) * 1947-08-06 1952-05-20 Merck & Co Inc Process for anion exchange of thiamin salts
US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
GB2178965B (en) 1985-07-30 1988-08-03 Glaxo Group Ltd Devices for administering medicaments to patients
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) * 1999-12-27 2007-12-19 和光純薬工業株式会社 スルホニウム塩化合物
BR0107304A (pt) 2000-10-12 2002-08-13 Boehringer Ingelheim Pharma Pó para inalação contendo tiotrópio
CA2425539C (en) * 2000-10-12 2007-04-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate, processes for the preparation thereof and the use thereof for preparing a pharmaceutical composition
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
RS50859B (sr) * 2000-10-31 2010-08-31 Boehringer Ingelheim Pharma Gmbh. & Co.Kg. Formulacija rastvora za inhalaciju sa soli tiotropijuma
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193393A1 (en) * 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10061877A1 (de) * 2000-12-12 2002-06-13 Basf Ag Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20020193394A1 (en) * 2001-03-13 2002-12-19 Bernd Disse Compounds for treating inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US6908055B2 (en) * 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
UY28590A1 (es) * 2003-11-03 2005-06-30 Boehringer Ingelheim Int Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
EP2319844A1 (de) 2011-05-11
IL175127A (en) 2011-10-31
ECSP066544A (es) 2006-10-17
DE502004011562D1 (de) 2010-09-30
ZA200602343B (en) 2007-12-27
AU2004285685B2 (en) 2011-03-24
CN101648950A (zh) 2010-02-17
RS20060293A (sr) 2008-08-07
EP2083007A1 (de) 2009-07-29
DK1682543T3 (da) 2010-12-13
CA2544357A1 (en) 2005-05-12
DK2083007T3 (da) 2013-07-29
ES2422730T3 (es) 2013-09-13
NZ547523A (en) 2009-07-31
NO20061441L (no) 2006-07-12
JP2007509895A (ja) 2007-04-19
EP2322522A1 (de) 2011-05-18
SG149876A1 (en) 2009-02-27
IL175127A0 (en) 2006-09-05
EP1682543A1 (de) 2006-07-26
EP2336127A1 (de) 2011-06-22
ATE478071T1 (de) 2010-09-15
PE20050485A1 (es) 2005-10-05
ES2350981T3 (es) 2011-01-28
CN101648950B (zh) 2014-05-07
EP1682543B1 (de) 2010-08-18
MY145166A (en) 2011-12-30
WO2005042528A1 (de) 2005-05-12
JP5165245B2 (ja) 2013-03-21
TW200523263A (en) 2005-07-16
ECSP066545A (es) 2006-10-17
CN102964344A (zh) 2013-03-13
UA82414C2 (uk) 2008-04-10
EA200600854A1 (ru) 2006-10-27
EP2083007B1 (de) 2013-04-24
KR20060102561A (ko) 2006-09-27
PL2083007T3 (pl) 2013-09-30
US20050096341A1 (en) 2005-05-05
AR046318A1 (es) 2005-11-30
HK1099753A1 (zh) 2007-08-24
AU2004285685A1 (en) 2005-05-12
CN1875020A (zh) 2006-12-06
CN102964344B (zh) 2014-12-31
CN1875020B (zh) 2010-04-28
UY28589A1 (es) 2005-06-30
EA012369B1 (ru) 2009-10-30

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