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ES2422729T3 - Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen - Google Patents

Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen

Info

Publication number
ES2422729T3
ES2422729T3 ES09153379T ES09153379T ES2422729T3 ES 2422729 T3 ES2422729 T3 ES 2422729T3 ES 09153379 T ES09153379 T ES 09153379T ES 09153379 T ES09153379 T ES 09153379T ES 2422729 T3 ES2422729 T3 ES 2422729T3
Authority
ES
Spain
Prior art keywords
formulations
procedure
preparation
medicines containing
tiotropium salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09153379T
Other languages
English (en)
Inventor
Rolf Banholzer
Peter Sieger
Waldemar Pfrengle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2422729(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2422729T3 publication Critical patent/ES2422729T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cloruro de tiotropio cristalino, el cual se caracteriza porque en el diagrama de rayos X en polvo presenta, entre otros, los valores característicos d >= 6,15 Å; 5,58 Å; 4,45 Å y 3,93 Å.
ES09153379T 2003-11-03 2004-10-29 Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen Expired - Lifetime ES2422729T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03

Publications (1)

Publication Number Publication Date
ES2422729T3 true ES2422729T3 (es) 2013-09-13

Family

ID=34530660

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09153379T Expired - Lifetime ES2422729T3 (es) 2003-11-03 2004-10-29 Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen
ES04791028T Expired - Lifetime ES2342468T3 (es) 2003-11-03 2004-10-29 Procedimiento para la preparacion de sales de tiotropio.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04791028T Expired - Lifetime ES2342468T3 (es) 2003-11-03 2004-10-29 Procedimiento para la preparacion de sales de tiotropio.

Country Status (34)

Country Link
US (1) US8686148B2 (es)
EP (3) EP1682541B1 (es)
JP (1) JP5165244B2 (es)
KR (1) KR20060117334A (es)
CN (3) CN101407514B (es)
AR (1) AR046317A1 (es)
AT (1) ATE460414T1 (es)
AU (1) AU2004285683C1 (es)
BR (1) BRPI0416136A (es)
CA (1) CA2544348A1 (es)
CO (1) CO5690553A2 (es)
CY (2) CY1110048T1 (es)
DE (1) DE502004010885D1 (es)
DK (2) DK2067779T3 (es)
EA (1) EA012326B1 (es)
ES (2) ES2422729T3 (es)
HR (1) HRP20100149T1 (es)
IL (1) IL175023A (es)
ME (1) ME00361B (es)
MX (1) MXPA06004697A (es)
MY (1) MY143364A (es)
NO (1) NO335814B1 (es)
NZ (1) NZ547276A (es)
PE (1) PE20050446A1 (es)
PL (2) PL2067779T3 (es)
PT (2) PT1682541E (es)
RS (2) RS20060292A (es)
SG (1) SG137859A1 (es)
SI (2) SI1682541T1 (es)
TW (2) TWI435876B (es)
UA (1) UA82413C2 (es)
UY (1) UY28590A1 (es)
WO (1) WO2005042526A1 (es)
ZA (1) ZA200602342B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20100149T1 (hr) 2003-11-03 2010-04-30 Boehringer Ingelheim International Gmbh Postupak priprave tiotropijevih soli
ATE478071T1 (de) * 2003-11-03 2010-09-15 Boehringer Ingelheim Int Verfahren zur herstellung neuer tiotropiumsalze
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
CN101227905A (zh) * 2005-06-15 2008-07-23 贝林格尔·英格海姆国际有限公司 制备噻托铵盐的方法、噻托铵盐及其药物组合物
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
BRPI0608427A2 (pt) * 2005-12-19 2009-12-29 Sicor Inc novas formas de brometo de tiotrópio e processos para seu preparo
SI1971332T1 (sl) * 2006-01-04 2011-05-31 Boehringer Ingelheim Int Uporaba tiotropijevih soli pri zdravljenju zmerne persistentne astme
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) * 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

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ATE478071T1 (de) 2003-11-03 2010-09-15 Boehringer Ingelheim Int Verfahren zur herstellung neuer tiotropiumsalze
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HRP20100149T1 (hr) 2003-11-03 2010-04-30 Boehringer Ingelheim International Gmbh Postupak priprave tiotropijevih soli
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303270L (sv) 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
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CN101227905A (zh) 2005-06-15 2008-07-23 贝林格尔·英格海姆国际有限公司 制备噻托铵盐的方法、噻托铵盐及其药物组合物

Also Published As

Publication number Publication date
HK1153409A1 (en) 2012-03-30
JP2007509893A (ja) 2007-04-19
PT2067779E (pt) 2013-07-25
CN101407514B (zh) 2013-05-29
WO2005042526A1 (de) 2005-05-12
RS20060292A (sr) 2008-08-07
TWI435876B (zh) 2014-05-01
AU2004285683A1 (en) 2005-05-12
MXPA06004697A (es) 2006-07-05
CO5690553A2 (es) 2006-10-31
DE502004010885D1 (de) 2010-04-22
HK1099748A1 (zh) 2007-08-24
RS51758B (sr) 2011-12-31
SI2067779T1 (sl) 2013-08-30
NZ547276A (en) 2009-08-28
NO20061440L (no) 2006-07-12
EP2336126A1 (de) 2011-06-22
UA82413C2 (uk) 2008-04-10
PE20050446A1 (es) 2005-08-02
MEP51308A (en) 2011-05-10
CN100549010C (zh) 2009-10-14
CN102070630A (zh) 2011-05-25
MY143364A (en) 2011-04-29
CY1114157T1 (el) 2016-08-31
KR20060117334A (ko) 2006-11-16
SI1682541T1 (sl) 2010-06-30
CN1882582A (zh) 2006-12-20
EP2067779B9 (de) 2013-10-16
ATE460414T1 (de) 2010-03-15
TWI363758B (en) 2012-05-11
JP5165244B2 (ja) 2013-03-21
SG137859A1 (en) 2007-12-28
BRPI0416136A (pt) 2007-01-02
PL2067779T3 (pl) 2013-09-30
AU2004285683B2 (en) 2011-04-21
NO335814B1 (no) 2015-02-23
CY1110048T1 (el) 2015-01-14
EP1682541B1 (de) 2010-03-10
ES2342468T3 (es) 2010-07-07
HK1129111A1 (en) 2009-11-20
PL1682541T3 (pl) 2010-08-31
DK1682541T3 (da) 2010-06-28
EA200600886A1 (ru) 2006-10-27
CN101407514A (zh) 2009-04-15
CN102070630B (zh) 2013-04-17
TW200526653A (en) 2005-08-16
ZA200602342B (en) 2007-06-27
EP1682541A1 (de) 2006-07-26
IL175023A0 (en) 2006-08-20
ME00361B (me) 2011-10-10
EP2067779A1 (de) 2009-06-10
AR046317A1 (es) 2005-11-30
EP2067779B1 (de) 2013-04-24
IL175023A (en) 2011-02-28
PT1682541E (pt) 2010-04-14
CA2544348A1 (en) 2005-05-12
TW201231465A (en) 2012-08-01
US20050131007A1 (en) 2005-06-16
US8686148B2 (en) 2014-04-01
EA012326B1 (ru) 2009-08-28
HRP20100149T1 (hr) 2010-04-30
DK2067779T3 (da) 2013-07-29
UY28590A1 (es) 2005-06-30
AU2004285683C1 (en) 2011-09-08

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