PL2067779T3 - Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne - Google Patents

Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne

Info

Publication number: PL2067779T3
Authority: PL; Poland
Prior art keywords: production; tiotropium salts; formulas containing; medicinal formulas; medicinal
Prior art date: 2003-11-03

Application number

PL09153379T

Other languages

English (en)

Inventor

Rolf Banholzer

Peter Sieger

Waldemar Pfrengle

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-03

Filing date

2004-10-29

Publication date

2013-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2067779(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-10-29 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2013-09-30 Publication of PL2067779T3 publication Critical patent/PL2067779T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL09153379T 2003-11-03 2004-10-29 Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne PL2067779T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03025075		2003-11-03
EP04791028A EP1682541B1 (de)	2003-11-03	2004-10-29	Verfahren zur herstellung von tiotropiumsalzen
EP09153379.4A EP2067779B9 (de)	2003-11-03	2004-10-29	Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend

Publications (1)

Publication Number	Publication Date
PL2067779T3 true PL2067779T3 (pl)	2013-09-30

Family

ID=34530660

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL09153379T PL2067779T3 (pl)	2003-11-03	2004-10-29	Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
PL04791028T PL1682541T3 (pl)	2003-11-03	2004-10-29	Sposób wytwarzania soli tiotropium

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL04791028T PL1682541T3 (pl)	2003-11-03	2004-10-29	Sposób wytwarzania soli tiotropium

Country Status (34)

Country	Link
US (1)	US8686148B2 (pl)
EP (3)	EP2336126A1 (pl)
JP (1)	JP5165244B2 (pl)
KR (1)	KR20060117334A (pl)
CN (3)	CN102070630B (pl)
AR (1)	AR046317A1 (pl)
AT (1)	ATE460414T1 (pl)
AU (1)	AU2004285683C1 (pl)
BR (1)	BRPI0416136A (pl)
CA (1)	CA2544348A1 (pl)
CO (1)	CO5690553A2 (pl)
CY (2)	CY1110048T1 (pl)
DE (1)	DE502004010885D1 (pl)
DK (2)	DK1682541T3 (pl)
EA (1)	EA012326B1 (pl)
ES (2)	ES2342468T3 (pl)
HR (1)	HRP20100149T1 (pl)
IL (1)	IL175023A (pl)
ME (1)	ME00361B (pl)
MX (1)	MXPA06004697A (pl)
MY (1)	MY143364A (pl)
NO (1)	NO335814B1 (pl)
NZ (1)	NZ547276A (pl)
PE (1)	PE20050446A1 (pl)
PL (2)	PL2067779T3 (pl)
PT (2)	PT2067779E (pl)
RS (2)	RS51758B (pl)
SG (1)	SG137859A1 (pl)
SI (2)	SI2067779T1 (pl)
TW (2)	TWI363758B (pl)
UA (1)	UA82413C2 (pl)
UY (1)	UY28590A1 (pl)
WO (1)	WO2005042526A1 (pl)
ZA (1)	ZA200602342B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1682543B1 (de) *	2003-11-03	2010-08-18	Boehringer Ingelheim International Gmbh	Verfahren zur herstellung neuer tiotropiumsalze
CN102070630B (zh)	2003-11-03	2013-04-17	贝林格尔.英格海姆国际有限公司	结晶噻托碘铵、包含该结晶噻托碘铵的药物制剂及其用途
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
NZ564697A (en) *	2005-06-15	2010-04-30	Boehringer Ingelheim Int	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) *	2005-07-27	2007-02-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) *	2005-08-02	2007-10-16	Astrazeneca Ab	New salt
CN102731494A (zh)	2005-12-19	2012-10-17	西科尔公司	噻托溴铵的新形式及其制备方法
EP1971332B1 (en) *	2006-01-04	2011-03-09	Boehringer Ingelheim International GmbH	Use of tiotropium salts in the treatment of moderate persistent asthma
EP1953156A1 (de) *	2007-01-29	2008-08-06	Boehringer Ingelheim Pharma GmbH & Co. KG	Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs)	2012-01-20	2013-07-31	Zentiva, K.S.	Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
EP2897955B1 (en) *	2012-09-11	2019-11-06	Bilgic, Mahmut	New tiotropium bromide crystalline form
JP6042197B2 (ja) *	2012-12-11	2016-12-14	エア・ウォーター株式会社	肺障害治療剤

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2597329A (en)	1947-08-06	1952-05-20	Merck & Co Inc	Process for anion exchange of thiamin salts
US3551492A (en) *	1967-10-31	1970-12-29	Ciba Geigy Corp	N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en)	1983-08-03	1986-02-18	Miles Laboratories, Inc.	Medicament inhalation device
JPS6165885A (ja) *	1984-09-07	1986-04-04	Tanabe Seiyaku Co Ltd	新規合成中間体及びその製法
AT396872B (de)	1985-07-30	1993-12-27	Glaxo Group Ltd	Gerät zur verabreichung von medikamenten in pulverform
US5610163A (en)	1989-09-16	1997-03-11	Boehringer Ingelheim Gmbh	Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de)	1989-09-16	2000-04-06	Boehringer Ingelheim Kg	Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JP3302647B2 (ja) *	1992-04-24	2002-07-15	小野薬品工業株式会社	フェニルアルカン酸エステルの塩酸塩、およびその製造方法
DE4318455A1 (de)	1993-06-03	1994-12-08	Boehringer Ingelheim Kg	Kapselhalterung
DE19536902A1 (de)	1995-10-04	1997-04-10	Boehringer Ingelheim Int	Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) *	1999-12-27	2007-12-19	和光純薬工業株式会社	スルホニウム塩化合物
UA75375C2 (en)	2000-10-12	2006-04-17	Boehringer Ingelheim Pharma	Method for producing powdery preparations for inhaling
US6908928B2 (en) *	2000-10-12	2005-06-21	Bi Pharma Kg.	Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
ES2228965T3 (es)	2000-10-12	2005-04-16	BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG	Monohidrato cristalino de bromuro de tiotropio, procedimiento para su preparacion y su uso para la produccion de un medicamento.
BR0107304A (pt)	2000-10-12	2002-08-13	Boehringer Ingelheim Pharma	Pó para inalação contendo tiotrópio
UA78690C2 (uk) *	2000-10-31	2007-04-25	Boehringer Ingelheim Pharma	Лікарська композиція для інгаляційного застосування у вигляді розчину із сіллю тіотропію
US20020137764A1 (en)	2000-10-31	2002-09-26	Karin Drechsel	Inhalable formulation of a solution containing a tiotropium salt
US20020183292A1 (en)	2000-10-31	2002-12-05	Michel Pairet	Pharmaceutical compositions based on anticholinergics and corticosteroids
US20020111363A1 (en)	2000-10-31	2002-08-15	Karin Drechsel	Inhalable formulation of a solution containing a tiotropium salt
US20020193393A1 (en)	2001-03-07	2002-12-19	Michel Pairet	Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20020193392A1 (en)	2000-11-13	2002-12-19	Christel Schmelzer	Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10056104A1 (de) *	2000-11-13	2002-05-23	Boehringer Ingelheim Pharma	Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
DE10061877A1 (de) *	2000-12-12	2002-06-13	Basf Ag	Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de)	2000-12-22	2002-06-27	Boehringer Ingelheim Pharma	Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) *	2001-01-31	2003-01-14	Boehringer Ingelheim Pharma Ag	Process for preparing a scopine ester intermediate
DE10111843A1 (de)	2001-03-13	2002-09-19	Boehringer Ingelheim Pharma	Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20020193394A1 (en) *	2001-03-13	2002-12-19	Bernd Disse	Compounds for treating inflammatory diseases
US20030070679A1 (en)	2001-06-01	2003-04-17	Boehringer Ingelheim Pharma Kg	Capsules containing inhalable tiotropium
US6608055B2 (en) *	2001-06-22	2003-08-19	Boehringer Ingelheim Pharma Kg	Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6919325B2 (en)	2001-09-14	2005-07-19	Boehringer Ingelheim Pharma Kg	Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) *	2002-01-12	2003-07-24	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Scopinestern
AU2003201745A1 (en)	2002-02-11	2003-09-04	Pfizer Limited	Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
GB0203193D0 (en)	2002-02-11	2002-03-27	Pfizer Ltd	Nicotinamide derivatives useful as pde4 inhibitors
US20030229227A1 (en) *	2002-03-16	2003-12-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
BR0308984A (pt)	2002-04-04	2005-02-09	Boehringer Ingelheim Pharma	Formulações em pó adequadas para inalação
UA80123C2 (en)	2002-04-09	2007-08-27	Boehringer Ingelheim Pharma	Inhalation kit comprising inhalable powder of tiotropium
US20030235538A1 (en)	2002-04-09	2003-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Method for the administration of an anticholinergic by inhalation
DE10216036A1 (de)	2002-04-11	2003-10-23	Boehringer Ingelheim Pharma	Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
US6908055B2 (en)	2003-02-27	2005-06-21	Tandberg Data Asa	System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) *	2003-06-27	2005-02-10	Mitch Budniak	Electrical testing device having voice annunciator
EP1682543B1 (de)	2003-11-03	2010-08-18	Boehringer Ingelheim International Gmbh	Verfahren zur herstellung neuer tiotropiumsalze
US7968717B2 (en) *	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
CN102070630B (zh)	2003-11-03	2013-04-17	贝林格尔.英格海姆国际有限公司	结晶噻托碘铵、包含该结晶噻托碘铵的药物制剂及其用途
SE0303570L (sv)	2003-12-03	2005-06-04	Microdrug Ag	Fukt-känslig medicinsk produkt
SE0303270L (sv)	2003-12-03	2005-06-04	Microdrug Ag	Metod för administration av tiotropium
DE102004041253A1 (de) *	2004-08-26	2006-03-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neues Verfahren zur Herstellung von Tiotropiumsalzen
NZ564697A (en)	2005-06-15	2010-04-30	Boehringer Ingelheim Int	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

2004
- 2004-10-29 CN CN2010105807004A patent/CN102070630B/zh not_active Expired - Lifetime
- 2004-10-29 HR HR20100149T patent/HRP20100149T1/hr unknown
- 2004-10-29 JP JP2006537207A patent/JP5165244B2/ja not_active Expired - Lifetime
- 2004-10-29 ME MEP-2008-513A patent/ME00361B/me unknown
- 2004-10-29 PE PE2004001045A patent/PE20050446A1/es not_active Application Discontinuation
- 2004-10-29 UA UAA200605764A patent/UA82413C2/uk unknown
- 2004-10-29 EP EP10180163A patent/EP2336126A1/de not_active Withdrawn
- 2004-10-29 EA EA200600886A patent/EA012326B1/ru not_active IP Right Cessation
- 2004-10-29 RS RS20060292A patent/RS51758B/sr unknown
- 2004-10-29 BR BRPI0416136-0A patent/BRPI0416136A/pt not_active IP Right Cessation
- 2004-10-29 EP EP04791028A patent/EP1682541B1/de not_active Expired - Lifetime
- 2004-10-29 ES ES04791028T patent/ES2342468T3/es not_active Expired - Lifetime
- 2004-10-29 DK DK04791028.6T patent/DK1682541T3/da active
- 2004-10-29 RS YUP-2006/0292A patent/RS20060292A/sr unknown
- 2004-10-29 AT AT04791028T patent/ATE460414T1/de active
- 2004-10-29 SI SI200432055T patent/SI2067779T1/sl unknown
- 2004-10-29 DE DE502004010885T patent/DE502004010885D1/de not_active Expired - Lifetime
- 2004-10-29 PL PL09153379T patent/PL2067779T3/pl unknown
- 2004-10-29 CN CN2008101664856A patent/CN101407514B/zh not_active Expired - Lifetime
- 2004-10-29 SI SI200431403T patent/SI1682541T1/sl unknown
- 2004-10-29 US US10/977,753 patent/US8686148B2/en active Active
- 2004-10-29 KR KR1020067010832A patent/KR20060117334A/ko not_active Ceased
- 2004-10-29 CA CA002544348A patent/CA2544348A1/en not_active Abandoned
- 2004-10-29 PT PT91533794T patent/PT2067779E/pt unknown
- 2004-10-29 NZ NZ547276A patent/NZ547276A/xx not_active IP Right Cessation
- 2004-10-29 AU AU2004285683A patent/AU2004285683C1/en not_active Expired
- 2004-10-29 PL PL04791028T patent/PL1682541T3/pl unknown
- 2004-10-29 PT PT04791028T patent/PT1682541E/pt unknown
- 2004-10-29 SG SG200718011-0A patent/SG137859A1/en unknown
- 2004-10-29 ES ES09153379T patent/ES2422729T3/es not_active Expired - Lifetime
- 2004-10-29 WO PCT/EP2004/012268 patent/WO2005042526A1/de not_active Ceased
- 2004-10-29 CN CNB2004800325281A patent/CN100549010C/zh not_active Expired - Lifetime
- 2004-10-29 MX MXPA06004697A patent/MXPA06004697A/es active IP Right Grant
- 2004-10-29 UY UY28590A patent/UY28590A1/es not_active Application Discontinuation
- 2004-10-29 EP EP09153379.4A patent/EP2067779B9/de not_active Expired - Lifetime
- 2004-10-29 DK DK09153379.4T patent/DK2067779T3/da active
- 2004-11-01 MY MYPI20044526A patent/MY143364A/en unknown
- 2004-11-02 TW TW093133283A patent/TWI363758B/zh not_active IP Right Cessation
- 2004-11-02 TW TW101107080A patent/TWI435876B/zh not_active IP Right Cessation
- 2004-11-03 AR ARP040104038A patent/AR046317A1/es unknown
2006
- 2006-03-22 ZA ZA200602342A patent/ZA200602342B/en unknown
- 2006-03-30 NO NO20061440A patent/NO335814B1/no unknown
- 2006-04-20 IL IL175023A patent/IL175023A/en active IP Right Grant
- 2006-05-02 CO CO06041171A patent/CO5690553A2/es not_active Application Discontinuation
2010
- 2010-05-17 CY CY20101100435T patent/CY1110048T1/el unknown
2013
- 2013-07-17 CY CY20131100607T patent/CY1114157T1/el unknown

Also Published As

Publication number	Publication date
MXPA06004697A (es)	2006-07-05
RS51758B (sr)	2011-12-31
AU2004285683B2 (en)	2011-04-21
PT1682541E (pt)	2010-04-14
ME00361B (me)	2011-10-10
EP1682541B1 (de)	2010-03-10
ZA200602342B (en)	2007-06-27
NO20061440L (no)	2006-07-12
IL175023A (en)	2011-02-28
CN102070630A (zh)	2011-05-25
EP2336126A1 (de)	2011-06-22
TWI435876B (zh)	2014-05-01
US8686148B2 (en)	2014-04-01
UA82413C2 (uk)	2008-04-10
WO2005042526A1 (de)	2005-05-12
TW200526653A (en)	2005-08-16
AR046317A1 (es)	2005-11-30
NZ547276A (en)	2009-08-28
HK1153409A1 (en)	2012-03-30
DE502004010885D1 (de)	2010-04-22
HRP20100149T1 (hr)	2010-04-30
CO5690553A2 (es)	2006-10-31
HK1099748A1 (zh)	2007-08-24
MEP51308A (en)	2011-05-10
SG137859A1 (en)	2007-12-28
DK2067779T3 (da)	2013-07-29
AU2004285683A1 (en)	2005-05-12
PE20050446A1 (es)	2005-08-02
TW201231465A (en)	2012-08-01
ES2422729T3 (es)	2013-09-13
JP5165244B2 (ja)	2013-03-21
NO335814B1 (no)	2015-02-23
EP2067779B9 (de)	2013-10-16
EP2067779B1 (de)	2013-04-24
CN102070630B (zh)	2013-04-17
PT2067779E (pt)	2013-07-25
MY143364A (en)	2011-04-29
DK1682541T3 (da)	2010-06-28
EA200600886A1 (ru)	2006-10-27
HK1129111A1 (en)	2009-11-20
EA012326B1 (ru)	2009-08-28
JP2007509893A (ja)	2007-04-19
US20050131007A1 (en)	2005-06-16
UY28590A1 (es)	2005-06-30
RS20060292A (sr)	2008-08-07
CN100549010C (zh)	2009-10-14
IL175023A0 (en)	2006-08-20
CY1114157T1 (el)	2016-08-31
ATE460414T1 (de)	2010-03-15
PL1682541T3 (pl)	2010-08-31
AU2004285683C1 (en)	2011-09-08
SI2067779T1 (sl)	2013-08-30
CN101407514B (zh)	2013-05-29
KR20060117334A (ko)	2006-11-16
CN101407514A (zh)	2009-04-15
BRPI0416136A (pt)	2007-01-02
CY1110048T1 (el)	2015-01-14
EP2067779A1 (de)	2009-06-10
TWI363758B (en)	2012-05-11
ES2342468T3 (es)	2010-07-07
EP1682541A1 (de)	2006-07-26
SI1682541T1 (sl)	2010-06-30
CN1882582A (zh)	2006-12-20
CA2544348A1 (en)	2005-05-12

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