ES2232880T3 - Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f. - Google Patents
Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f.Info
- Publication number
- ES2232880T3 ES2232880T3 ES97936814T ES97936814T ES2232880T3 ES 2232880 T3 ES2232880 T3 ES 2232880T3 ES 97936814 T ES97936814 T ES 97936814T ES 97936814 T ES97936814 T ES 97936814T ES 2232880 T3 ES2232880 T3 ES 2232880T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptide
- protein
- ubiquitination
- ubiquitin
- test according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617697.9A GB9617697D0 (en) | 1996-08-23 | 1996-08-23 | Assay |
| GB9617697 | 1996-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2232880T3 true ES2232880T3 (es) | 2005-06-01 |
Family
ID=10798859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97936814T Expired - Lifetime ES2232880T3 (es) | 1996-08-23 | 1997-08-22 | Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6368809B1 (fr) |
| EP (1) | EP0927249B1 (fr) |
| JP (1) | JP2000517178A (fr) |
| AT (1) | ATE281520T1 (fr) |
| AU (1) | AU3951097A (fr) |
| CA (1) | CA2263803A1 (fr) |
| DE (1) | DE69731478T2 (fr) |
| DK (1) | DK0927249T3 (fr) |
| ES (1) | ES2232880T3 (fr) |
| GB (1) | GB9617697D0 (fr) |
| PT (1) | PT927249E (fr) |
| WO (1) | WO1998007852A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4321697A (en) * | 1996-09-30 | 1998-04-24 | Kyowa Hakko Kogyo Co. Ltd. | E2f activity inhibitory compounds |
| AU5498001A (en) * | 2000-05-12 | 2001-11-20 | Prolifix Limited | Assay for cell cycle modulators based on the modulation of cyclin d1 degradationin response to ionising radiation |
| AU2003282751A1 (en) * | 2002-10-04 | 2004-05-04 | Sloan-Kettering Institute For Cancer Research | Liposomal system and method of using same |
| US7052843B2 (en) * | 2002-10-08 | 2006-05-30 | New York University | Transcription-based assay for identification of post-translational modification and its application in proteomics |
| CN119751591B (zh) * | 2025-03-06 | 2025-05-16 | 中南大学 | 一种靶向增稳brd7抑瘤蛋白的多肽及其在制备治疗实体肿瘤药物中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10509035A (ja) * | 1994-11-15 | 1998-09-08 | プロリフィックス リミテッド | 転写因子e2f−4 |
-
1996
- 1996-08-23 GB GBGB9617697.9A patent/GB9617697D0/en active Pending
-
1997
- 1997-08-22 AT AT97936814T patent/ATE281520T1/de not_active IP Right Cessation
- 1997-08-22 WO PCT/GB1997/002293 patent/WO1998007852A1/fr not_active Ceased
- 1997-08-22 CA CA002263803A patent/CA2263803A1/fr not_active Abandoned
- 1997-08-22 AU AU39510/97A patent/AU3951097A/en not_active Abandoned
- 1997-08-22 ES ES97936814T patent/ES2232880T3/es not_active Expired - Lifetime
- 1997-08-22 EP EP97936814A patent/EP0927249B1/fr not_active Expired - Lifetime
- 1997-08-22 DE DE69731478T patent/DE69731478T2/de not_active Expired - Lifetime
- 1997-08-22 PT PT97936814T patent/PT927249E/pt unknown
- 1997-08-22 US US09/242,737 patent/US6368809B1/en not_active Expired - Fee Related
- 1997-08-22 JP JP10510527A patent/JP2000517178A/ja not_active Ceased
- 1997-08-22 DK DK97936814T patent/DK0927249T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| GB9617697D0 (en) | 1996-10-02 |
| JP2000517178A (ja) | 2000-12-26 |
| PT927249E (pt) | 2005-03-31 |
| DK0927249T3 (da) | 2005-03-14 |
| AU3951097A (en) | 1998-03-06 |
| EP0927249B1 (fr) | 2004-11-03 |
| ATE281520T1 (de) | 2004-11-15 |
| CA2263803A1 (fr) | 1998-02-26 |
| WO1998007852A1 (fr) | 1998-02-26 |
| EP0927249A1 (fr) | 1999-07-07 |
| US6368809B1 (en) | 2002-04-09 |
| DE69731478T2 (de) | 2005-10-27 |
| DE69731478D1 (de) | 2004-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hateboer et al. | Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. | |
| Knudsen et al. | Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins. | |
| Adams et al. | Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes | |
| Sevilla et al. | Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK | |
| De Sepulveda et al. | Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation | |
| Trouche et al. | E2F1 and E1A (12S) have a homologous activation domain regulated by RB and CBP. | |
| Hattori et al. | Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9 | |
| Kapeller et al. | Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. | |
| Robbins et al. | Negative regulation of human c-fos expression by thes retinoblastoma gene product | |
| Kzhyshkowska et al. | Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 | |
| Paulson et al. | Stat protein transactivation domains recruit p300/CBP through widely divergent sequences | |
| Berthold et al. | Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes—evidence for an autoregulatory mechanism | |
| Hobert et al. | Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction. | |
| Warner et al. | Functional interaction between Smad, CREB binding protein, and p68 RNA helicase | |
| Wakabayashi et al. | Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and β-catenin at sites of cell-cell contact | |
| Huang et al. | Altered sumoylation of p63α contributes to the split-hand/foot malformation phenotype | |
| EP2268658B1 (fr) | Peptides et certains de leurs aptamères convenant comme modulateurs spécifiques de la fonction de p53 mutantes | |
| Bessa et al. | Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator | |
| Gupta et al. | The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1 | |
| ES2232880T3 (es) | Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f. | |
| Schwind et al. | CK2 phosphorylation of C/EBPδ regulates its transcription factor activity | |
| Kim et al. | Modulation of EWS/WT1 activity by the v-Src protein tyrosine kinase | |
| Wilson et al. | Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein | |
| US7364870B2 (en) | MK2 interacting proteins | |
| Birchenall-Roberts et al. | K-Ras4B proteins are expressed in the nucleolus: interaction with nucleolin |