[go: up one dir, main page]

ES2232880T3 - Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f. - Google Patents

Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f.

Info

Publication number
ES2232880T3
ES2232880T3 ES97936814T ES97936814T ES2232880T3 ES 2232880 T3 ES2232880 T3 ES 2232880T3 ES 97936814 T ES97936814 T ES 97936814T ES 97936814 T ES97936814 T ES 97936814T ES 2232880 T3 ES2232880 T3 ES 2232880T3
Authority
ES
Spain
Prior art keywords
polypeptide
protein
ubiquitination
ubiquitin
test according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97936814T
Other languages
English (en)
Spanish (es)
Inventor
Rene The Netherlands Cancer Institute Bernards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Topotarget UK Ltd
Original Assignee
Topotarget UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Topotarget UK Ltd filed Critical Topotarget UK Ltd
Application granted granted Critical
Publication of ES2232880T3 publication Critical patent/ES2232880T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4705Regulators; Modulating activity stimulating, promoting or activating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES97936814T 1996-08-23 1997-08-22 Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f. Expired - Lifetime ES2232880T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9617697.9A GB9617697D0 (en) 1996-08-23 1996-08-23 Assay
GB9617697 1996-08-23

Publications (1)

Publication Number Publication Date
ES2232880T3 true ES2232880T3 (es) 2005-06-01

Family

ID=10798859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97936814T Expired - Lifetime ES2232880T3 (es) 1996-08-23 1997-08-22 Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f.

Country Status (12)

Country Link
US (1) US6368809B1 (fr)
EP (1) EP0927249B1 (fr)
JP (1) JP2000517178A (fr)
AT (1) ATE281520T1 (fr)
AU (1) AU3951097A (fr)
CA (1) CA2263803A1 (fr)
DE (1) DE69731478T2 (fr)
DK (1) DK0927249T3 (fr)
ES (1) ES2232880T3 (fr)
GB (1) GB9617697D0 (fr)
PT (1) PT927249E (fr)
WO (1) WO1998007852A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4321697A (en) * 1996-09-30 1998-04-24 Kyowa Hakko Kogyo Co. Ltd. E2f activity inhibitory compounds
AU5498001A (en) * 2000-05-12 2001-11-20 Prolifix Limited Assay for cell cycle modulators based on the modulation of cyclin d1 degradationin response to ionising radiation
AU2003282751A1 (en) * 2002-10-04 2004-05-04 Sloan-Kettering Institute For Cancer Research Liposomal system and method of using same
US7052843B2 (en) * 2002-10-08 2006-05-30 New York University Transcription-based assay for identification of post-translational modification and its application in proteomics
CN119751591B (zh) * 2025-03-06 2025-05-16 中南大学 一种靶向增稳brd7抑瘤蛋白的多肽及其在制备治疗实体肿瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10509035A (ja) * 1994-11-15 1998-09-08 プロリフィックス リミテッド 転写因子e2f−4

Also Published As

Publication number Publication date
GB9617697D0 (en) 1996-10-02
JP2000517178A (ja) 2000-12-26
PT927249E (pt) 2005-03-31
DK0927249T3 (da) 2005-03-14
AU3951097A (en) 1998-03-06
EP0927249B1 (fr) 2004-11-03
ATE281520T1 (de) 2004-11-15
CA2263803A1 (fr) 1998-02-26
WO1998007852A1 (fr) 1998-02-26
EP0927249A1 (fr) 1999-07-07
US6368809B1 (en) 2002-04-09
DE69731478T2 (de) 2005-10-27
DE69731478D1 (de) 2004-12-09

Similar Documents

Publication Publication Date Title
Hateboer et al. Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.
Knudsen et al. Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins.
Adams et al. Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes
Sevilla et al. Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK
De Sepulveda et al. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation
Trouche et al. E2F1 and E1A (12S) have a homologous activation domain regulated by RB and CBP.
Hattori et al. Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9
Kapeller et al. Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
Robbins et al. Negative regulation of human c-fos expression by thes retinoblastoma gene product
Kzhyshkowska et al. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1
Paulson et al. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
Berthold et al. Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes—evidence for an autoregulatory mechanism
Hobert et al. Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction.
Warner et al. Functional interaction between Smad, CREB binding protein, and p68 RNA helicase
Wakabayashi et al. Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and β-catenin at sites of cell-cell contact
Huang et al. Altered sumoylation of p63α contributes to the split-hand/foot malformation phenotype
EP2268658B1 (fr) Peptides et certains de leurs aptamères convenant comme modulateurs spécifiques de la fonction de p53 mutantes
Bessa et al. Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator
Gupta et al. The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1
ES2232880T3 (es) Dominio de ubiquitinacion e2f y ensayos para inhibidores de la ubiquitinacion e2f.
Schwind et al. CK2 phosphorylation of C/EBPδ regulates its transcription factor activity
Kim et al. Modulation of EWS/WT1 activity by the v-Src protein tyrosine kinase
Wilson et al. Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein
US7364870B2 (en) MK2 interacting proteins
Birchenall-Roberts et al. K-Ras4B proteins are expressed in the nucleolus: interaction with nucleolin