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ES2136591T3 - Derivados de cefalosporina y procedimiento para su preparacion. - Google Patents

Derivados de cefalosporina y procedimiento para su preparacion.

Info

Publication number
ES2136591T3
ES2136591T3 ES89102198T ES89102198T ES2136591T3 ES 2136591 T3 ES2136591 T3 ES 2136591T3 ES 89102198 T ES89102198 T ES 89102198T ES 89102198 T ES89102198 T ES 89102198T ES 2136591 T3 ES2136591 T3 ES 2136591T3
Authority
ES
Spain
Prior art keywords
derivatives
procedure
preparation
cephalosporin derivatives
cefem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89102198T
Other languages
English (en)
Inventor
Friedhelm Dr Adam
Jurgen Dr Blumbach
Walter Dr Durckheimer
Gerd Dr Fischer
Burghard Dr Mencke
Dieter Dr Isert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2136591T3 publication Critical patent/ES2136591T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTER DEL ACIDO CEFEMCARBOXILICO DE FORMULA GENERAL, PREPARADOS FARMACEUTICOS CON EFECTO CONTRA INFECCIONES BACTERIANAS QUE CONTIENEN ESTOS DERIVADOS DE CEFEM, PROCESO DE PRODUCCION DE LOS DERIVADOS DE CEFEM Y DE LOS PREPARADOS FARMACEUTICOS, ASI COMO EL USO DE LOS DERIVADOS DE CEFEM PARA COMBATIR INFECCIONES BACTERIANAS.
ES89102198T 1988-02-17 1989-02-09 Derivados de cefalosporina y procedimiento para su preparacion. Expired - Lifetime ES2136591T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3804841A DE3804841A1 (de) 1988-02-17 1988-02-17 Cephalosporinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES2136591T3 true ES2136591T3 (es) 1999-12-01

Family

ID=6347539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89102198T Expired - Lifetime ES2136591T3 (es) 1988-02-17 1989-02-09 Derivados de cefalosporina y procedimiento para su preparacion.

Country Status (23)

Country Link
US (2) US5100887A (es)
EP (1) EP0329008B1 (es)
JP (1) JP2509689B2 (es)
KR (1) KR0140886B1 (es)
CN (1) CN1043042C (es)
AT (1) ATE183188T1 (es)
AU (1) AU613152B2 (es)
CA (1) CA1339421C (es)
DD (1) DD283629A5 (es)
DE (2) DE3804841A1 (es)
DK (1) DK174730B1 (es)
DZ (1) DZ1324A1 (es)
ES (1) ES2136591T3 (es)
FI (1) FI93458C (es)
GR (1) GR3031542T3 (es)
HU (1) HU205121B (es)
IL (1) IL89303A0 (es)
MY (1) MY104937A (es)
NO (1) NO173736C (es)
NZ (1) NZ227990A (es)
PT (1) PT89729B (es)
TN (1) TNSN89016A1 (es)
ZA (1) ZA891162B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3809561A1 (de) * 1988-03-22 1989-10-05 Hoechst Ag Ester der 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroxyiminoacetamido)-3-methoxymethyl-3-cephem-4-carbonsaeure, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
YU48484B (sh) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
EP0531875B1 (de) * 1991-09-07 2004-03-24 Aventis Pharma Deutschland GmbH Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung
TW212181B (es) * 1992-02-14 1993-09-01 Hoechst Ag
EP0570849B1 (de) * 1992-05-21 1998-03-25 Hoechst Aktiengesellschaft Verfahren zur Spaltung von Cephalosporin Prodrugestern zu 7-Amino-3-methoxymethylceph-3-em-4-carbonsäure
LT3871B (en) 1993-11-30 1996-04-25 Hoechst Ag Additive crystalline salts of pure diastereomers of 1-cefem-4-carboxylic acid 1-(2,2-dimethyl-propionyloxy)ethyl esters, process for the preparation thereof, pharmaceutical compositions and process for the preparation thereof
DE4418957A1 (de) * 1994-05-31 1995-12-07 Merck Patent Gmbh Cefixim-Zubereitung
SE524569C2 (sv) * 1998-11-20 2004-08-31 Perstorp Ab Förfarande för framställning av en allyloxikarboxylsyra, användning av allyoxikarboxylsyran framställd enligt förfarandet som komponent i oligomera och polymera bindemedel samt 6-allyloxihexansyra framställd enligt förfarandet
AT408226B (de) * 1999-05-05 2001-09-25 Biochemie Gmbh Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
AU2003282267A1 (en) * 2002-11-22 2004-06-18 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of cefpodoxime proxetil
WO2005019227A1 (en) * 2003-08-22 2005-03-03 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cephalosporin antibiotic
JP2010047550A (ja) * 2008-08-25 2010-03-04 Daicel Chem Ind Ltd アルコキシアルカンカルボン酸エステルの製造方法
EP3398038B1 (en) 2016-02-04 2024-01-17 Apple Inc. Controlling electronic devices and displaying information based on wireless ranging

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
JPS5760345B2 (es) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4668783A (en) * 1974-12-19 1987-05-26 Takeda Chemical Industries, Ltd. Thiazolylacetamido cephalosporin compounds
US4203899A (en) * 1974-12-19 1980-05-20 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4486425A (en) * 1980-09-30 1984-12-04 Sankyo Company Limited 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
JPS5759894A (en) * 1980-09-30 1982-04-10 Sankyo Co Ltd Cephalosporin for oral administration
JPS609757B2 (ja) * 1981-07-16 1985-03-12 三共株式会社 経口用セフアロスポリン化合物
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
JPH0631259B2 (ja) * 1984-02-17 1994-04-27 三共株式会社 経口用セフアロスポリン化合物
DE3809561A1 (de) * 1988-03-22 1989-10-05 Hoechst Ag Ester der 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroxyiminoacetamido)-3-methoxymethyl-3-cephem-4-carbonsaeure, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE3901405A1 (de) * 1989-01-19 1990-07-26 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
US5063224A (en) * 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil

Also Published As

Publication number Publication date
CA1339421C (en) 1997-09-02
CN1043042C (zh) 1999-04-21
ATE183188T1 (de) 1999-08-15
AU613152B2 (en) 1991-07-25
IL89303A0 (en) 1989-09-10
NO173736B (no) 1993-10-18
JP2509689B2 (ja) 1996-06-26
DE3804841A1 (de) 1989-08-31
JPH01249778A (ja) 1989-10-05
AU3003189A (en) 1989-08-17
KR0140886B1 (ko) 1998-06-01
DK72289D0 (da) 1989-02-16
DE58909854D1 (de) 1999-09-16
HU205121B (en) 1992-03-30
US5100887A (en) 1992-03-31
KR890013028A (ko) 1989-09-20
EP0329008A3 (de) 1991-08-28
HUT49614A (en) 1989-10-30
EP0329008B1 (de) 1999-08-11
NZ227990A (en) 1990-10-26
FI93458B (fi) 1994-12-30
MY104937A (en) 1994-07-30
GR3031542T3 (en) 2000-01-31
FI890722L (fi) 1989-08-18
FI93458C (fi) 1995-04-10
FI890722A0 (fi) 1989-02-15
CN1035509A (zh) 1989-09-13
EP0329008A2 (de) 1989-08-23
DZ1324A1 (fr) 2004-09-13
DK174730B1 (da) 2003-10-06
NO173736C (no) 1994-01-26
USRE34865E (en) 1995-02-21
DK72289A (da) 1989-08-18
DD283629A5 (de) 1990-10-17
NO890657D0 (no) 1989-02-16
TNSN89016A1 (fr) 1991-02-04
PT89729B (pt) 1994-03-31
PT89729A (pt) 1989-10-04
ZA891162B (en) 1989-10-25
NO890657L (no) 1989-08-18

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