ES8607336A1 - Un procedimiento para la preparacion de una macrolida - Google Patents
Un procedimiento para la preparacion de una macrolidaInfo
- Publication number
- ES8607336A1 ES8607336A1 ES548472A ES548472A ES8607336A1 ES 8607336 A1 ES8607336 A1 ES 8607336A1 ES 548472 A ES548472 A ES 548472A ES 548472 A ES548472 A ES 548472A ES 8607336 A1 ES8607336 A1 ES 8607336A1
- Authority
- ES
- Spain
- Prior art keywords
- macrolide
- procedure
- preparation
- tylosin
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 229940041033 macrolides Drugs 0.000 abstract 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical class O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Fodder In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
METODO DE OBTENCION DE UNA MACROLIDA DE FORMULA (I), DONDE R ES UN ANILLO MONOCICLICO, BICICLICO O TRICICLICO SATURADO O INSATURADO, QUE CONTIENE UN HETEROATOMO DE NITROGENO, EL ANILLO ES OPCIONALMENTE SUSTITUIDO EN UNO O MAS ATOMOS DE C; R1 ES HIDROGENO O UN GRUPO PROTECTOR DEL HIDROXILO; R2 PUEDE REPRESENTAR HIDROGENO, ALCANOILO DE 1 A 5 ATOMOS DE C, FENILACETILO, FENILPROPIONILO O BENZOILOXI; R3 PUEDE SER HIDROGENO, YODO, HIDROXI, ALCANOILOXI, BENZOILOXI, FENILACETOXI, FENOXIACETOXI Y R4 UN GRUPO SELECCIONADO DE ENTRE VARIOS PROPUESTOS. CONSISTENTE EN HACER REACCIONAR UNA AMINA HR DONDE R TIENE EL SIGNIFICADO ANTERIOR, CON UN COMPUESTO DE FORMULA (II), DONDE L ES UN GRUPO SALIENTE QUE PUEDE SER DESPLAZADO POR LA AMINA. LA REACCION SE LLEVA A CABO EN DISOLVENTE ORGANICO. DE APLICACION COMO AGENTES TERAPEUTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41724782A | 1982-09-13 | 1982-09-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES548472A0 ES548472A0 (es) | 1986-06-01 |
| ES8607336A1 true ES8607336A1 (es) | 1986-06-01 |
Family
ID=23653182
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525544A Expired ES8604596A1 (es) | 1982-09-13 | 1983-09-12 | Un procedimiento para la preparacion de una macrolida |
| ES548472A Expired ES8607336A1 (es) | 1982-09-13 | 1985-10-31 | Un procedimiento para la preparacion de una macrolida |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525544A Expired ES8604596A1 (es) | 1982-09-13 | 1983-09-12 | Un procedimiento para la preparacion de una macrolida |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP0103465B1 (es) |
| JP (1) | JPS5973598A (es) |
| KR (1) | KR850000961B1 (es) |
| AR (1) | AR241595A1 (es) |
| AT (1) | AT381707B (es) |
| AU (1) | AU561147B2 (es) |
| BG (1) | BG42675A3 (es) |
| CA (1) | CA1243310A (es) |
| CS (1) | CS259862B2 (es) |
| CY (1) | CY1417A (es) |
| DD (1) | DD210284A5 (es) |
| DE (1) | DE3366097D1 (es) |
| DK (1) | DK153555C (es) |
| EG (1) | EG16287A (es) |
| ES (2) | ES8604596A1 (es) |
| FI (1) | FI73222C (es) |
| GB (1) | GB2127017B (es) |
| GR (1) | GR79067B (es) |
| HK (1) | HK21888A (es) |
| HU (1) | HU194271B (es) |
| IE (1) | IE55916B1 (es) |
| IL (1) | IL69666A (es) |
| LU (1) | LU90240I2 (es) |
| MY (1) | MY8700756A (es) |
| NL (1) | NL950001I2 (es) |
| NZ (1) | NZ205501A (es) |
| PH (1) | PH23242A (es) |
| PL (2) | PL142304B1 (es) |
| PT (1) | PT77335B (es) |
| RO (1) | RO89235A (es) |
| SG (1) | SG99287G (es) |
| SU (1) | SU1375135A3 (es) |
| UA (1) | UA6045A1 (es) |
| ZA (1) | ZA836741B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59181294A (ja) * | 1983-03-30 | 1984-10-15 | Satoshi Omura | 抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法 |
| US4921947A (en) * | 1986-03-31 | 1990-05-01 | Eli Lilly And Company | Process for preparing macrolide derivatives |
| EP0262903A3 (en) * | 1986-09-29 | 1988-11-02 | Eli Lilly And Company | New acyl derivatives of 20-modified tylosin and desmycosin compounds |
| US4820694A (en) * | 1986-09-29 | 1989-04-11 | Eli Lilly And Company | Modifications of 3-O-demethylmycinose in macrocin and lactenocin |
| US5354708A (en) * | 1992-06-04 | 1994-10-11 | Taskar Nikhil R | Method of nitrogen doping of II-VI semiconductor compounds during epitaxial growth using an amine |
| TW226373B (es) * | 1992-07-15 | 1994-07-11 | Pfizer | |
| ES2076107B1 (es) * | 1993-09-20 | 1996-04-01 | Pfizer | Derivados de antibioticos macrolidos de anillos de 16 miembros. |
| AU3121095A (en) * | 1994-09-22 | 1996-04-09 | Pfizer Inc. | Antibiotic macrolides |
| EP0778283A3 (en) * | 1995-12-05 | 1998-01-28 | Pfizer Inc. | Antibiotic macrolides |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| DK0948967T3 (da) * | 1998-03-02 | 2005-02-14 | Lilly Co Eli | Behandling af virussygdom hos svin |
| EP2089408B1 (en) | 2006-07-28 | 2011-10-12 | Intervet International B.V. | Macrolide synthesis process |
| EP2019112A1 (en) | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
| EP2231635B1 (en) * | 2007-12-07 | 2014-03-19 | Eisai R&D Management Co., Ltd. | Intermediates and methods for making zearalenone macrolide analogs |
| PT2999707T (pt) * | 2013-05-23 | 2018-05-23 | Kitasato Inst | Derivados de tilosina e método para a preparação dos mesmos |
| CN103880903B (zh) * | 2014-03-21 | 2016-06-15 | 烟台万润药业有限公司 | 一种泰乐菌素类大环内酯及其衍生物的制备方法 |
| CN117510561B (zh) * | 2023-11-30 | 2024-04-02 | 中国农业科学院饲料研究所 | 一种泰乐菌素衍生物及其制备方法与应用 |
| CN117304241B (zh) * | 2023-11-30 | 2024-03-01 | 中国农业科学院饲料研究所 | 一种大环内酯类化合物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE32839B1 (en) * | 1967-12-04 | 1973-12-28 | Lilly Co Eli | Urea-antibiotic adducts and process for preparing the same |
| US4279896A (en) * | 1980-06-23 | 1981-07-21 | Schering Corporation | Novel 20-imino macrolide antibacterial agents |
| JPS58146595A (ja) * | 1982-02-25 | 1983-09-01 | Satoshi Omura | マクロライド系抗生物質 |
-
1983
- 1983-09-05 AU AU18710/83A patent/AU561147B2/en not_active Expired
- 1983-09-05 IL IL69666A patent/IL69666A/xx not_active IP Right Cessation
- 1983-09-06 NZ NZ205501A patent/NZ205501A/en unknown
- 1983-09-07 GR GR72394A patent/GR79067B/el unknown
- 1983-09-07 PH PH29508A patent/PH23242A/en unknown
- 1983-09-07 AR AR83294140A patent/AR241595A1/es active
- 1983-09-08 GB GB08324044A patent/GB2127017B/en not_active Expired
- 1983-09-08 UA UA3641764A patent/UA6045A1/uk unknown
- 1983-09-08 SU SU833641764A patent/SU1375135A3/ru active
- 1983-09-08 DE DE8383305241T patent/DE3366097D1/de not_active Expired
- 1983-09-08 CY CY141783A patent/CY1417A/xx unknown
- 1983-09-08 BG BG062310A patent/BG42675A3/xx unknown
- 1983-09-08 EP EP83305241A patent/EP0103465B1/en not_active Expired
- 1983-09-08 AT AT0320683A patent/AT381707B/de not_active IP Right Cessation
- 1983-09-09 RO RO83112026A patent/RO89235A/ro unknown
- 1983-09-09 FI FI833229A patent/FI73222C/fi not_active IP Right Cessation
- 1983-09-11 EG EG557/83A patent/EG16287A/xx active
- 1983-09-12 PL PL1983243718A patent/PL142304B1/pl unknown
- 1983-09-12 DK DK413783A patent/DK153555C/da not_active IP Right Cessation
- 1983-09-12 CA CA000436451A patent/CA1243310A/en not_active Expired
- 1983-09-12 IE IE2131/83A patent/IE55916B1/en not_active IP Right Cessation
- 1983-09-12 ES ES525544A patent/ES8604596A1/es not_active Expired
- 1983-09-12 DD DD83254748A patent/DD210284A5/de unknown
- 1983-09-12 HU HU833167A patent/HU194271B/hu unknown
- 1983-09-12 ZA ZA836741A patent/ZA836741B/xx unknown
- 1983-09-12 KR KR1019830004273A patent/KR850000961B1/ko not_active Expired
- 1983-09-12 PL PL1983250619A patent/PL142251B1/pl unknown
- 1983-09-13 CS CS836653A patent/CS259862B2/cs unknown
- 1983-09-13 JP JP58169127A patent/JPS5973598A/ja active Granted
- 1983-09-13 PT PT77335A patent/PT77335B/pt unknown
-
1985
- 1985-10-31 ES ES548472A patent/ES8607336A1/es not_active Expired
-
1987
- 1987-11-11 SG SG992/87A patent/SG99287G/en unknown
- 1987-12-30 MY MY756/87A patent/MY8700756A/xx unknown
-
1988
- 1988-03-24 HK HK218/88A patent/HK21888A/en not_active IP Right Cessation
-
1995
- 1995-01-10 NL NL950001C patent/NL950001I2/nl unknown
-
1998
- 1998-05-06 LU LU90240C patent/LU90240I2/fr unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051219 |