[go: up one dir, main page]

ES2032376T3 - Procedimiento para preparar 2-sustituidos-(amino-sustituidos)-n-arilalquil-3-(indol-3-il)propanimidas. - Google Patents

Procedimiento para preparar 2-sustituidos-(amino-sustituidos)-n-arilalquil-3-(indol-3-il)propanimidas.

Info

Publication number
ES2032376T3
ES2032376T3 ES198686115859T ES86115859T ES2032376T3 ES 2032376 T3 ES2032376 T3 ES 2032376T3 ES 198686115859 T ES198686115859 T ES 198686115859T ES 86115859 T ES86115859 T ES 86115859T ES 2032376 T3 ES2032376 T3 ES 2032376T3
Authority
ES
Spain
Prior art keywords
substituted
indol
amino
propanimides
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686115859T
Other languages
English (en)
Inventor
David C. Horwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2032376T3 publication Critical patent/ES2032376T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

CONSISTE EN COMPUESTOS Y COMPOSICIONES FARMACEUTICAS PARA SUPRIMIR EL APETITO, COMPRENDIENDO [PROPANAMIDAS - 2 - SUSTITUIDAS - ]2 - AMINO SUSTITUIDO[ - N - ARALQUIL - 3 - ]INDOL - 3 - IL.
ES198686115859T 1985-11-14 1986-11-14 Procedimiento para preparar 2-sustituidos-(amino-sustituidos)-n-arilalquil-3-(indol-3-il)propanimidas. Expired - Lifetime ES2032376T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79806885A 1985-11-14 1985-11-14
US06/912,731 US4757151A (en) 1985-11-14 1986-09-30 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]

Publications (1)

Publication Number Publication Date
ES2032376T3 true ES2032376T3 (es) 1993-02-16

Family

ID=27121955

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686115859T Expired - Lifetime ES2032376T3 (es) 1985-11-14 1986-11-14 Procedimiento para preparar 2-sustituidos-(amino-sustituidos)-n-arilalquil-3-(indol-3-il)propanimidas.

Country Status (8)

Country Link
US (1) US4757151A (es)
EP (1) EP0224151B1 (es)
AU (1) AU582921B2 (es)
CA (1) CA1274350A (es)
DE (1) DE3677335D1 (es)
DK (1) DK168006B1 (es)
ES (1) ES2032376T3 (es)
GR (1) GR3001413T3 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists
US5010089A (en) * 1988-08-12 1991-04-23 Biomeasure, Inc. CCK antagonists and their use in treating gastrointestinal disorders
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
US5580896A (en) * 1989-06-29 1996-12-03 Warner-Lambert Company Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives
US5631281A (en) * 1989-06-29 1997-05-20 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
US5278316A (en) * 1989-06-29 1994-01-11 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
US5340825A (en) * 1990-08-31 1994-08-23 Warner-Lambert Company Pro drugs for CCK antagonists
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
US5244905A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives
JPH06502627A (ja) * 1990-08-31 1994-03-24 ワーナー―ランバート・コンパニー 新規コレシストキニンアンタゴニスト、その製造および治療用使用
US5264419A (en) * 1990-08-31 1993-11-23 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
ES2167312T3 (es) * 1990-08-31 2002-05-16 Warner Lambert Co Profarmacos para antagonistas de la colecistoquinina.
US5244915A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company Amico acid derivatives cyclized at the c-terminal
JP3980052B2 (ja) * 1993-08-10 2007-09-19 ジェイムズ・ブラック・ファウンデーション・リミテッド ガストリンとｃｃｋレセプタリガンド
US6869957B1 (en) 1993-11-17 2005-03-22 Eli Lilly And Company Non-peptide tachykinin receptor antagonists
US6403577B1 (en) * 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
US5554644A (en) * 1994-06-08 1996-09-10 Warner-Lambert Company Tachykinin (NK2) antagonists
FI974436A7 (fi) * 1995-06-06 1998-01-27 Pfizer Substituoituja N-(indoli-2-karbonyyli)-glysiiniamideja ja -johdannaisi a glykogeenifosforylaasi-inhibiittoreina
EE9900497A (et) 1997-04-15 2000-06-15 Csir Söögiisu pärssiva toimega farmatseutilised kompositsioonid
GB2355657B (en) 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
WO2002030944A2 (en) * 2000-10-11 2002-04-18 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
CN103124722B (zh) * 2010-09-22 2014-11-12 三井化学Agro株式会社 具有含氟氨基甲酸酯基的氨基酸酰胺衍生物的制造方法、其制造中间体、及乙二胺衍生物的制造方法
CN118812515A (zh) * 2023-04-21 2024-10-22 中国科学技术大学 抑制gsdme蛋白膜穿孔功能的化合物或其药学上可接受的盐及其制备方法与应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899592A (en) * 1968-04-08 1975-08-12 Lilly Co Eli Sweetening agent
US3676458A (en) * 1970-06-11 1972-07-11 Lilly Co Eli (indolymethyl) malonate compound
CA1044142A (en) * 1975-07-04 1978-12-12 John N. Mcarthur Anti-inflammatory dipeptide
US3965260A (en) * 1975-07-07 1976-06-22 John N. McArthur Anti-inflammatory dipeptide
US4256641A (en) * 1976-06-22 1981-03-17 Hoffmann-La Roche Inc. Novel syntheses of tryptophans
US4073795A (en) * 1976-06-22 1978-02-14 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4198501A (en) * 1977-12-20 1980-04-15 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
DE2901667A1 (de) * 1979-01-17 1980-07-31 Troponwerke Gmbh & Co Kg Pharmazeutische verwendung von dipeptiden
DE2904512A1 (de) * 1979-02-07 1980-08-28 Troponwerke Gmbh & Co Kg Dehydropeptide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4316847A (en) * 1979-07-30 1982-02-23 Hoffmann-La Roche Inc. Pyrroles and pyrrolidines
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
JPS6028988A (ja) * 1983-06-29 1985-02-14 Ajinomoto Co Inc ペプチドの製造方法
EP0166355A2 (en) * 1984-06-26 1986-01-02 Merck & Co. Inc. Substituted aminophenyl compounds and acylaminophenyl compounds and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DK540986A (da) 1987-05-15
DE3677335D1 (de) 1991-03-07
AU6507386A (en) 1987-05-21
EP0224151A2 (en) 1987-06-03
AU582921B2 (en) 1989-04-13
EP0224151A3 (en) 1989-02-22
CA1274350A (en) 1990-09-18
EP0224151B1 (en) 1991-01-30
GR3001413T3 (en) 1992-09-25
US4757151A (en) 1988-07-12
DK168006B1 (da) 1994-01-17
DK540986D0 (da) 1986-11-12

Similar Documents

Publication Publication Date Title
ES2032376T3 (es) Procedimiento para preparar 2-sustituidos-(amino-sustituidos)-n-arilalquil-3-(indol-3-il)propanimidas.
ATE22562T1 (de) 6-substituierte s-triazolo(3,4-a)phthalazinderivate.
ES552627A0 (es) Procedimiento para la preparacion de carbamatos de fenilo
IE842494L (en) Pyrimidine derivatives
MY101544A (en) Pharmaceutical composition for external use containing active-type vitamin d3.
IS3156A7 (is) Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
PT83872A (de) Arzneimittel
KR890700125A (ko) 신규 벤즈이미다졸 유도체, 그 제조방법 및 이 화합물을 함유하는 제약 조성물
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
IL58782A0 (en) Hydroxypropyl-triazole compounds,their production and pharmaceutical compositions containing them
FI882912A0 (fi) Laekemedelspreparat med finfoerdelade ebselen-kristaller.
MY100900A (en) Substituted phenylsulfonyloxybenzimidazolecarbamates, processes for their preparation and their use as medicaments.
ES448588A1 (es) Un procedimiento para la preparacion de un compuesto hetero-arilico.
IT1216772B (it) Derivati di indolo ,procedimento per prepararli e composizioni farmaceutiche che li contengono per il trattamento di emicrania
IL88971A0 (en) Disubstituted pyridines,their preparation and pharmaceutical compositions containing them
SE8405588D0 (sv) New compounds
ES465215A1 (es) Procedimiento para la preparacion de compuestos poliomeri- cos.
SE8700555D0 (sv) Purine derivatives, their production and medicaments containing them
ES2021515A6 (es) Procedimiento para la preparacion de compuestos derivados de isotiazolo-piridona azetidinil substituidos.
DK328088A (da) Farmaceutisk komposition til behandling af tumorer
DK313587A (da) Tetrahydrobenzothiazolforbindelser, deres fremstilling og anvendelse
NZ216519A (en) Polycyclic compounds and pharmaceutical compositions
DK0457215T3 (da) 3-deamino-4-desoxy-4-amino-8-fluoranthracycliner samt fremgangsmåder til fremstilling deraf
ES373909A1 (es) Procedimiento para la preparacion de quinazolinas.
IT8023404A0 (it) Procedimento per la preparazione di derivati del15-idrossiimmino-e-omoeburnano.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 224151

Country of ref document: ES