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ES2135372T3 - Derivados del acido piridonacarboxilico opticamente activos. - Google Patents

Derivados del acido piridonacarboxilico opticamente activos.

Info

Publication number
ES2135372T3
ES2135372T3 ES89107550T ES89107550T ES2135372T3 ES 2135372 T3 ES2135372 T3 ES 2135372T3 ES 89107550 T ES89107550 T ES 89107550T ES 89107550 T ES89107550 T ES 89107550T ES 2135372 T3 ES2135372 T3 ES 2135372T3
Authority
ES
Spain
Prior art keywords
derivatives
pyridonacarboxylic
acid
optically active
halogenocide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89107550T
Other languages
English (en)
Inventor
Isao Hayakawa
Youichi Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2135372T3 publication Critical patent/ES2135372T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADOS DE ACIDOS PIRIDONE CARBOXILICO SUSTITUIDOS - N1 - (1, 2 - CIS - 2 - HALOGENOCIDO PROPIL) REPRESENTADOS POR LA FORMULA (I) Y LAS SALES DE ELLO SON DESCUBIERTOS. ESOS COMPONENTES TIENEN ACTIVIDADES ANTIBACTERIALES PATENTES CONTRA UNA ANCHA VARIEDAD DE BACTERIAS INFECCIOSAS, Y SON UTILES COMO AGENTES ANTIBACTERIALES POR ADMINISTRACION ORAL O PARENTERAL.
ES89107550T 1988-04-27 1989-04-26 Derivados del acido piridonacarboxilico opticamente activos. Expired - Lifetime ES2135372T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10462588 1988-04-27
JP29698488 1988-11-24

Publications (1)

Publication Number Publication Date
ES2135372T3 true ES2135372T3 (es) 1999-11-01

Family

ID=26445063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89107550T Expired - Lifetime ES2135372T3 (es) 1988-04-27 1989-04-26 Derivados del acido piridonacarboxilico opticamente activos.

Country Status (25)

Country Link
US (4) US5587386A (es)
EP (1) EP0341493B1 (es)
JP (5) JP2714597B2 (es)
KR (1) KR0184614B1 (es)
CN (1) CN1033751C (es)
AT (1) ATE182145T1 (es)
AU (1) AU625414B2 (es)
BG (1) BG61122B2 (es)
CA (1) CA1340801C (es)
DE (1) DE68929030T2 (es)
DK (1) DK175467B1 (es)
ES (1) ES2135372T3 (es)
FI (1) FI96947C (es)
GR (1) GR3031365T3 (es)
HU (1) HU211136A9 (es)
IL (1) IL90062A (es)
LV (1) LV10092B (es)
MY (1) MY105136A (es)
NO (1) NO175939C (es)
NZ (1) NZ228893A (es)
PT (1) PT90377B (es)
RU (1) RU2075475C1 (es)
SG (1) SG48036A1 (es)
UA (1) UA29378C2 (es)
YU (1) YU48432B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
HU208005B (en) * 1990-02-19 1993-07-28 Kyorin Seiyaku Kk Process for producing optically active 8-methoxy-quinolone-carboxylic acid derivatives and pharmaceutical compositions containing them
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
ATE196135T1 (de) * 1991-05-28 2000-09-15 Daiichi Seiyaku Co Pyridoncarbonsäurederivate
ATE184603T1 (de) * 1991-06-19 1999-10-15 Pfizer Azaspirochinolone als antibakterielle wirkstoffe
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
NO301165B1 (no) * 1992-12-25 1997-09-22 Daiichi Seiyaku Co Bicykliske aminderivater og antibakterielle midler inneholdende disse
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
AU683569B2 (en) * 1994-07-18 1997-11-13 Sankyo Company Limited Trifluoromethylquinolinecarboxylic acid derivative
PT807630E (pt) * 1995-02-02 2003-08-29 Daiichi Seiyaku Co Compostos heterociclicos
ES2199278T3 (es) 1995-02-07 2004-02-16 Daiichi Pharmaceutical Co., Ltd. Derivados de espiro heterociclicos.
JPH09124556A (ja) 1995-08-30 1997-05-13 Dai Ichi Seiyaku Co Ltd ハロゲン化シクロプロパン誘導体の製造方法
DK0911328T3 (da) * 1995-11-22 2006-06-06 Daiichi Seiyaku Co Substituerede aminocycloalkylpyrrolidinderivater
US6121285A (en) * 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
DE69717970T2 (de) * 1996-02-09 2003-04-30 Toyama Chemical Co. Ltd., Tokio/Tokyo Chinolin carbonsaure-derivate und ihre salze
ID16655A (id) * 1996-04-24 1997-10-30 Daiichi Seiyaku Co Turunan-turunan sikloalkilaminometilpirolidina
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
CA2351497A1 (en) 1998-11-24 2000-06-02 Daiichi Pharmaceutical Co., Ltd. Cycloalkyl-substituted aminomethylpyrrolidine derivative
WO2000053594A1 (en) * 1999-03-10 2000-09-14 Daiichi Pharmaceutical Co., Ltd. Aminomethylpyrrolidine derivatives having aromatic substituents
AU3192700A (en) 1999-03-17 2000-10-04 Daiichi Pharmaceutical Co., Ltd. Medicinal compositions
RU2297420C2 (ru) * 2000-02-09 2007-04-20 Дайити Фармасьютикал Ко., Лтд. Средство против кислотоустойчивых бактерий, содержащее гетероциклические производные бензоксазина в качестве активного компонента
AU2001244671B2 (en) 2000-03-31 2005-01-27 Daiichi Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivative
DK1277471T3 (da) 2000-04-24 2008-08-11 Daiichi Sankyo Co Ltd Stabilt væskepræparat omfattende sitafloxacin
CA2417764C (en) 2000-08-08 2009-05-05 Katsuo Kataoka Highly absorbable solid preparations containing sitafloxacin and tartaric acid
US20050143407A1 (en) * 2002-05-17 2005-06-30 Daiichi Pharmaceutical Co., Ltd Process for porducing quinolonecarboxylic acid derivative
JP4413864B2 (ja) * 2003-01-07 2010-02-10 第一三共株式会社 還元的脱ハロゲン化方法
US7085154B2 (en) * 2003-06-03 2006-08-01 Samsung Electronics Co., Ltd. Device and method for pulse width control in a phase change memory device
US7977327B2 (en) 2004-05-13 2011-07-12 Daiichi Sankyo Company, Limited Substituted pyrrolidine derivative
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
JP5063032B2 (ja) * 2005-05-19 2012-10-31 第一三共株式会社 トリ−、テトラ−置換−３−アミノピロリジン誘導体
WO2006123767A1 (ja) * 2005-05-20 2006-11-23 Daiichi Sankyo Company, Limited 不斉四置換炭素原子含有化合物の製法
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
TWI386401B (zh) * 2006-03-27 2013-02-21 Daiichi Seiyaku Co 醫藥用水合物
BRPI0720771A2 (pt) 2007-01-05 2014-07-15 Daiichi Sankyo Co Ltd Composto, droga, agentes antibacteriano e terapêutico para infecções, métodos para tratar doenças e infecções e para produzir uma droga, um agente antibacteriano e um agente terapêutico para infecções, e, uso do composto.
EP2311974B1 (en) 2008-07-11 2012-12-19 Sumitomo Chemical Company, Limited Process for producing (1s,2r)-2-chloro-2-fluorocyclopropanecarboxylic acid
FR2961207B1 (fr) * 2010-06-09 2013-01-18 Oreal Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes
CN103467448B (zh) * 2013-09-18 2015-04-15 浙江司太立制药股份有限公司 7-(3-氨基-4-烷氧亚胺基-1-哌啶基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法
EP2957561A1 (en) * 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections
CN105330590B (zh) * 2015-10-15 2018-09-25 广州市朗启医药科技有限责任公司 西他沙星五元环侧链中间体的制备方法
CN109912504B (zh) * 2019-04-04 2020-11-10 山东省联合农药工业有限公司 一种喹啉羧酸类化合物及其制备方法与用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6212760A (ja) * 1984-12-14 1987-01-21 Dai Ichi Seiyaku Co Ltd １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体
AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4657913A (en) 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4735949A (en) 1986-02-18 1988-04-05 Warner-Lambert Company Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
AU618823B2 (en) * 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
AU5123690A (en) * 1989-03-13 1990-09-13 Bristol-Myers Squibb Company 5-substituted-1,4-dihydro-4-oxo-nephthyridine-3-carboxylate antibacterial agents
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
AU2001244671B2 (en) * 2000-03-31 2005-01-27 Daiichi Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivative
US7977327B2 (en) * 2004-05-13 2011-07-12 Daiichi Sankyo Company, Limited Substituted pyrrolidine derivative

Also Published As

Publication number Publication date
DK175467B1 (da) 2004-11-01
NO891698L (no) 1989-10-30
YU48432B (sh) 1998-07-10
UA29378C2 (uk) 2000-11-15
HK1002108A1 (en) 1998-07-31
US5767127A (en) 1998-06-16
NO891698D0 (no) 1989-04-25
NZ228893A (en) 1990-06-26
US5587386A (en) 1996-12-24
USRE41149E1 (en) 2010-02-23
GR3031365T3 (en) 2000-01-31
DE68929030D1 (de) 1999-08-19
JPH1067779A (ja) 1998-03-10
SG48036A1 (en) 1998-04-17
RU2075475C1 (ru) 1997-03-20
PT90377B (pt) 1994-09-30
FI891980A0 (fi) 1989-04-26
JPH11124380A (ja) 1999-05-11
JPH11124367A (ja) 1999-05-11
EP0341493B1 (en) 1999-07-14
FI96947C (fi) 1996-09-25
IL90062A (en) 1994-10-07
EP0341493A3 (en) 1990-12-19
NO175939B (no) 1994-09-26
CN1037507A (zh) 1989-11-29
JPH02231475A (ja) 1990-09-13
EP0341493A2 (en) 1989-11-15
JP2903292B2 (ja) 1999-06-07
BG61122B2 (bg) 1996-11-29
JP2714597B2 (ja) 1998-02-16
CN1033751C (zh) 1997-01-08
JP2917010B2 (ja) 1999-07-12
KR900016205A (ko) 1990-11-12
LV10092B (en) 1995-02-20
AU3370289A (en) 1989-11-02
JPH07300416A (ja) 1995-11-14
US6031102A (en) 2000-02-29
MY105136A (en) 1994-08-30
IL90062A0 (en) 1989-12-15
FI891980A7 (fi) 1989-10-28
DK205789A (da) 1989-10-28
FI96947B (fi) 1996-06-14
DE68929030T2 (de) 2000-03-23
HU211136A9 (en) 1995-10-30
KR0184614B1 (ko) 1999-05-01
CA1340801C (en) 1999-10-26
ATE182145T1 (de) 1999-07-15
AU625414B2 (en) 1992-07-09
YU87589A (en) 1990-12-31
NO175939C (no) 1995-01-04
DK205789D0 (da) 1989-04-27
PT90377A (pt) 1989-11-10

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