ES2196000T3 - Compuesto de pirroloazepina. - Google Patents
Compuesto de pirroloazepina.Info
- Publication number
- ES2196000T3 ES2196000T3 ES92916814T ES92916814T ES2196000T3 ES 2196000 T3 ES2196000 T3 ES 2196000T3 ES 92916814 T ES92916814 T ES 92916814T ES 92916814 T ES92916814 T ES 92916814T ES 2196000 T3 ES2196000 T3 ES 2196000T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- aralquil
- aril
- represent
- general formulas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002131 composite material Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE PRESENTA UN COMPUESTO DE PIRROLOAZEPINA REPRESENTADO POR LAS FORMULAS GENERALES (I) O (II), UNA SAL DEL MISMO, UN PROCESO PARA LA PRODUCCION DEL MISMO, Y UN REMEDIO PARA LAS ENFERMEDADES DE LOS ORGANOS CIRCULATORIOS QUE CONTIENE EL COMPUESTO COMO INGREDIENTE ACTIVO. EN LAS FORMULAS GENERALES (I) O (II) Z1 REPRESENTA H CUANDO HAY UN ENLACE REPRESENTADO POR LA LINEA DISCONTINUA, Y CUANDO NO EXISTE DICHO ENLACE, Z1 REPRESENTA H Y Z2 REPRESENTA OH, O ALTERNATIVAMENTE Z1 Y Z2 SE COMBINAN JUNTAS PARA REPRESENTAR O O NOR1 (EN DONDE R1 REPRESENTA H, ALQUIL, ARIL O ARALQUIL); R REPRESENTA ALQUIL, CICLOALQUIL, CICLOALQUILALQUIL, ARIL O ARALQUIL; A REPRESENTA ALQUILENO, ALQUENILENO O ALQUNILENO; E Y REPRESENTA HETEROCICLO OPCIONALMENTE SUSTITUIDO O ((ALFA)) EN DONDE R1 Y R3 REPRESENTAN CADA UNA H, ALQUIL, ALCOXIDO INFERIOR, ALQUIL SUSTITUIDO CON ARILOXIDO, ARIL O ARALQUIL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22119291 | 1991-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196000T3 true ES2196000T3 (es) | 2003-12-16 |
Family
ID=16762916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92916814T Expired - Lifetime ES2196000T3 (es) | 1991-08-07 | 1992-08-06 | Compuesto de pirroloazepina. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5399557A (es) |
| EP (1) | EP0557526B8 (es) |
| JP (1) | JP3242653B2 (es) |
| KR (1) | KR100243513B1 (es) |
| AT (1) | ATE236163T1 (es) |
| CA (1) | CA2093630C (es) |
| DE (1) | DE69232981T2 (es) |
| ES (1) | ES2196000T3 (es) |
| WO (1) | WO1993003032A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565449A (en) * | 1991-10-18 | 1996-10-15 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
| CA2212092A1 (en) * | 1995-12-01 | 1997-06-12 | Makoto Shibata | Pyrroloazepine derivatives |
| JPH10251258A (ja) | 1997-03-14 | 1998-09-22 | Suntory Ltd | ピロロアゼピン系化合物 |
| JPH11193290A (ja) * | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド系化合物 |
| JPH11193289A (ja) * | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド誘導体 |
| ES2232202T3 (es) * | 1998-12-23 | 2005-05-16 | Bristol-Myers Squibb Pharma Company | Heterobiciclos que contienen nitrogeno como inhibidores del factor xa. |
| CN101735222B (zh) * | 2009-11-02 | 2012-05-23 | 中山大学 | 吡咯并氮杂卓酮类化合物及其作为蛋白酪氨酸磷酸酯酶1b抑制剂的应用 |
| CN102276612B (zh) * | 2011-06-21 | 2013-08-28 | 中山大学 | C-2位取代Aldisin衍生物及其药用盐，它们的药物组合物，及其在制备抗肿瘤药物中的应用 |
| CA3068254A1 (en) | 2017-06-20 | 2018-12-27 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| EP3866794B1 (en) | 2018-10-17 | 2024-12-04 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3563979A (en) * | 1966-10-21 | 1971-02-16 | Upjohn Co | 1,2,3,4,5,6 - hexahydroazepino(4,3 - b)indoles and 1,2,3,4,5,6-hexahydroazepino(3,2-b)indoles |
| US3573324A (en) * | 1969-02-28 | 1971-03-30 | Upjohn Co | 2,3,4,5,10,10a-hexahydroazepino(2,3-b)indoles |
| US3573323A (en) * | 1969-02-28 | 1971-03-30 | Upjohn Co | 1,2,3,4,5,10-hexahydroazepino(2,3-b)indoles |
| JPS62161786A (ja) * | 1986-01-08 | 1987-07-17 | Mitsubishi Chem Ind Ltd | ピロ−ル化合物 |
| US4729996A (en) * | 1986-05-29 | 1988-03-08 | Harbor Branch Oceanographic Institution, Inc. | Antitumor compositions and their methods of use |
| JP3198117B2 (ja) * | 1990-02-07 | 2001-08-13 | サントリー株式会社 | ピロロアゼピン誘導体 |
-
1992
- 1992-08-06 WO PCT/JP1992/001009 patent/WO1993003032A1/ja not_active Ceased
- 1992-08-06 DE DE69232981T patent/DE69232981T2/de not_active Expired - Fee Related
- 1992-08-06 JP JP50348193A patent/JP3242653B2/ja not_active Expired - Fee Related
- 1992-08-06 CA CA002093630A patent/CA2093630C/en not_active Expired - Fee Related
- 1992-08-06 US US08/030,427 patent/US5399557A/en not_active Expired - Fee Related
- 1992-08-06 EP EP92916814A patent/EP0557526B8/en not_active Expired - Lifetime
- 1992-08-06 ES ES92916814T patent/ES2196000T3/es not_active Expired - Lifetime
- 1992-08-06 AT AT92916814T patent/ATE236163T1/de not_active IP Right Cessation
-
1993
- 1993-04-03 KR KR1019930701045A patent/KR100243513B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE236163T1 (de) | 2003-04-15 |
| EP0557526A4 (es) | 1994-08-31 |
| CA2093630A1 (en) | 1993-02-08 |
| US5399557A (en) | 1995-03-21 |
| EP0557526B8 (en) | 2003-08-13 |
| KR100243513B1 (en) | 2000-03-02 |
| DE69232981T2 (de) | 2004-01-08 |
| EP0557526A1 (en) | 1993-09-01 |
| AU645441B2 (en) | 1994-01-13 |
| JP3242653B2 (ja) | 2001-12-25 |
| AU2403092A (en) | 1993-03-02 |
| EP0557526B1 (en) | 2003-04-02 |
| KR930702355A (ko) | 1993-09-08 |
| CA2093630C (en) | 2004-01-06 |
| WO1993003032A1 (fr) | 1993-02-18 |
| DE69232981D1 (de) | 2003-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2196000T3 (es) | Compuesto de pirroloazepina. | |
| UA19303A (uk) | Спосіб одержаhhя похідhих 2-аhіліhопіримідиhу | |
| SE8402549L (sv) | Substituerade moranolinderivat | |
| ES2177654T3 (es) | Remedio contra la degeneracion espinocerebelosa. | |
| ES2156155T3 (es) | Derivado de pirazol. | |
| ES8505405A1 (es) | Un procedimiento para producir un activador de plasminogeno purificado. | |
| DE59207084D1 (de) | Wässrige Dispersionen von Sulfonylharnstoffderivaten | |
| IS3284A7 (is) | Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar | |
| ES2171416T3 (es) | Remedio contra la trombocitopenia. | |
| ES2151908T3 (es) | Derivados del acido fenil-ciclohexano-carboxilico sustituidos con heterociclo. | |
| ES2084339T3 (es) | Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central. | |
| ES2109993T3 (es) | Derivados de 4-desoxi-4-epipodofilotoxina o sus sales farmaceuticamente aceptables. | |
| ES2074236T3 (es) | Composiciones farmaceuticas que comprenden calcitonina. | |
| CO4410202A1 (es) | Formulacion para aumentar el peso corporal y la absorcion del selenio por el ganado | |
| ES2196001T3 (es) | Derivado de pirroloazepina. | |
| NO891220L (no) | Middel som inneholder salicylsyre for behandling av lepidose. | |
| MX9300638A (es) | Derivados del acido aminobenzoico. | |
| ES8504182A1 (es) | Procedimiento para preparar nuevos derivados de piperidina | |
| ES2151572T3 (es) | Benzoilguanidinas sustituidas con trifluoropropilo y su empleo como medicamento o agente de diagnostico. | |
| ES367496A1 (es) | Un procedimiento para la preparacion de compuestos de ben- zofuranilo. | |
| ES2151891T3 (es) | Derivados de ciclohexano sustituidos con imidazolilo. | |
| AR008619A1 (es) | Utilizacion de la flupirtina para la profilaxis y la terapia de enfermedades que se acompanan de una tasa de mortalidad celular mas alta que lafisiologia y medicamentos que comprenden flupirtina para dicha profilaxis y dicha terapia. | |
| ES2128529T3 (es) | Derivados de oxazolina, procedimiento para su preparacion y composiciones agricolas y horticolas para el control de organismos nocivos que los contienen. | |
| RU96104214A (ru) | Способ лечения транссудативных форм центральных хориоретинальных дистрофий | |
| ES2131569T3 (es) | Proceso para preparar neuraminidasa. |