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ES2186737T3 - Composiciones de oxicodona de liberacion controlada. - Google Patents

Composiciones de oxicodona de liberacion controlada.

Info

Publication number
ES2186737T3
ES2186737T3 ES96102992T ES96102992T ES2186737T3 ES 2186737 T3 ES2186737 T3 ES 2186737T3 ES 96102992 T ES96102992 T ES 96102992T ES 96102992 T ES96102992 T ES 96102992T ES 2186737 T3 ES2186737 T3 ES 2186737T3
Authority
ES
Spain
Prior art keywords
oxycodone
hours
plasma
concentration
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96102992T
Other languages
English (en)
Other versions
ES2186737T5 (es
Inventor
Benjamin Oshlack
John Joseph Minogue
Mark Chasin
Robert Francis Kaiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25178688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2186737(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of ES2186737T3 publication Critical patent/ES2186737T3/es
Anticipated expiration legal-status Critical
Application granted granted Critical
Publication of ES2186737T5 publication Critical patent/ES2186737T5/es
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Fluid Pressure (AREA)
  • Polyethers (AREA)

Abstract

SE PRESENTA UN METODO PARA REDUCIR SUBSTANCIALMENTE LA DURACION EN LAS DOSIS DIARIAS REQUERIDAS PARA CONTROLAR EL DOLOR EN APROXIMADAMENTE EL 80% DE LOS PACIENTES MEDIANTE EL CUAL SE ADMINISTRA A UN PACIENTE UNA DOSIS SOLIDA, ORAL, DE LIBERACION CONTROLADA DE UNA FORMULACION QUE TIENE ENTRE 10 Y 40 MM DE OXICODONA O UNA SAL DE LA MISMA. LA FORMULACION SUMINISTRA UNA CONCENTRACION MEDIA, MAXIMA EN PLASMA DE OXICODONA DE ENTRE 6 Y 60 MG/ML DURANTE UNA MEDIA DE ENTRE 2 Y 4,5 HORAS DESPUES DE SU ADMINISTRACION, Y UNA CONCENTRACION MEDIA, MINIMA EN EL PLASMA DE ENTRE 3 Y 30 MG/ML DURANTE ENTRE 10 Y 14 HORAS DESPUES DE LA ADMINISTRACION REPETIDA (POR EJEMPLO CADA 12 HORAS). OTRA CONFORMACION SE DIRIGE A UN METODO PARA REDUCIR SUBSTANCIALMENTE LA DURACION EN LA DOSIFICACIONES DIARIAS REQUERIDAS PARA CONTROLAR EL DOLOR EN SUSTANCIALMENTE TODOS LOS PACIENTES. LA FIGURA 5 ES UN GRAFICO QUE MUESTRA LA CONCENTRACION MEDIA EN PLASMA DE LA OXICODONA PARA 10 MG DE OXICODONA DE LIBERACION CONTROLADA PREPARADA DE ACUERDO CON LA INVENCION, Y UN ESTANDAR DE REFERENCIA DE ESTUDIO.
ES96102992T 1991-11-27 1992-11-25 Composiciones de oxicodona de liberación controlada Expired - Lifetime ES2186737T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US800549 1991-11-27
US07/800,549 US5266331A (en) 1991-11-27 1991-11-27 Controlled release oxycodone compositions

Publications (2)

Publication Number Publication Date
ES2186737T3 true ES2186737T3 (es) 2003-05-16
ES2186737T5 ES2186737T5 (es) 2014-01-17

Family

ID=25178688

Family Applications (9)

Application Number Title Priority Date Filing Date
ES04026291T Expired - Lifetime ES2287625T3 (es) 1991-11-27 1992-11-25 Composicion de una sal de oxicodona de liberacion controlada.
ES92925406T Expired - Lifetime ES2096781T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodones de liberacion controlada.
ES02008249T Expired - Lifetime ES2213720T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.
ES04005576T Expired - Lifetime ES2286523T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.
ES03006022T Expired - Lifetime ES2215984T5 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.
ES96102992T Expired - Lifetime ES2186737T5 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberación controlada
ES03006020T Expired - Lifetime ES2268189T3 (es) 1991-11-27 1992-11-25 Composiciones de sal de oxicodona de liberacion controlada.
ES03006021T Expired - Lifetime ES2215983T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.
ES07100188T Expired - Lifetime ES2339392T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES04026291T Expired - Lifetime ES2287625T3 (es) 1991-11-27 1992-11-25 Composicion de una sal de oxicodona de liberacion controlada.
ES92925406T Expired - Lifetime ES2096781T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodones de liberacion controlada.
ES02008249T Expired - Lifetime ES2213720T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.
ES04005576T Expired - Lifetime ES2286523T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.
ES03006022T Expired - Lifetime ES2215984T5 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES03006020T Expired - Lifetime ES2268189T3 (es) 1991-11-27 1992-11-25 Composiciones de sal de oxicodona de liberacion controlada.
ES03006021T Expired - Lifetime ES2215983T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.
ES07100188T Expired - Lifetime ES2339392T3 (es) 1991-11-27 1992-11-25 Composiciones de oxicodona de liberacion controlada.

Country Status (30)

Country Link
US (13) US5266331A (es)
EP (15) EP1810679B1 (es)
JP (2) JP3375960B2 (es)
KR (1) KR100280973B1 (es)
CN (2) CN1245958C (es)
AT (9) ATE261725T1 (es)
AU (1) AU657027B2 (es)
BG (1) BG61753B1 (es)
BR (1) BR9205498A (es)
CA (1) CA2098738C (es)
CZ (4) CZ298499B6 (es)
DE (10) DE69233326T2 (es)
DK (10) DK1327446T4 (es)
ES (9) ES2287625T3 (es)
FI (7) FI113152B (es)
GR (1) GR3022273T3 (es)
HU (10) HU227516B1 (es)
IL (1) IL103909A (es)
MX (1) MX9302968A (es)
NO (6) NO307028B3 (es)
PH (1) PH31679A (es)
PL (2) PL173574B1 (es)
PT (8) PT1810679E (es)
RO (1) RO115112B1 (es)
RS (3) RS50056B (es)
RU (1) RU2122411C1 (es)
SK (1) SK280295B6 (es)
WO (1) WO1993010765A1 (es)
YU (1) YU49495B (es)
ZA (1) ZA929227B (es)

Families Citing this family (300)

* Cited by examiner, † Cited by third party
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DK200000364U3 (da) 2001-03-23
ATE261726T1 (de) 2004-04-15
FI20031891L (fi) 2003-12-22
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JP4016074B2 (ja) 2007-12-05
EP0722730B1 (en) 2002-10-30
IL103909A0 (en) 1993-04-04
DE69233640T2 (de) 2007-06-14
DK0722730T3 (da) 2002-11-25
WO1993010765A1 (en) 1993-06-10
PT1810679E (pt) 2010-02-18
SK280295B6 (sk) 1999-11-08
FI118252B (fi) 2007-09-14
PT1327446E (pt) 2004-06-30
ZA929227B (en) 1993-07-12
CZ286913B6 (cs) 2000-08-16
EP1258246A2 (en) 2002-11-20
DE69233691D1 (de) 2007-06-06
NO932661D0 (no) 1993-07-23
ATE332691T1 (de) 2006-08-15
CA2098738A1 (en) 1993-05-28
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DK1327446T3 (da) 2004-08-02
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US20030099704A1 (en) 2003-05-29
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NO996447L (no) 1993-09-24
US20060165792A1 (en) 2006-07-27
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CN1165307C (zh) 2004-09-08
DK1258246T3 (da) 2004-07-05
EP0576643B1 (en) 1996-10-23
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FI20070282L (fi) 2007-04-12
EP2340833A3 (en) 2012-09-12
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EP1502592A1 (en) 2005-02-02
RU2122411C1 (ru) 1998-11-27
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PT1327445E (pt) 2004-07-30
ATE226822T1 (de) 2002-11-15
CN1087262A (zh) 1994-06-01
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BR9205498A (pt) 1994-06-07
RO115112B1 (ro) 1999-11-30
ATE454150T1 (de) 2010-01-15
US20040105887A1 (en) 2004-06-03
US20060165791A1 (en) 2006-07-27
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US20010008639A1 (en) 2001-07-19
DK0722730T4 (da) 2013-11-18
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ES2339392T3 (es) 2010-05-19
BG61753B1 (bg) 1998-05-29
HU227815B1 (en) 2012-03-28
RS50054B (sr) 2008-11-28
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EP2106797A3 (en) 2009-11-04

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