[go: up one dir, main page]

ES2183866T3 - Derivados de beta-aril y beta-heteroaril-alfa-cianoacrilamidas sustituido como inhibidors de la tirosina quinasa. - Google Patents

Derivados de beta-aril y beta-heteroaril-alfa-cianoacrilamidas sustituido como inhibidors de la tirosina quinasa.

Info

Publication number
ES2183866T3
ES2183866T3 ES95910542T ES95910542T ES2183866T3 ES 2183866 T3 ES2183866 T3 ES 2183866T3 ES 95910542 T ES95910542 T ES 95910542T ES 95910542 T ES95910542 T ES 95910542T ES 2183866 T3 ES2183866 T3 ES 2183866T3
Authority
ES
Spain
Prior art keywords
sub
sup
beta
hydrogen
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95910542T
Other languages
English (en)
Inventor
Franco Buzzetti
Angelo Crugnola
Antonio Longo
Gabriella Maria Brasca
Dario Ballinari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of ES2183866T3 publication Critical patent/ES2183866T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS DE LA FORMULA (I) EN LA QUE A ES UN ANILLO BICICLICO SELECCIONADO DEL NAFTALENO, TETRAHIDRONAFTALENO, QUINOLINA, ISOQUINOLINA E INDOL; B ES UN ANILLO DE BENCENO SUSTITUIDO POR R{SUP,2} O UN ANILLO DE PIRIDINA O DE TIFENO NO SUSTITUIDO; R ES HIDROGENO, ALQUILO C{SUB,1}-C{SUB,6}, HALOGENO, NITRO, CIANO O UN GRUPO NR{SUP,3}R{SUP,4}, EN DONDE CADA UNO DE ENTRE R{SUP,3} Y R{SUP,4} ES, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO C{SUB,1}-C{SUB,6}; R{SUP,1} ES HIDROGENO, ALQUILO C{SUB,1}-C{SUB,6} O ALCANOILO C{SUB,1}-C{SUB,6}; R{SUP,2} ES HIDROGENO, ALQUILO C{SUB,1}C{SUB,6}, HALOGENO, NITRO, CIANO, CARBOXI, HIDROGENO, ALCOXI C{SUB,1}-C{SUB,6}, ALCANOILOXI C{SUB,1}-C{SUB,6} O UN GRUPO NR{SUP,3}R{SUP,4}, EN DONDE R{SUP,3} Y R{SUP,4} SON COMO SE HA DEFINIDO ARRIBA; N ES CERO O UN ENTERO DE 1 A 2; X ES CERO O UN ENTERO DE 1 A 5; A Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DE LA INVENCION SON UTILES COMO INHIBIDORES DE LA QUINASA DE TIROSINA.
ES95910542T 1994-03-28 1995-03-02 Derivados de beta-aril y beta-heteroaril-alfa-cianoacrilamidas sustituido como inhibidors de la tirosina quinasa. Expired - Lifetime ES2183866T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9406137A GB9406137D0 (en) 1994-03-28 1994-03-28 N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
ES2183866T3 true ES2183866T3 (es) 2003-04-01

Family

ID=10752648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95910542T Expired - Lifetime ES2183866T3 (es) 1994-03-28 1995-03-02 Derivados de beta-aril y beta-heteroaril-alfa-cianoacrilamidas sustituido como inhibidors de la tirosina quinasa.

Country Status (21)

Country Link
US (1) US5652250A (es)
EP (1) EP0700388B1 (es)
JP (1) JPH08511562A (es)
KR (1) KR960702442A (es)
CN (1) CN1125942A (es)
AT (1) ATE224371T1 (es)
AU (1) AU685599B2 (es)
DE (1) DE69528229T2 (es)
ES (1) ES2183866T3 (es)
FI (1) FI955661L (es)
GB (1) GB9406137D0 (es)
HU (1) HUT73811A (es)
IL (1) IL113044A0 (es)
MX (1) MX9504895A (es)
MY (1) MY130160A (es)
NO (1) NO954692D0 (es)
NZ (1) NZ281630A (es)
PL (1) PL311745A1 (es)
TW (1) TW347386B (es)
WO (1) WO1995026341A1 (es)
ZA (1) ZA952423B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9613021D0 (en) * 1996-06-21 1996-08-28 Pharmacia Spa Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
AU3577997A (en) * 1996-06-24 1998-01-14 Irori Solid phase tyrphostin library linked to matrices with memories
CA2321307A1 (en) 1998-02-27 1999-09-02 Venkatachala L. Narayanan Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs
HUP0000920A3 (en) * 2000-02-28 2002-03-28 Sanofi Synthelabo Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them
EP1752446A3 (en) * 2000-04-13 2007-03-21 HSC Research and Development Limited Partnership Compounds for modulating cell proliferation
CA2406160A1 (en) 2000-04-13 2001-10-25 Hsc Research And Development Limited Partnership Compounds for modulating cell proliferation
US20050014690A1 (en) * 2001-10-11 2005-01-20 Chaim Roifman Styryl acrylonitrile compounds and their use to promote myelopoiesis
PT1701941E (pt) * 2003-12-11 2012-08-03 Univ Texas Compostos para o tratamento de doenças proliferativas celulares
US7598419B2 (en) 2004-03-26 2009-10-06 Hsc Research And Development Limited Partnership Compounds for modulating cell proliferation
US20100292229A1 (en) * 2006-06-30 2010-11-18 The Board Of Regents Of The University Of Texas System Tryphostin-analogs for the treatment of cell proliferative diseases
NZ590372A (en) 2008-07-08 2012-09-28 Univ Texas Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
MX2012005678A (es) 2009-11-16 2012-09-07 Univ California Enhibidores de cinasas.
WO2012136120A1 (zh) * 2011-04-02 2012-10-11 中国人民解放军军事医学科学院毒物药物研究所 芳基丙烯酰胺化合物及其用于制备免疫抑制剂的用途
DK2710007T3 (da) * 2011-05-17 2020-01-27 Principia Biopharma Inc Kinasehæmmere
CN104093706A (zh) * 2011-12-30 2014-10-08 克莱蒙费朗国立高等化工学校 疼痛缓解化合物
WO2015054555A1 (en) * 2013-10-10 2015-04-16 The Regents Of The University Of Michigan Deubiquitinase inhibitors and methods for use of the same
CN108276366B (zh) * 2018-01-08 2021-09-03 四川大学 一种丙烯酰胺类衍生物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000939D0 (en) * 1990-01-16 1990-03-14 Erba Carlo Spa Improvement in the total synthesis of erbstatin analogs
GB9000950D0 (en) * 1990-01-16 1990-03-14 Erba Carlo Spa New arylvinylamide derivatives and process for their preparation
GB9004483D0 (en) * 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
US5196446A (en) * 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
AU662480B2 (en) * 1990-04-16 1995-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Heterocyclicethenediyl compounds which inhibit EGF receptor tyrosine kinase
GB9115160D0 (en) * 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
CA2080554A1 (en) * 1991-10-15 1993-04-16 Mitsubishi Chemical Corporation Styrene derivatives
GB9204945D0 (en) * 1992-03-06 1992-04-22 Erba Carlo Spa 3-aryl-glycidic ester derivatives and process for their preparation
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation

Also Published As

Publication number Publication date
MX9504895A (es) 1998-03-31
GB9406137D0 (en) 1994-05-18
KR960702442A (ko) 1996-04-27
EP0700388A1 (en) 1996-03-13
FI955661A7 (fi) 1996-01-19
FI955661A0 (fi) 1995-11-24
WO1995026341A1 (en) 1995-10-05
ZA952423B (en) 1995-12-19
JPH08511562A (ja) 1996-12-03
IL113044A0 (en) 1995-06-29
NZ281630A (en) 1998-02-26
NO954692L (no) 1995-11-20
FI955661L (fi) 1996-01-19
EP0700388B1 (en) 2002-09-18
AU1849895A (en) 1995-10-17
ATE224371T1 (de) 2002-10-15
AU685599B2 (en) 1998-01-22
HUT73811A (en) 1996-09-30
US5652250A (en) 1997-07-29
DE69528229T2 (de) 2003-08-14
PL311745A1 (en) 1996-03-18
DE69528229D1 (en) 2002-10-24
NO954692D0 (no) 1995-11-20
TW347386B (en) 1998-12-11
CN1125942A (zh) 1996-07-03
MY130160A (en) 2007-06-29
HU9503714D0 (en) 1996-02-28

Similar Documents

Publication Publication Date Title
ES2183866T3 (es) Derivados de beta-aril y beta-heteroaril-alfa-cianoacrilamidas sustituido como inhibidors de la tirosina quinasa.
ES2083569T3 (es) Nuevos derivados de ariletenileno y procedimiento para su preparacion.
ES2152317T3 (es) Derivados de arilideno y de heteroarilideno oxiindol utilizados como inhibidores de la tirosina quinasa.
AR004320A1 (es) Nuevos compuestos de pirimidina condensados biciclicos; un procedimiento para su preparacion; composiciones farmaceuticas que los contienen y su usocomo agentes terapeuticos, en particular como inhibidores de la tirosina quinasa.
ES2165357T3 (es) Derivados de metileno-oxiindol y procedimiento de elaboracion.
ES2188666T3 (es) Analogos de la distamicina utilies como agentes antitumorales o antivirales.
ES2159758T3 (es) Nuevas n-aminoalquilfluorenocarboxamidas; una nueva clase de ligandos especificos a subtipos del receptor de la dopamina.
ES2152207T3 (es) Derivados condensados de la purina.
ES2185999T3 (es) Derivados de quinazolina y composiciones farmaceuticas que los contienen.
ES2157224T3 (es) Derivados de 5-arilindol y su uso como agonistas de serotonina (5-ht 1).
PE20020720A1 (es) Derivados benzimidazol y piridilimidazol como ligandos para receptores gabaa
EA199700156A1 (ru) Производные индола как антагонисты рецептора 5-нт
ES2132223T3 (es) Derivados de indol condensados en calidad de antagonistas del receptor 5-ht4.
AR012870A1 (es) Derivados de ergolina ([6ar, 9r, 10ar]-6-[4-(5-bromo-7-metil-4,6,6a,7,8,9, 10,10a-octahidro-indol[4,3-fg]quinolin-9-carbonil)-piperazin-1-il]-1-metil-1h-piridin-2-ona), proceso para su produccion, composicion farmaceutica, y su uso para la fabricacion de un medicamento para el tratamiento de depresi
AR048567A1 (es) Derivados de benzoxazinona, su preparacion y composiciones farmaceuticas.
AR028817A1 (es) Compuestos derivados de la 1-arenosulfonil-2-arilo-pirrolidina, su empleo, un procedimiento para obtenerlos y medicamentos que los contienen
ES2154470T3 (es) Derivados de tetrahidroisoquinolina y su uso farmaceutico.
ES2159749T3 (es) Derivados de bencilamino-2-metil-propanamidas 2-(4-sustituidas).
ES2042593T3 (es) Procedimiento para la obtencion de derivados de la benzhidriloxietil-piperazina.
ES2191180T3 (es) Antagonistas de los receptores de la dopamina benzoxazinona d4.
ES2038766T3 (es) 4-aril-5-carbamoil-1,4-dihidropiridinas.
ES2297837T3 (es) Derivados de 1,3-dihidro-1-(fenilalquenil)-2h-imidazol-2-ona que tienen actividad inhibidora de pde iv y de citoquina.
ES2111492B1 (es) Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central.
ES2143630T3 (es) Derivados azabicicloalquilos de imidazo(1,5-a)indol-3-ona utilizados como antagonistas de 5ht3.
AR036735A1 (es) Derivados de 5-metoxi-8-aril-[1,2,4]triazolo[1,5-a]piridina