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ES2157224T3 - Derivados de 5-arilindol y su uso como agonistas de serotonina (5-ht 1). - Google Patents

Derivados de 5-arilindol y su uso como agonistas de serotonina (5-ht 1).

Info

Publication number
ES2157224T3
ES2157224T3 ES93923389T ES93923389T ES2157224T3 ES 2157224 T3 ES2157224 T3 ES 2157224T3 ES 93923389 T ES93923389 T ES 93923389T ES 93923389 T ES93923389 T ES 93923389T ES 2157224 T3 ES2157224 T3 ES 2157224T3
Authority
ES
Spain
Prior art keywords
compounds
members
agonists
ring
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93923389T
Other languages
English (en)
Inventor
John Eugene Macor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2157224T3 publication Critical patent/ES2157224T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I), EN LA QUE R1 ES (A), (B), (C) O (D); N ES 0, 1 O 2; A, B, C Y D SON CADA UNO, INDEPENDIENTEMENTE, NITROGENO O CARBONO; R2, R3, R4 Y R5 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, ALQUILO C1 A C6, ARILO, ALQUILARILO C1 A C3, HALOGENO (EJ. FLUOR, CLORO, BROMO O YODO), CIANO, NITRO, (CH2)MNR14R15, -(CH2)MOR9, -SR9, -SO2NR14R15, -(CH2)MNR14SO2R15, (CH2)MNR14CO2R9, -(CH2)MNR14COR9, -(CH2)MNR14CONHR9, -CONR14R15 O CO2R9; R2 Y R3, R3 Y R4 O R4 Y R5 PUEDEN FORMAR JUNTOS UN ANILLO DE ALQUILO DE CINCO A SIETE MIEMBROS, UN ANILLO DE ARILO DE SEIS MIEMBROS, UN ANILLO DE HETEROALQUILO DE SIETE MIEMBROS CON UN HETEROATOMO DE N, O O S, O UN ANILLO DE HETEROARILO DE CINCO A SEIS MIEMBROS CON 1 O 2 HETEROATOMOS DE N, O O S Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. ESTOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE LA JAQUECA Y DE OTROS TRASTORNOS. ESTOS COMPUESTOS SON PSICOTERAPEUTICOS UTILES Y SON POTENTES AGONISTAS DE LA SEROTONINA (5-HT1) Y AGONISTAS Y ANTAGONISTAS DE LA BENZODIAZEPINA Y SE PUEDEN UTILIZAR EN EL TRATAMIENTO DE LA DEPRESION, ANSIEDAD, TRASTORNOS EN EL COMER, OBESIDAD, ABUSO DE FARMACOS, DOLORES DE CABEZA FRECUENTES, JAQUECAS, DOLORES, HEMICRANEA PAROXISMAL CRONICA Y DOLORES DE CABEZA ASOCIADOS A TRASTORNOS VASCULARES Y OTROS TRASTORNOS QUE SURGEN DE UNA NEUROTRANSMISION SEROTONERGICA DEFICIENTE. LOS COMPUESTOS TAMBIEN SE PUEDEN UTILIZAR COMO AGENTES CONTRA LA HIPERSENSIBILIDAD Y COMO VASODILATADORES QUE ACTUAN EN EL SISTEMA CENTRAL.
ES93923389T 1992-11-02 1993-10-19 Derivados de 5-arilindol y su uso como agonistas de serotonina (5-ht 1). Expired - Lifetime ES2157224T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02

Publications (1)

Publication Number Publication Date
ES2157224T3 true ES2157224T3 (es) 2001-08-16

Family

ID=25517470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93923389T Expired - Lifetime ES2157224T3 (es) 1992-11-02 1993-10-19 Derivados de 5-arilindol y su uso como agonistas de serotonina (5-ht 1).

Country Status (27)

Country Link
US (1) US5886008A (es)
EP (2) EP1094064A1 (es)
JP (1) JP2788551B2 (es)
KR (1) KR0163371B1 (es)
CN (1) CN1051313C (es)
AT (1) ATE202102T1 (es)
AU (1) AU685066B2 (es)
BR (1) BR9307348A (es)
CA (2) CA2148380C (es)
CZ (1) CZ283001B6 (es)
DE (1) DE69330351T2 (es)
DK (1) DK0666858T3 (es)
EG (1) EG20396A (es)
ES (1) ES2157224T3 (es)
FI (2) FI111257B (es)
GR (1) GR3036579T3 (es)
HU (1) HU222235B1 (es)
IL (1) IL107386A (es)
MY (1) MY109696A (es)
NO (1) NO309652B1 (es)
NZ (1) NZ257059A (es)
PL (1) PL176091B1 (es)
PT (1) PT666858E (es)
RU (1) RU2134266C1 (es)
TW (1) TW251284B (es)
WO (1) WO1994010171A1 (es)
ZA (1) ZA938137B (es)

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CN1809351A (zh) 2003-04-24 2006-07-26 麦克公司 Akt活性抑制剂
DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
AU2004268950A1 (en) * 2003-08-21 2005-03-10 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine-derivatives as c-kit inhibitors
EP1673087B1 (en) 2003-10-03 2015-05-13 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
DE102004014304A1 (de) 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
ES2346157T3 (es) * 2006-03-22 2010-10-11 Janssen Pharmaceutica N.V. Derivados de alquilaminas ciclicas como inhibidores de la interaccion entre mdm2 y p53.
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
WO2016176449A1 (en) 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators
AU2016256413B2 (en) 2015-04-29 2020-10-08 Janssen Pharmaceutica Nv Indolone compounds and their use as AMPA receptor modulators
WO2016176457A1 (en) 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators
DK3288940T5 (da) 2015-04-29 2021-09-20 Janssen Pharmaceutica Nv Azabenzimidazoler og deres anvendelse som ampa-receptormodulatorer
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JP6857653B2 (ja) 2015-11-06 2021-04-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体
CR20180255A (es) 2015-11-06 2018-06-22 Hoffmann La Roche Derivados de indolin-2-ona
CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法
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WO2025104491A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

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Also Published As

Publication number Publication date
CA2340999C (en) 2005-01-04
NO951633D0 (no) 1995-04-28
CN1094727A (zh) 1994-11-09
HUT66011A (en) 1994-08-29
NZ257059A (en) 1997-07-27
PL308669A1 (en) 1995-08-21
CZ283001B6 (cs) 1997-12-17
EP0666858A1 (en) 1995-08-16
RU2134266C1 (ru) 1999-08-10
CZ110895A3 (en) 1995-11-15
JP2788551B2 (ja) 1998-08-20
IL107386A (en) 1999-03-12
MY109696A (en) 1997-04-30
FI111257B (fi) 2003-06-30
IL107386A0 (en) 1994-01-25
EG20396A (en) 1999-02-28
WO1994010171A1 (en) 1994-05-11
PL176091B1 (pl) 1999-04-30
EP0666858B1 (en) 2001-06-13
GR3036579T3 (en) 2001-12-31
ZA938137B (en) 1995-05-02
RU95109927A (ru) 1997-01-10
KR950704313A (ko) 1995-11-17
BR9307348A (pt) 1999-05-11
FI20002505L (fi) 2000-11-15
FI20002505A7 (fi) 2000-11-15
NO309652B1 (no) 2001-03-05
DE69330351T2 (de) 2001-09-20
KR0163371B1 (ko) 1998-12-01
DK0666858T3 (da) 2001-08-27
US5886008A (en) 1999-03-23
DE69330351D1 (de) 2001-07-19
CA2148380C (en) 2001-08-14
FI934825L (fi) 1994-05-03
HU222235B1 (hu) 2003-05-28
EP1094064A1 (en) 2001-04-25
FI934825A0 (fi) 1993-11-01
JPH07508759A (ja) 1995-09-28
CA2148380A1 (en) 1994-05-11
CA2340999A1 (en) 1994-05-11
ATE202102T1 (de) 2001-06-15
NO951633L (no) 1995-04-28
AU685066B2 (en) 1998-01-15
AU5329494A (en) 1994-05-24
TW251284B (es) 1995-07-11
CN1051313C (zh) 2000-04-12
PT666858E (pt) 2001-09-28

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