ES2165357T3 - Derivados de metileno-oxiindol y procedimiento de elaboracion. - Google Patents
Derivados de metileno-oxiindol y procedimiento de elaboracion.Info
- Publication number
- ES2165357T3 ES2165357T3 ES92914619T ES92914619T ES2165357T3 ES 2165357 T3 ES2165357 T3 ES 2165357T3 ES 92914619 T ES92914619 T ES 92914619T ES 92914619 T ES92914619 T ES 92914619T ES 2165357 T3 ES2165357 T3 ES 2165357T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- rent
- methylene
- halogen
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 METHYLENE-OXYINDOL Chemical class 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- DQNVJWKDCCSMLW-UHFFFAOYSA-N 2-methylideneindole Chemical class C1=CC=CC2=NC(=C)C=C21 DQNVJWKDCCSMLW-UHFFFAOYSA-N 0.000 abstract 1
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION PRESENTA NUEVOS DERIVADOS DE METILEN-INDOL DE LA FORMULA (I), EN DONDE R ES UN GRUPO (A) EN QUE R4 ES HIDROGENO, HIDROXI, ALCOXI C1-C6, ALCANOILOXI C2-C6, CARBOXI, NITRO, O NHR7, EN DONDE R7 ES HIDROGENO O ALQUILO C1-C6; R5 ES HIDROGENO, ALQUILO C1-C6 O HALOGENO; R6 ES HIDROGENO O ALQUILO C1-C6; N ES CERO, 1 O 2; R1 ES HIDROGENO, ALQUILO C1-C6 O ALCANOILO C2-C6; R2 ES HIDROGENO, ALQUILO C1-C6, HALOGENO, CIANO, CARBOXILO, NITRO O -NHR7 EN QUE R7 SE DEFINE COMO SE HA HECHO ARRIBA; R3 ES HIDROGENO, ALQUILO C1-C6 O ALCANOILO C2-C6; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS; Y EN DONDE, CUANDO R2 ES HIDROGENO, ALQUILO C1-C6, HALOGENO O CIANO Y R3 ES HIDROGENO Y N ES COMO SE HA DEFINIDO ARRIBA, AL MISMO TIEMPO, ENTONCES POR LO MENOS UNO DE ENTRE R4, R5 Y R6 ES DISTINTO DE HIDROGENO, QUE SON UTILES COMO INHIBIDORES DE LA QUINASA DE TIROSINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919115160A GB9115160D0 (en) | 1991-07-12 | 1991-07-12 | Methylen-oxindole derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2165357T3 true ES2165357T3 (es) | 2002-03-16 |
Family
ID=10698323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92914619T Expired - Lifetime ES2165357T3 (es) | 1991-07-12 | 1992-07-10 | Derivados de metileno-oxiindol y procedimiento de elaboracion. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5409949A (es) |
| EP (2) | EP0525472A3 (es) |
| JP (1) | JP3188701B2 (es) |
| KR (1) | KR930702337A (es) |
| AT (1) | ATE206420T1 (es) |
| AU (1) | AU656015B2 (es) |
| CA (1) | CA2091058C (es) |
| DE (1) | DE69232093T2 (es) |
| DK (1) | DK0552329T3 (es) |
| ES (1) | ES2165357T3 (es) |
| FI (1) | FI931061A0 (es) |
| GB (1) | GB9115160D0 (es) |
| HU (1) | HUT67496A (es) |
| IE (1) | IE922253A1 (es) |
| IL (1) | IL102383A (es) |
| MX (1) | MX9204008A (es) |
| NZ (1) | NZ243454A (es) |
| PT (1) | PT552329E (es) |
| RU (1) | RU2072989C1 (es) |
| TW (1) | TW202444B (es) |
| WO (1) | WO1993001182A1 (es) |
| ZA (1) | ZA925169B (es) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
| US5587385A (en) * | 1991-12-24 | 1996-12-24 | Farmitalia Carlo Erba S.R.L. | Arylidene-heterocyclic derivatives and process for their preparation |
| GB9313638D0 (en) * | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
| GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
| GB9406137D0 (en) * | 1994-03-28 | 1994-05-18 | Erba Carlo Spa | N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation |
| GB9412719D0 (en) * | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| GB9507298D0 (en) * | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9610964D0 (en) * | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| EP1247803A3 (en) * | 1996-08-23 | 2002-10-16 | Sugen, Inc. | Indolinone compounds suitable for modulation of protein kinases |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| US6051597A (en) * | 1997-06-13 | 2000-04-18 | Merck & Co., Inc. | Indolylquinones as antidiabetic agents |
| US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| CA2321307A1 (en) | 1998-02-27 | 1999-09-02 | Venkatachala L. Narayanan | Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs |
| US6102942A (en) | 1998-03-30 | 2000-08-15 | Endovascular Technologies, Inc. | Stent/graft deployment catheter with a stent/graft attachment mechanism |
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| DE19826517B4 (de) * | 1998-06-15 | 2006-03-23 | Baxter Healthcare S.A. | Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette |
| CA2383623A1 (en) * | 1998-08-04 | 2000-02-17 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
| US6680335B2 (en) | 1998-09-28 | 2004-01-20 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| BR9916324A (pt) | 1998-12-17 | 2001-10-02 | Hoffmann La Roche | 4,5-pirazinoxindóis como inibidores de proteìna quinase |
| US6153634A (en) * | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| JP2002532493A (ja) | 1998-12-17 | 2002-10-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｊｎｋプロテインキナーゼ阻害剤としての４−アリールオキシインドール |
| EP1157019B1 (en) * | 1998-12-17 | 2003-03-19 | F. Hoffmann-La Roche Ag | 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular cdk2 |
| JP2000247949A (ja) * | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| JP2002540096A (ja) * | 1999-03-24 | 2002-11-26 | スージェン・インコーポレーテッド | キナーゼ阻害剤としてのインドリノン化合物 |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| ES2341843T3 (es) | 2000-02-03 | 2010-06-29 | EISAI R&D MANAGEMENT CO., LTD. | Inhibidores de la expresion de integrina. |
| US6573293B2 (en) | 2000-02-15 | 2003-06-03 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| MY128449A (en) | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| US6706709B2 (en) | 2000-06-02 | 2004-03-16 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| US6599902B2 (en) | 2001-05-30 | 2003-07-29 | Sugen, Inc. | 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| AR038957A1 (es) * | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| JP2005508953A (ja) | 2001-10-10 | 2005-04-07 | スージェン・インコーポレーテッド | キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体 |
| EP1481678A4 (en) * | 2002-03-05 | 2009-12-30 | Eisai R&D Man Co Ltd | ANTITUMORAL AGENT CONTAINING A SULFONAMIDE-CONTAINING HETEROCYCLIC COMPOUND AND AN ANGIOGENESIS INHIBITOR |
| US20050107819A1 (en) * | 2003-11-14 | 2005-05-19 | Medtronic Vascular, Inc. | Catheter with a sectional guidewire shaft |
| US8772269B2 (en) * | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| WO2010149943A1 (en) * | 2009-06-25 | 2010-12-29 | Oncorel Ab | New compounds and medical use |
| CN103274988B (zh) * | 2013-06-20 | 2016-04-13 | 河北大学 | 3-(氰基-p-硝基苯甲撑基)-2-吲哚酮衍生物及其合成方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3310891A1 (de) * | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| JPH03213847A (ja) * | 1990-01-18 | 1991-09-19 | Konica Corp | ハロゲン化銀写真感光材料 |
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
-
1991
- 1991-07-12 GB GB919115160A patent/GB9115160D0/en active Pending
-
1992
- 1992-07-02 IL IL102383A patent/IL102383A/xx not_active IP Right Cessation
- 1992-07-06 TW TW081105346A patent/TW202444B/zh active
- 1992-07-06 NZ NZ243454A patent/NZ243454A/en unknown
- 1992-07-08 MX MX9204008A patent/MX9204008A/es not_active IP Right Cessation
- 1992-07-10 EP EP19920111757 patent/EP0525472A3/en active Pending
- 1992-07-10 ES ES92914619T patent/ES2165357T3/es not_active Expired - Lifetime
- 1992-07-10 RU RU9293004893A patent/RU2072989C1/ru active
- 1992-07-10 DK DK92914619T patent/DK0552329T3/da active
- 1992-07-10 ZA ZA925169A patent/ZA925169B/xx unknown
- 1992-07-10 JP JP50198193A patent/JP3188701B2/ja not_active Expired - Fee Related
- 1992-07-10 HU HU9300723A patent/HUT67496A/hu unknown
- 1992-07-10 CA CA002091058A patent/CA2091058C/en not_active Expired - Fee Related
- 1992-07-10 AU AU22777/92A patent/AU656015B2/en not_active Ceased
- 1992-07-10 WO PCT/EP1992/001569 patent/WO1993001182A1/en not_active Ceased
- 1992-07-10 PT PT92914619T patent/PT552329E/pt unknown
- 1992-07-10 IE IE225392A patent/IE922253A1/en not_active Application Discontinuation
- 1992-07-10 DE DE69232093T patent/DE69232093T2/de not_active Expired - Fee Related
- 1992-07-10 AT AT92914619T patent/ATE206420T1/de not_active IP Right Cessation
- 1992-07-10 EP EP92914619A patent/EP0552329B1/en not_active Expired - Lifetime
- 1992-07-10 US US07/987,280 patent/US5409949A/en not_active Expired - Lifetime
-
1993
- 1993-03-10 FI FI931061A patent/FI931061A0/fi not_active Application Discontinuation
- 1993-03-12 KR KR1019930700756A patent/KR930702337A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NZ243454A (en) | 1995-02-24 |
| DE69232093T2 (de) | 2002-05-16 |
| CA2091058C (en) | 2004-03-30 |
| DE69232093D1 (de) | 2001-11-08 |
| WO1993001182A1 (en) | 1993-01-21 |
| JPH06501494A (ja) | 1994-02-17 |
| PT552329E (pt) | 2002-02-28 |
| KR930702337A (ko) | 1993-09-08 |
| GB9115160D0 (en) | 1991-08-28 |
| IE922253A1 (en) | 1993-01-13 |
| FI931061A7 (fi) | 1993-03-10 |
| EP0552329A1 (en) | 1993-07-28 |
| EP0525472A3 (en) | 1993-02-24 |
| US5409949A (en) | 1995-04-25 |
| TW202444B (es) | 1993-03-21 |
| CA2091058A1 (en) | 1993-01-13 |
| HU9300723D0 (en) | 1993-06-28 |
| HUT67496A (en) | 1995-04-28 |
| EP0552329B1 (en) | 2001-10-04 |
| AU2277792A (en) | 1993-02-11 |
| FI931061A0 (fi) | 1993-03-10 |
| IL102383A0 (en) | 1993-01-14 |
| MX9204008A (es) | 1993-01-01 |
| ATE206420T1 (de) | 2001-10-15 |
| AU656015B2 (en) | 1995-01-19 |
| JP3188701B2 (ja) | 2001-07-16 |
| RU2072989C1 (ru) | 1997-02-10 |
| EP0525472A2 (en) | 1993-02-03 |
| ZA925169B (en) | 1993-04-28 |
| DK0552329T3 (da) | 2001-11-12 |
| IL102383A (en) | 1997-09-30 |
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