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ES2178693T3 - Agentes antifungicos peptidicos ciclicos. - Google Patents

Agentes antifungicos peptidicos ciclicos.

Info

Publication number
ES2178693T3
ES2178693T3 ES96303603T ES96303603T ES2178693T3 ES 2178693 T3 ES2178693 T3 ES 2178693T3 ES 96303603 T ES96303603 T ES 96303603T ES 96303603 T ES96303603 T ES 96303603T ES 2178693 T3 ES2178693 T3 ES 2178693T3
Authority
ES
Spain
Prior art keywords
chem
alkyl
antifungic
agents
cyclic peptidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96303603T
Other languages
English (en)
Inventor
Lisa Marie Hammond Lagrandeur
Michael John Rodriguez
Mark James Zweifel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2178693T3 publication Critical patent/ES2178693T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE PROPORCIONAN FORMULACIONES FARMACEUTICAS Y METODOS PARA LA INHIBICION DE LA ACTIVIDAD FUNGAL Y PARASITARIA UTILIZANDO UN COMPUESTO DE FORMULA I DONDE R'', R", R"'', R{SUP,X1}, R{SUP,X2}, R{SUP,Y1}, R{SUP,Y2}, R{SUP,Y3}, R{SUP,Y4} Y R{SUP,0} SON COMO SE DEFINEN ANTERIORMENTE; Y R{SUP,2} ES O R{SUP,3} ES O R{SUP,3A} ES ALQUILO C{SUB,1}-C{SUB,6} O ALCOXI C{SUB,1}C{SUB,6}; R{SUP3B} Y R{SUP,3C} SON INDEPENDIENTEMENTE FENILO O NAFTILO; R{SUP,3D} ES ALQUILO C{SUB,1}-C{SUB,12}, ALCOXI C{SUB,1}C{SUB,12} O -O-(CH{SUB,2}){SUB,M}-[O-(CH{SUB,2}){SUB,N}]{SUB,P}O-(ALQUILO C{SUB,1}-C{SUB,12}); M ES 2, 3 O 4; N ES 2, 3 O 4; P ES O O 1; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS
ES96303603T 1995-05-26 1996-05-21 Agentes antifungicos peptidicos ciclicos. Expired - Lifetime ES2178693T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45170595A 1995-05-26 1995-05-26

Publications (1)

Publication Number Publication Date
ES2178693T3 true ES2178693T3 (es) 2003-01-01

Family

ID=23793379

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96303603T Expired - Lifetime ES2178693T3 (es) 1995-05-26 1996-05-21 Agentes antifungicos peptidicos ciclicos.

Country Status (12)

Country Link
US (1) US5629290A (es)
EP (1) EP0744406B1 (es)
JP (1) JPH11505846A (es)
AT (1) ATE223432T1 (es)
AU (1) AU5799396A (es)
CA (1) CA2220688A1 (es)
DE (1) DE69623387T2 (es)
ES (1) ES2178693T3 (es)
IL (1) IL118332A0 (es)
PE (1) PE38297A1 (es)
WO (1) WO1996037511A1 (es)
ZA (1) ZA964012B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
ATE287899T1 (de) 1998-08-20 2005-02-15 Lilly Co Eli Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
RU2001118849A (ru) 1998-12-09 2003-08-10 Эли Лилли энд Компани (US) Очистка циклопептидных соединений эхинокандина
ATE248187T1 (de) 1999-03-03 2003-09-15 Lilly Co Eli Echinocandin-kohlenhydrate-komplexe
ES2433678T3 (es) * 1999-03-03 2013-12-12 Eli Lilly & Company Formulaciones farmacéuticas de equinocandina que contienen tensioactivos formadores de micelas
HK1040369A1 (zh) 1999-03-03 2002-06-07 Eli Lilly And Company 制备药物口服ecb配方和组合物的方法
BR0009248A (pt) 1999-03-03 2001-11-20 Lilly Co Eli Formação e troca de ânion de sais de amÈnioequinocandina cristalinos
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
US7109519B2 (en) * 2003-07-15 2006-09-19 3M Innovative Properties Company Bis(2-acenyl)acetylene semiconductors
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IE912046A1 (en) * 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
CZ288974B6 (cs) * 1992-03-19 2001-10-17 Eli Lilly And Company Acylový derivát echinocandinu, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a jeho pouľití

Also Published As

Publication number Publication date
JPH11505846A (ja) 1999-05-25
ATE223432T1 (de) 2002-09-15
DE69623387D1 (de) 2002-10-10
PE38297A1 (es) 1997-10-09
EP0744406A3 (en) 1998-05-20
IL118332A0 (en) 1996-09-12
CA2220688A1 (en) 1996-11-28
EP0744406A2 (en) 1996-11-27
WO1996037511A1 (en) 1996-11-28
US5629290A (en) 1997-05-13
EP0744406B1 (en) 2002-09-04
AU5799396A (en) 1996-12-11
ZA964012B (en) 1997-11-20
DE69623387T2 (de) 2003-01-09

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