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EA199700307A1 - Циклические пептидные антигрибковые агенты - Google Patents

Циклические пептидные антигрибковые агенты

Info

Publication number
EA199700307A1
EA199700307A1 EA199700307A EA199700307A EA199700307A1 EA 199700307 A1 EA199700307 A1 EA 199700307A1 EA 199700307 A EA199700307 A EA 199700307A EA 199700307 A EA199700307 A EA 199700307A EA 199700307 A1 EA199700307 A1 EA 199700307A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrogen
antigribus
agents
cyclic peptide
methyl
Prior art date
Application number
EA199700307A
Other languages
English (en)
Other versions
EA000464B1 (ru
Inventor
Питер С. Борромео
Джеймс Э. Джемисон
Майкл Дж. Родригез
Уильям В. мл. Тернер
Венкатрагхаван Васудеван
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199700307A1 publication Critical patent/EA199700307A1/ru
Publication of EA000464B1 publication Critical patent/EA000464B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Предложены фармацевтические препараты и методы ингибирования грибковой и паразитарной активности с использованием соединения формулы (I)где R' обозначает водород, метил или NHC(O)CH-; R" и R'" обозначают, независимо, метил или водород; R, R, R, R, Rи Rобозначают, независимо, гидрокси или водород; Rпредставляет собой группу с общей формулой (1); Rявляется C-Cалкилом, C-Cалкокси, фенилом, п-галогенфенилом, п-нитрофенилом, фенокси, бензилом, п-галогенбензилом или п-нитробензилом; и Rявляется боковой цепью, структура которой определена здесь.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700307A 1995-04-07 1996-04-03 Циклические пептидные антигрибковые агенты EA000464B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41834195A 1995-04-07 1995-04-07
PCT/US1996/004543 WO1996031228A1 (en) 1995-04-07 1996-04-03 Cyclic peptide antifungal agents

Publications (2)

Publication Number Publication Date
EA199700307A1 true EA199700307A1 (ru) 1998-04-30
EA000464B1 EA000464B1 (ru) 1999-08-26

Family

ID=23657711

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700307A EA000464B1 (ru) 1995-04-07 1996-04-03 Циклические пептидные антигрибковые агенты

Country Status (29)

Country Link
US (1) US5646111A (ru)
EP (1) EP0736541B1 (ru)
JP (1) JPH11504005A (ru)
KR (1) KR19980703646A (ru)
CN (1) CN1185739A (ru)
AR (2) AR002731A1 (ru)
AT (1) ATE228535T1 (ru)
AU (1) AU702841B2 (ru)
BR (1) BR9604906A (ru)
CA (1) CA2217048A1 (ru)
CO (1) CO4700480A1 (ru)
CZ (1) CZ291702B6 (ru)
DE (1) DE69624966T2 (ru)
EA (1) EA000464B1 (ru)
ES (1) ES2187617T3 (ru)
HU (1) HUP9800809A3 (ru)
IL (1) IL117749A (ru)
IN (1) IN181897B (ru)
MX (1) MX9707611A (ru)
MY (1) MY132116A (ru)
NO (1) NO974562L (ru)
NZ (1) NZ305735A (ru)
PE (1) PE39097A1 (ru)
PL (1) PL322821A1 (ru)
TR (1) TR199701122T1 (ru)
UA (1) UA46759C2 (ru)
WO (1) WO1996031228A1 (ru)
YU (1) YU22496A (ru)
ZA (1) ZA962598B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
CA2244238A1 (en) * 1996-02-01 1997-08-07 Eli Lilly And Company Cyclic peptide antifungal agents
WO1999006062A1 (en) * 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
UA72200C2 (ru) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Производные эхинокандина, способ их получения и их применение в качестве противогрибковых средств
AU2003200556B2 (en) * 1997-12-10 2005-12-01 Novexel Echinocandin derivative and their preparation method
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
MA26663A1 (fr) 1998-07-23 2004-12-20 Hoffmann La Roche Nouvelles aerothricines et leurs applications antifongiques
ATE287899T1 (de) 1998-08-20 2005-02-15 Lilly Co Eli Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
JP2003511345A (ja) 1998-12-09 2003-03-25 イーライ リリー アンド カンパニー Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製
IL145186A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Formation and anion-exchange of crystalline echinocandin ammonium salts
KR20020003864A (ko) 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
BR0008713A (pt) 1999-03-03 2001-12-26 Lilly Co Eli Processos para preparar formulações ecomposições farmacêuticas orais com ecb
RU2250763C2 (ru) * 1999-03-03 2005-04-27 Эли Лилли Энд Компани Фармацевтические препараты эхинокандина, содержащие мицелообразующие поверхностно-активные вещества
FR2794747B1 (fr) 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
DE60110209T2 (de) 2000-01-17 2006-05-11 Basilea Pharmaceutica Ag Aerothricin analoge, deren herstellung und verwendung
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
CN103570530B (zh) * 2012-07-26 2016-08-10 鲁南新时代生物技术有限公司 一种阿尼芬净侧链中间体的制备方法
CN104003895B (zh) * 2014-05-29 2016-02-24 黑龙江大学 一种钯催化的串联反应合成三联苯类化合物的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
NZ247149A (en) * 1992-03-19 1996-10-28 Lilly Co Eli Cyclic peptide antifungal agents and compositions thereof

Also Published As

Publication number Publication date
IN181897B (ru) 1998-10-24
CN1185739A (zh) 1998-06-24
IL117749A (en) 2000-06-01
MX9707611A (es) 1997-12-31
KR19980703646A (ko) 1998-12-05
CA2217048A1 (en) 1996-10-10
PE39097A1 (es) 1997-10-13
DE69624966D1 (de) 2003-01-09
CO4700480A1 (es) 1998-12-29
AU5383496A (en) 1996-10-23
EP0736541B1 (en) 2002-11-27
MY132116A (en) 2007-09-28
BR9604906A (pt) 1998-07-21
YU22496A (sh) 1999-06-15
AU702841B2 (en) 1999-03-04
CZ310297A3 (cs) 1998-06-17
NZ305735A (en) 1999-01-28
DE69624966T2 (de) 2003-03-27
EP0736541A1 (en) 1996-10-09
TR199701122T1 (xx) 1998-02-21
UA46759C2 (uk) 2002-06-17
NO974562L (no) 1997-11-28
US5646111A (en) 1997-07-08
NO974562D0 (no) 1997-10-02
HUP9800809A2 (hu) 1998-08-28
AR004170A1 (es) 1998-11-04
CZ291702B6 (cs) 2003-05-14
ES2187617T3 (es) 2003-06-16
JPH11504005A (ja) 1999-04-06
ATE228535T1 (de) 2002-12-15
WO1996031228A1 (en) 1996-10-10
PL322821A1 (en) 1998-02-16
EA000464B1 (ru) 1999-08-26
AR002731A1 (es) 1998-04-29
IL117749A0 (en) 1996-08-04
ZA962598B (en) 1997-10-01
HUP9800809A3 (en) 1998-12-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU