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EA200300792A1 - Хиназолины в качестве ингибиторов ммр-13 - Google Patents

Хиназолины в качестве ингибиторов ммр-13

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Publication number
EA200300792A1
EA200300792A1 EA200300792A EA200300792A EA200300792A1 EA 200300792 A1 EA200300792 A1 EA 200300792A1 EA 200300792 A EA200300792 A EA 200300792A EA 200300792 A EA200300792 A EA 200300792A EA 200300792 A1 EA200300792 A1 EA 200300792A1
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EA
Eurasian Patent Office
Prior art keywords
description
sulfur
alkyl
oxygen
possibly
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Application number
EA200300792A
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English (en)
Inventor
Шарль Андрианьяра
Николь Шантэль-Бэрвиан
Бернар Годийер
Анри Якобелли
Дэниел Фред Ортвайн
Уильям Честер Патт
Лай Фам
Кэтрин Роуз Костлэн
Майкл Уильям Уилсон
Original Assignee
УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си
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Publication of EA200300792A1 publication Critical patent/EA200300792A1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Соединение, выбранное из соединений формулы (I), в котором Rпредставляет собой группу, выбранную из водорода, амино, алкила, алкенила, аминоалкила, арила, арилалкила, гетероцикла и циклоалкилалкила, возможно замещенных, W представляет собой кислород, серу или =N-R', где R' является таким, как определено в описании, X, Xи Xпредставляют собой азот или -C-R, где Rявляется таким, как определено в описании, Y представляет собой кислород, серу, -NH или -N(C-C)алкил, Z представляет собой кислород, серу, -NR, где Rявляется таким, как определено в описании, и, возможно, атом углерода, n является целым числом от 1 до 8 включительно, Zпредставляет собой -CRR, где Rи Rявляются такими, как определено в описании, A представляет собой ароматическую или неароматическую гетероциклическую или негетероциклическую кольцевую систему, m является целым числом от 0 до 7 включительно, группа(ы) Rявляется(ются) такой(ими), как определено в описании, Rпредставляет собой водород, алкил, алкенил, алкинил или группу формулы, в которой Z, B, R, P и q являются такими, как определено в описании, возможно, его рацемические формы, его изомеры, его N-оксиды и его фармацевтически приемлемые соли и лекарственные продукты, содержащие их, полезны в качестве специфических ингибиторов матриксной металлопротеазы типа 13.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300792A 2001-02-14 2002-02-11 Хиназолины в качестве ингибиторов ммр-13 EA200300792A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26866101P 2001-02-14 2001-02-14
PCT/EP2002/001979 WO2002064572A1 (en) 2001-02-14 2002-02-11 Quinazolines as mmp-13 inhibitors

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EA200300792A1 true EA200300792A1 (ru) 2004-02-26

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US (1) US20020193377A1 (ru)
EP (1) EP1368324A1 (ru)
JP (1) JP2004523546A (ru)
KR (1) KR20030074827A (ru)
CN (1) CN1537105A (ru)
AP (1) AP2003002841A0 (ru)
AR (1) AR032676A1 (ru)
BG (1) BG108091A (ru)
BR (1) BR0207268A (ru)
CA (1) CA2437122A1 (ru)
CZ (1) CZ20032142A3 (ru)
EA (1) EA200300792A1 (ru)
EC (1) ECSP034730A (ru)
EE (1) EE200300384A (ru)
HU (1) HUP0303164A2 (ru)
IL (1) IL157109A0 (ru)
IS (1) IS6886A (ru)
MA (1) MA26994A1 (ru)
MX (1) MXPA03007248A (ru)
NO (1) NO20033593D0 (ru)
OA (1) OA12550A (ru)
PA (1) PA8539401A1 (ru)
PE (1) PE20021005A1 (ru)
PL (1) PL367396A1 (ru)
SK (1) SK10012003A3 (ru)
SV (1) SV2003000876A (ru)
TN (1) TNSN03045A1 (ru)
UY (1) UY27173A1 (ru)
WO (1) WO2002064572A1 (ru)
ZA (1) ZA200306008B (ru)

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MXPA05000754A (es) * 2002-07-17 2005-04-19 Warner Lambert Co Combinacion de un inhibidor carboxilico alosterico de la metaloproteinasa de matriz-13 con celecoxib o valdecoxib.
EP1531904A1 (en) * 2002-07-17 2005-05-25 Warner-Lambert Company LLC Combination of an allosteric inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
CA2492387A1 (en) * 2002-07-17 2004-01-22 Warner-Lambert Company Llc Combination of an allosteric carboxylic of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
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