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ES2004856T3 - Agente tensioactivo pulmonar natural, procedimiento de preparacion y composiciones farmaceuticas. - Google Patents

Agente tensioactivo pulmonar natural, procedimiento de preparacion y composiciones farmaceuticas.

Info

Publication number
ES2004856T3
ES2004856T3 ES88105232T ES88105232T ES2004856T3 ES 2004856 T3 ES2004856 T3 ES 2004856T3 ES 88105232 T ES88105232 T ES 88105232T ES 88105232 T ES88105232 T ES 88105232T ES 2004856 T3 ES2004856 T3 ES 2004856T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
preparation procedure
natural pulmonary
tensioactive agent
tensioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88105232T
Other languages
English (en)
Other versions
ES2004856A4 (es
Inventor
Bengt Dept Of Pediat Robertson
Tore Dept Of Pediatri Curstedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of ES2004856A4 publication Critical patent/ES2004856A4/es
Application granted granted Critical
Publication of ES2004856T3 publication Critical patent/ES2004856T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN TENSIOACTIVO PULMONAR DE ORIGEN ANIMAL HECHO CON UN ALTO PORCENTAJE DE FOSFOLIPIDOS (99%) POR UNA FRACCION PROTEINICA Y CARACTERIZADO POR LA AUSENCIA DE HIDRATOS DE CARBONO Y COLESTEROL. EL TENSIOACTIVO DE ESTA INVENCION, OBTENIDO POR FILTRACION, CENTRIFUGACION Y EXTRACCION Y POR CROMATOGRAFIA EN FASE INVERSA, PERMITE MEJORES RESULTADOS TERAPEUTICOS EN EL TRATAMIENTO DEL SINDROME DE DISTRES RESPIRATORIO DEL RECIEN NACIDO Y DEL ADULTO (SDRRN Y SRDA).
ES88105232T 1987-04-08 1988-03-31 Agente tensioactivo pulmonar natural, procedimiento de preparacion y composiciones farmaceuticas. Expired - Lifetime ES2004856T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8720032A IT1203873B (it) 1987-04-08 1987-04-08 Composizioni farmaceutiche che lo surfattante polmonare naturale, contengono. metodo di preparazione e

Publications (2)

Publication Number Publication Date
ES2004856A4 ES2004856A4 (es) 1989-02-16
ES2004856T3 true ES2004856T3 (es) 1994-12-16

Family

ID=11163272

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88105232T Expired - Lifetime ES2004856T3 (es) 1987-04-08 1988-03-31 Agente tensioactivo pulmonar natural, procedimiento de preparacion y composiciones farmaceuticas.

Country Status (22)

Country Link
US (1) US5024995A (es)
EP (1) EP0286011B1 (es)
JP (1) JP2700323B2 (es)
AT (1) ATE99949T1 (es)
AU (1) AU619462B2 (es)
CA (1) CA1320440C (es)
DE (2) DE3886970T2 (es)
DK (1) DK172921B1 (es)
EG (1) EG19626A (es)
ES (1) ES2004856T3 (es)
FI (1) FI92905C (es)
GR (1) GR890300026T1 (es)
HK (1) HK1007103A1 (es)
HU (1) HU211950A9 (es)
IE (1) IE61384B1 (es)
IT (1) IT1203873B (es)
MY (1) MY103260A (es)
NO (1) NO174733C (es)
NZ (1) NZ224146A (es)
PH (1) PH25300A (es)
PT (1) PT87188B (es)
ZA (1) ZA882416B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
DE3921954A1 (de) * 1989-07-04 1991-01-17 Thomae Gmbh Dr K Niedrig-viskose, hochkonzentrierte surfactant-suspension
WO1991017766A1 (fr) * 1990-05-18 1991-11-28 Tokyo Tanabe Company Limited Remede contre l'asthme
US5437272A (en) * 1991-05-01 1995-08-01 Alliance Pharmaceutical Corp. Perfluorocarbon associated gas exchange
ATE173920T1 (de) * 1991-05-03 1998-12-15 Alliance Pharma Partielle flüssigkeitsbeatmung mittels fluorkohlenwasserstoffen
DE69226372T2 (de) * 1991-11-14 1999-04-01 Alliance Pharmaceutical Corp., San Diego, Calif. Vorrichtung zur teilweisen flüssigen beatmung mit fluorkohlenwasserstoffen
IT1255967B (it) * 1992-11-27 1995-11-17 Chiesi Farma Spa Procedimento per la purificazione di materiale surfattante polmonare naturale con l'impiego di fluidi supercritici
US5531219A (en) * 1994-11-04 1996-07-02 Alliance Pharmaceutical Corp. Use of liquid fluorocarbons to facilitate pulmonary drug delivery
BR9506114A (pt) * 1994-12-29 1997-12-23 Ctro Nac Sanidad Agropecuaria Tensoativo pulmonar de origem suína e processo para a sua obtenção
US6129934A (en) * 1995-06-07 2000-10-10 Ony, Inc. Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
US6172203B1 (en) * 1996-02-07 2001-01-09 Alfredo Adolfo Hager Method for extracting and purifying pulmonary surfactant
WO1997029738A1 (en) * 1996-02-16 1997-08-21 The Administrators Of The Tulane Educational Fund Methods and compositions for treating eustachian tube dysfunction by inhalation
US7053176B1 (en) 1999-09-16 2006-05-30 Altana Pharma Ag Combination of C1-INH and lung surfactant for the treatment of respiratory disorders
US6676930B2 (en) 1999-11-28 2004-01-13 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
DE10018022A1 (de) * 2000-04-12 2001-10-31 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant zur Prophylaxe oder Frühbehandlung von akuten Lungenerkrankungen
ATE468131T1 (de) 2001-10-11 2010-06-15 Nycomed Gmbh Neue verwendung von lungensurfactant
RU2198670C1 (ru) * 2002-02-19 2003-02-20 ООО "Биосурф" Способ получения сурфактанта из легких крупного рогатого скота
CA2575513C (en) 2004-08-06 2014-09-16 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
SI1841458T1 (sl) 2005-01-06 2012-04-30 Discovery Lab Inc Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije
GB2426703B (en) * 2005-05-31 2007-09-19 Malvern Cosmeceutics Ltd Compositions
ZA200902487B (en) * 2006-09-19 2010-07-28 Discovery Lab Inc Pulmonary surfactant formulations and methods for promoting mucus clearance
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
DE102007025898A1 (de) * 2007-06-01 2008-12-04 Matthias W. Dr. Amrein Behandlung von Surfactanten
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
KR102113754B1 (ko) * 2017-07-07 2020-05-20 주식회사 리포바이오메드 화상 및 욕창의 완화 및 치료용 조성물
US11219843B2 (en) * 2019-07-08 2022-01-11 Nik Paya Karen Pharmed Extraction of animal-derived pulmonary surfactants
JP2024524512A (ja) 2021-07-05 2024-07-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 肺サーファクタントを調製する方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55160721A (en) * 1979-06-02 1980-12-13 Tokyo Tanabe Co Ltd Pulmonary surfactant ta-546, its preparation, and remedy for pulmonary hyaline membrane syndrome comprising it as active constituent
US4312860A (en) * 1980-10-24 1982-01-26 Regents Of The University Of California Lung surfactant compositions
JPS5845299A (ja) * 1981-09-10 1983-03-16 東京田辺製薬株式会社 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤
JPS58222022A (ja) * 1982-06-21 1983-12-23 Teijin Ltd 合成肺表面活性剤及びそれを有効成分とする呼吸窮迫症候群治療剤
JPS59164724A (ja) * 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
CS938384A1 (en) * 1983-12-08 1990-08-14 Lachmann Burkhardt Pharmaceutical agent for breathlesness therapy and method of its production
JPS6165821A (ja) * 1984-09-07 1986-04-04 Tokyo Tanabe Co Ltd 合成サ−フアクタント及びそれを有効成分とする肺表面活性物質喪失性無気肺の治療剤
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
EP0273916A4 (en) * 1986-05-06 1989-11-30 Childrens Hosp Medical Center LUNG HYDROPHOBES, PROTEIN ASSOCIATED TO A SURFACE ACTIVE MEDIUM OF 6000 DALTON MOLECULAR WEIGHT AND MULTIMEREOUS ITEMS.

Also Published As

Publication number Publication date
PT87188A (pt) 1988-05-01
DE3886970D1 (de) 1994-02-24
AU619462B2 (en) 1992-01-30
HU211950A9 (en) 1996-01-29
ES2004856A4 (es) 1989-02-16
DE286011T1 (de) 1989-03-09
AU1433788A (en) 1988-10-13
ZA882416B (en) 1988-09-28
PT87188B (pt) 1992-07-31
US5024995A (en) 1991-06-18
IT8720032A0 (it) 1987-04-08
EP0286011A3 (en) 1990-02-07
IE881008L (en) 1988-10-08
EP0286011B1 (en) 1994-01-12
FI881508A0 (fi) 1988-03-30
NO881515L (no) 1988-10-10
FI881508L (fi) 1988-10-09
EG19626A (en) 1995-09-30
HK1007103A1 (en) 1999-04-01
NO174733B (no) 1994-03-21
JP2700323B2 (ja) 1998-01-21
IT1203873B (it) 1989-02-23
CA1320440C (en) 1993-07-20
EP0286011A2 (en) 1988-10-12
NO174733C (no) 1994-06-29
JPS6463526A (en) 1989-03-09
GR890300026T1 (en) 1989-04-12
MY103260A (en) 1993-05-29
PH25300A (en) 1991-04-30
NZ224146A (en) 1991-06-25
IE61384B1 (en) 1994-11-02
DK190088A (da) 1988-10-09
DK172921B1 (da) 1999-10-04
NO881515D0 (no) 1988-04-07
DK190088D0 (da) 1988-04-07
FI92905B (fi) 1994-10-14
FI92905C (fi) 1995-01-25
DE3886970T2 (de) 1994-05-26
ATE99949T1 (de) 1994-01-15

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