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ES2083949T3 - Derivados de acridinio quimioluminiscentes y su empleo en inmunoanalisis por luminiscencia. - Google Patents

Derivados de acridinio quimioluminiscentes y su empleo en inmunoanalisis por luminiscencia.

Info

Publication number
ES2083949T3
ES2083949T3 ES87112022T ES87112022T ES2083949T3 ES 2083949 T3 ES2083949 T3 ES 2083949T3 ES 87112022 T ES87112022 T ES 87112022T ES 87112022 T ES87112022 T ES 87112022T ES 2083949 T3 ES2083949 T3 ES 2083949T3
Authority
ES
Spain
Prior art keywords
group
luminiscent
chemi
rest
acridinary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87112022T
Other languages
English (en)
Inventor
Peter Dr Molz
Heinz-Jurgen Dr Skrzipczyk
Henning Dr Lubbers
Helmut Dr Strecker
Gerd Dr Schnorr
Tonio Dr Kinkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2083949T3 publication Critical patent/ES2083949T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

DERIVADO DE ACRIDINA QUIMIOLUMINISCENTE DE FORMULA (I) EN EL QUE R1 ES HIDROGENO, ALQUILO, ALQUENILO, O UN RESTO ALQUINILO CON 1 A 10 ATOMOS DE , UN GRUPO BENCILO O ARILO; R2 Y R3 SON HIDROGENO, UN GRUPO ALQUILO CON 1 A 4 ATOMOS DE CARBONO, UN GRUPO AMINO SUSTITUIDO O NO, UN GRUPO CARBOXI, C1-C4ALCOXICIANO-, NITRO-, O CON HALOGENOS, R4 UN RESTO EN EL QUE UN GRUPO SULFONAMIDO ESTA COMBINADO DIRECTAMENTE CON UN GRUPO CARBONILO O UN RESTO TIOALQUILO O TIOARILO DE FORMULA -S-X-R5, EN EL QUE X ES UN GRUPO ALIFATICO O AROMATICO RAMIFICADO O NO QUE TAMBIEN PUEDE TENER HETEROATOMOS Y R5 UN GRUPO REACTIVO QUE TAMBIEN PUEDE ESTAR COMBINADO EN CONDICIONES CONVENIENTEMENTE SELECTIVAS CON AMINO-, CARBOXI-, TIOL- U OTROS GRUPOS FUNCIONALES EN SUSTANCIAS DE INTERES BIOLOGICO, Y A- ES UN ANION QUE PERJUDICA LA QUIMIOLUMINISCENCIA ASI COMO SU UTILIZACION EN ENSAYOS ENZIMO LUMINISCENTES.
ES87112022T 1986-08-22 1987-08-19 Derivados de acridinio quimioluminiscentes y su empleo en inmunoanalisis por luminiscencia. Expired - Lifetime ES2083949T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3628573A DE3628573C2 (de) 1986-08-22 1986-08-22 Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays

Publications (1)

Publication Number Publication Date
ES2083949T3 true ES2083949T3 (es) 1996-05-01

Family

ID=6307971

Family Applications (2)

Application Number Title Priority Date Filing Date
ES87112022T Expired - Lifetime ES2083949T3 (es) 1986-08-22 1987-08-19 Derivados de acridinio quimioluminiscentes y su empleo en inmunoanalisis por luminiscencia.
ES94119395T Expired - Lifetime ES2182835T3 (es) 1986-08-22 1987-08-19 Derivados de acridinio y su utilizacion en inmunoensayos de luminiscencia.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES94119395T Expired - Lifetime ES2182835T3 (es) 1986-08-22 1987-08-19 Derivados de acridinio y su utilizacion en inmunoensayos de luminiscencia.

Country Status (12)

Country Link
EP (2) EP0647628B1 (es)
JP (2) JPH0699401B2 (es)
AT (2) ATE132490T1 (es)
CA (1) CA1341402C (es)
DE (4) DE3645292C2 (es)
DK (1) DK171437B1 (es)
ES (2) ES2083949T3 (es)
FI (1) FI90542C (es)
GR (1) GR3019470T3 (es)
IE (1) IE74678B1 (es)
NO (1) NO171725C (es)
PT (1) PT85563B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3279029D1 (en) * 1981-12-11 1988-10-20 Welsh Nat School Med Luminescent labelling materials and procedures
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
EP0273115B1 (en) * 1986-10-22 1994-09-07 Abbott Laboratories Chemiluminescent acridinium and phenanthridinium salts
FR2625565A1 (fr) * 1987-12-31 1989-07-07 London Diagnostics Inc Esters, thioesters et amides chimioluminescents perfectionnes, et analyses les utilisant
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
DE3844954C2 (de) * 1988-02-20 1998-07-16 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
US6002007A (en) * 1988-02-20 1999-12-14 Dade Behring Marburg Gmbh Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
WO1992009580A1 (en) * 1990-11-21 1992-06-11 Beckman Instruments, Inc. Chemiluminescent compounds
DE4041080A1 (de) 1990-12-21 1992-06-25 Behringwerke Ag Verfahren zur bestimmung eines analyten
DE4228839A1 (de) 1992-08-29 1994-03-03 Behringwerke Ag Verfahren zum Nachweis und zur Bestimmung von Mediatoren
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
BE1008216A4 (fr) * 1994-01-25 1996-02-20 Biocode Sa Derives chemoluminescents heterocycliques.
MX9606598A (es) * 1994-06-24 1997-05-31 Behringwerke Ag Procedimiento para la estabilizacion de moleculas, o partes de moleculas, sensibles a la hidrolisis.
WO1996002839A1 (en) * 1994-07-15 1996-02-01 Abbott Laboratories Chemiluminescent signal enhancement
WO1996027785A1 (en) * 1995-03-03 1996-09-12 Abbott Laboratories Article and method for conducting chemiluminescent reaction
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (en) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof
WO1997033884A1 (en) * 1996-03-15 1997-09-18 Ss Pharmaceutical Co., Ltd. Reagents for labeling sh groups, process for the preparation of them, and method for labeling with them
CA2261032C (en) * 1996-07-16 2003-11-25 De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods
BE1011206A4 (fr) * 1997-06-11 1999-06-01 Biocode Sa Derives chimioluminescents heterocycliques.
EP1496050A1 (en) 2003-07-08 2005-01-12 Roche Diagnostics GmbH Novel chemiluminescent compounds and their use
EP1658495A1 (en) 2003-07-30 2006-05-24 Roche Diagnostics GmbH Novel chemiluminescent compounds and their use
DE602004027737D1 (de) 2003-07-30 2010-07-29 Roche Diagnostics Gmbh Neue chemilumineszenzverbindungen und ihre verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
GB2008247B (en) * 1977-11-17 1982-12-15 Welsh Nat School Med Detecting or quantifying substances using labelling techniques
DE3279029D1 (en) * 1981-12-11 1988-10-20 Welsh Nat School Med Luminescent labelling materials and procedures

Also Published As

Publication number Publication date
JPH0699401B2 (ja) 1994-12-07
PT85563A (de) 1987-09-01
FI90542C (fi) 1994-02-25
ATE132490T1 (de) 1996-01-15
JP2766780B2 (ja) 1998-06-18
EP0257541A2 (de) 1988-03-02
DE3645292C2 (de) 1997-12-11
GR3019470T3 (en) 1996-06-30
DK437187D0 (da) 1987-08-21
NO873520L (no) 1988-02-23
JPS6357572A (ja) 1988-03-12
IE872245L (en) 1988-02-22
CA1341402C (en) 2002-11-26
FI873609A7 (fi) 1988-02-23
DE3628573C2 (de) 1994-10-13
FI873609A0 (fi) 1987-08-20
IE74678B1 (en) 1997-07-30
FI90542B (fi) 1993-11-15
ATE223903T1 (de) 2002-09-15
DE3751659D1 (de) 1996-02-15
ES2182835T3 (es) 2003-03-16
NO171725B (no) 1993-01-18
EP0257541A3 (en) 1988-11-30
IE960911L (en) 1988-02-22
DE3752357D1 (de) 2002-10-17
DE3628573A1 (de) 1988-02-25
DK437187A (da) 1988-02-23
NO873520D0 (no) 1987-08-20
NO171725C (no) 1993-04-28
EP0647628A1 (de) 1995-04-12
PT85563B (pt) 1990-05-31
EP0257541B1 (de) 1996-01-03
JPH07179428A (ja) 1995-07-18
DK171437B1 (da) 1996-10-28
EP0647628B1 (de) 2002-09-11

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