EE200300328A - IL-18 inhibiitorite kasutamine südamehaiguse raviks ja/või ennetamiseks - Google Patents

IL-18 inhibiitorite kasutamine südamehaiguse raviks ja/või ennetamiseks

Info

Publication number: EE200300328A
Authority: EE; Estonia
Prior art keywords: inhibitors; prevention; treatment; heart disease; heart
Prior art date: 2001-01-29

Application number

EEP200300328A

Other languages

English (en)

Inventor

Dinarello Charles

Pomerantz Benjamin

Reznikov Leonid

Harken Alden

Chvatchko Yolande

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-29

Filing date

2002-01-28

Publication date

2003-10-15

2002-01-28 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

2003-10-15 Publication of EE200300328A publication Critical patent/EE200300328A/et

2012-04-16 Publication of EE05534B1 publication Critical patent/EE05534B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cell Biology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

EEP200300328A 2001-01-29 2002-01-28 IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks EE05534B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01101959		2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en)	2001-01-29	2002-01-28	Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (2)

Publication Number	Publication Date
EE200300328A true EE200300328A (et)	2003-10-15
EE05534B1 EE05534B1 (et)	2012-04-16

Family

ID=8176323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300328A EE05534B1 (et)	2001-01-29	2002-01-28	IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks

Country Status (31)

Country	Link
US (1)	US20040234523A1 (et)
EP (1)	EP1355668B1 (et)
JP (2)	JP4860897B2 (et)
KR (1)	KR100857376B1 (et)
CN (1)	CN1326562C (et)
AR (1)	AR032422A1 (et)
AT (1)	ATE380558T1 (et)
BG (1)	BG66483B1 (et)
BR (1)	BR0206819A (et)
CA (1)	CA2435466C (et)
CY (1)	CY1107203T1 (et)
CZ (1)	CZ305653B6 (et)
DE (1)	DE60224004T2 (et)
DK (1)	DK1355668T3 (et)
EA (2)	EA010180B1 (et)
EE (1)	EE05534B1 (et)
ES (1)	ES2295332T3 (et)
HR (1)	HRP20030609A2 (et)
HU (1)	HU229164B1 (et)
IL (2)	IL157024A0 (et)
ME (1)	ME00549B (et)
MX (1)	MXPA03006776A (et)
NO (1)	NO331083B1 (et)
PL (1)	PL213568B1 (et)
PT (1)	PT1355668E (et)
RS (1)	RS51125B (et)
SI (1)	SI1355668T1 (et)
SK (1)	SK287620B6 (et)
UA (1)	UA80676C2 (et)
WO (1)	WO2002060479A1 (et)
ZA (1)	ZA200305439B (et)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20110032012A (ko)	2000-02-10	2011-03-29	아보트 러보러터리즈	사람 인터류킨-１８에 결합하는 항체 및 이를 제조하고 사용하는 방법
EP1331943A4 (en)	2000-10-11	2005-01-26	Viron Therapeutics Inc	NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR IMMUNOMODULATION
US7718368B2 (en)	2000-12-04	2010-05-18	Viron Therapeutics Inc.	Immunomodulatory protein and useful embodiments thereof
SI1622939T1 (sl)	2003-05-13	2012-06-29	Merck Serono Sa	Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega
US7968684B2 (en)	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
JP4961559B2 (ja) *	2004-03-11	2012-06-27	友昭星野	インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
PT1885753E (pt)	2005-06-03	2011-10-06	Ares Trading Sa	Produção de proteína recombinante de ligação a il-18
RS52273B (sr)	2005-06-10	2012-10-31	Ares Trading S.A.	Proces za purifikaciju il-18 vezujućeg proteina
WO2009061832A1 (en)	2007-11-05	2009-05-14	Kci Licensing Inc.	Identification of tissue for debridement
JOP20200308A1 (ar)	2012-09-07	2017-06-16	Novartis Ag	جزيئات إرتباط il-18
HUE055608T2 (hu)	2013-09-05	2021-12-28	Ab2 Bio Sa	IL-18-kötõ fehérje (IL-18BP) gyulladásos betegségekben
JP7274259B2 (ja) *	2015-03-05	2023-05-16	エイビー２バイオソシエテアノニム	炎症性疾患におけるｉｌ－１８結合タンパク質（ｉｌ－１８ｂｐ）および抗体
US11091795B2 (en)	2016-07-11	2021-08-17	Arizona Board Of Regents On Behalf Of The University Of Arizona	Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

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US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) *	1989-09-05	1997-02-25	Immunex Corporation	Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) *	1995-11-21	1999-02-25	Yamanouchi Pharma Co Ltd	Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
IL125190A (en) *	1996-09-12	2003-01-12	Idun Pharmaceuticals Inc	Tricyclic compounds for the inhibition of the ice/ced-3 protease family of enzymes and pharmaceutical compositions containing the same
ATE346085T1 (de) *	1996-12-06	2006-12-15	Vertex Pharma	Inhibitoren des interleukin-1-beta konvertierenden enzyms
SI20110A (sl) *	1997-03-18	2000-06-30	Basf Aktiengesellschaft	Metode in sestavki za moduliranje odzivnosti na kortikosteroide
IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) *	1997-10-06	1998-11-26	Henkel Kgaa	Detergensgemische und deren Verwendung
WO2000000490A2 (en) *	1998-06-26	2000-01-06	Eli Lilly And Company	5-ht1f agonists
BR9816013A (pt) *	1998-09-01	2003-01-21	Hayashibara Biochem Lab	Proteìna de ligação de interleucina-18
EP1022027A1 (en) *	1999-01-22	2000-07-26	Applied Research Systems ARS Holding N.V.	Tumor necrosis factor antagonists and their use in endometriosis
CN1346344A (zh) *	1999-03-16	2002-04-24	西托维亚公司	取代的2－氨基苯甲酰胺天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其应用
US6355618B1 (en) *	1999-04-09	2002-03-12	Cytovia, Inc.	Caspase inhibitors and the use thereof
AU6078500A (en) *	1999-07-09	2001-01-30	Amgen, Inc.	Combination therapy for conditions leading to bone loss
KR20110032012A (ko) *	2000-02-10	2011-03-29	아보트 러보러터리즈	사람 인터류킨-１８에 결합하는 항체 및 이를 제조하고 사용하는 방법
CN1841066B (zh) *	2000-05-05	2012-08-29	默克雪兰诺有限公司	Il-18抑制剂在治疗和/或预防动脉粥样硬化中的应用
AU2002224417A1 (en) *	2000-10-18	2002-04-29	Immunex Corporation	Methods for treating il-18 mediated disorders

2002
- 2002-01-28 JP JP2002560670A patent/JP4860897B2/ja not_active Expired - Lifetime
- 2002-01-28 PL PL366802A patent/PL213568B1/pl unknown
- 2002-01-28 IL IL15702402A patent/IL157024A0/xx unknown
- 2002-01-28 EE EEP200300328A patent/EE05534B1/et unknown
- 2002-01-28 SK SK1089-2003A patent/SK287620B6/sk not_active IP Right Cessation
- 2002-01-28 HR HR20030609A patent/HRP20030609A2/xx not_active Application Discontinuation
- 2002-01-28 EA EA200501549A patent/EA010180B1/ru not_active IP Right Cessation
- 2002-01-28 DK DK02718052T patent/DK1355668T3/da active
- 2002-01-28 CZ CZ2003-2335A patent/CZ305653B6/cs not_active IP Right Cessation
- 2002-01-28 PT PT02718052T patent/PT1355668E/pt unknown
- 2002-01-28 BR BR0206819-2A patent/BR0206819A/pt not_active Application Discontinuation
- 2002-01-28 EP EP02718052A patent/EP1355668B1/en not_active Expired - Lifetime
- 2002-01-28 ME MEP-2008-681A patent/ME00549B/me unknown
- 2002-01-28 KR KR1020037009941A patent/KR100857376B1/ko not_active Expired - Lifetime
- 2002-01-28 CA CA2435466A patent/CA2435466C/en not_active Expired - Lifetime
- 2002-01-28 ES ES02718052T patent/ES2295332T3/es not_active Expired - Lifetime
- 2002-01-28 SI SI200230667T patent/SI1355668T1/sl unknown
- 2002-01-28 AT AT02718052T patent/ATE380558T1/de active
- 2002-01-28 RS YUP-578/03A patent/RS51125B/sr unknown
- 2002-01-28 DE DE60224004T patent/DE60224004T2/de not_active Expired - Lifetime
- 2002-01-28 ZA ZA200305439A patent/ZA200305439B/en unknown
- 2002-01-28 US US10/470,303 patent/US20040234523A1/en not_active Abandoned
- 2002-01-28 UA UA2003088056A patent/UA80676C2/uk unknown
- 2002-01-28 WO PCT/EP2002/000844 patent/WO2002060479A1/en not_active Ceased
- 2002-01-28 EA EA200300844A patent/EA006767B1/ru not_active IP Right Cessation
- 2002-01-28 HU HU0303306A patent/HU229164B1/hu unknown
- 2002-01-28 CN CNB02807503XA patent/CN1326562C/zh not_active Expired - Lifetime
- 2002-01-28 MX MXPA03006776A patent/MXPA03006776A/es active IP Right Grant
- 2002-01-29 AR ARP020100315A patent/AR032422A1/es unknown
2003
- 2003-07-16 NO NO20033228A patent/NO331083B1/no not_active IP Right Cessation
- 2003-07-20 IL IL157024A patent/IL157024A/en active IP Right Grant
- 2003-08-25 BG BG108128A patent/BG66483B1/bg unknown
2008
- 2008-02-18 CY CY20081100195T patent/CY1107203T1/el unknown
- 2008-12-16 JP JP2008319532A patent/JP2009102354A/ja active Pending

Also Published As

Publication number	Publication date
SK10892003A3 (sk)	2004-02-03
ES2295332T3 (es)	2008-04-16
EA006767B1 (ru)	2006-04-28
DE60224004D1 (de)	2008-01-24
CA2435466A1 (en)	2002-08-08
HUP0303306A3 (en)	2005-12-28
BG108128A (bg)	2004-11-30
EP1355668B1 (en)	2007-12-12
PT1355668E (pt)	2008-01-04
RS51125B (sr)	2010-10-31
EA200501549A1 (ru)	2006-04-28
ATE380558T1 (de)	2007-12-15
PL366802A1 (en)	2005-02-07
BR0206819A (pt)	2004-02-03
SI1355668T1 (sl)	2008-06-30
WO2002060479A1 (en)	2002-08-08
JP2009102354A (ja)	2009-05-14
KR100857376B1 (ko)	2008-09-05
DK1355668T3 (da)	2008-05-05
CA2435466C (en)	2012-04-03
CN1499982A (zh)	2004-05-26
CZ20032335A3 (en)	2004-07-14
NO331083B1 (no)	2011-10-03
JP2004522748A (ja)	2004-07-29
EP1355668A1 (en)	2003-10-29
HU229164B1 (en)	2013-09-30
NO20033228D0 (no)	2003-07-16
IL157024A0 (en)	2004-02-08
KR20030070143A (ko)	2003-08-27
SK287620B6 (sk)	2011-04-05
UA80676C2 (en)	2007-10-25
DE60224004T2 (de)	2009-07-23
ME00549B (me)	2011-10-10
BG66483B1 (bg)	2015-03-31
JP4860897B2 (ja)	2012-01-25
EE05534B1 (et)	2012-04-16
CZ305653B6 (cs)	2016-01-27
HUP0303306A2 (hu)	2004-01-28
HRP20030609A2 (en)	2005-06-30
NO20033228L (no)	2003-09-26
EA200300844A1 (ru)	2003-12-25
HK1062810A1 (en)	2004-11-26
MXPA03006776A (es)	2003-10-24
IL157024A (en)	2014-02-27
ZA200305439B (en)	2004-07-15
YU57803A (sh)	2006-05-25
EA010180B1 (ru)	2008-06-30
CY1107203T1 (el)	2012-11-21
PL213568B1 (pl)	2013-03-29
US20040234523A1 (en)	2004-11-25
AR032422A1 (es)	2003-11-05
CN1326562C (zh)	2007-07-18

Publication	Publication Date	Title
SI1487541T1 (sl)	2009-02-28	Uporaba inhibitorjev il-18 za zdravljenje in /alipreventivo bolezni perifernega oĺ˝ilja
DE60237823D1 (de)	2010-11-11	Medizinisches behandlungsinstrument
HUP0401127A3 (en)	2006-03-28	Treatment and diagnosis of macrophage disease
AU2003290548A8 (en)	2004-06-07	Prevention and treatment of synucleinopathic disease
EE200300485A (et)	2004-02-16	Tiohüdantoinid ja nende kasutamine diabeedi raviks
DE60322451D1 (de)	2008-09-04	4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung
NO20034590L (no)	2003-12-12	Fremgangsmåter for behandling av vaskul¶r sykdom
SI1627639T1 (sl)	2010-04-30	Uporaba inhibitorjev COX-2 za zdravljenje afektivnih motenj
FIU20060389U0 (fi)	2006-09-22	Luusairauksien hoito
EE200300585A (et)	2004-04-15	PDE4 inhibiitori ja antikolinergilise vahendi kombinatsioon obstruktiivsete hingamisteede haiguste raviks
PT1411926E (pt)	2005-10-31	Inibidores de integrina para o tratamento de doencas oftalmicas
NO20050569D0 (no)	2005-02-02	Fremgangsmate for behandling av alvorlig hjertesvikt og medikament for dette
ZA200208228B (en)	2005-07-27	Use of il-18 inhibitors for the treatment and/or prevention of athesclerosis
IS6966A (is)	2003-09-24	Cýanó-tengd díhýdrópýrimídín efnasambönd og notkun þeirra við meðhöndlun sjúkdóma
EE200300328A (et)	2003-10-15	IL-18 inhibiitorite kasutamine südamehaiguse raviks ja/või ennetamiseks
NO20041214L (no)	2004-06-24	Substituerte benzimidazolforbindelser og deres anvendelse for behandling av cancer
IS6967A (is)	2003-09-24	Ný cýanó-tengd díhýdrópýrimídín efnasambönd og notkun þeirra við meðhöndlun sjúkdóma
NO20054913D0 (no)	2005-10-24	Anvendelse av clustein for behandling og/eller forebyggelse av perifere nevrologiske lidelser
DE60222664D1 (de)	2007-11-08	Hautbehandlungsmittel
FI20021617A0 (fi)	2002-09-10	Diagnostisia ja terapeuttisia menetelmiä
EE200300057A (et)	2004-12-15	Koostis vähi profülaktikaks ja raviks
NO20042476L (no)	2004-06-14	Anvendelse av desoxypeganin for behandling av klinisk depresjon
PT1381620E (pt)	2006-06-30	Dissacaridos hipersulfatados e metodos de utilizacao dos mesmos para o tratamento de inflamacoes
EE200300570A (et)	2004-04-15	Imidasotriasinoonide derivaadid ja nende kasutamine põletikuliste protsesside ja/või immuunhaigustevastu
NO20043113L (no)	2004-09-01	Fremgangsmate for behandling av benforstyrrelse

Legal Events

Date	Code	Title	Description
2007-10-15	GB1A	Change in the ownership or in the address of the owner
2012-04-16	HC1A	Change of owner name