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EE05675B1 - Meetod konformse haiguse diagnoosimiseks v?i tuvastamiseks, selleks vajalik katsemenetlus, reaktiivikomplekt ning seade - Google Patents

Meetod konformse haiguse diagnoosimiseks v?i tuvastamiseks, selleks vajalik katsemenetlus, reaktiivikomplekt ning seade

Info

Publication number
EE05675B1
EE05675B1 EEP200300005A EEP200300005A EE05675B1 EE 05675 B1 EE05675 B1 EE 05675B1 EE P200300005 A EEP200300005 A EE P200300005A EE P200300005 A EEP200300005 A EE P200300005A EE 05675 B1 EE05675 B1 EE 05675B1
Authority
EE
Estonia
Prior art keywords
diagnosis
detection
test procedure
reagent kit
required test
Prior art date
Application number
EEP200300005A
Other languages
English (en)
Inventor
Soto Claudio
Saborio Gabriella
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200300005A publication Critical patent/EE200300005A/et
Publication of EE05675B1 publication Critical patent/EE05675B1/et

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200300005A 2000-07-07 2001-06-13 Meetod konformse haiguse diagnoosimiseks v?i tuvastamiseks, selleks vajalik katsemenetlus, reaktiivikomplekt ning seade EE05675B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (2)

Publication Number Publication Date
EE200300005A EE200300005A (et) 2004-08-16
EE05675B1 true EE05675B1 (et) 2013-08-15

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300005A EE05675B1 (et) 2000-07-07 2001-06-13 Meetod konformse haiguse diagnoosimiseks v?i tuvastamiseks, selleks vajalik katsemenetlus, reaktiivikomplekt ning seade

Country Status (30)

Country Link
US (1) US7351526B2 (et)
EP (2) EP1712920B1 (et)
JP (1) JP4790966B2 (et)
KR (1) KR100764981B1 (et)
CN (1) CN1221807C (et)
AR (1) AR029583A1 (et)
AT (2) ATE335204T1 (et)
AU (2) AU6408901A (et)
BG (1) BG66272B1 (et)
BR (1) BRPI0112262B8 (et)
CA (1) CA2413078C (et)
CY (1) CY1109106T1 (et)
CZ (1) CZ304365B6 (et)
DE (2) DE60138146D1 (et)
DK (2) DK1299729T3 (et)
EA (1) EA007391B1 (et)
EE (1) EE05675B1 (et)
ES (2) ES2322660T3 (et)
HR (1) HRP20030033B1 (et)
HU (1) HU228813B1 (et)
IL (2) IL153824A0 (et)
MX (1) MXPA03000226A (et)
NO (1) NO331624B1 (et)
NZ (1) NZ523213A (et)
PL (1) PL211154B1 (et)
PT (2) PT1712920E (et)
RS (1) RS51523B (et)
SI (2) SI1712920T1 (et)
SK (1) SK287768B6 (et)
WO (1) WO2002004954A2 (et)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002073210A1 (de) * 2001-03-13 2002-09-19 Manfred Eigen Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
WO2002097444A2 (en) 2001-05-31 2002-12-05 Arete Associates Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
CA2525517C (en) 2003-06-19 2016-05-31 Applied Research Systems Ars Holding N.V. Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
KR101166012B1 (ko) 2003-08-13 2012-07-23 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 프리온-특이적 펩티드 시약
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
CN101156068B (zh) * 2005-02-15 2015-03-18 阿德利夫股份有限公司 检测错折叠蛋白和朊病毒的方法
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
NZ566020A (en) 2005-09-09 2012-08-31 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
BRPI0714930A2 (pt) * 2006-07-28 2013-05-21 Adlyfe Inc sondas peptÍdicas para fins diagnàsticos e terapÊuticos
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders
EP2179293B1 (en) * 2007-07-20 2014-09-03 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
WO2009145194A1 (ja) 2008-05-28 2009-12-03 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
WO2009145195A1 (ja) 2008-05-28 2009-12-03 独立行政法人農業・食品産業技術総合研究機構 Ｂｓｅ由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
WO2011057029A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
US11249092B2 (en) 2017-05-16 2022-02-15 Amprion, Inc. Detection of misfolded tau protein
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
AU2012207454B2 (en) * 2011-01-18 2016-11-17 Prionics Ag Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
KR101483438B1 (ko) * 2014-04-17 2015-01-16 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
AU2015314783B2 (en) 2014-09-11 2021-10-21 Amprion, Inc. Detection of misfolded proteins
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ATE272842T1 (de) * 1996-10-15 2004-08-15 D Gen Ltd Diagnose spongiformer encephalopathie
WO2001000235A1 (en) * 1999-06-29 2001-01-04 Mcgill University Prion protein binding proteins and uses thereof
JP2003517848A (ja) * 1999-12-10 2003-06-03 ミソニクス インコーポレイテッド 超音波角アッセンブリ
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
MXPA03000226A (es) 2004-05-21
AU6408901A (en) 2002-01-21
AR029583A1 (es) 2003-07-02
DE60121958T2 (de) 2007-02-01
HUP0301020A2 (hu) 2003-07-28
SI1712920T1 (sl) 2009-10-31
ES2264691T3 (es) 2007-01-16
JP2004503748A (ja) 2004-02-05
PT1299729E (pt) 2006-10-31
EP1712920A1 (en) 2006-10-18
US7351526B2 (en) 2008-04-01
NZ523213A (en) 2005-01-28
EA007391B1 (ru) 2006-10-27
CY1109106T1 (el) 2014-07-02
HRP20030033B1 (hr) 2008-04-30
HUP0301020A3 (en) 2010-03-29
RS51523B (sr) 2011-06-30
SK18582002A3 (sk) 2003-05-02
DE60138146D1 (de) 2009-05-07
BRPI0112262B8 (pt) 2021-07-27
ATE335204T1 (de) 2006-08-15
YU101202A (sh) 2006-01-16
EE200300005A (et) 2004-08-16
WO2002004954A3 (en) 2002-10-24
SI1299729T1 (sl) 2006-10-31
CZ200336A3 (cs) 2003-06-18
PL360397A1 (en) 2004-09-06
PT1712920E (pt) 2009-04-09
JP4790966B2 (ja) 2011-10-12
HRP20030033A2 (en) 2004-02-29
PL211154B1 (pl) 2012-04-30
EP1299729A2 (en) 2003-04-09
ATE426816T1 (de) 2009-04-15
HK1058065A1 (en) 2004-04-30
DE60121958D1 (de) 2006-09-14
KR20030036257A (ko) 2003-05-09
BR0112262A (pt) 2003-05-20
BG107498A (bg) 2003-11-28
ES2322660T3 (es) 2009-06-24
US20050064505A1 (en) 2005-03-24
EP1712920B1 (en) 2009-03-25
EP1299729B1 (en) 2006-08-02
HU228813B1 (en) 2013-05-28
IL153824A (en) 2010-02-17
CA2413078C (en) 2010-08-03
CA2413078A1 (en) 2002-01-17
AU2001264089B2 (en) 2006-03-30
CN1449497A (zh) 2003-10-15
EA200300126A1 (ru) 2003-06-26
BRPI0112262B1 (pt) 2016-08-09
IL153824A0 (en) 2003-07-31
CZ304365B6 (cs) 2014-04-02
NO20030059L (no) 2003-03-07
BG66272B1 (bg) 2012-11-30
SK287768B6 (sk) 2011-09-05
DK1299729T3 (da) 2006-12-04
NO331624B1 (no) 2012-02-06
DK1712920T3 (da) 2009-05-11
CN1221807C (zh) 2005-10-05
WO2002004954A2 (en) 2002-01-17
KR100764981B1 (ko) 2007-10-09
NO20030059D0 (no) 2003-01-06

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