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EA200300126A1 - Ранняя диагностика конформационных заболеваний - Google Patents

Ранняя диагностика конформационных заболеваний

Info

Publication number
EA200300126A1
EA200300126A1 EA200300126A EA200300126A EA200300126A1 EA 200300126 A1 EA200300126 A1 EA 200300126A1 EA 200300126 A EA200300126 A EA 200300126A EA 200300126 A EA200300126 A EA 200300126A EA 200300126 A1 EA200300126 A1 EA 200300126A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diseases
conformational diseases
early diagnostics
conformational
pathogenic conformer
Prior art date
Application number
EA200300126A
Other languages
English (en)
Other versions
EA007391B1 (ru
Inventor
Клаудио Сото
Габриэлла Саборио
Original Assignee
Апплайд Резеч Системз Арс Холдинг Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Апплайд Резеч Системз Арс Холдинг Н.В. filed Critical Апплайд Резеч Системз Арс Холдинг Н.В.
Publication of EA200300126A1 publication Critical patent/EA200300126A1/ru
Publication of EA007391B1 publication Critical patent/EA007391B1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Описан способ диагностики или выявления конформационных заболеваний путем анализа образца на наличие маркера (патогенный конформер) указанных заболеваний; способ включает в себя систему циклической амплификации для повышения уровней патогенного конформера, который вызывает указанные заболевания. В частности, указанными трансмиссивными конформационными заболеваниями могут быть прионные энцефалопатии. Описаны также анализы, диагностические наборы и аппарат, основанные на указанных способах.Отчет о международном поиске был опубликован 2002.10.24.
EA200300126A 2000-07-07 2001-06-13 Способ диагностики или выявления конформационного заболевания или его маркера и набор для использования в способе EA007391B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (2)

Publication Number Publication Date
EA200300126A1 true EA200300126A1 (ru) 2003-06-26
EA007391B1 EA007391B1 (ru) 2006-10-27

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300126A EA007391B1 (ru) 2000-07-07 2001-06-13 Способ диагностики или выявления конформационного заболевания или его маркера и набор для использования в способе

Country Status (30)

Country Link
US (1) US7351526B2 (ru)
EP (2) EP1299729B1 (ru)
JP (1) JP4790966B2 (ru)
KR (1) KR100764981B1 (ru)
CN (1) CN1221807C (ru)
AR (1) AR029583A1 (ru)
AT (2) ATE335204T1 (ru)
AU (2) AU2001264089B2 (ru)
BG (1) BG66272B1 (ru)
BR (1) BRPI0112262B8 (ru)
CA (1) CA2413078C (ru)
CY (1) CY1109106T1 (ru)
CZ (1) CZ304365B6 (ru)
DE (2) DE60121958T2 (ru)
DK (2) DK1299729T3 (ru)
EA (1) EA007391B1 (ru)
EE (1) EE05675B1 (ru)
ES (2) ES2322660T3 (ru)
HR (1) HRP20030033B1 (ru)
HU (1) HU228813B1 (ru)
IL (2) IL153824A0 (ru)
MX (1) MXPA03000226A (ru)
NO (1) NO331624B1 (ru)
NZ (1) NZ523213A (ru)
PL (1) PL211154B1 (ru)
PT (2) PT1712920E (ru)
RS (1) RS51523B (ru)
SI (2) SI1299729T1 (ru)
SK (1) SK287768B6 (ru)
WO (1) WO2002004954A2 (ru)

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EP1373904A1 (de) * 2001-03-13 2004-01-02 Eigen, Manfred, Prof. Dr. Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
JP4235544B2 (ja) 2001-05-31 2009-03-11 アドライフ インコーポレーティッド 欠陥折畳み蛋白質センサー方法
AU2004248302B2 (en) 2003-06-19 2009-07-30 Merck Serono Sa Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
EP1651964A2 (en) * 2003-07-31 2006-05-03 Hadasit Medical Research Services & Development Ltd. Methods and kits for the detection of prion diseases
KR101166012B1 (ko) 2003-08-13 2012-07-23 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 프리온-특이적 펩티드 시약
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
BRPI0607350A2 (pt) * 2005-02-15 2009-09-01 Adlyfe Inc método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
ES2404940T3 (es) 2005-09-09 2013-05-29 Novartis Ag Reactivos de peptoide específicos para prión
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
EP2156181B1 (en) * 2006-07-28 2015-11-04 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
EP2074222A4 (en) * 2006-09-06 2010-03-03 Univ Texas METHOD AND COMPOSITIONS FOR DETECTING PROTEIN DISORDERING
WO2009015091A1 (en) * 2007-07-20 2009-01-29 The Government of the United States of America as represented by the Secretary of the Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
WO2009145195A1 (ja) 2008-05-28 2009-12-03 独立行政法人農業・食品産業技術総合研究機構 Ｂｓｅ由来異常プリオン蛋白質の効率的増幅方法
JP5209711B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
CA2779846A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US20160077112A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of Misfolded Proteins
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
AU2012207454B2 (en) * 2011-01-18 2016-11-17 Prionics Ag Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
WO2015160007A1 (ko) * 2014-04-17 2015-10-22 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
TW201901153A (zh) 2017-05-16 2019-01-01 美商安培恩股份有限公司 折疊錯誤之ｔａｕ蛋白的檢測及檢測折疊錯誤之ｔａｕ蛋白的套組
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
EA202092684A1 (ru) 2018-08-27 2021-03-11 Ридженерон Фармасьютикалз, Инк. Применение рамановской спектроскопии для последующей очистки
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

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US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
EP0934531B1 (en) * 1996-10-15 2004-08-04 D-Gen Limited Diagnosis of spongiform encephalopathy
EP1210110A4 (en) * 1999-06-29 2003-03-19 Univ Mcgill PRION PROTEIN BINDING PROTEINS, AND USES THEREOF
CA2393607A1 (en) * 1999-12-10 2001-06-28 Ronald R. Manna Ultrasonic horn assembly
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
CA2413078C (en) 2010-08-03
CA2413078A1 (en) 2002-01-17
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
CZ304365B6 (cs) 2014-04-02
PL360397A1 (en) 2004-09-06
SI1299729T1 (sl) 2006-10-31
EP1299729A2 (en) 2003-04-09
US20050064505A1 (en) 2005-03-24
BG107498A (bg) 2003-11-28
CN1449497A (zh) 2003-10-15
BRPI0112262B8 (pt) 2021-07-27
EE200300005A (et) 2004-08-16
DE60121958T2 (de) 2007-02-01
EP1299729B1 (en) 2006-08-02
NZ523213A (en) 2005-01-28
IL153824A0 (en) 2003-07-31
AU2001264089B2 (en) 2006-03-30
YU101202A (sh) 2006-01-16
JP2004503748A (ja) 2004-02-05
MXPA03000226A (es) 2004-05-21
US7351526B2 (en) 2008-04-01
CN1221807C (zh) 2005-10-05
PT1712920E (pt) 2009-04-09
EP1712920A1 (en) 2006-10-18
HRP20030033B1 (hr) 2008-04-30
SK287768B6 (sk) 2011-09-05
BR0112262A (pt) 2003-05-20
BRPI0112262B1 (pt) 2016-08-09
IL153824A (en) 2010-02-17
ATE335204T1 (de) 2006-08-15
EE05675B1 (et) 2013-08-15
DE60121958D1 (de) 2006-09-14
JP4790966B2 (ja) 2011-10-12
HU228813B1 (en) 2013-05-28
NO20030059L (no) 2003-03-07
ES2322660T3 (es) 2009-06-24
HUP0301020A3 (en) 2010-03-29
DK1712920T3 (da) 2009-05-11
BG66272B1 (bg) 2012-11-30
PL211154B1 (pl) 2012-04-30
EP1712920B1 (en) 2009-03-25
ES2264691T3 (es) 2007-01-16
KR20030036257A (ko) 2003-05-09
CZ200336A3 (cs) 2003-06-18
RS51523B (sr) 2011-06-30
DE60138146D1 (de) 2009-05-07
AR029583A1 (es) 2003-07-02
HRP20030033A2 (en) 2004-02-29
DK1299729T3 (da) 2006-12-04
NO331624B1 (no) 2012-02-06
SK18582002A3 (sk) 2003-05-02
WO2002004954A3 (en) 2002-10-24
ATE426816T1 (de) 2009-04-15
SI1712920T1 (sl) 2009-10-31
PT1299729E (pt) 2006-10-31
NO20030059D0 (no) 2003-01-06
CY1109106T1 (el) 2014-07-02
HK1058065A1 (en) 2004-04-30
AU6408901A (en) 2002-01-21
WO2002004954A2 (en) 2002-01-17
KR100764981B1 (ko) 2007-10-09

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