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EA200300781A1 - Конъюгаты специфичных к иммунным клеткам макролидных соединений и противовоспалительных соединений с улучшенной способностью к целевому поступлению в клетку при противовоспалительной терапии - Google Patents

Конъюгаты специфичных к иммунным клеткам макролидных соединений и противовоспалительных соединений с улучшенной способностью к целевому поступлению в клетку при противовоспалительной терапии

Info

Publication number
EA200300781A1
EA200300781A1 EA200300781A EA200300781A EA200300781A1 EA 200300781 A1 EA200300781 A1 EA 200300781A1 EA 200300781 A EA200300781 A EA 200300781A EA 200300781 A EA200300781 A EA 200300781A EA 200300781 A1 EA200300781 A1 EA 200300781A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
inflammatory
macrolidal
conjugats
specific
Prior art date
Application number
EA200300781A
Other languages
English (en)
Other versions
EA007061B1 (ru
Inventor
Младен Мерчеп
Милан Месич
Линда Томаскович
Марияна Комач
Бошка Хрвачич
Стрибор Маркович
Original Assignee
Плива Д.Д.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Плива Д.Д. filed Critical Плива Д.Д.
Publication of EA200300781A1 publication Critical patent/EA200300781A1/ru
Publication of EA007061B1 publication Critical patent/EA007061B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к новым соединениям, описываемым структурой I, и к их фармацевтическим препаратам, предназначенным для лечения воспалительных заболеваний человека и животных.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300781A 2001-01-09 2002-01-03 Конъюгаты специфичных к иммунным клеткам макролидных соединений и противовоспалительных соединений с улучшенной способностью к целевому поступлению в клетку при противовоспалительной терапии EA007061B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20010018A HRP20010018A2 (en) 2001-01-09 2001-01-09 Novel anti-inflammatory compounds
PCT/HR2002/000001 WO2002055531A1 (en) 2001-01-09 2002-01-03 Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy

Publications (2)

Publication Number Publication Date
EA200300781A1 true EA200300781A1 (ru) 2003-12-25
EA007061B1 EA007061B1 (ru) 2006-06-30

Family

ID=10947235

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300781A EA007061B1 (ru) 2001-01-09 2002-01-03 Конъюгаты специфичных к иммунным клеткам макролидных соединений и противовоспалительных соединений с улучшенной способностью к целевому поступлению в клетку при противовоспалительной терапии

Country Status (23)

Country Link
US (2) US7446097B2 (ru)
EP (1) EP1351973B1 (ru)
JP (1) JP4474101B2 (ru)
CN (1) CN1269836C (ru)
AR (1) AR035727A1 (ru)
AT (1) ATE462713T1 (ru)
BG (1) BG108073A (ru)
BR (1) BR0206347A (ru)
CA (1) CA2434009C (ru)
CZ (1) CZ20031825A3 (ru)
DE (1) DE60235794D1 (ru)
EA (1) EA007061B1 (ru)
EE (1) EE05333B1 (ru)
ES (1) ES2342364T3 (ru)
GE (1) GEP20053607B (ru)
HR (1) HRP20010018A2 (ru)
HU (1) HUP0500180A3 (ru)
IL (1) IL156673A0 (ru)
PL (1) PL207636B1 (ru)
RS (1) RS51308B (ru)
SK (1) SK9792003A3 (ru)
UA (1) UA77166C2 (ru)
WO (1) WO2002055531A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002109169A (ja) * 2000-09-29 2002-04-12 Hitachi Ltd 作業支援方法並びにシステム及び作業支援方法を記録した記録媒体
AU2003211113B2 (en) 2002-02-15 2007-08-09 Merckle Gmbh Antibiotic conjugates
EP1483277A4 (en) * 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2004005310A2 (en) 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
RS20050007A (sr) * 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., NOVE NESTEROIDNE-ANTI- INFLAMATORNE SUPSTANCE, KOMPOZICIJE I POSTUPCI ZA NjIHOVU UPOTREBU
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
HRP20030324A2 (en) * 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
JP4737495B2 (ja) * 2004-01-14 2011-08-03 塩野義製薬株式会社 エリスロマイシン誘導体
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
MX2007001669A (es) * 2004-08-12 2007-04-10 Glaxosmithkline Zagreb Uso de conjugados especificos celulares para el tratamiento de enfermedades inflamatorias del tracto gastrointestinal.
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
ES2337915T3 (es) * 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US20080249034A1 (en) * 2005-03-21 2008-10-09 Zambon S.P.A. Use of Macrolides for Treating Intestinal Inflammation
US20130045939A1 (en) * 2010-03-19 2013-02-21 Catabasis Pharmaceuticals, Inc. Fatty acid macrolide derivatives and their uses
EP3309166A3 (en) * 2013-01-23 2018-08-22 Sphaera Pharma Pvt. Ltd. 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion
EP3795578A3 (en) 2014-07-23 2021-05-26 Sphaera Pharma Pvt. Ltd. Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof
GB201520419D0 (en) * 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
WO2023248010A2 (en) * 2022-06-23 2023-12-28 Synovo Gmbh Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
HU198913B (en) 1987-09-03 1989-12-28 Pliva Pharm & Chem Works Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components
JPH01163124A (ja) * 1987-12-21 1989-06-27 Yamayuu Seikatsushiya:Kk 外用鎮痛消炎消腫消膿剤
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
JP2657982B2 (ja) 1992-12-24 1997-09-30 ローン−プーラン・ロレ・リミテツド 新規ステロイド
EP0775489A4 (en) 1994-08-12 1998-05-06 Taisho Pharmaceutical Co Ltd INTERLEUKIN-5 PRODUCTION INHIBITOR
CA2196879A1 (en) 1994-08-12 1996-02-22 Akihiko Hoshino Interleukin-5 production inhibitor
DE19542949A1 (de) 1995-11-17 1997-07-17 Hilti Ag Bolzen zum Eintreiben in harte Aufnahmewerkstoffe
CA2252886C (en) 1996-04-26 2008-02-12 Massachusetts Institute Of Technology Three-hybrid screening assay
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
EP1085846A2 (en) * 1998-06-08 2001-03-28 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
AU4549999A (en) * 1998-06-08 1999-12-30 Advanced Medicine, Inc. Novel polyene macrolide compounds and uses
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS

Also Published As

Publication number Publication date
HK1065320A1 (en) 2005-02-18
EP1351973B1 (en) 2010-03-31
US20040198677A1 (en) 2004-10-07
EE05333B1 (et) 2010-08-16
US7446097B2 (en) 2008-11-04
YU55203A (sh) 2006-03-03
SK9792003A3 (en) 2004-01-08
PL207636B1 (pl) 2011-01-31
CN1269836C (zh) 2006-08-16
CZ20031825A3 (cs) 2003-11-12
JP2004518670A (ja) 2004-06-24
EA007061B1 (ru) 2006-06-30
JP4474101B2 (ja) 2010-06-02
DE60235794D1 (de) 2010-05-12
US7928078B2 (en) 2011-04-19
HUP0500180A3 (en) 2009-12-28
CN1491230A (zh) 2004-04-21
WO2002055531A1 (en) 2002-07-18
ATE462713T1 (de) 2010-04-15
UA77166C2 (en) 2006-11-15
PL363478A1 (en) 2004-11-15
EP1351973A1 (en) 2003-10-15
RS51308B (sr) 2010-12-31
BR0206347A (pt) 2004-02-10
HUP0500180A2 (en) 2006-09-28
ES2342364T3 (es) 2010-07-06
CA2434009C (en) 2009-09-29
HRP20010018A2 (en) 2002-12-31
AR035727A1 (es) 2004-07-07
CA2434009A1 (en) 2002-07-18
GEP20053607B (en) 2005-09-12
IL156673A0 (en) 2004-01-04
US20090105163A1 (en) 2009-04-23
BG108073A (bg) 2005-05-31
EE200300293A (et) 2003-10-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU