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DZ2515A1 - Dérivés de macrolides substitués en position c-4. - Google Patents

Dérivés de macrolides substitués en position c-4.

Info

Publication number
DZ2515A1
DZ2515A1 DZ980125A DZ980125A DZ2515A1 DZ 2515 A1 DZ2515 A1 DZ 2515A1 DZ 980125 A DZ980125 A DZ 980125A DZ 980125 A DZ980125 A DZ 980125A DZ 2515 A1 DZ2515 A1 DZ 2515A1
Authority
DZ
Algeria
Prior art keywords
derivatives substituted
macrolide derivatives
macrolide
substituted
derivatives
Prior art date
Application number
DZ980125A
Other languages
English (en)
Inventor
Brian Scott Bronk
Takushi Kaneko
Michael Anthony Letavic
Hengmiao Cheng
Edward Alan Glazer
Beingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DZ2515A1 publication Critical patent/DZ2515A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DZ980125A 1997-06-11 1998-06-10 Dérivés de macrolides substitués en position c-4. DZ2515A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
DZ2515A1 true DZ2515A1 (fr) 2003-02-01

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ980125A DZ2515A1 (fr) 1997-06-11 1998-06-10 Dérivés de macrolides substitués en position c-4.

Country Status (39)

Country Link
EP (1) EP0988309B1 (fr)
JP (1) JP3262806B2 (fr)
KR (1) KR100369959B1 (fr)
CN (1) CN1145636C (fr)
AP (1) AP1189A (fr)
AR (1) AR013085A1 (fr)
AT (1) ATE310742T1 (fr)
AU (1) AU745006C (fr)
BG (1) BG64357B1 (fr)
BR (1) BR9810097A (fr)
CA (1) CA2293397C (fr)
CO (1) CO4950584A1 (fr)
DE (1) DE69832486T2 (fr)
DZ (1) DZ2515A1 (fr)
EA (1) EA002440B1 (fr)
ES (1) ES2251081T3 (fr)
GT (1) GT199800075A (fr)
HN (1) HN1998000074A (fr)
HR (1) HRP980315A2 (fr)
HU (1) HUP0004076A3 (fr)
ID (1) ID24530A (fr)
IL (1) IL132808A (fr)
IS (1) IS1979B (fr)
MA (1) MA24563A1 (fr)
MY (1) MY133027A (fr)
NO (1) NO315560B1 (fr)
NZ (1) NZ500652A (fr)
OA (1) OA11226A (fr)
PA (1) PA8452001A1 (fr)
PE (1) PE79999A1 (fr)
PL (1) PL337497A1 (fr)
SK (1) SK168299A3 (fr)
TN (1) TNSN98084A1 (fr)
TW (2) TW200418871A (fr)
UA (1) UA70298A (fr)
UY (1) UY25041A1 (fr)
WO (1) WO1998056801A1 (fr)
YU (1) YU62999A (fr)
ZA (1) ZA985016B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1779853A3 (fr) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides en tant qu'agents anti-microbiens à usage vétérinaire
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
DK1011689T3 (da) * 1997-09-10 2007-05-21 Merial Ltd Anvendelse af 9a-azalider som veterinære antimikrobielle midler
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (fr) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11-carbamates des macrolides antibactériens
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
TR200200434T2 (tr) 1998-11-03 2002-09-23 Pfizer Products Inc. Yeni makrolit antibiyotikler.
CA2411293A1 (fr) * 1999-01-28 2000-07-28 Pfizer Products Inc. Nouveaux azalides et procede de fabrication
DE60025370T2 (de) * 1999-08-24 2006-09-21 Abbott Laboratories, Abbott Park 9a-azalide mit antibakterieller wirkung
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
WO2001055158A1 (fr) 2000-01-27 2001-08-02 Pfizer Products Inc. Compositions antibiotiques a base d'azalide
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
WO2004005310A2 (fr) 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. Nouveaux composes, compositions et procedes pour traiter les maladies et etats inflammatoires
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
RS20050007A (sr) * 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., NOVE NESTEROIDNE-ANTI- INFLAMATORNE SUPSTANCE, KOMPOZICIJE I POSTUPCI ZA NjIHOVU UPOTREBU
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
EP3738591A3 (fr) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Nouveaux agents antibactériens
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
JPWO2009019868A1 (ja) 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
US9072759B2 (en) 2008-10-24 2015-07-07 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN103080121B (zh) * 2010-09-20 2015-11-25 瑞士诺华动物保健有限公司 用于制备在二脱氧甲基己糖环的C-4”处被环氧基团修饰的9-脱氧-9a-氮杂-9a-高红霉素A的新方法
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
IN2014DN08939A (fr) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
MX377459B (es) 2013-04-04 2025-03-10 Harvard College Macrolidos y metodos para su preparacion y uso.
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
WO2016057798A1 (fr) 2014-10-08 2016-04-14 President And Fellows Of Harvard College Kétolides à 14 chaînons et leurs procédés de préparation et d'utilisation
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
US11771677B2 (en) * 2020-03-12 2023-10-03 Zoetis Services Llc Immunomodulating urea azalides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
DE3475073D1 (en) * 1983-09-06 1988-12-15 Pfizer Azahomoerythromycin b derivatives and intermediates thereof
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (fr) * 1991-04-04 1998-08-04 James V. Heck Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
AU7228198A (en) 1998-12-30
DE69832486D1 (de) 2005-12-29
PL337497A1 (en) 2000-08-28
NO996107D0 (no) 1999-12-10
OA11226A (en) 2003-07-16
PE79999A1 (es) 1999-08-25
BG103969A (en) 2000-07-31
HN1998000074A (es) 1999-01-08
HRP980315A2 (en) 1999-04-30
BG64357B1 (bg) 2004-11-30
DE69832486T2 (de) 2006-07-27
AU745006B2 (en) 2002-03-07
HUP0004076A2 (hu) 2001-04-28
GT199800075A (es) 1999-11-30
ZA985016B (en) 1999-12-10
AP9801254A0 (en) 1998-06-30
ID24530A (id) 2000-07-20
TNSN98084A1 (fr) 2005-03-15
MY133027A (en) 2007-10-31
CA2293397C (fr) 2004-08-31
HUP0004076A3 (en) 2003-05-28
CO4950584A1 (es) 2000-09-01
AR013085A1 (es) 2000-12-13
CN1259955A (zh) 2000-07-12
IS5250A (is) 1999-11-16
SK168299A3 (en) 2000-09-12
TWI224106B (en) 2004-11-21
ATE310742T1 (de) 2005-12-15
NO996107L (no) 2000-02-10
IS1979B (is) 2005-01-14
EP0988309A1 (fr) 2000-03-29
YU62999A (sh) 2002-10-18
AP1189A (en) 2003-07-16
IL132808A0 (en) 2001-03-19
EA002440B1 (ru) 2002-04-25
NZ500652A (en) 2001-10-26
JP2000514097A (ja) 2000-10-24
UA70298C2 (uk) 2004-10-15
CN1145636C (zh) 2004-04-14
JP3262806B2 (ja) 2002-03-04
WO1998056801A1 (fr) 1998-12-17
PA8452001A1 (es) 2000-05-24
ES2251081T3 (es) 2006-04-16
EA199901014A1 (ru) 2000-06-26
MA24563A1 (fr) 1998-12-31
BR9810097A (pt) 2000-08-08
KR100369959B1 (ko) 2003-02-12
EP0988309B1 (fr) 2005-11-23
UY25041A1 (es) 2000-09-29
AU745006C (en) 2006-02-23
CA2293397A1 (fr) 1998-12-17
IL132808A (en) 2004-08-31
UA70298A (uk) 2004-10-15
TW200418871A (en) 2004-10-01
HK1025974A1 (en) 2000-12-01
KR20010013633A (ko) 2001-02-26
NO315560B1 (no) 2003-09-22

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