NO996107L - C-4"-substituerte makrolidderivater - Google Patents

C-4"-substituerte makrolidderivater

Info

Publication number: NO996107L
Authority: NO; Norway
Prior art keywords: macrolide derivatives; substituted macrolide; substituted; derivatives; macrolide
Prior art date: 1997-06-11

Application number

NO996107A

Other languages

English (en)

Other versions

NO315560B1 (no

NO996107D0 (no

Inventor

Brian Scott Bronk

Takushi Kaneko

Michael Anthony Letavic

Hengmiao Cheng

Edward Alan Glazer

Bingwei Vera Yang

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-11

Filing date

1999-12-10

Publication date

2000-02-10

1999-12-10 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

1999-12-10 Publication of NO996107D0 publication Critical patent/NO996107D0/no

2000-02-10 Publication of NO996107L publication Critical patent/NO996107L/no

2003-09-22 Publication of NO315560B1 publication Critical patent/NO315560B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO19996107A 1997-06-11 1999-12-10 C-4"-substituerte makrolidderivater og fremgangsmåte for fremstilling derav, samt farmasöytisk blanding NO315560B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4998097P	1997-06-11	1997-06-11
PCT/IB1998/000799 WO1998056801A1 (en)	1997-06-11	1998-05-25	C-4''-substituted macrolide derivatives

Publications (3)

Publication Number	Publication Date
NO996107D0 NO996107D0 (no)	1999-12-10
NO996107L true NO996107L (no)	2000-02-10
NO315560B1 NO315560B1 (no)	2003-09-22

Family

ID=21962765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19996107A NO315560B1 (no)	1997-06-11	1999-12-10	C-4"-substituerte makrolidderivater og fremgangsmåte for fremstilling derav, samt farmasöytisk blanding

Country Status (39)

Country	Link
EP (1)	EP0988309B1 (no)
JP (1)	JP3262806B2 (no)
KR (1)	KR100369959B1 (no)
CN (1)	CN1145636C (no)
AP (1)	AP1189A (no)
AR (1)	AR013085A1 (no)
AT (1)	ATE310742T1 (no)
AU (1)	AU745006C (no)
BG (1)	BG64357B1 (no)
BR (1)	BR9810097A (no)
CA (1)	CA2293397C (no)
CO (1)	CO4950584A1 (no)
DE (1)	DE69832486T2 (no)
DZ (1)	DZ2515A1 (no)
EA (1)	EA002440B1 (no)
ES (1)	ES2251081T3 (no)
GT (1)	GT199800075A (no)
HN (1)	HN1998000074A (no)
HR (1)	HRP980315A2 (no)
HU (1)	HUP0004076A3 (no)
ID (1)	ID24530A (no)
IL (1)	IL132808A (no)
IS (1)	IS1979B (no)
MA (1)	MA24563A1 (no)
MY (1)	MY133027A (no)
NO (1)	NO315560B1 (no)
NZ (1)	NZ500652A (no)
OA (1)	OA11226A (no)
PA (1)	PA8452001A1 (no)
PE (1)	PE79999A1 (no)
PL (1)	PL337497A1 (no)
SK (1)	SK168299A3 (no)
TN (1)	TNSN98084A1 (no)
TW (2)	TWI224106B (no)
UA (1)	UA70298C2 (no)
UY (1)	UY25041A1 (no)
WO (1)	WO1998056801A1 (no)
YU (1)	YU62999A (no)
ZA (1)	ZA985016B (no)

Families Citing this family (38)

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DK1011689T3 (da) *	1997-09-10	2007-05-21	Merial Ltd	Anvendelse af 9a-azalider som veterinære antimikrobielle midler
EP1779853A3 (en) *	1997-09-10	2010-01-27	Merial Ltd.	9a-azalides as veterinary antimicrobial agents
US6339063B1 (en)	1997-09-10	2002-01-15	Merck & Co., Inc.	9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) *	1998-01-02	1998-12-31	Pfizer Prod Inc	Novel macrolides.
EP1437360A3 (en) *	1998-08-19	2005-04-06	Pfizer Products Inc.	C11 Carbamates of macrolide antibacterials
US6043227A (en) *	1998-08-19	2000-03-28	Pfizer Inc.	C11 carbamates of macrolide antibacterials
US6100240A (en) *	1998-10-09	2000-08-08	Pfizer Inc	Macrolide derivatives
CZ20011512A3 (cs)	1998-11-03	2001-09-12	Pfizer Products Inc.	Nová makrolidová antibiotika
CA2292359C (en) *	1999-01-28	2004-09-28	Pfizer Products Inc.	Novel azalides and methods of making same
BR0009101A (pt) *	1999-08-24	2002-02-05	Abbott Lab	9a-azalidas com atividade antibacteriana
US6764996B1 (en)	1999-08-24	2004-07-20	Abbott Laboratories	9a-azalides with antibacterial activity
AU779748C (en) *	2000-01-27	2005-12-08	Zoetis Services Llc	Azalide antibiotic compositions
CN1297564C (zh) *	2001-04-27	2007-01-31	辉瑞产品公司	4″－取代－9－脱氧－9a－氮杂－9a－高红霉素A衍生物的制备方法
JP2003040782A (ja) *	2001-05-31	2003-02-13	Pfizer Prod Inc	アザリド抗生物質組成物
AU2003255851B2 (en)	2002-07-08	2009-07-23	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	New compounds, compositions and methods for treatment of inflammatory diseases and conditions
ES2325495T3 (es)	2002-07-08	2009-09-07	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
AU2003255849A1 (en) *	2002-07-08	2004-01-23	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
US7091196B2 (en)	2002-09-26	2006-08-15	Rib-X Pharmaceuticals, Inc.	Bifunctional heterocyclic compounds and methods of making and using same
EP1638549A4 (en) *	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	NEW ANTIBACTERIAL AGENTS
US7276487B2 (en)	2003-09-23	2007-10-02	Enanta Pharmaceuticals, Inc.	9a, 11-3C-bicyclic 9a-azalide derivatives
EP1723159B1 (en)	2004-02-27	2019-06-12	Melinta Therapeutics, Inc.	Macrocyclic compounds and methods of making and using the same
WO2009019868A1 (ja)	2007-08-06	2009-02-12	Taisho Pharmaceutical Co., Ltd.	１０ａ、１２位架橋型１０ａ－アザライド化合物
US9453042B2 (en)	2007-10-25	2016-09-27	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
JPWO2009139181A1 (ja)	2008-05-15	2011-09-15	大正製薬株式会社	４員環構造を有する１０ａ−アザライド化合物
HRP20160222T1 (hr)	2008-10-24	2016-04-08	Cempra Pharmaceuticals, Inc.	Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
WO2012038372A1 (en) *	2010-09-20	2012-03-29	Novartis Ag	Novel process for the preparation of 9-deoxo-9a-aza- 9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
AR085286A1 (es) *	2011-02-21	2013-09-18	Taisho Pharmaceutical Co Ltd	Derivado de macrolido sustituido en la posicion c-4
IN2014DN08939A (no)	2012-03-27	2015-05-22	Cempra Pharmaceuticals Inc
JP5857008B2 (ja) *	2012-08-20	2016-02-10	大正製薬株式会社	Ｃ−４”位置換マクロライド誘導体を含有する医薬
MX377459B (es)	2013-04-04	2025-03-10	Harvard College	Macrolidos y metodos para su preparacion y uso.
CN105669798B (zh) *	2013-08-23	2019-07-26	普莱柯生物工程股份有限公司	一种大环内酯类化合物
CN103965273B (zh) *	2013-08-23	2016-05-25	普莱柯生物工程股份有限公司	一种大环内酯类化合物
AR102810A1 (es)	2014-08-18	2017-03-29	Taisho Pharmaceutical Co Ltd	Derivado de macrólido sustituido en la posición c-4
WO2016057798A1 (en)	2014-10-08	2016-04-14	President And Fellows Of Harvard College	14-membered ketolides and methods of their preparation and use
WO2016154591A1 (en)	2015-03-25	2016-09-29	President And Fellows Of Harvard College	Macrolides with modified desosamine sugars and uses thereof
CN108003207B (zh)	2017-12-19	2019-05-10	海门慧聚药业有限公司	制备泰拉霉素的方法
TWI847935B (zh) *	2020-03-12	2024-07-01	美商碩騰服務公司	氮雜內酯

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE445223B (sv) *	1977-02-04	1986-06-09	Pfizer	Sett att framstella 4"-amino-erytomylin-a-derivat
US4150220A (en) *	1977-02-04	1979-04-17	Pfizer Inc.	Semi-synthetic 4"-erythromycin A derivatives
YU43006B (en) *	1981-03-06	1989-02-28	Pliva Pharm & Chem Works	Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
GR80277B (en) *	1983-09-06	1985-01-04	Pfizer	Azahomoerythromycin b derivatives and intermediates therefor
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) *	1991-04-04	1998-08-04	James V. Heck	9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5441939A (en) *	1994-03-04	1995-08-15	Pfizer Inc.	3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) *	1994-03-10	1995-05-09	Potts; James K.	Windsock support

1998
- 1998-05-20 HN HN1998000074A patent/HN1998000074A/es unknown
- 1998-05-22 PA PA19988452001A patent/PA8452001A1/es unknown
- 1998-05-25 JP JP50192999A patent/JP3262806B2/ja not_active Expired - Fee Related
- 1998-05-25 EA EA199901014A patent/EA002440B1/ru not_active IP Right Cessation
- 1998-05-25 KR KR10-1999-7011643A patent/KR100369959B1/ko not_active Expired - Fee Related
- 1998-05-25 HU HU0004076A patent/HUP0004076A3/hu unknown
- 1998-05-25 YU YU62999A patent/YU62999A/sh unknown
- 1998-05-25 SK SK1682-99A patent/SK168299A3/sk unknown
- 1998-05-25 CA CA002293397A patent/CA2293397C/en not_active Expired - Fee Related
- 1998-05-25 PL PL98337497A patent/PL337497A1/xx unknown
- 1998-05-25 DE DE69832486T patent/DE69832486T2/de not_active Expired - Fee Related
- 1998-05-25 IL IL13280898A patent/IL132808A/en not_active IP Right Cessation
- 1998-05-25 BR BR9810097-1A patent/BR9810097A/pt not_active IP Right Cessation
- 1998-05-25 UA UA99126737A patent/UA70298C2/uk unknown
- 1998-05-25 NZ NZ500652A patent/NZ500652A/en unknown
- 1998-05-25 AT AT98919414T patent/ATE310742T1/de not_active IP Right Cessation
- 1998-05-25 CN CNB988060493A patent/CN1145636C/zh not_active Expired - Fee Related
- 1998-05-25 ID IDW991565A patent/ID24530A/id unknown
- 1998-05-25 ES ES98919414T patent/ES2251081T3/es not_active Expired - Lifetime
- 1998-05-25 AU AU72281/98A patent/AU745006C/en not_active Ceased
- 1998-05-25 WO PCT/IB1998/000799 patent/WO1998056801A1/en not_active Ceased
- 1998-05-25 EP EP98919414A patent/EP0988309B1/en not_active Expired - Lifetime
- 1998-06-04 AP APAP/P/1998/001254A patent/AP1189A/en active
- 1998-06-08 PE PE1998000469A patent/PE79999A1/es not_active Application Discontinuation
- 1998-06-08 TW TW087109085A patent/TWI224106B/zh active
- 1998-06-08 TW TW093111859A patent/TW200418871A/zh unknown
- 1998-06-08 GT GT199800075A patent/GT199800075A/es unknown
- 1998-06-09 AR ARP980102704A patent/AR013085A1/es active IP Right Grant
- 1998-06-09 MY MYPI98002563A patent/MY133027A/en unknown
- 1998-06-10 CO CO98033231A patent/CO4950584A1/es unknown
- 1998-06-10 DZ DZ980125A patent/DZ2515A1/xx active
- 1998-06-10 MA MA25106A patent/MA24563A1/fr unknown
- 1998-06-10 ZA ZA9805016A patent/ZA985016B/xx unknown
- 1998-06-10 TN TNTNSN98084A patent/TNSN98084A1/fr unknown
- 1998-06-11 HR HR60/049,980A patent/HRP980315A2/hr not_active Application Discontinuation
- 1998-06-11 UY UY25041A patent/UY25041A1/es not_active IP Right Cessation
1999
- 1999-11-16 IS IS5250A patent/IS1979B/is unknown
- 1999-12-03 OA OA9900270A patent/OA11226A/en unknown
- 1999-12-08 BG BG103969A patent/BG64357B1/bg unknown
- 1999-12-10 NO NO19996107A patent/NO315560B1/no unknown

Also Published As

Publication number	Publication date
AP9801254A0 (en)	1998-06-30
CA2293397A1 (en)	1998-12-17
OA11226A (en)	2003-07-16
HUP0004076A3 (en)	2003-05-28
EA002440B1 (ru)	2002-04-25
GT199800075A (es)	1999-11-30
AR013085A1 (es)	2000-12-13
NO315560B1 (no)	2003-09-22
ATE310742T1 (de)	2005-12-15
UA70298A (uk)	2004-10-15
PL337497A1 (en)	2000-08-28
KR100369959B1 (ko)	2003-02-12
HN1998000074A (es)	1999-01-08
EP0988309A1 (en)	2000-03-29
JP2000514097A (ja)	2000-10-24
MA24563A1 (fr)	1998-12-31
AP1189A (en)	2003-07-16
YU62999A (sh)	2002-10-18
CN1259955A (zh)	2000-07-12
KR20010013633A (ko)	2001-02-26
UY25041A1 (es)	2000-09-29
CA2293397C (en)	2004-08-31
IL132808A (en)	2004-08-31
TWI224106B (en)	2004-11-21
HRP980315A2 (en)	1999-04-30
EA199901014A1 (ru)	2000-06-26
AU745006C (en)	2006-02-23
SK168299A3 (en)	2000-09-12
AU745006B2 (en)	2002-03-07
ES2251081T3 (es)	2006-04-16
DE69832486T2 (de)	2006-07-27
NO996107D0 (no)	1999-12-10
IL132808A0 (en)	2001-03-19
TW200418871A (en)	2004-10-01
DE69832486D1 (de)	2005-12-29
IS1979B (is)	2005-01-14
HK1025974A1 (en)	2000-12-01
PA8452001A1 (es)	2000-05-24
AU7228198A (en)	1998-12-30
UA70298C2 (uk)	2004-10-15
ZA985016B (en)	1999-12-10
PE79999A1 (es)	1999-08-25
BG103969A (en)	2000-07-31
BG64357B1 (bg)	2004-11-30
MY133027A (en)	2007-10-31
JP3262806B2 (ja)	2002-03-04
NZ500652A (en)	2001-10-26
WO1998056801A1 (en)	1998-12-17
IS5250A (is)	1999-11-16
EP0988309B1 (en)	2005-11-23
CO4950584A1 (es)	2000-09-01
HUP0004076A2 (hu)	2001-04-28
DZ2515A1 (fr)	2003-02-01
ID24530A (id)	2000-07-20
CN1145636C (zh)	2004-04-14
BR9810097A (pt)	2000-08-08
TNSN98084A1 (fr)	2005-03-15

Publication	Publication Date	Title
NO996107L (no)	2000-02-10	C-4"-substituerte makrolidderivater
NL300150I2 (nl)	2004-09-01	4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.
ATE340176T1 (de)	2006-10-15	Substituierte 6,5-heterobicyclische-derivate
NO983169L (no)	1998-09-09	Hetrosykel-kondenserte morfinoidderivater (31)
DK1000048T3 (da)	2003-03-03	Substituerede 1,2,3,4-tetrahydronapthalenderivater
IS5251A (is)	1999-11-16	9-oxím erýþrómýsín afleiður
ATE377018T1 (de)	2007-11-15	Erythromycinderivate
FI963148L (fi)	1996-08-12	3'-substituoidut nukleosidijohdannaiset
ATE231847T1 (de)	2003-02-15	Substituierte 1,2,3,4- tetrahydronaphthalinderivate
ATE257484T1 (de)	2004-01-15	6,9-verbrückte erythromycin-derivate
ATE239750T1 (de)	2003-05-15	6,11-verbrückte erythromycinderivate
DK1027362T3 (da)	2005-10-31	2-halogen-6-O-substituerede ketolidderivater
ATE231508T1 (de)	2003-02-15	Azyklische nukleosidderivate
DK1032579T3 (da)	2003-08-25	Carbohydratderivater
LV11898A (lv)	1997-12-20	Eritromicina atvasinajumi
ATE215547T1 (de)	2002-04-15	Kohlerhydratderivate
PT1060183E (pt)	2003-08-29	Derivados de 5'-desoxicitidina
EP1044985A4 (en)	2001-04-18	ERYTHROMYCIN
DK1077984T3 (da)	2003-09-15	2'-Deoxyhygromycin derivater
BR9701404A (pt)	1998-11-03	Derivados de 1,25-diidróxi-16,22,23-trisdeidro-colecal-ciferol
PT984975E (pt)	2003-09-30	Derivados de eritromicina multiciclicos
BR1100453A (pt)	2006-05-09	derivados de eritromicina
BR1100649A (pt)	2003-10-07	Derivados de 10,11-metano dibenzo suberano