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DK4008344T3 - Kerne/skal struktur platform til immunterapi - Google Patents

Kerne/skal struktur platform til immunterapi Download PDF

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Publication number
DK4008344T3
DK4008344T3 DK21210308.9T DK21210308T DK4008344T3 DK 4008344 T3 DK4008344 T3 DK 4008344T3 DK 21210308 T DK21210308 T DK 21210308T DK 4008344 T3 DK4008344 T3 DK 4008344T3
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DK
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Prior art keywords
core
shell structure
immune therapy
structure platform
platform
Prior art date
Application number
DK21210308.9T
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English (en)
Other versions
DK4008344T5 (da
Inventor
Haifa Shen
Original Assignee
Methodist Hospital
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Publication of DK4008344T3 publication Critical patent/DK4008344T3/da
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Publication of DK4008344T5 publication Critical patent/DK4008344T5/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/13—B-cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
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    • A61K40/24—Antigen-presenting cells [APC]
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    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK21210308.9T 2017-01-27 2018-01-26 Kerne/skal struktur platform til immunterapi DK4008344T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762451575P 2017-01-27 2017-01-27
EP18715827.4A EP3573656B1 (en) 2017-01-27 2018-01-26 Core/shell structure platform for immunotherapy

Publications (2)

Publication Number Publication Date
DK4008344T3 true DK4008344T3 (da) 2024-01-29
DK4008344T5 DK4008344T5 (da) 2024-08-05

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK21210308.9T DK4008344T5 (da) 2017-01-27 2018-01-26 Kerne/skal struktur platform til immunterapi
DK18715827.4T DK3573656T3 (da) 2017-01-27 2018-01-26 Kerne/skal-struktur-platform til immunterapi

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK18715827.4T DK3573656T3 (da) 2017-01-27 2018-01-26 Kerne/skal-struktur-platform til immunterapi

Country Status (11)

Country Link
US (2) US11382964B2 (da)
EP (3) EP4309739A3 (da)
JP (2) JP7181880B2 (da)
KR (2) KR20240014586A (da)
CN (2) CN109152830B (da)
AU (1) AU2018212887B2 (da)
CA (1) CA3051136A1 (da)
DK (2) DK4008344T5 (da)
ES (2) ES2905591T3 (da)
SG (1) SG11201906744VA (da)
WO (1) WO2018140826A1 (da)

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JP7659497B2 (ja) * 2019-01-12 2025-04-09 ザ・メソジスト・ホスピタル 自己組織化ペプチドナノ粒子およびその使用
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DE102019122014A1 (de) * 2019-08-15 2021-02-18 Technische Universität Darmstadt Reduktion der Knochenresorption, insbesondere bei chronischen Gelenkerkrankungen
US20220370488A1 (en) * 2019-10-22 2022-11-24 The Johns Hopkins University Mucus penetrating particle compositions and methods of use thereof enhancing immune response
KR102579284B1 (ko) * 2020-09-22 2023-09-18 비피진 주식회사 신규의 cd47 바인더와 폴리뉴클레오티드를 포함하는 암 치료를 위한 리포좀 복합체
CN112245575B (zh) * 2020-10-26 2024-07-26 上海杏禾医疗科技有限公司 含支化聚合物和mRNA的核壳结构的抗肿瘤疫苗及其用途
WO2023034957A1 (en) * 2021-09-03 2023-03-09 University Of Connecticut Stabilization of antigens for long term administration in transdermal microneedle patches
CN114699420A (zh) * 2022-03-08 2022-07-05 南方科技大学 一种用于治疗前列腺癌组合物及其制备方法与应用
CN114699538A (zh) * 2022-04-02 2022-07-05 中国药科大学 一种核-壳式高效基因药物递送系统及其制备方法
BE1031668B1 (fr) * 2023-06-02 2025-01-16 Inhatarget Therapeutics Composition pharmaceutique pour inhalation
BE1031669B1 (fr) * 2023-06-02 2025-01-14 Inhatarget Therapeutics Composition pharmaceutique pour inhalation
CN117045809B (zh) * 2023-09-27 2025-08-29 国家纳米科学中心 异种哺乳动物细胞来源的囊泡在制备疫苗载体中的应用
KR20250063352A (ko) * 2023-11-01 2025-05-08 가톨릭대학교 산학협력단 mRNA가 봉입된 이중 나노입자, 이의 제조방법 및 이의 약학적 용도
CN117442552B (zh) * 2023-11-20 2024-03-26 山东大学 一种淋巴结内t细胞区靶向纳米粒及其水凝胶
CN117883410A (zh) * 2024-01-22 2024-04-16 华中科技大学同济医学院附属协和医院 包封有mRNA及Acod1基因si-RNA的脂质体纳米颗粒及其应用
CN118001254B (zh) 2024-04-09 2024-07-26 北京悦康科创医药科技股份有限公司 靶向抗原呈递细胞的脂质组合物及其应用
DE102024112307A1 (de) * 2024-05-02 2025-11-06 INM - Leibniz-Institut für Neue Materialien gemeinnützige Gesellschaft mit beschränkter Haftung Kompositpartikel
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CN109152830A (zh) 2019-01-04
CN109152830B (zh) 2023-11-03
EP4008344B1 (en) 2023-12-06
KR20240014586A (ko) 2024-02-01
ES2905591T3 (es) 2022-04-11
KR102627347B1 (ko) 2024-01-22
KR20190108150A (ko) 2019-09-23
US20180360756A1 (en) 2018-12-20
ES2973040T3 (es) 2024-06-18
AU2018212887B2 (en) 2024-08-01
JP2020505403A (ja) 2020-02-20
JP2023015346A (ja) 2023-01-31
CA3051136A1 (en) 2018-08-02
DK4008344T5 (da) 2024-08-05
SG11201906744VA (en) 2019-08-27
EP4309739A3 (en) 2024-04-17
EP4008344A1 (en) 2022-06-08
WO2018140826A1 (en) 2018-08-02
EP3573656A1 (en) 2019-12-04
AU2018212887A1 (en) 2019-08-08
JP7181880B2 (ja) 2022-12-01
EP3573656B1 (en) 2021-12-22
WO2018140826A9 (en) 2018-10-11
US11382964B2 (en) 2022-07-12
DK3573656T3 (da) 2022-03-14
US20220305103A1 (en) 2022-09-29
EP4309739A2 (en) 2024-01-24
CN115845040A (zh) 2023-03-28

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