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DK3453721T3 - Process of manufacture of annexin v - Google Patents

Process of manufacture of annexin v Download PDF

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Publication number
DK3453721T3
DK3453721T3 DK18182321.2T DK18182321T DK3453721T3 DK 3453721 T3 DK3453721 T3 DK 3453721T3 DK 18182321 T DK18182321 T DK 18182321T DK 3453721 T3 DK3453721 T3 DK 3453721T3
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DK
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Prior art keywords
annexin
manufacture
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Application number
DK18182321.2T
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English (en)
Inventor
Toomas Moks
Jan Christoph Reich
Original Assignee
Annexin Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Annexin Pharmaceuticals Ab filed Critical Annexin Pharmaceuticals Ab
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Publication of DK3453721T3 publication Critical patent/DK3453721T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pain & Pain Management (AREA)
DK18182321.2T 2015-09-17 2016-09-16 Process of manufacture of annexin v DK3453721T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1516516.0A GB2542391A (en) 2015-09-17 2015-09-17 Process of manufacture
EP16766559.5A EP3283506B1 (en) 2015-09-17 2016-09-16 Process of manufacture of annexin v

Publications (1)

Publication Number Publication Date
DK3453721T3 true DK3453721T3 (da) 2022-06-07

Family

ID=54544424

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18182321.2T DK3453721T3 (da) 2015-09-17 2016-09-16 Process of manufacture of annexin v
DK16766559.5T DK3283506T3 (da) 2015-09-17 2016-09-16 Fremgangsmåde til fremstilling af annexin v

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK16766559.5T DK3283506T3 (da) 2015-09-17 2016-09-16 Fremgangsmåde til fremstilling af annexin v

Country Status (11)

Country Link
US (3) US11773134B2 (da)
EP (3) EP3283506B1 (da)
JP (5) JP6689371B2 (da)
CN (3) CN108137662B (da)
CA (2) CA3193026A1 (da)
DK (2) DK3453721T3 (da)
ES (2) ES2920156T3 (da)
GB (1) GB2542391A (da)
HK (1) HK1251580B (da)
PL (2) PL3283506T3 (da)
WO (1) WO2017046391A2 (da)

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GB2542391A (en) * 2015-09-17 2017-03-22 Annexin Pharmaceuticals Ab Process of manufacture
EP3495376A1 (en) * 2017-12-05 2019-06-12 ChromaCon AG Improved chromatographic process for cell culture harvest
EP3560945A1 (en) * 2018-04-27 2019-10-30 F. Hoffmann-La Roche AG Methods for purification of polypeptides using polysorbates
JP7352555B2 (ja) * 2018-08-31 2023-09-28 株式会社カネカ 抗体または抗体様分子の精製方法
TWI871300B (zh) * 2019-01-28 2025-02-01 美商安進公司 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程
CN110669141A (zh) * 2019-09-29 2020-01-10 杭州联科生物技术股份有限公司 一种别藻蓝蛋白(APC)与Annexin V蛋白偶联方法
TW202146042A (zh) * 2020-03-06 2021-12-16 瑞典商阿斯特捷利康公司 用於治療動脈和靜脈血栓形成的協同且靶向的組成物
CN111378005B (zh) * 2020-04-03 2021-08-17 安徽环球基因科技有限公司 一种可调式纯化蛋白装置
CN112057623A (zh) * 2020-06-03 2020-12-11 江苏靶标生物医药研究所有限公司 一种磷脂酰丝氨酸在制备治疗炎症性肠病药物中的应用
EP4444738A2 (en) * 2021-12-08 2024-10-16 Ferring B.V. Method of protein purification
CN114539383B (zh) * 2022-02-24 2024-03-26 南京大学 一种人源膜联蛋白人源膜联蛋白a5突变体二聚体的晶体结构的制备方法和应用
GB202207263D0 (en) * 2022-05-18 2022-06-29 Annexin Pharmaceuticals Ab Therapeutic compositions
CN118001376A (zh) * 2023-02-27 2024-05-10 上海萨美细胞技术有限公司 膜联蛋白a5在生发、育发、护发、防脱发以及治疗脱发中的用途和相关产品和药物组合物
WO2024236190A1 (en) * 2023-05-18 2024-11-21 Annexin Pharmaceuticals Ab Monomeric annexin a5 for use in the treatment of macular oedema or retinal vein occlusion
CN119158000B (zh) * 2023-10-25 2025-07-18 上海萨美细胞技术有限公司 一种用于治疗肺纤维化的药物

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